Cathepsin B contributes to traumatic brain injury-induced cell death through a mitochondria-mediated apoptotic pathway

Journal of Neuroscience Research

Volumn 88, Issue 13, 2010, Pages 2847-2858

  Luo, Cheng Liang ^a   Chen, Xi Ping ^a   Yang, Rui ^a   Sun, Yu Xia ^a   Li, Qian Qian ^a   Bao, Hai Jun ^a   Cao, Qiang Qiang ^a   Ni, Hong ^a   Qin, Zheng Hong ^a   Tao, Lu Yang ^a,b  

^a SOOCHOW UNIVERSITY   (China)

^b Shanghai Key Laboratory of Forensic Medicine   (China)

Author keywords

Apoptosis; Caspase 3; Cathepsin B; tBid; Traumatic brain injury

Indexed keywords

CASPASE 3; CATHEPSIN B; CATHEPSIN B INHIBITOR; CYTOCHROME C; N 3 (PROLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BEHAVIOR DISORDER; BRAIN SLICE; CELL DAMAGE; COGNITIVE DEFECT; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; MALE; MITOCHONDRION; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; UPREGULATION;

ANIMALS; APOPTOSIS; BRAIN INJURIES; CATHEPSIN B; CHAPERONIN 60; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GLIAL FIBRILLARY ACIDIC PROTEIN; MAZE LEARNING; MICE; MITOCHONDRIA; MOTOR ACTIVITY; PROTO-ONCOGENE PROTEINS C-BCL-2; STATISTICS, NONPARAMETRIC; TIME FACTORS; UP-REGULATION;

EID: 77957239085     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22453     Document Type: Article

References (32)

1. Adams JM, Cory S. 2007. Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr Opin Immunol 19:488-496. (Pubitemid 47487452)
2. Arnoult D. 2007. Mitochondrial fragmentation in apoptosis. Trends Cell Biol 17:6-12.
3. Bagci EZ, Vodovotz Y, Billiar TR, Ermentrout GB, Bahar I. 2006. Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophys J 90:1546-1559.
4. Chwieralski CE, Wehe T, Bühling F. 2006. Cathepsin-regulated apoptosis. Apoptosis 11:143-149.
5. Di-Giovanni S, Movsesvan V, Ahmed F, Cernak I, Schinelli S, Stoica B, Faden AI. 2005. Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci U S A 23:8333-8335.
6. Ellis R C, O'steen WA, Hayes RL, Nick HS, Wang KK, Anderson DK. 2005. Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat. Exp Neurol 193:19-28.
7. Feeney DM, Boyeson MG, Linnn RT, Murray HM, Dail WG. 1981. Responses to cortical injury I. Methodology and local effects of contusion in the rat. Brain Res 211:67-77.
8. Fox GB, Fan L, Levasseur RA, Faden AI. 1998. Sustained sensory/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse. J Neurotrauma 15:599-614.
9. Guicciardi ME, Leist M, Gores GJ. 2004. Lysosomes in cell death. Oncogene 23:2881-2890.
10. Halestrap AP, Doran E, Gillespie JP, O'Toole A. 2000. Mitochondria and cell death. Biochem Soc Trans 278:170-177.
11. Hengartner MO. 2000. The biochemistry of apoptosis. Nature 407:770-776.
12. Im E, Venkatakrishnan A, Kazlauskas A. 2005. Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. Mol Biol Cell 16:3488-3500.
13. Jiang X, Wang X. 2000. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1? J Biol Chem 275:159-163.
14. Kim R, Emi M, Tanabe K. 2006. Role of mitochondria as the gardens of cell death. Cancer Chemother Pharmacol 57:545-553. (Pubitemid 43237837)
15. Krysko DV, Vanden-Berghe T, D,Herdek , Vandenabeele P. 2008. Apoptosis and necrosis: detection, discrimination and phagocytosis. Methods 44:205-221.
16. Lin KM, Hsiao G, Shih CM, Chou DS, Sheu JR. 2009. Mechanism of resveratrol-induced platelet apoptosis. Cardiovasc Res 83:575-585.
17. Mammis A, Mclntosh TK, Maniker AH. 2009. Erythropoietin as a neuroprotective agent in traumatic brain injury. Rev Surg Neurol 74:527-531.
18. Qin ZH, Chen RW, Wang Y, Nakai M, Chuang DM, Chase TN. 1999. NF-jB nuclear translocation up-regulates c-Myc and p53 during N-methyl-D-aspartate receptor-mediatedapoptosis. J Neurosci 19:4023-4033.
19. Qin ZH, Wang Y, Kikly KK, Sapp E, Kegel KB, Aronin N, DiFiglia M. 2001. Pro-caspase-8 is predominantly localized in mitochondria and released into cytoplasm upon apoptotic stimulation. J Biol Chem 276:8079-8086. (Pubitemid 33650351)
20. Reiners JJ, Caruso JA, Mathieu P, Chelladurai B, Yin XM, Kessel D. 2002. Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage. Cell Death Differ 9:934-944.
21. Shaw NA. 2002. The neurophysiology of concussion. Prog Neurobiol 67:281-344.
22. Siegel RM, Chan FK, Chun HJ, Lenardo MJ. 2000. The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. Nat Immunol 1:469-474.
23. Tao LY, Chen XP, Ding M. 2003. The study on expression of caspase-1 after brain contusion of different severity in rat. J Forensic Med 19:4-7.
24. Tardy C, Codogno P, Autefage H, Levade T, Andrieu-Abadie N. 2006. Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle). Biochim Biophys Acta 1765:101-112.
25. Tsuchiya K, Kohda Y, Yoshida M, Zhao L, Ueno T, Yamashita J, Yoshioka T, Kominami E, Yamashima T. 1999. Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors. Exp Neurol 155:187-194.
26. Tsukada T, Watanabe M, Yamashima T. 2001. Implications of CAD and DNase II in ischemic neuronal necrosis specific for the primate hippocampus. J Neurochem 79:1196-1206.
27. Uryu K, Laurer H, McIntosh T, Praticò D, Martinez D, Leight S, Lee VM, Trojanowski JQ. 2002. Repetitive mild brain trauma accelerates Ab deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis. J Neurosci 22:446-454.
28. Wang Y, Han R, Liang ZQ, Wu JC, Zhang XD, Gu ZL, Qin ZH. 2008. An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid. Autophagy 4:1-13.
29. Whalen MJ, Dalkara T, You Z, Qiu J, Bermpohl D, Mehta N, Suter B, Bhide PG, Lo EH, Ericsson M, Moskowitz MA. 2008. Acute plasma-lemma permeability and protracted clearance of injured cells after controlled cortical impact in mice. J Cereb Blood Flow Metab 28:490-505. (Pubitemid 351304258)
30. Yamashima T, Kohda Y, Tsuchiya K, Ueno T, Yamashita J, Yoshioka T, Kominami E. 1998. Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on "calpain-cathepsin hypothesis." Eur J Neurosci 10:1723-1733.
31. Zhao M, Eaton JW, Brunk UT. 2001. Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis. FEBS Lett 509:405-412.
32. Zhao Y, Li R, Xia W, Neuzil J, Lu Y, Zhang H, Zhao X, Zhang X, Sun C, Wu K. 2009. Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells. Cancer Lett 288:42-49.