Respiratory chain complex I, a main regulatory target of the cAMP/PKA pathway is defective in different human diseases

FEBS Letters

Volumn 586, Issue 5, 2012, Pages 568-577

  Papa, Sergio ^a,b   Rasmo, Domenico De ^a,e   Technikova Dobrova, Zuzana ^c   Panelli, Damiano ^a   Signorile, Anna ^a   Scacco, Salvatore ^a   Petruzzella, Vittoria ^a   Papa, Francesco ^a   Palmisano, Giuseppe ^d   Gnoni, Antonio ^a   Micelli, Loris ^a   Sardanelli, Anna Maria ^a  

^a UNIVERSITY OF BARI   (Italy)

^b CNR   (Italy)

^c INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^e Institute of Biomembranes and Bioenergetics (IBBE)   (Italy)

Author keywords

cAMP PKA pathway; Complex I; Mitochondrial diseases; NDUFS4

Indexed keywords

ANTIOXIDANT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 3; GRANZYME A; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SIRTUIN 1; SUPEROXIDE; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2;

ALTERNATIVE RNA SPLICING; CATALYSIS; CELL CULTURE; COMPLEX I DEFICIENCY; DOWN SYNDROME; DRUG EFFECT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SUBUNIT; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; RESPIRATORY CHAIN; REVIEW; SIGNAL TRANSDUCTION;

CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ELECTRON TRANSPORT COMPLEX I; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION; NADH DEHYDROGENASE; NERVOUS SYSTEM DISEASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

MAMMALIA; PROKARYOTA;

EID: 84857918871     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.09.019     Document Type: Review

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