Hyperleptinemia is associated with hypertension, systemic inflammation and insulin resistance in overweight but not in normal weight men

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 22, Issue 3, 2012, Pages 300-306

  Galletti, F ^a   D'Elia, L ^a   De Palma, D ^a   Russo, O ^a   Barba, G ^b   Siani, A ^b   Miller, M A ^c   Cappuccio, F P ^c   Rossi, G ^a   Zampa, G ^a   Strazzullo, P ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Adipocytokines; Hypertension; Insulin resistance; Leptin; Obesity

Indexed keywords

AUTACOID; BIOLOGICAL MARKER; C REACTIVE PROTEIN; LEPTIN;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; BLOOD PRESSURE; BODY MASS; CASE CONTROL STUDY; HUMAN; HYPERTENSION; INFLAMMATION; INSULIN RESISTANCE; ITALY; MALE; MIDDLE AGED; OBESITY; PATHOPHYSIOLOGY; RISK; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; STATISTICAL MODEL; UPREGULATION;

ADIPOSITY; ADULT; AGED; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BLOOD PRESSURE; BODY MASS INDEX; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; HUMANS; HYPERTENSION; INFLAMMATION; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; ITALY; LEPTIN; LINEAR MODELS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; OVERWEIGHT; RISK ASSESSMENT; RISK FACTORS; SEX FACTORS; UP-REGULATION;

EID: 84857917242     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.numecd.2011.05.007     Document Type: Article

References (45)

1. Eikelis N., Lambert G., Wiesner G., Kaye D., Schlaich M., Morris M., et al. Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function. Am J Physiol Endocrinol Metab 2004, 286(5):E744-E752.
2. Haynes W.G. Role of leptin in obesity-related hypertension. Exp Physiol 2005, 90:683-688.
3. Rabe K., Lehrke M., Parhofer K.G., Broedl U.C. Adipokines and insulin resistance. Mol Med 2008, 14:741-751.
4. Loffreda S., Yang S.Q., Lin H.Z., Karp C.L., Brengman M.L., Wang D.J., et al. Leptin regulates proinflammatory immune responses. FASEB J 1998, 12:57-65.
5. Rasouli N., Kern P.A. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 2008, 93(11 Suppl. 1):S64-S73.
6. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996, 334:292-295.
7. Barba G., Russo O., Siani A., Iacone R., Farinaro E., Gerardi M.C., et al. Plasma leptin and blood pressure in men: graded association independent of body mass and fat pattern. Obes Res 2003, 11:160-166.
8. Shankar A., Xiao J. Positive relationship between plasma leptin level and hypertension. Hypertension 2010, 56:623-628.
9. Galletti F., D'Elia L., Barba G., Siani A., Cappuccio F.P., Farinaro E., et al. High-circulating leptin levels are associated with greater risk of hypertension in men independently of body mass and insulin resistance: result of an eight-year follow-up study. J Clin Endocrinol Metab 2008, 93:3922-3926.
10. Galletti F., Barbato A., Versiero M., Iacone R., Russo O., Barba G., et al. Circulating leptin levels predict the development of metabolic syndrome in middle-aged men: an 8-year follow-up study. J.Hypertens 2007, 25:1671-1677.
11. Barbato A., Iacone R., Tarantino G., Russo O., Sorrentino P., Avallone S., et al. Olivetti heart study research group. relationships of PAI-1 levels to central obesity and liver steatosis in a sample of adult male population in southern Italy. Intern Emerg Med 2009, 4:315-323.
12. Iacone R., Russo O., Russo P., Venezia A., Varriale V., Gerardi M.C., et al. Plasma leptin measurements in epidemiological investigation: comparison of two commonly used assays and estimate of regression dilution bias. Nutr Metab Cardiovasc Dis 2002, 12:71-79.
13. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
14. Haffner S.M., Mykkanen L., Rainwater D.L., Karhapaa P., Laakso M. Is leptin concentration associated with the insulin resistance syndrome in nondiabetic men?. Obes Res 1999, 7:164-169.
15. Mallamaci F., Cuzzola F., Tripepi G., Cutrupi S., Parlongo S., Tripepi R., et al. Gender-dependent differences in plasma leptin in essential hypertension. Am J Hypertens 2000, 13:914-920.
16. Khokhar K.K., Sidhu S., Kaur G. Correlation between leptin level and hypertension in normal and obese pre- and postmenopausal women. Eur J Endocrinol 2010, 163(6):873-878.
17. Itoh K., Imai K., Masuda T., Abe S., Tanaka M., Koga R., et al. Relationship between changes in serum leptin levels and blood pressure after weight loss. Hypertens Res 2002, 25:881-886.
18. Ma D., Feitosa M.F., Wilk J.B., Abe S., Tanaka M., Koga R., et al. Leptin is associated with blood pressure and hypertension in women from the national heart, lung, and blood institute family heart study. Hypertension 2009, 53:473-479.
19. Aizawa-Abe M., Ogawa Y., Masuzaki H., Ebihara K., Satoh N., Iwai H., et al. Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest 2000, 105:1243-1252.
20. Correia M.L.G., Rahmouni K. Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome diabetes. Obes Metab 2006, 8:603-610.
21. Carlyle M., Jones O.B., Kuo J.J., Hall J.E. Chronic cardiovascular and renal actions of leptin: role of adrenergic activity. Hypertension 2002, 39:496-501.
22. Correia M.L., Morgan D.A., Sivitz W.I., Mark A.L., Haynes W.G. Leptin acts in the central nervous systemto produce dosedependent changes in arterial pressure. Hypertension 2001, 37:936-942.
23. Paolisso G., Tagliamonte M.R., Galderisi M., Zito G.A., Petrocelli A., Carella C., et al. Plasma leptin is associated with myocardial wall thickness in hypertensive insulin-resistant men. Hypertension 1999, 34:1047-1052.
24. Söderberg S., Ahrén B., Stegmayr B., Zito G.A., Petrocelli A., Carella C., et al. Leptin is a risk marker for first-ever hemorrhagic stroke in a population based cohort. Stroke 1999, 30:328-337.
25. Söderberg S., Ahrén B., Jansson J.H., Johnson O., Hallmans G., Asplund K., et al. Leptin is associated with increased risk of myocardial infarction. J Intern Med 1999, 246:409-418.
26. Eikelis N., Schlaich M., Aggarwal A., Kaye D., Esler M. Interactions between leptin and the human sympathetic nervous system. Hypertension 2003, 41:1072-1079.
27. Ihara S., Shimamoto K., Watanabe H., Sakai R., Kawana M. An alpha1-receptor blocker reduces plasma leptin levels in hypertensive patients with obesity and hyperleptinemia. Hypertens Res 2006, 29:805-811.
28. Morgan D.A., Thedens D.R., Weiss R., Rahmouni K. Mechanisms mediating renal sympathetic activation to leptin in obesity. Am J Physiol Regul Integr Comp Physiol 2008, 295:R1730-R1736.
29. Esler M., Straznicky N., Eikelis N., Masuo K., Lambert G., Lambert E. Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension 2006, 48:787-796.
30. Martin S.S., Qasim A., Reilly M.P. Leptin resistance a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol 2008, 52:1201-1210.
31. Singh P., Hoffmann M., Wolk R., Shamsuzzaman A.S., Somers V.K. Leptin induces C-reactive protein expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol 2007, 27:e302-e307.
32. Shamsuzzaman A.S., Winnicki M., Wolk R., Svatikova A., Phillips B.G., Davison D.E., et al. Independent association between plasma leptin and C-reactive protein in healthy humans. Circulation 2004, 109:2181-2185.
33. Mackintosh R.M., Hirsch J. The effects of leptin administration in non-obese human subjects. Obes Res 2001, 9:462-469.
34. Hukshorn C.J., van Dielen F.M., Buurman W.A., Westerterp-Plantenga M.S., Campfield L.A., Saris W.H. The effect of pegylated recombinant human leptin (PEG-OB) on weight loss and inflammatory status in obese subjects. Int J Obes Relat Metab Disord 2002, 26:504-509.
35. Yamagishi S.I., Edelstein D., Du X.L., Kaneda Y., Guzman M., Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 2001, 276:25096-25100.
36. O'Rourke L., Gronning L.M., Yeaman S.J., Shepherd P.R. Glucose dependent regulation of cholesterol ester metabolism in macrophages by insulin and leptin. J Biol Chem 2002, 277:42557-42562.
37. Lam Q.L., Lu L. Role of leptin in immunity. Cell Mol Immunol 2007, 4:1-13.
38. Chen K., Li F., Li J., Cai H., Strom S., Bisello A., et al. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 2006, 12:425-432.
39. Pignatti P., Ciapponi L., Galle P., Hansen M.B., Massa M., Meazza C., et al. High circulating levels of biologically inactive IL-6/SIL-6 receptor complexes in systemic juvenile idiopathic arthritis: evidence for serum factors interfering with the binding to gp130. Clin Exp Immunol 2003, 131:355-363.
40. Seufert J., Kieffer T.J., Leech C.A., Holz G.G., Moritz W., Ricordi C., et al. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab 1999, 84:670-676.
41. Wang J.L., Chinookoswong N., Scully S., Qi M., Shi Z.Q. Differential effects of leptin in regulation of tissue glucose utilization in vivo. Endocrinology 1999, 140:2117-2124.
42. Rossetti L., Massillon D., Barzilai N., Vuguin P., Chen W., Hawkins M., et al. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 1997, 272:27758-27763.
43. Sonnenberg G.E., Krakower G.R., Hoffmann R.G., Maas D.L., Hennes M.M., Kissebah A.H. Plasma leptin concentrations during extended fasting and graded glucose infusions: relationships with changes in glucose, insulin, and FFA. J Clin Endocrinol Metab 2001, 86:4895-4900.
44. Pecoits-Filho R., Nordfors L., Heimbürger O., Lindholm B., Anderstam B., Marchlewska A., et al. Soluble leptin receptors and serum leptin in end-stage renal disease: relationship with inflammation and body composition. Eur J Clin Invest 2002, 32(11):811-817.
45. Risch L., Saely C., Hoefle G., Rein P., Langer P., Gouya G., et al. Relationship between glomerular filtration rate and the adipokines adiponectin, resistin and leptin in coronary patients with predominantly normal or mildly impaired renal function. Clin Chim Acta 2007 Feb, 376(1-2):108-113.