Plasma leptin measurements in epidemiological investigation: Comparison of two commonly used assays and estimate of regression dilution bias

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 12, Issue 2, 2002, Pages 71-79

  Iacone, R ^a   Russo, O ^a   Russo, P ^b   Venezia, A ^b   Varriale, V ^a   Gerardi, M C ^a   Strazzullo, P ^a,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Enzyme linked immunosorbent assay; Human plasma leptin measurement; Intra and inter individual variability; Method comparison; Radio immunoassay

Indexed keywords

LEPTIN;

ADULT; AGED; ARTICLE; BLOOD; COMPARATIVE STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDEMIOLOGY; FEMALE; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; RADIOIMMUNOASSAY; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; BIAS (EPIDEMIOLOGY); ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; LEPTIN; MALE; MIDDLE AGED; RADIOIMMUNOASSAY; SENSITIVITY AND SPECIFICITY;

EID: 0036528448     PISSN: 09394753     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432
2. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F (1995) Effects of the obese gene product on body regulation in ob/ob mice. Science 269: 540-543
3. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM (1995) Weight reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546
4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549
5. Tartaglia LA, Dembsky M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, et al (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271
6. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379: 632-635
7. Stephens TW, Basinski M, Bristow PK, Blue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, et al (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377: 530-532
8. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252
9. Rohner-Jeanrenaud F, Cusin I, Sainsbury A, Zakrzewska KE, Jeanrenaud B (1996) The loop system between neuropeptide Y and leptin in normal and obese rodents. Horm Metab Res 28: 642-648
10. Barash IA, Cheung CC, Weigle DS, Ren H, Kabingting EB, Kuijper JL, Clifton DK, Steiner RA (1996) Leptin is a metabolic signal to the reproductive system. Endocrinology 137: 3144-3147
11. Carro E, Senaris R, Considine RV, Casanueva FF, Dieguez C (1997) Regulation of in vivo growth hormone secretion by leptin. Endocrinology 138: 2203-2205
12. Chehab FF, Lim ME, Lu R (1997) Early onset of reproductive function in normal female mice treated with leptin. Science 275: 88-90
13. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295
14. Ma Z, Gingerich RL, Klein S, Smith CH, Landt M (1996) Radioimmunoassay of leptin in human plasma. Clin Chem 42: 942-946
15. Horn R, Geldszus R, Potter E, von zur Mühlen A, Brabant G (1996) Radioimmunoassay for the detection of leptin in human serum. Exp Clin Endocrinol Diabetes 104: 454-458
16. McGregor GP, Desaga JF, Ehlenz K, Fischer A, Heese F, Hegele A, Lammer C, Peiser C, Lang RE (1996) Radioimmunological measurement of leptin in plasma of obese and diabetic human subjects. Endocrinology 137: 1501-1504
17. Hardie LJ, Rayner DV, Holmes S, Trayhurn P (1996) Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Commun 25: 660-665
18. Rosenbaun M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL (1996) Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81: 3424-3427
19. Imagawa K, Matsumoto Y, Numata Y, Morita A, Kikuoka S, Tamaki M, Higashikubo C, Tsuji T, Sasakura K, Teraoka H, Masuzaki H, Hosoda K, Ogawa Y, Nakao K (1998) Development of a sensitive ELISA for human leptin, using monoclonal antibodies. Clin Chem 44: 2165-2171
20. Carlson MG, Snead WL, Oeser AM, Butler MG (1999) Plasma leptin concentrations in lean and obese human subjects and Prader-Willi syndrome: comparison of RIA and ELISA methods. J Lab Clin Med 133: 75-80
21. Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Skakkebaek NE, Heiman ML, Birkett M, Attanasio AM, Kiess W, Rascher W (1997) Serum leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab 82: 2904-2910
22. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee JH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S (1995) Leptin levels in human and rodent measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1: 1155-1161
23. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1: 1311-1314
24. Blum WF, Englaro P, Attanasio AM, Kiess W, Rascher W (1998) Human and clinical perspectives on leptin. Proc Nutr Soc 57: 477-485
25. Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W, Heinze E, Teller W, Hauner H (1997) Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 100: 808-813
26. Vettor R, De Pergola G, Pagano C, Englaro P, Laudadio E, Giorgino F, et al (1997) Relationship between serum leptin and testosterone in obese men. In: Blum WF, Kiess W, Rascher W (eds) Leptin - The Voice of Adipose Tissue. Barth Verlag J.A., Heidelberg, pp 237-245
27. Jockenhövel F, Blum WF, Vogel E, Englaro P, Müller-Wieland D, Reinwein D, Rascher W, Krone W (1997) Testosterone substitution normalizes elevated leptin serum levels in hypogonadal men. J Clin Endocrinol Metab 82: 2510-2513
28. Elbers JM, Asscheman H, Seidell JC, Frölich M, Meinders AE, Gooren LJG (1997) Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals. J Clin Endocrinol Metab 82: 3267-3270
29. Kiess W, Englaro P, Hanitsch S, Rascher W, Attanasio A, Blum WF (1996) High leptin concentration in serum of very obese children further stimulated by dexamethasone. Horm Metab Res 28: 708-710
30. Wabitsch M, Jensen PB, Blum WF, Christoffersen CT, Englaro P, Heinze E, Rascher W, Teller W, Tornqvist H, Hauner H (1996) Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes 45: 1435-1438
31. Kolaczynski JW, Considine RV, Ohannesian J, Marco C, Opentanova I, Nyce MR, Mudaliar SR, Olefsky J, Caro JF (1996) Responses of leptin to short-term fasting and refeeding in humans. Diabetes 45: 1511-1515
32. Malström R, Taskinen MR, Karonen SL, Yki-Järvinen H (1996) Insulin increases plasma leptin concentration in normal subjects and patients with NIDDM. Diabetologia 39: 993-996
33. Saladin R, De Vos P, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J (1995) Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529
34. Sinha MK, Ohannesian JP, Heiman ML, Kriauciunas A, Stephens TW, Magosin S, Marco C, Caro JF (1996) Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest 97: 1344-1347
35. Strazzullo P, Siani A, Cappuccio FP, Trevisan M, Ragone E, Russo L, Iacone R, Farinaro E (1998) Red blood cell sodium-lithium countertransport and risk of future hypertension. Hypertension 31: 1284-1289
36. Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1: 307-310
37. Liu K, Stamler J, Dyer A, McKeever J, McKeever P (1978) Statistical methods to assess and minimize the role of intraindividual variability in obscuring the relationship between dietary lipids and serum cholesterol. J Chronic Dis 31: 399-418