EphA2 targeting peptide tethered bioreducible poly(cystamine bisacrylamide-diamino hexane) for the delivery of therapeutic pCMV-RAE-1γ to pancreatic islets

Journal of Controlled Release

Volumn 158, Issue 1, 2012, Pages 115-122

  Blevins, Katherine S ^a   Jeong, Ji Hoon ^b   Ou, Mei ^b   Brumbach, Jonathan H ^b   Kim, Sung Wan ^a,b  

^a University of Utah   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Biodegradation; Copolymer; Drug delivery; Gene therapy

Indexed keywords

CATIONIC POLYMERS; CYSTAMINE; DELIVERY SYSTEMS; EXPRESSION SYSTEM; GENE DELIVERY SYSTEMS; MICRO-VASCULATURE; NATURAL PHENOMENA; PANCREATIC ISLET; PLASMID DNA; SINGLE MECHANISMS; SYSTEMIC ADMINISTRATION; TARGET CELLS; TISSUE SELECTIVITY; TYPE 1 DIABETES;

BIODEGRADATION; CELL CULTURE; COPOLYMERS; DNA; DRUG DELIVERY; GENE THERAPY; GENE TRANSFER; HEXANE; MICROBIOLOGY; PEPTIDES; POLYETHYLENE GLYCOLS; TISSUE;

POLYMERS;

EPHRIN RECEPTOR A2; EPHRIN RECEPTOR A4; GENE THERAPY AGENT; MACROGOL; NATURAL KILLER CELL RECEPTOR NKG2D; PLASMID DNA; POLY(CYSTAMINE BISACRYLAMIDE DIAMINO HEXANE); UNCLASSIFIED DRUG; VIRUS VECTOR;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG STABILITY; ENZYME DEGRADATION; INSULIN DEPENDENT DIABETES MELLITUS; MICROVASCULATURE; PANCREAS ISLET; PANCREAS ISLET CELL; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SYNTHESIS; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CELL LINE; CELL SURVIVAL; DNA; GENE TRANSFER TECHNIQUES; HUMANS; ISLETS OF LANGERHANS; MEMBRANE PROTEINS; MICE; NANOPARTICLES; NIH 3T3 CELLS; OLIGOPEPTIDES; PLASMIDS; POLYMERS; RECEPTOR, EPHA2;

EID: 84857916386     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.10.022     Document Type: Article

References (114)

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74. D.H. Raulet Roles of the NKG2D immunoreceptor and its ligands Nat. Rev. Immunol. 3 2003 781 790 (Pubitemid 37328656)
75. J.A. Hughes, and G.A. Rao Targeted polymers for gene delivery Expert Opin. Drug Deliv. 2 2005 145 157 (Pubitemid 40123889)
76. G. Saito, J.A. Swanson, and K.D. Lee Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities Adv. Drug Deliv. Rev. 55 2003 199 215 (Pubitemid 36135916)
77. G. Wu, Y.Z. Fang, S. Yang, J.R. Lupton, and N.D. Turner Glutathione metabolism and its implications for health J. Nutr. 134 2004 489 492 (Pubitemid 38298485)
78. I.R. Hill, M.C. Garnett, F. Bignotti, and S.S. Davis In vitro cytotoxicity of poly(amidoamine)s: relevance to DNA delivery Biochim. Biophys. Acta 1427 1999 161 174 (Pubitemid 29182768)
79. H. Eliyahu, Y. Barenholz, and A.J. Domb Polymers for DNA delivery Molecules 10 2005 34 64 (Pubitemid 40404885)
80. L.E. van Vlerken, T.K. Vyas, and M.M. Amiji Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery Pharm. Res. 24 2007 1405 1414 (Pubitemid 46988224)
81. C. Aspord, S. Rome, and C. Thivolet Early events in islets and pancreatic lymph nodes in autoimmune diabetes J. Autoimmun. 23 2004 27 35 (Pubitemid 38953790)
82. V.J. Yao, M.G. Ozawa, M. Trepel, W. Arap, D.M. McDonald, and R. Pasqualini Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection Am. J. Pathol. 166 2005 625 636 (Pubitemid 40189057)
83. M. Ou, X.L. Wang, R. Xu, C.W. Chang, D.A. Bull, and S.W. Kim Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity Bioconjug. Chem. 19 2008 626 633 (Pubitemid 351431393)
84. M. Ou, R. Xu, S.H. Kim, D.A. Bull, and S.W. Kim A family of bioreducible poly(disulfide amine)s for gene delivery Biomaterials 30 2009 5804 5814
85. M. Ou, T-i. Kim, J.W. Yockman, B.A. Borden, D.A. Bull, and S.W. Kim Polymer transfected primary myoblasts mediated efficient gene expression and angiogenic proliferation J. Control. Release 142 2010 61 69
86. L.V. Christensen, C.W. Chang, W.J. Kim, S.W. Kim, Z. Zhong, C. Lin, J.F. Engbersen, and J. Feijen Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery Bioconjug. Chem. 17 2006 1233 1240 (Pubitemid 44455332)
87. T.I. Kim, M. Ou, M. Lee, and S.W. Kim Arginine-grafted bioreducible poly(disulfide amine) for gene delivery systems Biomaterials 30 2009 658 664
88. D.V. Schaffer, N.A. Fidelman, N. Dan, and D.A. Lauffenburger Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery Biotechnol. Bioeng. 67 2000 598 606 (Pubitemid 30096964)
89. M.L. Forrest, J.T. Koerber, and D.W. Pack A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery Bioconjug. Chem. 14 2003 934 940 (Pubitemid 37152952)
90. R. Kircheis, L. Wightman, and E. Wagner Design and gene delivery activity of modified polyethylenimines Adv. Drug Deliv. Rev. 53 2001 341 358 (Pubitemid 34024914)
91. F.M. Veronese, and G. Pasut PEGylation, successful approach to drug delivery Drug Discov. Today 10 2005 1451 1458 (Pubitemid 41483874)
92. M.L. Read, K.H. Bremner, D. Oupicky, N.K. Green, P.F. Searle, and L.W. Seymour Vectors based on reducible polycations facilitate intracellular release of nucleic acids J. Gene Med. 5 2003 232 245 (Pubitemid 40310377)
93. S.H. Kim, M. Ou, D.A. Bull, and S.W. Kim Reductive degradation behavior of bioreducible poly(disulfide amine) for enhancing siRNA efficiency Macromol. Biosci. 10 8 2010 898 905
94. T-i. Kim, T. Rothmund, T. Kissel, and S.W. Kim Bioreducible polymers with cell penetrating and endosome buffering functionality for gene delivery systems Journal of Controlled Release 152 2011 110 119
95. M.S. Shim, X. Wang, R. Ragan, and Y.J. Kwon Dynamics of nucleic acid/cationic polymer complexation and disassembly under biologically simulated conditions using in situ atomic force microscopy Microsc. Res. Tech. 73 2010 845 856
96. Y. Liu, L.C. Mounkes, H.D. Liggitt, C.S. Brown, I. Solodin, T.D. Heath, and R.J. Debs Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery Nat. Biotechnol. 15 1997 167 173 (Pubitemid 27081784)
97. M. Nishikawa, Y. Takakura, and M. Hashida Pharmacokinetic evaluation of polymeric carriers Adv. Drug Deliv. Rev. 21 1996 135 155 (Pubitemid 26401715)
98. D.E. Owens III, and N.A. Peppas Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles Int. J. Pharm. 307 2006 93 102 (Pubitemid 41773257)
99. Y. Takakura, and M. Hashida Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution Pharm. Res. 13 1996 820 831 (Pubitemid 26227738)
100. V.A. Bloomfield DNA condensation by multivalent cations Biopolymers 44 1997 269 282
101. H.G. Hansma, R. Golan, W. Hsieh, C.P. Lollo, P. Mullen-Ley, and D. Kwoh DNA condensation for gene therapy as monitored by atomic force microscopy Nucleic Acids Res. 26 1998 2481 2487 (Pubitemid 28297352)
102. C. Lin, Z. Zhong, M.C. Lok, X. Jiang, W.E. Hennink, J. Feijen, and J.F.J. Engbersen Novel bioreducible poly(amido amine)s for highly efficient gene delivery Bioconjug. Chem. 18 2007 138 145 (Pubitemid 46146003)
103. C. Brus, H. Petersen, A. Aigner, F. Czubayko, and T. Kissel Efficiency of polyethylenimines and polyethylenimine-graft-poly(ethylene glycol) block copolymers to protect oligonucleotides against enzymatic degradation Eur. J. Pharm. Biopharm. 57 2004 427 430 (Pubitemid 38490558)
104. M. Hamidi, A. Azadi, and P. Rafiei Pharmacokinetic consequences of pegylation Drug Deliv. 13 2006 399 409 (Pubitemid 44470219)
105. M. Lee, and S.W. Kim Polyethylene glycol-conjugated copolymers for plasmid DNA delivery Pharm. Res. 22 2005 1 10 (Pubitemid 40558140)
106. M. Ogris, P. Steinlein, S. Carotta, S. Brunner, and E. Wagner DNA/polyethylenimine transfection particles: Influence of ligands, polymer size, and PEGylation on internalization and gene expression AAPS PharmSci 3 2001
107. J.H. Jeong, M. Lee, W.J. Kim, J.W. Yockman, T.G. Park, Y.H. Kim, and S.W. Kim Anti-GAD antibody targeted non-viral gene delivery to islet beta cells J. Control. Release 107 2005 562 570 (Pubitemid 41393362)
108. W. Suh, S.O. Han, L. Yu, and S.W. Kim An angiogenic, endothelial-cell- targeted polymeric gene carrier Mol. Ther. 6 2002 664 672 (Pubitemid 35363699)
109. M. Lee, S. Oh, C.-H. Ahn, S.W. Kim, B.D. Rhee, and K.S. Ko An efficient GLP-1 expression system using two-step transcription amplification J. Control. Release 115 2006 316 321 (Pubitemid 44634840)
110. I.A. Khalil, K. Kogure, H. Akita, and H. Harashima Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery Pharmacol. Rev. 58 2006 32 45
111. M.J. Smyth, J. Swann, E. Cretney, N. Zerafa, W.M. Yokoyama, and Y. Hayakawa NKG2D function protects the host from tumor initiation J. Exp. Med. 202 2005 583 588 (Pubitemid 41248410)
112. S.C. Makrides Components of vectors for gene transfer and expression in mammalian cells Protein Expr. Purif. 17 1999 183 202 (Pubitemid 29536799)
113. S.M. Najjar, and R.E. Lewis Persistent expression of foreign genes in cultured hepatocytes: expression vectors Gene 230 1999 41 45 (Pubitemid 29193193)
114. E. Lobbestael, V. Reumers, A. Ibrahimi, K. Paesen, I. Thiry, R. Gijsbers, C. Van den Haute, Z. Debyser, V. Baekelandt, and J.-M. Taymans Immunohistochemical detection of transgene expression in the brain using small epitope tags BMC Biotechnol. 10 2010 16