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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 6, 2012, Pages 2204-2208

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

(7) Bianchi, Aldo a Ugazzi, Marcello b Ferrante, Luca a Lecis, Daniele c Scavullo, Cinzia b Mastrangelo, Eloise b Seneci, Pierfausto a,b

a CISI Scrl (Italy)

b UNIVERSITY OF MILAN (Italy)

c NATIONAL CANCER INSTITUTE (Italy)

Author keywords

Apoptosis; IAP inhibitors; Oncology; Peptidomimetics; Smac mimetics

Indexed keywords

ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; INHIBITOR OF APOPTOSIS PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN INHIBITOR; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE INHIBTOR; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ARTICLE; CELL ASSAY; CELL FREE SYSTEM; CELL MEMBRANE PERMEABILITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDOMIMETICS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857910227 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.01.098 Document Type: Article

Times cited : (7)

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