Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 16, 2009, Pages 5834-5856

  Seneci, Pierfausto ^a   Bianchi, Aldo ^a   Battaglia, Cristina ^a   Belvisi, Laura ^a   Bolognesi, Martino ^a   Caprini, Andrea ^a   Cossu, Federica ^a   Franco, Elena de ^a   Matteo, Marilenia de ^a   Delia, Domenico ^b   Drago, Carmelo ^a   Khaled, Amira ^a   Lecis, Daniele ^b   Manzoni, Leonardo ^a,c   Marizzoni, Moira ^a   Mastrangelo, Eloise ^a   Milani, Mario ^a   Motto, Ilaria ^a   Moroni, Elisabetta ^a   Potenza, Donatella ^a   Rizzo, Vincenzo ^a   Servida, Federica ^d   Turlizzi, Elisa ^e   Varrone, Maurizio ^e   Vasile, Francesca ^a   Scolastico, Carlo ^a   more..

^a UNIVERSITY OF MILAN   (Italy)

^b NATIONAL CANCER INSTITUTE   (Italy)

^c CNR Consiglio Nazionale delle Ricerche   (Italy)

^d Dipartimento di Farmacologia   (Italy)

^e Siena Biotech SpA   (Italy)

Author keywords

Apoptosis; Crystallography; Medicinal chemistry; NMR; Oncology; Rational drug design; Smac; XIAP

Indexed keywords

1 AZA 2 OXO 3 AMINOBICYCLO[5.3.0]DECANE 10 CARBOXYLIC ACID; ANTINEOPLASTIC AGENT; BICYCLO COMPOUND; CARBOXYLIC ACID DERIVATIVE; PROTEIN INHIBITOR; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE MIMETIC AGENT; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CANCER THERAPY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TARGETING; FLUORESCENCE POLARIZATION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; BICYCLO COMPOUNDS; CELL LINE, TUMOR; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIAL PROTEINS; NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 68149131330     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.009     Document Type: Article

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