Bmi1 is down-regulated in the aging brain and displays antioxidant and protective activities in neurons

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Abdouh, Mohamed ^a   Chatoo, Wassim ^a   El Hajjar, Jida ^a   David, Jocelyn ^a   Ferreira, José ^a   Bernier, Gilbert ^a,b  

^a MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; CELL DNA; LIPID; PROTEIN P53; REACTIVE OXYGEN METABOLITE; ANTIOXIDANT; BMI1 PROTEIN, HUMAN; BMI1 PROTEIN, MOUSE; DNA; NUCLEAR PROTEIN; ONCOPROTEIN; REPRESSOR PROTEIN;

AGING; ANIMAL CELL; ANTIOXIDANT ACTIVITY; AOR GENE; ARTICLE; BIOACCUMULATION; BMI1 GENE; BRAIN AGING; CELL AGING; CHROMATIN; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DOWN REGULATION; GENE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; IL 6 GENE; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; NOXA GENE; P19ARF GENE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; APOPTOSIS; BRAIN; C57BL MOUSE; CHEMISTRY; DEGENERATIVE DISEASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; LIPID PEROXIDATION; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PHYSIOLOGY; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

MUS;

AGING; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN; CHROMATIN; DNA; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, P53; HUMANS; LIPID PEROXIDATION; LIPIDS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURODEGENERATIVE DISEASES; NEURONS; NUCLEAR PROTEINS; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84857567368     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031870     Document Type: Article

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