메뉴 건너뛰기




Volumn 6, Issue 1, 2011, Pages

P38 mapk-mediated bmi-1 down-regulation and defective proliferation in atm-deficient neural stem cells can be restored by akt activation

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ATM PROTEIN; BMI1 PROTEIN; EPIDERMAL GROWTH FACTOR; HISTONE H2A; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; BMI1 PROTEIN, HUMAN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; REPRESSOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

EID: 79551522948     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016615     Document Type: Article
Times cited : (37)

References (37)
  • 1
    • 0035281565 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated is essential during adult neurogenesis
    • Allen DM, van Praag H, Ray J, Weaver Z, Winrow CJ, et al. (2000) Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev 15: 554-566.
    • (2000) Genes Dev , vol.15 , pp. 554-566
    • Allen, D.M.1    van Praag, H.2    Ray, J.3    Weaver, Z.4    Winrow, C.J.5
  • 2
    • 0034712047 scopus 로고    scopus 로고
    • Mammalian neural stem cells
    • Gage FH (2000) Mammalian neural stem cells. Science 287: 1433-1438.
    • (2000) Science , vol.287 , pp. 1433-1438
    • Gage, F.H.1
  • 3
    • 0347479231 scopus 로고    scopus 로고
    • Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice
    • Chen P, Peng C, Luff J, Spring K, Watters D, et al. (2003) Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice. J Neurosci 23: 11453-11460.
    • (2003) J Neurosci , vol.23 , pp. 11453-11460
    • Chen, P.1    Peng, C.2    Luff, J.3    Spring, K.4    Watters, D.5
  • 4
    • 27944476980 scopus 로고    scopus 로고
    • ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes
    • Liu N, Stoica G, Yan M, Scofield VL, Qiang W, et al. (2005) ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes. Lab Invest 85: 1471-1480.
    • (2005) Lab Invest , vol.85 , pp. 1471-1480
    • Liu, N.1    Stoica, G.2    Yan, M.3    Scofield, V.L.4    Qiang, W.5
  • 5
    • 67649794703 scopus 로고    scopus 로고
    • Oxidative Stress Is Linked to ERK1/2-p16 Signalingmediated Growth Defect in ATM-deficient Astrocytes
    • Kim J, Wong PK (2009) Oxidative Stress Is Linked to ERK1/2-p16 Signalingmediated Growth Defect in ATM-deficient Astrocytes. J Biol Chem 284: 14396-14404.
    • (2009) J Biol Chem , vol.284 , pp. 14396-14404
    • Kim, J.1    Wong, P.K.2
  • 6
    • 69249127963 scopus 로고    scopus 로고
    • Loss of ATM Impairs Proliferation of Neural Stem Cells Through Oxidative Stress-Mediated p38 MAPK Signaling
    • Kim J, Wong PK (2009) Loss of ATM Impairs Proliferation of Neural Stem Cells Through Oxidative Stress-Mediated p38 MAPK Signaling. Stem Cells 27: 1987-1998.
    • (2009) Stem Cells , vol.27 , pp. 1987-1998
    • Kim, J.1    Wong, P.K.2
  • 7
    • 0242667922 scopus 로고    scopus 로고
    • Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    • Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, et al. (2003) Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425: 962-967.
    • (2003) Nature , vol.425 , pp. 962-967
    • Molofsky, A.V.1    Pardal, R.2    Iwashita, T.3    Park, I.K.4    Clarke, M.F.5
  • 8
    • 22344449361 scopus 로고    scopus 로고
    • Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways
    • Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R (2005) Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev 19: 1432-1437.
    • (2005) Genes Dev , vol.19 , pp. 1432-1437
    • Molofsky, A.V.1    He, S.2    Bydon, M.3    Morrison, S.J.4    Pardal, R.5
  • 9
    • 33746008541 scopus 로고    scopus 로고
    • Structure of a Bmi-1- Ring1B polycomb group ubiquitin ligase complex
    • Li Z, Cao R, Wang M, Myers MP, Zhang Y, et al. (2006) Structure of a Bmi-1- Ring1B polycomb group ubiquitin ligase complex. J Biol Chem 281: 20643-20649.
    • (2006) J Biol Chem , vol.281 , pp. 20643-20649
    • Li, Z.1    Cao, R.2    Wang, M.3    Myers, M.P.4    Zhang, Y.5
  • 10
    • 1642633053 scopus 로고    scopus 로고
    • Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
    • Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, et al. (2004) Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 428: 337-341.
    • (2004) Nature , vol.428 , pp. 337-341
    • Leung, C.1    Lingbeek, M.2    Shakhova, O.3    Liu, J.4    Tanger, E.5
  • 11
    • 34249907279 scopus 로고    scopus 로고
    • ShRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development
    • Fasano CA, Dimos JT, Ivanova NB, Lowry N, Lemischka IR, et al. (2007) ShRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development. Cell Stem Cell 1: 87-99.
    • (2007) Cell Stem Cell , vol.1 , pp. 87-99
    • Fasano, C.A.1    Dimos, J.T.2    Ivanova, N.B.3    Lowry, N.4    Lemischka, I.R.5
  • 12
    • 67349156082 scopus 로고    scopus 로고
    • Bmi1 regulates mitochondrial function and the DNA damage response pathway
    • Liu J, Cao L, Chen J, Song S, Lee IH, et al. (2009) Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 459: 387-392.
    • (2009) Nature , vol.459 , pp. 387-392
    • Liu, J.1    Cao, L.2    Chen, J.3    Song, S.4    Lee, I.H.5
  • 13
    • 58849166901 scopus 로고    scopus 로고
    • The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity
    • Chatoo W, Abdouh M, David J, Champagne MP, Ferreira J, et al. (2009) The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci 29: 529-542.
    • (2009) J Neurosci , vol.29 , pp. 529-542
    • Chatoo, W.1    Abdouh, M.2    David, J.3    Champagne, M.P.4    Ferreira, J.5
  • 14
    • 63549087793 scopus 로고    scopus 로고
    • Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo
    • He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, et al. (2009) Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo. Dev Biol 328: 257-272.
    • (2009) Dev Biol , vol.328 , pp. 257-272
    • He, S.1    Iwashita, T.2    Buchstaller, J.3    Molofsky, A.V.4    Thomas, D.5
  • 15
    • 60749115380 scopus 로고    scopus 로고
    • BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during the progression of chronic myeloid leukemia
    • Bhattacharyya J, Mihara K, Yasunaga S, Tanaka H, Hoshi M, et al. (2009) BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during the progression of chronic myeloid leukemia. Ann Hematol 88: 333-340.
    • (2009) Ann Hematol , vol.88 , pp. 333-340
    • Bhattacharyya, J.1    Mihara, K.2    Yasunaga, S.3    Tanaka, H.4    Hoshi, M.5
  • 16
    • 67449128222 scopus 로고    scopus 로고
    • Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
    • Chen W, Sun Z, Wang XJ, Jiang T, Huang Z, et al. (2009) Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell 34: 663-673.
    • (2009) Mol Cell , vol.34 , pp. 663-673
    • Chen, W.1    Sun, Z.2    Wang, X.J.3    Jiang, T.4    Huang, Z.5
  • 17
    • 33845999883 scopus 로고    scopus 로고
    • Nitric oxide decreases subventricular zone stem cell proliferation by inhibition of epidermal growth factor receptor and phosphoinositide-3-kinase/Akt pathway
    • Torroglosa A, Murillo-Carretero M, Romero-Grimaldi C, Matarredona ER, Campos-Caro A, et al. (2007) Nitric oxide decreases subventricular zone stem cell proliferation by inhibition of epidermal growth factor receptor and phosphoinositide-3-kinase/Akt pathway. Stem Cells 25: 88-97.
    • (2007) Stem Cells , vol.25 , pp. 88-97
    • Torroglosa, A.1    Murillo-Carretero, M.2    Romero-Grimaldi, C.3    Matarredona, E.R.4    Campos-Caro, A.5
  • 18
    • 36749089980 scopus 로고    scopus 로고
    • Ring1- mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells
    • Stock JK, Giadrossi S, Casanova M, Brookes E, Vidal M, et al. (2007) Ring1- mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol 9: 1428-1435.
    • (2007) Nat Cell Biol , vol.9 , pp. 1428-1435
    • Stock, J.K.1    Giadrossi, S.2    Casanova, M.3    Brookes, E.4    Vidal, M.5
  • 19
    • 33746008541 scopus 로고    scopus 로고
    • Structure of a Bmi-1- Ring1B polycomb group ubiquitin ligase complex
    • Li Z, Cao R, Wang M, Myers MP, Zhang Y, et al. (2006) Structure of a Bmi-1- Ring1B polycomb group ubiquitin ligase complex. J Biol Chem 281: 20643-20649.
    • (2006) J Biol Chem , vol.281 , pp. 20643-20649
    • Li, Z.1    Cao, R.2    Wang, M.3    Myers, M.P.4    Zhang, Y.5
  • 20
    • 33845291508 scopus 로고    scopus 로고
    • Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1
    • Zuluaga S, Alvarez-Barrientos A, Gutie ́rrez-Uzquiza A, Benito M, Nebreda AR, et al. (2007) Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1. Cell Signal 19: 62-74.
    • (2007) Cell Signal , vol.19 , pp. 62-74
    • Zuluaga, S.1    Alvarez-Barrientos, A.2    Gutiérrez-Uzquiza, A.3    Benito, M.4    Nebreda, A.R.5
  • 21
    • 0035105516 scopus 로고    scopus 로고
    • P38 mitogenactivated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression
    • Westermarck J, Li SP, Kallunki T, Han J, Kähäri VM (2001) P38 mitogenactivated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression. Mol Cell Biol 21: 2373-2383.
    • (2001) Mol Cell Biol , vol.21 , pp. 2373-2383
    • Westermarck, J.1    Li, S.P.2    Kallunki, T.3    Han, J.4    Kähäri, V.M.5
  • 22
    • 1942518724 scopus 로고    scopus 로고
    • Akt2, a Novel Functional Link between p38 Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in Myogenesis
    • Gonzalez I, Tripathi G, Carter EJ, Cobb LJ, Salih DAM, et al. (2004) Akt2, a Novel Functional Link between p38 Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in Myogenesis. Mol Cell Biol 24: 3607-3622.
    • (2004) Mol Cell Biol , vol.24 , pp. 3607-3622
    • Gonzalez, I.1    Tripathi, G.2    Carter, E.J.3    Cobb, L.J.4    Salih, D.A.M.5
  • 23
    • 33748967935 scopus 로고    scopus 로고
    • Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells
    • Lee B, Kim CH, Moon SK (2006) Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells. FEBS Lett 580: 5177-5184.
    • (2006) FEBS Lett , vol.580 , pp. 5177-5184
    • Lee, B.1    Kim, C.H.2    Moon, S.K.3
  • 24
    • 0033614357 scopus 로고    scopus 로고
    • SSX and the synovialsarcoma specific chimaeric protein SYT-SSX co-localize with the human Polycomb group complex
    • Soulez M, Saurin AJ, Freemont PS, Knight JC (1999) SSX and the synovialsarcoma specific chimaeric protein SYT-SSX co-localize with the human Polycomb group complex. Oncogene 18: 2739-2746.
    • (1999) Oncogene , vol.18 , pp. 2739-2746
    • Soulez, M.1    Saurin, A.J.2    Freemont, P.S.3    Knight, J.C.4
  • 25
    • 1542330121 scopus 로고    scopus 로고
    • Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase
    • Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, et al. (2004) Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. Genes Cells 9: 105-120.
    • (2004) Genes Cells , vol.9 , pp. 105-120
    • Obuse, C.1    Yang, H.2    Nozaki, N.3    Goto, S.4    Okazaki, T.5
  • 26
    • 14044263532 scopus 로고    scopus 로고
    • MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1
    • Voncken JW, Niessen H, Neufeld B, Rennefahrt U, Dahlmans V, et al. (2005) MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. J Biol Chem 280: 5178-5187.
    • (2005) J Biol Chem , vol.280 , pp. 5178-5187
    • Voncken, J.W.1    Niessen, H.2    Neufeld, B.3    Rennefahrt, U.4    Dahlmans, V.5
  • 27
    • 0033398254 scopus 로고    scopus 로고
    • Chromatin-association of the Polycomb group protein BMI1 is cell cycleregulated and correlates with its phosphorylation status
    • Voncken JW, Schweizer D, Aagaard L, Sattler L, Jantsch MF, et al. (1999) Chromatin-association of the Polycomb group protein BMI1 is cell cycleregulated and correlates with its phosphorylation status. J Cell Sci 112: 4627-4639.
    • (1999) J Cell Sci , vol.112 , pp. 4627-4639
    • Voncken, J.W.1    Schweizer, D.2    Aagaard, L.3    Sattler, L.4    Jantsch, M.F.5
  • 28
    • 48249083398 scopus 로고    scopus 로고
    • Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling
    • Davila D, Torres-Aleman I (2008) Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling. Mol Biol Cell 9: 2014-2025.
    • (2008) Mol Biol Cell , vol.9 , pp. 2014-2025
    • Davila, D.1    Torres-Aleman, I.2
  • 32
    • 34147160607 scopus 로고    scopus 로고
    • Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease
    • Lee JP, Jeyakuma M, Gonzalez R, Takahashi H, Lee PJ, et al. (2007) Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med 13: 439-447.
    • (2007) Nat Med , vol.13 , pp. 439-447
    • Lee, J.P.1    Jeyakuma, M.2    Gonzalez, R.3    Takahashi, H.4    Lee, P.J.5
  • 33
    • 61849144426 scopus 로고    scopus 로고
    • Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain
    • Fasano CA, Phoenix TN, Kokovay E, Lowry N, Elkabetz Y, et al. (2009) Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain. Genes Dev 23: 561-574.
    • (2009) Genes Dev , vol.23 , pp. 561-574
    • Fasano, C.A.1    Phoenix, T.N.2    Kokovay, E.3    Lowry, N.4    Elkabetz, Y.5
  • 35
    • 33746877155 scopus 로고    scopus 로고
    • NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling
    • Yang SR, Kim SJ, Byun KH, Hutchinson B, Lee BH, et al. (2006) NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling. Stem Cells 24: 292-298.
    • (2006) Stem Cells , vol.24 , pp. 292-298
    • Yang, S.R.1    Kim, S.J.2    Byun, K.H.3    Hutchinson, B.4    Lee, B.H.5
  • 36
    • 33747062755 scopus 로고    scopus 로고
    • Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets
    • Li J, Imitola J, Snyder EY, Sidman RL (2006) Neural stem cells rescue nervous purkinje neurons by restoring molecular homeostasis of tissue plasminogen activator and downstream targets. J Neurosci 26: 7839-7848.
    • (2006) J Neurosci , vol.26 , pp. 7839-7848
    • Li, J.1    Imitola, J.2    Snyder, E.Y.3    Sidman, R.L.4
  • 37
    • 33749171885 scopus 로고    scopus 로고
    • Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
    • Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, et al. (2006) Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443: 448-452.
    • (2006) Nature , vol.443 , pp. 448-452
    • Molofsky, A.V.1    Slutsky, S.G.2    Joseph, N.M.3    He, S.4    Pardal, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.