Age-dependent down-regulation of mitochondrial 8-oxoguanine dna glycosylase in sam-p/8 mouse brain and its effect on brain aging

Rejuvenation Research

Volumn 12, Issue 3, 2009, Pages 209-215

  Tian, Feng ^a   Tong, Tan Jun ^a   Zhang, Zong Yu ^a   McNutt, Michael A ^a   Liu, Xin Wen ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; 8 OXOGUANINE DNA GLYCOSYLASE; CYTOCHROME C OXIDASE; CYTOCHROME C OXIDASE SUBUNIT 3; DNA GLYCOSYLTRANSFERASE; MESSENGER RNA; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AGED; AGING; AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; BRAIN NUCLEUS; BRAIN TISSUE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; LEARNING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE ACCELERATED MOUSE;

AGING; ANIMALS; BRAIN; DNA GLYCOSYLASES; DNA, MITOCHONDRIAL; DOWN-REGULATION; GENE DELETION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; OXYGEN; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

MUS;

EID: 70349084193     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2009.0849     Document Type: Article

References (15)

1. Simon DK, Lin MT, Zheng L, Liu GJ, Ahn CH, Kim LM, Mauck WM, Twu F, Beal MF, Johns DR. Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease. Neurobiol Aging 2004;25:71-81.
2. Nakabeppu Y, Tsuchimoto D, Yamaguchi H, Sakumi K. Oxidative damage in nucleic acids and Parkinson's disease. J Neurosci Res 2007;85:919-934.
3. Imam SZ, Karahalil B, Hogue BA, Souza-Pinto NC, Bohr VA. Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging 2006;27:1129-1136.
4. Chatterjee A, Mambo E, Zhang Y, Deweese T, Sidransky, D. Targeting of mutant hOGG1 in mammalian mitochondria and nucleus: Effect on cellular survival upon oxidative stress. BMC Cancer 2006;6:235.
5. Wang AL, Lukas TJ, Yuan M, Neufeld AH. Increased mitochondrial DNA damage and down-regulation of DNA repair enzymes in aged rodent retinal pigment epithelium and choroid. Mol Vis 2008;14:644-651.
6. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG. Premature aging in mice expressing defective mitochondrial DNA polymerase. Nature 2004;429:417-423.
7. Fukae J, Mizuno Y, Hattori N. Mitochondrial dysfunction in Parkinson's disease. Mitochondrion 2007;7:58-62.
8. Z, Zhang Z, Yu H, Corbley MJ, Tang Z, Tong T. Mitochondrial DNA deletions are associated with ischemia and aging in Balb/c mouse brain. J Cell Biochem1999;4:545-553.
9. Choi JY, Kim HS, Kang HK, Lee DW, Choi EM, Chung MH. Thermolabile 8-hydroxyguantine and glycosylase with low activity in senescence-accelerated mice due to a single-base mutation. Free Radical Biol Med 1999;27:848-854.
10. Calabrese V, Lodi R, Tonon C, D'Agata V, Sapienza M, Scapagnini G, Mangiameli A, Pennisi G, Stella AM, Butterfield DA. Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia. J Neurol Sci 2005;233:145-162.
11. Crouch PJ, Cimdins K, Duce JA, Bush AI, Trounce IA. Mitochondria in aging and Alzheimer's disease. Rejuvenation Res 2007;3:349-357.
12. Wang AL, Lukas TJ, Yuan M, Neufeld AH. Age-related increase in mitochondrial DNA damage and loss of DNA repair capacity in the neural retina.Neurobiol Aging 2008;Dec.10. [Epub ahead of print, PMID: 19084291].
13. De Souza-Pinto NC, Eide L, Hogue BA, Thybo T, Stevnsner T, Seeberg E, Klungland A, Bohr VA. Repair of 8-oxodeoxyguanosine lesions in mitochondrial DNA depends on the oxoguanine DNA glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial DNA of OGG1- defective mice. Cancer Res 2001;61:5378-5381.
14. Gredilla R, Garm C, Holm R, Bohr VA, Stevnsner T. Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions. Neurobiol Aging 2008; DOI: 10.1016/j.neurobiolaging/2008.07.004.
15. Weissman L, de Souza-Pinto NC, Stevnsner T, Bohr VA. DNA repair, mitochondria , and neurodegeneration. Neuroscience 2007;145:1318-1329.