The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity

Journal of Neuroscience

Volumn 29, Issue 2, 2009, Pages 529-542

  Chatoo, Wassim ^a   Abdouh, Mohamed ^a   David, Jocelyn ^a   Champagne, Marie Pier ^a   Ferreira, José ^a   Rodier, Francis ^c   Bernier, Gilbert ^a,b  

^a MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Aging; Antioxidant; Bmi1; Neuronal cell death; p53; ROS

Indexed keywords

BMI1 PROTEIN; NEUROTOXIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

AEROBIC METABOLISM; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CATARACT; CELL AGING; CELL METABOLISM; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE REPRESSION; LIFESPAN; LIPID PEROXIDATION; MOUSE; NERVE CELL NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; TUMOR SUPPRESSOR GENE; WEANING;

AGE FACTORS; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BETA-GALACTOSIDASE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; EMBRYO, MAMMALIAN; EYE PROTEINS; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; HISTONES; HOMEODOMAIN PROTEINS; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; NEUROTOXINS; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PEROXIREDOXINS; PHOSPHOPYRUVATE HYDRATASE; PROTO-ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 58849166901     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5303-08.2009     Document Type: Article

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