Cell contact-dependent functional selectivity of β 2- adrenergic receptor ligands in stimulating cAMP accumulation and extracellular signal-regulated kinase phosphorylation

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6362-6374

  Kaya, Ali I ^a,c   Onaran, H Ongun ^a   Özcan, Gülnihal ^a   Ambrosio, Caterina ^b   Costa, Tommaso ^b   Balli, Sezen ^a   Uǧur, Özlem ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHERENT CELLS; ADRENERGIC RECEPTORS; CELL-CELL CONTACT; CLENBUTEROL; EXTRACELLULAR SIGNAL-REGULATED KINASE; G PROTEIN COUPLED RECEPTORS; HEK293 CELLS; INTRINSIC ACTIVITIES; PROCATEROL; SECOND GROUP; SELECTIVE LIGANDS; SIGNALING PATHWAYS; TERBUTALINE;

BIOACTIVITY; CELLS; CYTOLOGY; PHOSPHORYLATION;

LIGANDS;

1 (2 CYANOPHENOXY) 3 [2 (3 PHENYLUREIDO)ETHYLAMINO] 2 PROPANOL; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ADENYLATE CYCLASE; ADRENALIN; ALPRENOLOL; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CIMATEROL; CLENBUTEROL; CYANOPINDOLOL; CYCLIC AMP; DOBUTAMINE; DOPAMINE; G PROTEIN COUPLED RECEPTOR; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE; NORADRENALIN; PINDOLOL; PROCATEROL; PRONETHANOL; PROPRANOLOL; TERBUTALINE; TIMOLOL; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL CONTACT; CELL DENSITY; CELL SPECIFICITY; CELL STIMULATION; CELL STRAIN HEK293; CELL SUSPENSION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ARRESTINS; CELL ADHESION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; ISOQUINOLINES; LIGANDS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RECEPTOR CROSS-TALK; RECEPTORS, ADRENERGIC, BETA-2; RNA, SMALL INTERFERING; SULFONAMIDES;

EID: 84857483788     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.301820     Document Type: Article

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