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Volumn 15, Issue 5, 2003, Pages 509-514

Cadherin-mediated cellular signaling

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CATENIN; GUANOSINE TRIPHOSPHATASE; RHO FACTOR; TYROSINE KINASE RECEPTOR; WNT PROTEIN;

EID: 0141533082     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(03)00101-7     Document Type: Review
Times cited : (239)

References (47)
  • 1
    • 0034625313 scopus 로고    scopus 로고
    • Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members
    • Nollet F., Kools P., van Roy F. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. J Mol Biol. 299:2000;551-572.
    • (2000) J Mol Biol , vol.299 , pp. 551-572
    • Nollet, F.1    Kools, P.2    Van Roy, F.3
  • 2
    • 0035077317 scopus 로고    scopus 로고
    • The cadherin superfamily: Diversity in form and function
    • Angst B.D., Marcozzi C., Magee A.I. The cadherin superfamily: diversity in form and function. J Cell Sci. 114:2001;629-641.
    • (2001) J Cell Sci , vol.114 , pp. 629-641
    • Angst, B.D.1    Marcozzi, C.2    Magee, A.I.3
  • 3
    • 0034657319 scopus 로고    scopus 로고
    • Cadherin superfamily genes: Functions, genomic organization, and neurologic diversity
    • Yagi T., Takeichi M. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. Genes Dev. 14:2000;1169-1180.
    • (2000) Genes Dev , vol.14 , pp. 1169-1180
    • Yagi, T.1    Takeichi, M.2
  • 4
    • 0141651204 scopus 로고    scopus 로고
    • Cadherins as modulators of cellular phenotype
    • Wheelock M.J., Johnson K.R. Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol. 19:2003;207-235.
    • (2003) Annu Rev Cell Dev Biol , vol.19 , pp. 207-235
    • Wheelock, M.J.1    Johnson, K.R.2
  • 5
    • 0035651254 scopus 로고    scopus 로고
    • Rho-family GTPases in cadherin-mediated cell-cell adhesion
    • Fukata M., Kaibuchi K. Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nat Rev Mol Cell Biol. 2:2001;887-897.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 887-897
    • Fukata, M.1    Kaibuchi, K.2
  • 6
    • 0034618050 scopus 로고    scopus 로고
    • P120 catenin regulates the actin cytoskeleton via Rho family GTPases
    • Noren N.K., Liu B.P., Burridge K., Kreft B. p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol. 150:2000;567-580.
    • (2000) J Cell Biol , vol.150 , pp. 567-580
    • Noren, N.K.1    Liu, B.P.2    Burridge, K.3    Kreft, B.4
  • 7
    • 0035084335 scopus 로고    scopus 로고
    • P120 catenin affects cell motility via modulation of activity of Rho-family GTPases: A link between cell-cell contact formation and regulation of cell locomotion
    • Grosheva I., Shtutman M., Elbaum M., Bershadsky A.D. p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion. J Cell Sci. 114:2001;695-707.
    • (2001) J Cell Sci , vol.114 , pp. 695-707
    • Grosheva, I.1    Shtutman, M.2    Elbaum, M.3    Bershadsky, A.D.4
  • 9
    • 0036774217 scopus 로고    scopus 로고
    • Cell-cell adhesion and signalling
    • Braga V.M. Cell-cell adhesion and signalling. Curr Opin Cell Biol. 14:2002;546-556.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 546-556
    • Braga, V.M.1
  • 10
    • 0037421188 scopus 로고    scopus 로고
    • Direct cadherin-activated cell signaling: A view from the plasma membrane
    • Yap A.S., Kovacs E.M. Direct cadherin-activated cell signaling: a view from the plasma membrane. J Cell Biol. 160:2003;11-16.
    • (2003) J Cell Biol , vol.160 , pp. 11-16
    • Yap, A.S.1    Kovacs, E.M.2
  • 11
    • 0036696823 scopus 로고    scopus 로고
    • Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion
    • This paper shows the recruitment of Rac1 to lamellipodia upon cell-cell contact and defines the temporal importance of Rac1 localization in these regions of cell contact.
    • Ehrlich J.S., Hansen M.D., Nelson W.J. Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev Cell. 3:2002;259-270 This paper shows the recruitment of Rac1 to lamellipodia upon cell-cell contact and defines the temporal importance of Rac1 localization in these regions of cell contact.
    • (2002) Dev Cell , vol.3 , pp. 259-270
    • Ehrlich, J.S.1    Hansen, M.D.2    Nelson, W.J.3
  • 12
    • 0037155159 scopus 로고    scopus 로고
    • E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts
    • Kovacs E.M., Ali R.G., McCormack A.J., Yap A.S. E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. J Biol Chem. 277:2002;6708-6718.
    • (2002) J Biol Chem , vol.277 , pp. 6708-6718
    • Kovacs, E.M.1    Ali, R.G.2    McCormack, A.J.3    Yap, A.S.4
  • 13
    • 0037743623 scopus 로고    scopus 로고
    • Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate rac but not PI3-kinase. Direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation
    • in press
    • Goodwin M, Kovacs EM, Thoreson MA, Reynolds AB, Yap AS: Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate rac but not PI3-kinase. Direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation. J Biol Chem 2003, in press.
    • (2003) J Biol Chem
    • Goodwin, M.1    Kovacs, E.M.2    Thoreson, M.A.3    Reynolds, A.B.4    Yap, A.S.5
  • 14
    • 0034731148 scopus 로고    scopus 로고
    • Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation
    • Pece S., Gutkind J.S. Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J Biol Chem. 275:2000;41227-41233.
    • (2000) J Biol Chem , vol.275 , pp. 41227-41233
    • Pece, S.1    Gutkind, J.S.2
  • 15
    • 0037020084 scopus 로고    scopus 로고
    • Rac activation upon cell-cell contact formation is dependent on signaling from the epidermal growth factor receptor
    • This paper shows that clustering of cadherins is sufficient to activate Rac1 and implicates EGF receptor in E-cadherin signaling in keratinocytes.
    • Betson M., Lozano E., Zhang J., Braga V.M. Rac activation upon cell-cell contact formation is dependent on signaling from the epidermal growth factor receptor. J Biol Chem. 277:2002;36962-36969 This paper shows that clustering of cadherins is sufficient to activate Rac1 and implicates EGF receptor in E-cadherin signaling in keratinocytes.
    • (2002) J Biol Chem , vol.277 , pp. 36962-36969
    • Betson, M.1    Lozano, E.2    Zhang, J.3    Braga, V.M.4
  • 16
    • 0031149420 scopus 로고    scopus 로고
    • N-cadherin promotes the commitment and differentiation of skeletal muscle precursor cells
    • George-Weinstein M., Gerhart J., Blitz J., Simak E., Knudsen K.A. N-cadherin promotes the commitment and differentiation of skeletal muscle precursor cells. Dev Biol. 185:1997;14-24.
    • (1997) Dev Biol , vol.185 , pp. 14-24
    • George-Weinstein, M.1    Gerhart, J.2    Blitz, J.3    Simak, E.4    Knudsen, K.A.5
  • 17
    • 0033836513 scopus 로고    scopus 로고
    • Critical activities of Rac1 and Cdc42Hs in skeletal myogenesis: Antagonistic effects of JNK and p38 pathways
    • Meriane M., Roux P., Primig M., Fort P., Gauthier-Rouviere C. Critical activities of Rac1 and Cdc42Hs in skeletal myogenesis: antagonistic effects of JNK and p38 pathways. Mol Biol Cell. 11:2000;2513-2528.
    • (2000) Mol Biol Cell , vol.11 , pp. 2513-2528
    • Meriane, M.1    Roux, P.2    Primig, M.3    Fort, P.4    Gauthier-Rouviere, C.5
  • 18
    • 0031846156 scopus 로고    scopus 로고
    • RhoA GTPase and serum response factor control selectively the expression of MyoD without affecting Myf5 in mouse myoblasts
    • Carnac G., Primig M., Kitzmann M., Chafey P., Tuil D., Lamb N., Fernandez A. RhoA GTPase and serum response factor control selectively the expression of MyoD without affecting Myf5 in mouse myoblasts. Mol Biol Cell. 9:1998;1891-1902.
    • (1998) Mol Biol Cell , vol.9 , pp. 1891-1902
    • Carnac, G.1    Primig, M.2    Kitzmann, M.3    Chafey, P.4    Tuil, D.5    Lamb, N.6    Fernandez, A.7
  • 19
    • 0037009074 scopus 로고    scopus 로고
    • N-cadherin-dependent cell-cell contact regulates Rho GTPases and β-catenin localization in mouse C2C12 myoblasts
    • This paper is important because it points out differences between N-cadherin signaling and E-cadherin signaling. This paper proposes that N-cadherin-mediated contacts promote myogenesis by positively regulating RhoA and negatively regulating Rac1 and Cdc42.
    • Charrasse S., Meriane M., Comunale F., Blangy A., Gauthier-Rouviere C. N-cadherin-dependent cell-cell contact regulates Rho GTPases and β-catenin localization in mouse C2C12 myoblasts. J Cell Biol. 158:2002;953-965 This paper is important because it points out differences between N-cadherin signaling and E-cadherin signaling. This paper proposes that N-cadherin-mediated contacts promote myogenesis by positively regulating RhoA and negatively regulating Rac1 and Cdc42.
    • (2002) J Cell Biol , vol.158 , pp. 953-965
    • Charrasse, S.1    Meriane, M.2    Comunale, F.3    Blangy, A.4    Gauthier-Rouviere, C.5
  • 20
    • 0037193462 scopus 로고    scopus 로고
    • Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton
    • Lambert M., Choquet D., Mege R.M. Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton. J Cell Biol. 157:2002;469-479.
    • (2002) J Cell Biol , vol.157 , pp. 469-479
    • Lambert, M.1    Choquet, D.2    Mege, R.M.3
  • 21
    • 0036226067 scopus 로고    scopus 로고
    • VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam
    • This paper examines the mechanism whereby Rac1 activation is maintained in endothelial cells and finds that tiam1, a rac1-specific guanine nucleotide exchange factor, is localized to junctions when cells make contact via VE-cadherin.
    • Lampugnani M.G., Zanetti A., Breviario F., Balconi G., Orsenigo F., Corada M., Spagnuolo R., Betson M., Braga V., Dejana E. VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol Biol Cell. 13:2002;1175-1189 This paper examines the mechanism whereby Rac1 activation is maintained in endothelial cells and finds that tiam1, a rac1-specific guanine nucleotide exchange factor, is localized to junctions when cells make contact via VE-cadherin.
    • (2002) Mol Biol Cell , vol.13 , pp. 1175-1189
    • Lampugnani, M.G.1    Zanetti, A.2    Breviario, F.3    Balconi, G.4    Orsenigo, F.5    Corada, M.6    Spagnuolo, R.7    Betson, M.8    Braga, V.9    Dejana, E.10
  • 22
    • 0038182545 scopus 로고    scopus 로고
    • VE-cadherin induced Cdc42 signaling regulates formation of membrane protrusions in endothelial cells
    • in press
    • Kouklis P, Konstantoulaki M, Malik AB: VE-cadherin induced Cdc42 signaling regulates formation of membrane protrusions in endothelial cells. J Biol Chem 2003, in press.
    • (2003) J Biol Chem
    • Kouklis, P.1    Konstantoulaki, M.2    Malik, A.B.3
  • 23
    • 0036120562 scopus 로고    scopus 로고
    • The cadherin-catenin adhesion system in signaling and cancer
    • Conacci-Sorrell M., Zhurinsky J., Ben-Ze'ev A. The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest. 109:2002;987-991.
    • (2002) J Clin Invest , vol.109 , pp. 987-991
    • Conacci-Sorrell, M.1    Zhurinsky, J.2    Ben-Ze'ev, A.3
  • 25
    • 0034627772 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of β-catenin and upregulation of β-catenin/lymphoid enhancer binding factor-1 transcriptional activity
    • Eger A., Stockinger A., Schaffhauser B., Beug H., Foisner R. Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of β-catenin and upregulation of β-catenin/lymphoid enhancer binding factor-1 transcriptional activity. J Cell Biol. 148:2000;173-188.
    • (2000) J Cell Biol , vol.148 , pp. 173-188
    • Eger, A.1    Stockinger, A.2    Schaffhauser, B.3    Beug, H.4    Foisner, R.5
  • 26
    • 0035904231 scopus 로고    scopus 로고
    • E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity
    • Stockinger A., Eger A., Wolf J., Beug H., Foisner R. E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity. J Cell Biol. 154:2001;1185-1196.
    • (2001) J Cell Biol , vol.154 , pp. 1185-1196
    • Stockinger, A.1    Eger, A.2    Wolf, J.3    Beug, H.4    Foisner, R.5
  • 28
    • 0035947772 scopus 로고    scopus 로고
    • E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner
    • Gottardi C.J., Wong E., Gumbiner B.M. E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner. J Cell Biol. 153:2001;1049-1060.
    • (2001) J Cell Biol , vol.153 , pp. 1049-1060
    • Gottardi, C.J.1    Wong, E.2    Gumbiner, B.M.3
  • 29
    • 0033759294 scopus 로고    scopus 로고
    • CAMs and axonal growth: A critical evaluation of the role of calcium and the MAPK cascade
    • Doherty P., Williams G., Williams E.J. CAMs and axonal growth: a critical evaluation of the role of calcium and the MAPK cascade. Mol Cell Neurosci. 16:2000;283-295.
    • (2000) Mol Cell Neurosci , vol.16 , pp. 283-295
    • Doherty, P.1    Williams, G.2    Williams, E.J.3
  • 30
    • 0035207271 scopus 로고    scopus 로고
    • Cell signalling cascades regulating neuronal growth-promoting and inhibitory cues
    • Skaper S.D., Moore S.E., Walsh F.S. Cell signalling cascades regulating neuronal growth-promoting and inhibitory cues. Prog Neurobiol. 65:2001;593-608.
    • (2001) Prog Neurobiol , vol.65 , pp. 593-608
    • Skaper, S.D.1    Moore, S.E.2    Walsh, F.S.3
  • 31
    • 0035089312 scopus 로고    scopus 로고
    • Soluble N-cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and N-cadherin and the fibroblast growth factor receptor co-cluster in cells
    • Utton M.A., Eickholt B., Howell F.V., Wallis J., Doherty P. Soluble N-cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and N-cadherin and the fibroblast growth factor receptor co-cluster in cells. J Neurochem. 76:2001;1421-1430.
    • (2001) J Neurochem , vol.76 , pp. 1421-1430
    • Utton, M.A.1    Eickholt, B.2    Howell, F.V.3    Wallis, J.4    Doherty, P.5
  • 32
    • 0037040279 scopus 로고    scopus 로고
    • Dimeric versions of two short N-cadherin binding motifs (HAVDI and INPISG) function as N-cadherin agonists
    • Williams G., Williams E.J., Doherty P. Dimeric versions of two short N-cadherin binding motifs (HAVDI and INPISG) function as N-cadherin agonists. J Biol Chem. 277:2002;4361-4367.
    • (2002) J Biol Chem , vol.277 , pp. 4361-4367
    • Williams, G.1    Williams, E.J.2    Doherty, P.3
  • 33
    • 0034638833 scopus 로고    scopus 로고
    • N-cadherin extracellular repeat 4 mediates epithelial-to-mesenchymal transition and increased motility
    • Kim J.B., Islam S., Kim Y.J., Prudoff R.S., Sass K.M., Wheelock M.J., Johnson K.R. N-cadherin extracellular repeat 4 mediates epithelial-to-mesenchymal transition and increased motility. J Cell Biol. 151:2000;1193-1206.
    • (2000) J Cell Biol , vol.151 , pp. 1193-1206
    • Kim, J.B.1    Islam, S.2    Kim, Y.J.3    Prudoff, R.S.4    Sass, K.M.5    Wheelock, M.J.6    Johnson, K.R.7
  • 34
    • 0033230475 scopus 로고    scopus 로고
    • N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression
    • Nieman M.T., Prudoff R.S., Johnson K.R., Wheelock M.J. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol. 147:1999;631-644.
    • (1999) J Cell Biol , vol.147 , pp. 631-644
    • Nieman, M.T.1    Prudoff, R.S.2    Johnson, K.R.3    Wheelock, M.J.4
  • 35
    • 0034695913 scopus 로고    scopus 로고
    • Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis
    • Hazan R.B., Phillips G.R., Qiao R.F., Norton L., Aaronson S.A. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol. 148:2000;779-790.
    • (2000) J Cell Biol , vol.148 , pp. 779-790
    • Hazan, R.B.1    Phillips, G.R.2    Qiao, R.F.3    Norton, L.4    Aaronson, S.A.5
  • 37
    • 0036781973 scopus 로고    scopus 로고
    • A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
    • This paper shows that N-cadherin interactions with the FGF receptor prolong its lifetime on the cell surface and thus enhance signaling.
    • Suyama K., Shapiro I., Guttman M., Hazan R.B. A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell. 2:2002;301-314 This paper shows that N-cadherin interactions with the FGF receptor prolong its lifetime on the cell surface and thus enhance signaling.
    • (2002) Cancer Cell , vol.2 , pp. 301-314
    • Suyama, K.1    Shapiro, I.2    Guttman, M.3    Hazan, R.B.4
  • 39
    • 0036118004 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: A potential feedback mechanism to control vascular endothelial growth factor receptor 2 signaling
    • Zanetti A., Lampugnani M.G., Balconi G., Breviario F., Corada M., Lanfrancone L., Dejana E. Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor 2 signaling. Arterioscler Thromb Vasc Biol. 22:2002;617-622.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 617-622
    • Zanetti, A.1    Lampugnani, M.G.2    Balconi, G.3    Breviario, F.4    Corada, M.5    Lanfrancone, L.6    Dejana, E.7
  • 41
    • 0034994490 scopus 로고    scopus 로고
    • Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites
    • Nakagawa M., Fukata M., Yamaga M., Itoh N., Kaibuchi K. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J Cell Sci. 114:2001;1829-1838.
    • (2001) J Cell Sci , vol.114 , pp. 1829-1838
    • Nakagawa, M.1    Fukata, M.2    Yamaga, M.3    Itoh, N.4    Kaibuchi, K.5
  • 42
    • 0032493903 scopus 로고    scopus 로고
    • Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion
    • Kuroda S., Fukata M., Nakagawa M., Fujii K., Nakamura T., Ookubo T., Izawa I., Nagase T., Nomura N., Tani H.et al. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science. 281:1998;832-835.
    • (1998) Science , vol.281 , pp. 832-835
    • Kuroda, S.1    Fukata, M.2    Nakagawa, M.3    Fujii, K.4    Nakamura, T.5    Ookubo, T.6    Izawa, I.7    Nagase, T.8    Nomura, N.9    Tani, H.10
  • 43
    • 0030718609 scopus 로고    scopus 로고
    • Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells
    • Takaishi K., Sasaki T., Kotani H., Nishioka H., Takai Y. Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol. 139:1997;1047-1059.
    • (1997) J Cell Biol , vol.139 , pp. 1047-1059
    • Takaishi, K.1    Sasaki, T.2    Kotani, H.3    Nishioka, H.4    Takai, Y.5
  • 44
    • 0033584471 scopus 로고    scopus 로고
    • Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion
    • Kuroda S., Fukata M., Nakagawa M., Kaibuchi K. Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion. Biochem Biophys Res Commun. 262:1999;1-6.
    • (1999) Biochem Biophys Res Commun , vol.262 , pp. 1-6
    • Kuroda, S.1    Fukata, M.2    Nakagawa, M.3    Kaibuchi, K.4
  • 46
    • 0037853126 scopus 로고    scopus 로고
    • Cadherin engagement inhibits RhoA via p190RhoGAP
    • in press
    • Noren NK, Arthur WT, Burridge K: Cadherin engagement inhibits RhoA via p190RhoGAP. J Biol Chem 2003, in press.
    • (2003) J Biol Chem
    • Noren, N.K.1    Arthur, W.T.2    Burridge, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.