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Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members
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Nollet F., Kools P., van Roy F. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. J Mol Biol. 299:2000;551-572.
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Angst B.D., Marcozzi C., Magee A.I. The cadherin superfamily: diversity in form and function. J Cell Sci. 114:2001;629-641.
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Cadherin superfamily genes: Functions, genomic organization, and neurologic diversity
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Yagi T., Takeichi M. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. Genes Dev. 14:2000;1169-1180.
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Yagi, T.1
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Wheelock M.J., Johnson K.R. Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol. 19:2003;207-235.
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Wheelock, M.J.1
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Rho-family GTPases in cadherin-mediated cell-cell adhesion
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Fukata M., Kaibuchi K. Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nat Rev Mol Cell Biol. 2:2001;887-897.
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Fukata, M.1
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P120 catenin regulates the actin cytoskeleton via Rho family GTPases
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Noren N.K., Liu B.P., Burridge K., Kreft B. p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol. 150:2000;567-580.
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Noren, N.K.1
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P120 catenin affects cell motility via modulation of activity of Rho-family GTPases: A link between cell-cell contact formation and regulation of cell locomotion
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Grosheva I., Shtutman M., Elbaum M., Bershadsky A.D. p120 catenin affects cell motility via modulation of activity of Rho-family GTPases: a link between cell-cell contact formation and regulation of cell locomotion. J Cell Sci. 114:2001;695-707.
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Grosheva, I.1
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Braga V.M. Cell-cell adhesion and signalling. Curr Opin Cell Biol. 14:2002;546-556.
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Direct cadherin-activated cell signaling: A view from the plasma membrane
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Yap A.S., Kovacs E.M. Direct cadherin-activated cell signaling: a view from the plasma membrane. J Cell Biol. 160:2003;11-16.
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Yap, A.S.1
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11
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0036696823
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Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion
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This paper shows the recruitment of Rac1 to lamellipodia upon cell-cell contact and defines the temporal importance of Rac1 localization in these regions of cell contact.
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Ehrlich J.S., Hansen M.D., Nelson W.J. Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev Cell. 3:2002;259-270 This paper shows the recruitment of Rac1 to lamellipodia upon cell-cell contact and defines the temporal importance of Rac1 localization in these regions of cell contact.
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Ehrlich, J.S.1
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12
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E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts
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Kovacs E.M., Ali R.G., McCormack A.J., Yap A.S. E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts. J Biol Chem. 277:2002;6708-6718.
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Kovacs, E.M.1
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13
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0037743623
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Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate rac but not PI3-kinase. Direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation
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in press
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Goodwin M, Kovacs EM, Thoreson MA, Reynolds AB, Yap AS: Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate rac but not PI3-kinase. Direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation. J Biol Chem 2003, in press.
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J Biol Chem
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Goodwin, M.1
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14
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Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation
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Pece S., Gutkind J.S. Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J Biol Chem. 275:2000;41227-41233.
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Pece, S.1
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15
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Rac activation upon cell-cell contact formation is dependent on signaling from the epidermal growth factor receptor
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This paper shows that clustering of cadherins is sufficient to activate Rac1 and implicates EGF receptor in E-cadherin signaling in keratinocytes.
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Betson M., Lozano E., Zhang J., Braga V.M. Rac activation upon cell-cell contact formation is dependent on signaling from the epidermal growth factor receptor. J Biol Chem. 277:2002;36962-36969 This paper shows that clustering of cadherins is sufficient to activate Rac1 and implicates EGF receptor in E-cadherin signaling in keratinocytes.
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J Biol Chem
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Betson, M.1
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George-Weinstein M., Gerhart J., Blitz J., Simak E., Knudsen K.A. N-cadherin promotes the commitment and differentiation of skeletal muscle precursor cells. Dev Biol. 185:1997;14-24.
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George-Weinstein, M.1
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17
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Meriane M., Roux P., Primig M., Fort P., Gauthier-Rouviere C. Critical activities of Rac1 and Cdc42Hs in skeletal myogenesis: antagonistic effects of JNK and p38 pathways. Mol Biol Cell. 11:2000;2513-2528.
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Meriane, M.1
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18
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0031846156
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RhoA GTPase and serum response factor control selectively the expression of MyoD without affecting Myf5 in mouse myoblasts
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Carnac G., Primig M., Kitzmann M., Chafey P., Tuil D., Lamb N., Fernandez A. RhoA GTPase and serum response factor control selectively the expression of MyoD without affecting Myf5 in mouse myoblasts. Mol Biol Cell. 9:1998;1891-1902.
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Carnac, G.1
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19
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0037009074
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N-cadherin-dependent cell-cell contact regulates Rho GTPases and β-catenin localization in mouse C2C12 myoblasts
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This paper is important because it points out differences between N-cadherin signaling and E-cadherin signaling. This paper proposes that N-cadherin-mediated contacts promote myogenesis by positively regulating RhoA and negatively regulating Rac1 and Cdc42.
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Charrasse S., Meriane M., Comunale F., Blangy A., Gauthier-Rouviere C. N-cadherin-dependent cell-cell contact regulates Rho GTPases and β-catenin localization in mouse C2C12 myoblasts. J Cell Biol. 158:2002;953-965 This paper is important because it points out differences between N-cadherin signaling and E-cadherin signaling. This paper proposes that N-cadherin-mediated contacts promote myogenesis by positively regulating RhoA and negatively regulating Rac1 and Cdc42.
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Charrasse, S.1
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Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton
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Lambert M., Choquet D., Mege R.M. Dynamics of ligand-induced, Rac1-dependent anchoring of cadherins to the actin cytoskeleton. J Cell Biol. 157:2002;469-479.
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Lambert, M.1
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21
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VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam
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This paper examines the mechanism whereby Rac1 activation is maintained in endothelial cells and finds that tiam1, a rac1-specific guanine nucleotide exchange factor, is localized to junctions when cells make contact via VE-cadherin.
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Lampugnani M.G., Zanetti A., Breviario F., Balconi G., Orsenigo F., Corada M., Spagnuolo R., Betson M., Braga V., Dejana E. VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol Biol Cell. 13:2002;1175-1189 This paper examines the mechanism whereby Rac1 activation is maintained in endothelial cells and finds that tiam1, a rac1-specific guanine nucleotide exchange factor, is localized to junctions when cells make contact via VE-cadherin.
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Lampugnani, M.G.1
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22
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VE-cadherin induced Cdc42 signaling regulates formation of membrane protrusions in endothelial cells
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Kouklis P, Konstantoulaki M, Malik AB: VE-cadherin induced Cdc42 signaling regulates formation of membrane protrusions in endothelial cells. J Biol Chem 2003, in press.
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J Biol Chem
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Kouklis, P.1
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23
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The cadherin-catenin adhesion system in signaling and cancer
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Conacci-Sorrell M., Zhurinsky J., Ben-Ze'ev A. The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest. 109:2002;987-991.
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Simcha I., Kirkpatrick C., Sadot E., Shtutman M., Polevoy G., Geiger B., Peifer M., Ben-Ze'ev A. Cadherin sequences that inhibit β-catenin signaling: a study in yeast and mammalian cells. Mol Biol Cell. 12:2001;1177-1188.
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25
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Eger A., Stockinger A., Schaffhauser B., Beug H., Foisner R. Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of β-catenin and upregulation of β-catenin/lymphoid enhancer binding factor-1 transcriptional activity. J Cell Biol. 148:2000;173-188.
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Eger, A.1
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Stockinger A., Eger A., Wolf J., Beug H., Foisner R. E-cadherin regulates cell growth by modulating proliferation-dependent β-catenin transcriptional activity. J Cell Biol. 154:2001;1185-1196.
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Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling
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van de Wetering M., Barker N., Harkes I.C., van der Heyden M., Dijk N.J., Hollestelle A., Klijn J.G., Clevers H., Schutte M. Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling. Cancer Res. 61:2001;278-284.
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E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner
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Gottardi C.J., Wong E., Gumbiner B.M. E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner. J Cell Biol. 153:2001;1049-1060.
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Doherty P., Williams G., Williams E.J. CAMs and axonal growth: a critical evaluation of the role of calcium and the MAPK cascade. Mol Cell Neurosci. 16:2000;283-295.
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Skaper S.D., Moore S.E., Walsh F.S. Cell signalling cascades regulating neuronal growth-promoting and inhibitory cues. Prog Neurobiol. 65:2001;593-608.
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Soluble N-cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and N-cadherin and the fibroblast growth factor receptor co-cluster in cells
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Utton M.A., Eickholt B., Howell F.V., Wallis J., Doherty P. Soluble N-cadherin stimulates fibroblast growth factor receptor dependent neurite outgrowth and N-cadherin and the fibroblast growth factor receptor co-cluster in cells. J Neurochem. 76:2001;1421-1430.
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Utton, M.A.1
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Williams G., Williams E.J., Doherty P. Dimeric versions of two short N-cadherin binding motifs (HAVDI and INPISG) function as N-cadherin agonists. J Biol Chem. 277:2002;4361-4367.
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N-cadherin extracellular repeat 4 mediates epithelial-to-mesenchymal transition and increased motility
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Kim J.B., Islam S., Kim Y.J., Prudoff R.S., Sass K.M., Wheelock M.J., Johnson K.R. N-cadherin extracellular repeat 4 mediates epithelial-to-mesenchymal transition and increased motility. J Cell Biol. 151:2000;1193-1206.
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Kim, J.B.1
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N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression
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Nieman M.T., Prudoff R.S., Johnson K.R., Wheelock M.J. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol. 147:1999;631-644.
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35
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Hazan R.B., Phillips G.R., Qiao R.F., Norton L., Aaronson S.A. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol. 148:2000;779-790.
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37
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0036781973
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A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
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This paper shows that N-cadherin interactions with the FGF receptor prolong its lifetime on the cell surface and thus enhance signaling.
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Suyama K., Shapiro I., Guttman M., Hazan R.B. A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell. 2:2002;301-314 This paper shows that N-cadherin interactions with the FGF receptor prolong its lifetime on the cell surface and thus enhance signaling.
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Suyama, K.1
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Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
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Carmeliet P., Lampugnani M.G., Moons L., Breviario F., Compernolle V., Bono F., Balconi G., Spagnuolo R., Oostuyse B., Dewerchin M.et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 98:1999;147-157.
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Carmeliet, P.1
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Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: A potential feedback mechanism to control vascular endothelial growth factor receptor 2 signaling
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Zanetti A., Lampugnani M.G., Balconi G., Breviario F., Corada M., Lanfrancone L., Dejana E. Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor 2 signaling. Arterioscler Thromb Vasc Biol. 22:2002;617-622.
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40
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VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells
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Shay-Salit A., Shushy M., Wolfovitz E., Yahav H., Breviario F., Dejana E., Resnick N. VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. Proc Natl Acad Sci USA. 99:2002;9462-9467.
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Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites
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Nakagawa M., Fukata M., Yamaga M., Itoh N., Kaibuchi K. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J Cell Sci. 114:2001;1829-1838.
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42
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Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion
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Kuroda S., Fukata M., Nakagawa M., Fujii K., Nakamura T., Ookubo T., Izawa I., Nagase T., Nomura N., Tani H.et al. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science. 281:1998;832-835.
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Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells
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Takaishi K., Sasaki T., Kotani H., Nishioka H., Takai Y. Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol. 139:1997;1047-1059.
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Kuroda S., Fukata M., Nakagawa M., Kaibuchi K. Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion. Biochem Biophys Res Commun. 262:1999;1-6.
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Anastasiadis P.Z., Moon S.Y., Thoreson M.A., Mariner D.J., Crawford H.C., Zheng Y., Reynolds A.B. Inhibition of RhoA by p120 catenin. Nat Cell Biol. 2:2000;637-644.
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Nat Cell Biol
, vol.2
, pp. 637-644
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Anastasiadis, P.Z.1
Moon, S.Y.2
Thoreson, M.A.3
Mariner, D.J.4
Crawford, H.C.5
Zheng, Y.6
Reynolds, A.B.7
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