Divergent agonist selectivity in activating β 1- and β 2-adrenoceptors for G-protein and arrestin coupling

Biochemical Journal

Volumn 438, Issue 1, 2011, Pages 191-202

  Casella, Ida ^a   Ambrosio, Caterina ^a   Grò, Maria Cristina ^a   Molinari, Paola ^a   Costa, Tommaso ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

adrenoceptor; arrestin 2; G protein coupled receptor (GPCR); Ligand efficacy; Protein protein interaction; Resonance energy transfer

Indexed keywords

1 (2 CYANOPHENOXY) 3 [2 (3 PHENYLUREIDO)ETHYLAMINO] 2 PROPANOL; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [(2 HYDROXY 3 PHENOXYPROPYL)AMINO]ETHOXY]PHENOXYACETIC ACID; ACETYLCYSTEINE PLUS ISOPRENALINE; ADRENALIN; ADRENALONE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN 2; CLENBUTEROL; DOBUTAMINE; DOPAMINE; FENOTEROL; HEXOPRENALINE; ISOPRENALINE; LABETALOL; NORADRENALIN; ORCIPRENALINE; PINDOLOL; PRACTOLOL; PRONETALOL; PROPRANOLOL; RITODRINE; SALBUTAMOL; SKF 42469; TERBUTALINE; TIMOLOL; TULOBUTEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG; XAMOTEROL; XAMOTEROL HYDROGEN FUMARATE;

ADRENERGIC ACTIVITY; ARTICLE; BINDING AFFINITY; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CELL STRAIN HEK293; DRUG ANTAGONISM; HUMAN; HUMAN CELL; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADENOSINE DIPHOSPHATE RIBOSE; ADRENERGIC BETA-1 RECEPTOR AGONISTS; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; ARRESTIN; CATECHOLAMINES; CELL MEMBRANE; CELLS, CULTURED; CYCLIC AMP; GREEN FLUORESCENT PROTEINS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; KIDNEY; MICE; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION;

EID: 79960760639     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110374     Document Type: Article

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