Structural link between γ-Aminobutyric Acid type A (GABA A) receptor agonist binding site and inner β-sheet governs channel activation and allosteric drug modulation

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6714-6724

  Venkatachalan, Srinivasan P ^a   Czajkowski, Cynthia ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGONIST BINDING SITE; ALLOSTERIC MODULATORS; AMINOBUTYRIC ACIDS; ASYMMETRIC MOTION; BENZODIAZEPINES; CHANNEL ACTIVATION; EXTRACELLULAR; EXTRACELLULAR DOMAINS; HOMOLOGY MODELING; INFORMATION FLOWS; KEY ELEMENTS; LIGAND-GATED ION CHANNELS; NEUROTRANSMITTER BINDING; SIGNAL PROPAGATION; STRUCTURAL LINKS;

NEUROPHYSIOLOGY;

AMINO ACIDS;

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; BENZODIAZEPINE DERIVATIVE; GLYCINE; ION CHANNEL; PENTOBARBITAL;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BETA SHEET; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; EXTRACELLULAR MATRIX; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; BENZODIAZEPINES; BINDING SITES; DRUG DESIGN; GABA AGONISTS; GABA ANTAGONISTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; GLYCINE; MOLECULAR SEQUENCE DATA; OOCYTES; PENTOBARBITAL; PROTEIN STRUCTURE, SECONDARY; PYRIDAZINES; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 84857477731     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.316836     Document Type: Article

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