Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence

Journal of Biological Chemistry

Volumn 280, Issue 9, 2005, Pages 8443-8451

  Gao, Fan ^a   Bren, Nina ^a   Burghardt, Thomas P ^a   Hansen, Scott ^b   Henchman, Richard H ^b   Taylor, Palmer ^b   McCammon, J Andrew ^b   Sine, Steven M ^a  

^a Mayo Clinic Arizona   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; CONFORMATIONS; FLUORESCENCE; MOLECULAR DYNAMICS; MUTAGENESIS; QUENCHING;

BINDING CAVITY; BINDING SITE; INTRINSIC TRYPTOPHAN (TRP) FLUORESCENCE; NICOTINIC RECEPTOR LIGANDS;

PROTEINS;

ACETYLCHOLINE; BINDING PROTEIN; PROTEIN SUBUNIT; TRYPTOPHAN;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; FLUORESCENCE; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; SIMULATION; STEADY STATE;

ACETYLCHOLINE; ACRYLAMIDE; ANIMALS; BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SNAILS; SPECTROMETRY, FLUORESCENCE; TIME FACTORS; TRYPTOPHAN;

EID: 14844300820     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412389200     Document Type: Article

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