Asymmetric Structural Motions of the Homomeric α7 Nicotinic Receptor Ligand Binding Domain Revealed by Molecular Dynamics Simulation

Biophysical Journal

Volumn 85, Issue 5, 2003, Pages 3007-3018

  Henchman, Richard H ^a,c   Wang, Hai Long ^b   Sine, Steven M ^b   Taylor, Palmer ^a   McCammon, J Andrew ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAYO CLINIC   (United States)

^c Mail Code 0365 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINE BINDING PROTEIN; AMINO ACID; BINDING PROTEIN; BUNGAROTOXIN RECEPTOR; CYSTEINE; ION; ION CHANNEL; NICOTINIC RECEPTOR; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

AGONIST; ALLOSTERISM; ARTICLE; BINDING SITE; CELL MEMBRANE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; HUMAN; HYPOTHESIS; LIGAND BINDING; MOLECULAR DYNAMICS; MOTION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; SEQUENCE ALIGNMENT; SIMULATION; STRUCTURAL HOMOLOGY;

EID: 0242385357     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(03)74720-1     Document Type: Article

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