Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA A receptors supports an allosteric model of modulation

British Journal of Pharmacology

Volumn 145, Issue 7, 2005, Pages 894-906

  Downing, Scott S ^a   Lee, Yan T ^a   Farb, David H ^a,b   Gibbs, Terrell T ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

Author keywords

Diazepam; Flumazenil; Kojic amine; Partial agonist; Two state model; Zolpidem

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; FLURAZEPAM; KOJIC AMINE; ZOLPIDEM;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; CHICKEN; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SPINAL CORD NERVE CELL; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; WILD TYPE;

ALLOSTERIC REGULATION; ANIMALS; BENZODIAZEPINES; CELLS, CULTURED; CHICK EMBRYO; COMPUTER SIMULATION; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; FLURAZEPAM; GABA AGONISTS; GABA MODULATORS; MUTAGENESIS, SITE-DIRECTED; NEURONS; PYRONES; RECEPTORS, GABA-A; TRANSFECTION;

EID: 23744445277     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706251     Document Type: Article

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