Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor

Neuropharmacology

Volumn 60, Issue 2-3, 2011, Pages 520-528

  Sancar, Feyza ^a,b   Czajkowski, Cynthia ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Allosteric modulation; Benzodiazepine efficacy; GABA; GABA A receptor; Oocyte expression; Pentobarbital

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; COMPLEMENTARY DNA; CYSTEINE; FLUMAZENIL; FLURAZEPAM; PENTOBARBITAL; THIOMESYLIC ACID METHYL ESTER;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FEMALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; FEMALE; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; OOCYTES; RATS; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 78650851998     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.11.009     Document Type: Article

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