Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen

Journal of Medicinal Chemistry

Volumn 55, Issue 4, 2012, Pages 1526-1537

  Jester, Benjamin W ^a   Gaj, Alicia ^a   Shomin, Carolyn D ^a   Cox, Kurt J ^a   Ghosh, Indraneel ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 CHLORO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; 1 NAPHTHYL PP1; 2 (5 CHLORO 2 FLUOROPHENYL) 4 (4 PYRIDINYLAMINO)PTERIDINE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 4,5 BIS(4 FLUOROANILINO)PHTHALIMIDE; AMINOPURVALANOL A; ARCYRIAFLAVIN A; CGP 57380; FASUDIL; HA 1100; IKK 16; KI 8751; LUCIFERASE; MIDOSTAURIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; PD 407824; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE; PROTEIN KINASE AGC; PURVALANOL A; PURVALANOL B; ROTTLERIN; SB 218078; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; NEOPLASM; PREDICTIVE VALUE; RADIOASSAY; REPORTER GENE;

ANIMALS; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CELL-FREE SYSTEM; CYCLIC AMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNITS; CYCLIC GMP-DEPENDENT PROTEIN KINASE TYPE I; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DATABASES, FACTUAL; GENES, REPORTER; LUCIFERASES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RABBITS; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857422382     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201265f     Document Type: Article

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