A coiled-coil enabled split-luciferase three-hybrid system: Applied toward profiling inhibitors of protein kinases

Journal of the American Chemical Society

Volumn 132, Issue 33, 2010, Pages 11727-11735

  Jester, Benjamin W ^a   Cox, Kurt J ^a   Gaj, Alicia ^a   Shomin, Carolyn D ^a   Porter, Jason R ^a   Ghosh, Indraneel ^a  

^a University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY ASSAYS; ALLOSTERIC INHIBITOR; C-TERMINAL FRAGMENTS; COILED COIL; FIREFLY LUCIFERASE; HUMAN DISEASE; HUMAN GENOMES; HYBRID APPROACH; HYBRID COMPLEXES; KINASE FAMILY; KINASE INHIBITORS; LARGE ARRAYS; LUCIFERASE ACTIVITIES; LUCIFERASE ENZYMES; N-TERMINALS; PRACTICAL METHOD; PROTEIN KINASE; PROTEIN KINASE INHIBITORS; PURIFIED PROTEIN; RAPID METHOD; REASSEMBLY; SPECIFIC INHIBITORS; STAUROSPORINES; TARGET PROTEINS;

ELECTRIC GROUNDING; HYBRID COMPUTERS; HYBRID SYSTEMS; PLANTS (BOTANY); SIGNAL TRANSDUCTION;

PROTEINS;

2 MORPHOLINO 8 PHENYLCHROMONE; FIREFLY LUCIFERASE; LUCIFERASE; MIDOSTAURIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NITROGEN; NU 7026; PROTEIN FOS; PROTEIN KINASE; PROTEIN KINASE C INHIBITOR; PURVALANOL A; STAUROSPORINE; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; BIOSENSOR; DIMERIZATION; DRUG IDENTIFICATION; ENZYME ACTIVITY; ENZYME INHIBITION; FAMILY; HUMAN; METHODOLOGY; NONHUMAN; PROTEIN EXPRESSION; RETICULOCYTE LYSATE; SCREENING;

HUMANS; LUCIFERASES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 77955836287     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja104491h     Document Type: Article

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