Cathepsin B-sensitive polymers for compartment-specific degradation and nucleic acid release

Journal of Controlled Release

Volumn 157, Issue 3, 2012, Pages 445-454

  Chu, David S H ^a   Johnson, Russell N ^a   Pun, Suzie H ^a  

^a University of Washington   (United States)

Author keywords

Cathepsin B; Non viral gene delivery; RAFT polymerization

Indexed keywords

CATHEPSIN B; CATIONIC POLYMERS; DNA RELEASE; HIGH SPECIFICITY; IN-VIVO; MACRO-MONOMERS; NON-VIRAL GENE DELIVERY; PEPTIDE LINKERS; POLYPLEXES; RAFT POLYMERIZATION; TRANSFECTION EFFICIENCY;

AMINO ACIDS; BIOMOLECULES; COPOLYMERS; DEGRADATION; DNA; GENE THERAPY; GENE TRANSFER; LIVING POLYMERIZATION; PEPTIDES; POLYDISPERSITY;

POLYMERS;

CATHEPSIN B; COPOLYMER; DNA; LYSINE; N (2 HYDROXYPROPYL)METHACRYLAMIDE; OLIGOLYSINE; OLIGOPEPTIDE; PLASMID DNA; POLYETHYLENEIMINE; POLYLYSINE; POLYMER; POLYMETHACRYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN 3T3; COLLOID; CONTROLLED STUDY; CYTOTOXICITY; DISPERSION; DRUG RELEASE; ENZYMATIC DEGRADATION; GEL PERMEATION CHROMATOGRAPHY; GENETIC TRANSFECTION; HELA CELL; IC 50; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR STABILITY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH; POLYMERIZATION; PRIORITY JOURNAL; REVERSE ADDITION FRAGMENTATION CHAIN TRANSFER POLYMERIZATION;

ANIMALS; CATHEPSIN B; CELL SURVIVAL; DNA; HELA CELLS; HUMANS; MICE; NANOPARTICLES; NIH 3T3 CELLS; OLIGOPEPTIDES; POLYMERS; TRANSFECTION;

EID: 84857357099     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.10.016     Document Type: Article

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