Reducible DNA nanoparticles enhance in vitro gene transfer via an extracellular mechanism

Journal of Controlled Release

Volumn 146, Issue 1, 2010, Pages 118-127

  Sun, Wenchao ^a   Davis, Pamela B ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cellular uptake; DePEGylation; Disulfide linkage; DNA nanoparticles; Extracellular mechanism

Indexed keywords

CELLULAR UPTAKE; DEPEGYLATION; DISULFIDE LINKAGE; DISULFIDE LINKAGES; EXTRACELLULAR; EXTRACELLULAR MECHANISM;

DNA; ENZYME ACTIVITY; GENE TRANSFER; MACHINE DESIGN; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

GENES;

DNA NANOPARTICLE; MACROGOL; NANOPARTICLE; PLASMID DNA; POLYLYSINE; THIOL; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONJUGATE; CONJUGATION; CONTROLLED STUDY; DISULFIDE BOND; EXTRACELLULAR SPACE; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TRANSFER; HETEROZYGOTE; HUMAN; HUMAN CELL; IN VITRO STUDY; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; TRANSGENE;

CELL CULTURE TECHNIQUES; CELL MEMBRANE; CELL SURVIVAL; CYSTEINE; DNA; DRUG CARRIERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EXTRACELLULAR SPACE; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PLASMIDS; POLYETHYLENE; POLYLYSINE; SULFHYDRYL COMPOUNDS; TRANSFECTION;

EID: 77955279132     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.04.031     Document Type: Article

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