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Volumn 351, Issue 1, 2012, Pages 101-110

Towards an understanding of the role of p53 in adrenocortical carcinogenesis

Author keywords

ACC; Adrenocortical carcinoma; P53; Pediatric

Indexed keywords

ARGININE; PROLINE; PROTEIN P53;

EID: 84857111395     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.09.010     Document Type: Review
Times cited : (67)

References (133)
  • 1
    • 33845645820 scopus 로고    scopus 로고
    • The TP53 mutation, R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families
    • Achatz M.I., Olivier M., Le Calvez F., et al. The TP53 mutation, R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families. Cancer Lett. 2007, 245(1-2):96-102.
    • (2007) Cancer Lett. , vol.245 , Issue.1-2 , pp. 96-102
    • Achatz, M.I.1    Olivier, M.2    Le Calvez, F.3
  • 2
    • 66349113796 scopus 로고    scopus 로고
    • Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors
    • Almeida L.O., Custodio A.C., Pinto G.R., et al. Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors. Genet. Mol. Res. 2009, 8(1):8-18.
    • (2009) Genet. Mol. Res. , vol.8 , Issue.1 , pp. 8-18
    • Almeida, L.O.1    Custodio, A.C.2    Pinto, G.R.3
  • 3
    • 77956331627 scopus 로고    scopus 로고
    • Integrating common and rare genetic variation in diverse human populations
    • Altshuler D.M., Gibbs R.A., Peltonen L., et al. Integrating common and rare genetic variation in diverse human populations. Nature 2010, 467(7311):52-58.
    • (2010) Nature , vol.467 , Issue.7311 , pp. 52-58
    • Altshuler, D.M.1    Gibbs, R.A.2    Peltonen, L.3
  • 4
    • 84857114382 scopus 로고    scopus 로고
    • American Cancer Society Cancer Facts & Figures 2010
    • American Cancer Society, 2010. Cancer Facts & Figures 2010.
    • (2010)
  • 5
    • 60649108223 scopus 로고    scopus 로고
    • Association of the germline TP53 R337H mutation with breast cancer in southern Brazil, BMC Cancer. 8357
    • Assumpcao, J.G., Seidinger, A.L., Mastellaro, M.J. et al., 2008. Association of the germline TP53 R337H mutation with breast cancer in southern Brazil, BMC Cancer. 8357.
    • (2008)
    • Assumpcao, J.G.1    Seidinger, A.L.2    Mastellaro, M.J.3
  • 6
    • 0034905733 scopus 로고    scopus 로고
    • Molecular analysis of CDKN1C and TP53 in sporadic adrenal tumors
    • Barzon L., Chilosi M., Fallo F., et al. Molecular analysis of CDKN1C and TP53 in sporadic adrenal tumors. Eur. J. Endocrinol. 2001, 145(2):207-212.
    • (2001) Eur. J. Endocrinol. , vol.145 , Issue.2 , pp. 207-212
    • Barzon, L.1    Chilosi, M.2    Fallo, F.3
  • 7
    • 77952300541 scopus 로고    scopus 로고
    • Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development
    • Berthon A., Sahut-Barnola I., Lambert-Langlais S., et al. Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development. Hum. Mol. Genet. 2010, 19(8):1561-1576.
    • (2010) Hum. Mol. Genet. , vol.19 , Issue.8 , pp. 1561-1576
    • Berthon, A.1    Sahut-Barnola, I.2    Lambert-Langlais, S.3
  • 8
    • 48749103325 scopus 로고    scopus 로고
    • Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
    • Boeckler F.M., Joerger A.C., Jaggi G., et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc. Natl. Acad. Sci. USA 2008, 105(30):10360-10365.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.30 , pp. 10360-10365
    • Boeckler, F.M.1    Joerger, A.C.2    Jaggi, G.3
  • 9
    • 70450235184 scopus 로고    scopus 로고
    • Regulation of p53-insights into a complex process
    • Boehme K.A., Blattner C. Regulation of p53-insights into a complex process. Crit. Rev. Biochem. Mol. Biol. 2009, 44(6):367-392.
    • (2009) Crit. Rev. Biochem. Mol. Biol. , vol.44 , Issue.6 , pp. 367-392
    • Boehme, K.A.1    Blattner, C.2
  • 10
    • 40249110406 scopus 로고    scopus 로고
    • Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients
    • Boldrini L., Gisfredi S., Ursino S., et al. Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients. Oncol. Rep. 2008, 19(3):771-773.
    • (2008) Oncol. Rep. , vol.19 , Issue.3 , pp. 771-773
    • Boldrini, L.1    Gisfredi, S.2    Ursino, S.3
  • 11
    • 8844278362 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
    • Bond G.L., Hu W., Bond E.E., et al. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell 2004, 119(5):591-602.
    • (2004) Cell , vol.119 , Issue.5 , pp. 591-602
    • Bond, G.L.1    Hu, W.2    Bond, E.E.3
  • 12
    • 21344470650 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect
    • Bond G.L., Hu W., Levine A. A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect. Cancer Res. 2005, 65(13):5481-5484.
    • (2005) Cancer Res. , vol.65 , Issue.13 , pp. 5481-5484
    • Bond, G.L.1    Hu, W.2    Levine, A.3
  • 13
    • 33745235771 scopus 로고    scopus 로고
    • Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome
    • Bougeard G., Baert-Desurmont S., Tournier I., et al. Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome. J. Med. Genet. 2006, 43(6):531-533.
    • (2006) J. Med. Genet. , vol.43 , Issue.6 , pp. 531-533
    • Bougeard, G.1    Baert-Desurmont, S.2    Tournier, I.3
  • 14
    • 0033485261 scopus 로고    scopus 로고
    • Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    • Bulavin D.V., Saito S., Hollander M.C., et al. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 1999, 18(23):6845-6854.
    • (1999) EMBO J. , vol.18 , Issue.23 , pp. 6845-6854
    • Bulavin, D.V.1    Saito, S.2    Hollander, M.C.3
  • 15
    • 33749641724 scopus 로고    scopus 로고
    • Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis
    • Cecchinelli B., Porrello A., Lazzari C., et al. Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis. Cell Death Differ. 2006, 13(11):1994-1997.
    • (2006) Cell Death Differ. , vol.13 , Issue.11 , pp. 1994-1997
    • Cecchinelli, B.1    Porrello, A.2    Lazzari, C.3
  • 16
    • 69749128490 scopus 로고    scopus 로고
    • Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy
    • Choong M.L., Yang H., Lee M.A., et al. Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy. Cell Cycle 2009, 8(17):2810-2818.
    • (2009) Cell Cycle , vol.8 , Issue.17 , pp. 2810-2818
    • Choong, M.L.1    Yang, H.2    Lee, M.A.3
  • 17
    • 39849089291 scopus 로고    scopus 로고
    • Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer, BMC Cancer. 832
    • Costa, S., Pinto, D., Pereira, D. et al., 2008. Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer, BMC Cancer. 832.
    • (2008)
    • Costa, S.1    Pinto, D.2    Pereira, D.3
  • 18
    • 79952933734 scopus 로고    scopus 로고
    • Increased Incidence of Choroid Plexus Carcinoma Due to the Germline TP53 R337H Mutation in Southern Brazil
    • Custodio G., Taques G.R., Figueiredo B.C., et al. Increased Incidence of Choroid Plexus Carcinoma Due to the Germline TP53 R337H Mutation in Southern Brazil. PLoS One 2011, 6(3):e18015.
    • (2011) PLoS One , vol.6 , Issue.3
    • Custodio, G.1    Taques, G.R.2    Figueiredo, B.C.3
  • 19
    • 78049302116 scopus 로고    scopus 로고
    • P53 post-translational modification: deregulated in tumorigenesis
    • Dai C., Gu W. P53 post-translational modification: deregulated in tumorigenesis. Trends Mol. Med. 2010, 16(11):528-536.
    • (2010) Trends Mol. Med. , vol.16 , Issue.11 , pp. 528-536
    • Dai, C.1    Gu, W.2
  • 20
    • 61449137784 scopus 로고    scopus 로고
    • Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival
    • de Reynies A., Assie G., Rickman D.S., et al. Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival. J. Clin. Oncol. 2009, 27(7):1108-1115.
    • (2009) J. Clin. Oncol. , vol.27 , Issue.7 , pp. 1108-1115
    • de Reynies, A.1    Assie, G.2    Rickman, D.S.3
  • 21
    • 33847326819 scopus 로고    scopus 로고
    • Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers
    • Dearth L.R., Qian H., Wang T., et al. Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers. Carcinogenesis 2007, 28(2):289-298.
    • (2007) Carcinogenesis , vol.28 , Issue.2 , pp. 289-298
    • Dearth, L.R.1    Qian, H.2    Wang, T.3
  • 22
    • 77951238151 scopus 로고    scopus 로고
    • SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53
    • Demma M., Maxwell E., Ramos R., et al. SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. J. Biol. Chem. 2010, 285(14):10198-10212.
    • (2010) J. Biol. Chem. , vol.285 , Issue.14 , pp. 10198-10212
    • Demma, M.1    Maxwell, E.2    Ramos, R.3
  • 23
    • 39749118523 scopus 로고    scopus 로고
    • Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians
    • den Reijer P.M., Maier A.B., Westendorp R.G., et al. Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians. Mech. Ageing Dev. 2008, 129(4):175-182.
    • (2008) Mech. Ageing Dev. , vol.129 , Issue.4 , pp. 175-182
    • den Reijer, P.M.1    Maier, A.B.2    Westendorp, R.G.3
  • 24
    • 0036143771 scopus 로고    scopus 로고
    • A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer
    • DiGiammarino E.L., Lee A.S., Cadwell C., et al. A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer. Nat. Struct. Biol. 2002, 9(1):12-16.
    • (2002) Nat. Struct. Biol. , vol.9 , Issue.1 , pp. 12-16
    • DiGiammarino, E.L.1    Lee, A.S.2    Cadwell, C.3
  • 25
    • 33745154819 scopus 로고    scopus 로고
    • Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction
    • Ding K., Lu Y., Nikolovska-Coleska Z., et al. Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. J. Med. Chem. 2006, 49(12):3432-3435.
    • (2006) J. Med. Chem. , vol.49 , Issue.12 , pp. 3432-3435
    • Ding, K.1    Lu, Y.2    Nikolovska-Coleska, Z.3
  • 26
    • 36849073202 scopus 로고    scopus 로고
    • Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer
    • Doghman M., Karpova T., Rodrigues G.A., et al. Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer. Mol. Endocrinol. 2007, 21(12):2968-2987.
    • (2007) Mol. Endocrinol. , vol.21 , Issue.12 , pp. 2968-2987
    • Doghman, M.1    Karpova, T.2    Rodrigues, G.A.3
  • 27
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower L.A., Harvey M., Slagle B.L., et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992, 356(6366):215-221.
    • (1992) Nature , vol.356 , Issue.6366 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3
  • 28
    • 0037372005 scopus 로고    scopus 로고
    • The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
    • Dumont P., Leu J.I., Della Pietra A.C., et al. The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat. Genet. 2003, 33(3):357-365.
    • (2003) Nat. Genet. , vol.33 , Issue.3 , pp. 357-365
    • Dumont, P.1    Leu, J.I.2    Della Pietra, A.C.3
  • 29
    • 42049093996 scopus 로고    scopus 로고
    • Evaluation of telomere length maintenance mechanisms in adrenocortical carcinoma
    • Else T., Giordano T.J., Hammer G.D. Evaluation of telomere length maintenance mechanisms in adrenocortical carcinoma. J. Clin. Endocrinol. Metab. 2008, 93(4):1442-1449.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , Issue.4 , pp. 1442-1449
    • Else, T.1    Giordano, T.J.2    Hammer, G.D.3
  • 30
    • 65649133036 scopus 로고    scopus 로고
    • Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis
    • Else T., Trovato A., Kim A.C., et al. Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis. Cancer Cell 2009, 15(6):465-476.
    • (2009) Cancer Cell , vol.15 , Issue.6 , pp. 465-476
    • Else, T.1    Trovato, A.2    Kim, A.C.3
  • 31
    • 79951784529 scopus 로고    scopus 로고
    • CKIalpha ablation highlights a critical role for p53 in invasiveness control
    • Elyada E., Pribluda A., Goldstein R.E., et al. CKIalpha ablation highlights a critical role for p53 in invasiveness control. Nature 2011, 470(7334):409-413.
    • (2011) Nature , vol.470 , Issue.7334 , pp. 409-413
    • Elyada, E.1    Pribluda, A.2    Goldstein, R.E.3
  • 32
    • 30744441388 scopus 로고    scopus 로고
    • Penetrance of adrenocortical tumours associated with the germline TP53 R337H mutation
    • Figueiredo B.C., Sandrini R., Zambetti G.P., et al. Penetrance of adrenocortical tumours associated with the germline TP53 R337H mutation. J. Med. Genet. 2006, 43(1):91-96.
    • (2006) J. Med. Genet. , vol.43 , Issue.1 , pp. 91-96
    • Figueiredo, B.C.1    Sandrini, R.2    Zambetti, G.P.3
  • 33
    • 0033032905 scopus 로고    scopus 로고
    • Comparative genomic hybridization analysis of adrenocortical tumors of childhood
    • Figueiredo B.C., Stratakis C.A., Sandrini R., et al. Comparative genomic hybridization analysis of adrenocortical tumors of childhood. J. Clin. Endocrinol. Metab. 1999, 84(3):1116-1121.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , Issue.3 , pp. 1116-1121
    • Figueiredo, B.C.1    Stratakis, C.A.2    Sandrini, R.3
  • 34
    • 0033601370 scopus 로고    scopus 로고
    • Pharmacological rescue of mutant p53 conformation and function
    • Foster B.A., Coffey H.A., Morin M.J., et al. Pharmacological rescue of mutant p53 conformation and function. Science 1999, 286(5449):2507-2510.
    • (1999) Science , vol.286 , Issue.5449 , pp. 2507-2510
    • Foster, B.A.1    Coffey, H.A.2    Morin, M.J.3
  • 35
    • 79952275158 scopus 로고    scopus 로고
    • The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation
    • Frank A.K., Leu J.I., Zhou Y., et al. The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation. Mol. Cell. Biol. 2011, 31(6):1201-1213.
    • (2011) Mol. Cell. Biol. , vol.31 , Issue.6 , pp. 1201-1213
    • Frank, A.K.1    Leu, J.I.2    Zhou, Y.3
  • 36
    • 11144356056 scopus 로고    scopus 로고
    • A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA
    • Gemignani F., Moreno V., Landi S., et al. A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA. Oncogene 2004, 23(10):1954-1956.
    • (2004) Oncogene , vol.23 , Issue.10 , pp. 1954-1956
    • Gemignani, F.1    Moreno, V.2    Landi, S.3
  • 37
    • 59449098488 scopus 로고    scopus 로고
    • Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling
    • Giordano T.J., Kuick R., Else T., et al. Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clin. Cancer Res. 2009, 15(2):668-676.
    • (2009) Clin. Cancer Res. , vol.15 , Issue.2 , pp. 668-676
    • Giordano, T.J.1    Kuick, R.2    Else, T.3
  • 38
    • 0037331277 scopus 로고    scopus 로고
    • Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis
    • Giordano T.J., Thomas D.G., Kuick R., et al. Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis. Am. J. Pathol. 2003, 162(2):521-531.
    • (2003) Am. J. Pathol. , vol.162 , Issue.2 , pp. 521-531
    • Giordano, T.J.1    Thomas, D.G.2    Kuick, R.3
  • 39
    • 3242806015 scopus 로고    scopus 로고
    • Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease
    • Goodman J.E., Hofseth L.J., Hussain S.P., et al. Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease. Environ. Mol. Mutagen. 2004, 44(1):3-9.
    • (2004) Environ. Mol. Mutagen. , vol.44 , Issue.1 , pp. 3-9
    • Goodman, J.E.1    Hofseth, L.J.2    Hussain, S.P.3
  • 40
    • 13944274061 scopus 로고    scopus 로고
    • Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
    • Grasberger B.L., Lu T., Schubert C., et al. Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells. J. Med. Chem. 2005, 48(4):909-912.
    • (2005) J. Med. Chem. , vol.48 , Issue.4 , pp. 909-912
    • Grasberger, B.L.1    Lu, T.2    Schubert, C.3
  • 41
    • 0033992478 scopus 로고    scopus 로고
    • P53 and human cancer: the first ten thousand mutations
    • Hainaut P., Hollstein M. P53 and human cancer: the first ten thousand mutations. Adv. Cancer Res. 2000, 77:81-137.
    • (2000) Adv. Cancer Res. , vol.77 , pp. 81-137
    • Hainaut, P.1    Hollstein, M.2
  • 43
    • 77956188419 scopus 로고    scopus 로고
    • Regulation of the p53 pathway by ubiquitin and related proteins
    • Hock A., Vousden K.H. Regulation of the p53 pathway by ubiquitin and related proteins. Int. J. Biochem. Cell Biol. 2010, 42(10):1618-1621.
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , Issue.10 , pp. 1618-1621
    • Hock, A.1    Vousden, K.H.2
  • 44
    • 73949117703 scopus 로고    scopus 로고
    • Massively regulated genes: the example of TP53
    • Hollstein M., Hainaut P. Massively regulated genes: the example of TP53. J. Pathol. 2010, 220(2):164-173.
    • (2010) J. Pathol. , vol.220 , Issue.2 , pp. 164-173
    • Hollstein, M.1    Hainaut, P.2
  • 45
    • 0002881327 scopus 로고    scopus 로고
    • On the origins of tumor mutations in cancer genes: insights from the p53 gene
    • Hollstein M., Moeckel G., Hergenhahn M., et al. On the origins of tumor mutations in cancer genes: insights from the p53 gene. Mutat. Res. 1998, 405(2):145-154.
    • (1998) Mutat. Res. , vol.405 , Issue.2 , pp. 145-154
    • Hollstein, M.1    Moeckel, G.2    Hergenhahn, M.3
  • 46
    • 84862740746 scopus 로고    scopus 로고
    • The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells
    • Huang C., Zhang X.M., Tavaluc R.T., et al. The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells. Cancer Biol. Ther. 2009, 8(22):2186-2193.
    • (2009) Cancer Biol. Ther. , vol.8 , Issue.22 , pp. 2186-2193
    • Huang, C.1    Zhang, X.M.2    Tavaluc, R.T.3
  • 47
    • 35148847384 scopus 로고    scopus 로고
    • Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
    • Itahana K., Mao H., Jin A., et al. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 2007, 12(4):355-366.
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 355-366
    • Itahana, K.1    Mao, H.2    Jin, A.3
  • 48
    • 0028118111 scopus 로고
    • Tumor spectrum analysis in p53-mutant mice
    • Jacks T., Remington L., Williams B.O., et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 1994, 4(1):1-7.
    • (1994) Curr. Biol. , vol.4 , Issue.1 , pp. 1-7
    • Jacks, T.1    Remington, L.2    Williams, B.O.3
  • 49
    • 0032832821 scopus 로고    scopus 로고
    • Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization
    • James L.A., Kelsey A.M., Birch J.M., et al. Highly consistent genetic alterations in childhood adrenocortical tumours detected by comparative genomic hybridization. Br. J. Cancer 1999, 81(2):300-304.
    • (1999) Br. J. Cancer , vol.81 , Issue.2 , pp. 300-304
    • James, L.A.1    Kelsey, A.M.2    Birch, J.M.3
  • 50
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones S.N., Roe A.E., Donehower L.A., et al. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995, 378(6553):206-208.
    • (1995) Nature , vol.378 , Issue.6553 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3
  • 51
    • 16844362817 scopus 로고    scopus 로고
    • Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s
    • Kakudo Y., Shibata H., Otsuka K., et al. Lack of correlation between p53-dependent transcriptional activity and the ability to induce apoptosis among 179 mutant p53s. Cancer Res. 2005, 65(6):2108-2114.
    • (2005) Cancer Res. , vol.65 , Issue.6 , pp. 2108-2114
    • Kakudo, Y.1    Shibata, H.2    Otsuka, K.3
  • 52
    • 0037816165 scopus 로고    scopus 로고
    • Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
    • Kato S., Han S.Y., Liu W., et al. Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. Proc. Natl. Acad. Sci. USA 2003, 100(14):8424-8429.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , Issue.14 , pp. 8424-8429
    • Kato, S.1    Han, S.Y.2    Liu, W.3
  • 53
    • 0028882757 scopus 로고
    • Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo
    • Keeney D.S., Jenkins C.M., Waterman M.R. Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo. Endocrinology 1995, 136(11):4872-4879.
    • (1995) Endocrinology , vol.136 , Issue.11 , pp. 4872-4879
    • Keeney, D.S.1    Jenkins, C.M.2    Waterman, M.R.3
  • 54
    • 0029810445 scopus 로고    scopus 로고
    • Genetic aberrations in adrenocortical tumors detected using comparative genomic hybridization correlate with tumor size and malignancy
    • Kjellman M., Kallioniemi O.P., Karhu R., et al. Genetic aberrations in adrenocortical tumors detected using comparative genomic hybridization correlate with tumor size and malignancy. Cancer Res. 1996, 56(18):4219-4223.
    • (1996) Cancer Res. , vol.56 , Issue.18 , pp. 4219-4223
    • Kjellman, M.1    Kallioniemi, O.P.2    Karhu, R.3
  • 55
    • 7944239221 scopus 로고    scopus 로고
    • Targeting the p53-MDM2 interaction to treat cancer
    • Klein C., Vassilev L.T. Targeting the p53-MDM2 interaction to treat cancer. Br. J. Cancer 2004, 91(8):1415-1419.
    • (2004) Br. J. Cancer , vol.91 , Issue.8 , pp. 1415-1419
    • Klein, C.1    Vassilev, L.T.2
  • 56
    • 65549120715 scopus 로고    scopus 로고
    • Modes of p53 regulation
    • Kruse J.P., Gu W. Modes of p53 regulation. Cell 2009, 137(4):609-622.
    • (2009) Cell , vol.137 , Issue.4 , pp. 609-622
    • Kruse, J.P.1    Gu, W.2
  • 57
    • 42949114938 scopus 로고    scopus 로고
    • Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
    • Lain S., Hollick J.J., Campbell J., et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 2008, 13(5):454-463.
    • (2008) Cancer Cell , vol.13 , Issue.5 , pp. 454-463
    • Lain, S.1    Hollick, J.J.2    Campbell, J.3
  • 58
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane D.P. Cancer. p53, guardian of the genome. Nature 1992, 358(6381):15-16.
    • (1992) Nature , vol.358 , Issue.6381 , pp. 15-16
    • Lane, D.P.1
  • 59
    • 13644260907 scopus 로고    scopus 로고
    • Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
    • Lang G.A., Iwakuma T., Suh Y.A., et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 2004, 119(6):861-872.
    • (2004) Cell , vol.119 , Issue.6 , pp. 861-872
    • Lang, G.A.1    Iwakuma, T.2    Suh, Y.A.3
  • 60
    • 0034750121 scopus 로고    scopus 로고
    • An inherited mutation outside the highly conserved DNA-binding domain of the p53 tumor suppressor protein in children and adults with sporadic adrenocortical tumors
    • Latronico A.C., Pinto E.M., Domenice S., et al. An inherited mutation outside the highly conserved DNA-binding domain of the p53 tumor suppressor protein in children and adults with sporadic adrenocortical tumors. J. Clin. Endocrinol. Metab. 2001, 86(10):4970-4973.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , Issue.10 , pp. 4970-4973
    • Latronico, A.C.1    Pinto, E.M.2    Domenice, S.3
  • 61
    • 67650736272 scopus 로고    scopus 로고
    • Transcriptional profiling enables molecular classification of adrenocortical tumours
    • Laurell C., Velazquez-Fernandez D., Lindsten K., et al. Transcriptional profiling enables molecular classification of adrenocortical tumours. Eur. J. Endocrinol. 2009, 161(1):141-152.
    • (2009) Eur. J. Endocrinol. , vol.161 , Issue.1 , pp. 141-152
    • Laurell, C.1    Velazquez-Fernandez, D.2    Lindsten, K.3
  • 62
    • 0024431245 scopus 로고
    • High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene
    • Lavigueur A., Maltby V., Mock D., et al. High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol. Cell. Biol. 1989, 9(9):3982-3991.
    • (1989) Mol. Cell. Biol. , vol.9 , Issue.9 , pp. 3982-3991
    • Lavigueur, A.1    Maltby, V.2    Mock, D.3
  • 63
    • 77449155637 scopus 로고    scopus 로고
    • The multiple levels of regulation by p53 ubiquitination
    • Lee J.T., Gu W. The multiple levels of regulation by p53 ubiquitination. Cell Death Differ. 2010, 17(1):86-92.
    • (2010) Cell Death Differ. , vol.17 , Issue.1 , pp. 86-92
    • Lee, J.T.1    Gu, W.2
  • 64
    • 0023715595 scopus 로고
    • A cancer family syndrome in twenty-four kindreds
    • Li F.P., Fraumeni J.F., Mulvihill J.J., et al. A cancer family syndrome in twenty-four kindreds. Cancer Res. 1988, 48(18):5358-5362.
    • (1988) Cancer Res. , vol.48 , Issue.18 , pp. 5358-5362
    • Li, F.P.1    Fraumeni, J.F.2    Mulvihill, J.J.3
  • 65
    • 21244467583 scopus 로고    scopus 로고
    • The codon 47 polymorphism in p53 is functionally significant
    • Li X., Dumont P., Della Pietra A., et al. The codon 47 polymorphism in p53 is functionally significant. J. Biol. Chem. 2005, 280(25):24245-24251.
    • (2005) J. Biol. Chem. , vol.280 , Issue.25 , pp. 24245-24251
    • Li, X.1    Dumont, P.2    Della Pietra, A.3
  • 66
    • 33847415406 scopus 로고    scopus 로고
    • Somatic TP53 mutations are relatively rare among adrenocortical cancers with the frequent 17p13 loss of heterozygosity
    • Libe R., Groussin L., Tissier F., et al. Somatic TP53 mutations are relatively rare among adrenocortical cancers with the frequent 17p13 loss of heterozygosity. Clin. Cancer Res. 2007, 13(3):844-850.
    • (2007) Clin. Cancer Res. , vol.13 , Issue.3 , pp. 844-850
    • Libe, R.1    Groussin, L.2    Tissier, F.3
  • 67
    • 0032490875 scopus 로고    scopus 로고
    • Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members
    • Lomax M.E., Barnes D.M., Hupp T.R., et al. Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members. Oncogene 1998, 17(5):643-649.
    • (1998) Oncogene , vol.17 , Issue.5 , pp. 643-649
    • Lomax, M.E.1    Barnes, D.M.2    Hupp, T.R.3
  • 68
    • 2342488713 scopus 로고    scopus 로고
    • Inhibin alpha-subunit (INHA) gene and locus changes in paediatric adrenocortical tumours from TP53 R337H mutation heterozygote carriers
    • Longui C.A., Lemos-Marini S.H., Figueiredo B., et al. Inhibin alpha-subunit (INHA) gene and locus changes in paediatric adrenocortical tumours from TP53 R337H mutation heterozygote carriers. J. Med. Genet. 2004, 41(5):354-359.
    • (2004) J. Med. Genet. , vol.41 , Issue.5 , pp. 354-359
    • Longui, C.A.1    Lemos-Marini, S.H.2    Figueiredo, B.3
  • 69
    • 0026665911 scopus 로고
    • Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients
    • Lustbader E.D., Williams W.R., Bondy M.L., et al. Segregation analysis of cancer in families of childhood soft-tissue-sarcoma patients. Am. J. Hum. Genet. 1992, 51(2):344-356.
    • (1992) Am. J. Hum. Genet. , vol.51 , Issue.2 , pp. 344-356
    • Lustbader, E.D.1    Williams, W.R.2    Bondy, M.L.3
  • 70
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    • Malkin D., Li F.P., Strong L.C., et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990, 250(4985):1233-1238.
    • (1990) Science , vol.250 , Issue.4985 , pp. 1233-1238
    • Malkin, D.1    Li, F.P.2    Strong, L.C.3
  • 71
    • 33845611951 scopus 로고    scopus 로고
    • Modeling the therapeutic efficacy of p53 restoration in tumors
    • Martins C.P., Brown-Swigart L., Evan G.I. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 2006, 127(7):1323-1334.
    • (2006) Cell , vol.127 , Issue.7 , pp. 1323-1334
    • Martins, C.P.1    Brown-Swigart, L.2    Evan, G.I.3
  • 72
    • 0038121757 scopus 로고    scopus 로고
    • An overview of inhibitors of Na(+)/H(+) exchanger
    • Masereel B., Pochet L., Laeckmann D. An overview of inhibitors of Na(+)/H(+) exchanger. Eur. J. Med. Chem. 2003, 38(6):547-554.
    • (2003) Eur. J. Med. Chem. , vol.38 , Issue.6 , pp. 547-554
    • Masereel, B.1    Pochet, L.2    Laeckmann, D.3
  • 73
    • 0028557211 scopus 로고
    • Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice
    • Matzuk M.M., Finegold M.J., Mather J.P., et al. Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. Proc. Natl. Acad. Sci. USA 1994, 91(19):8817-8821.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , Issue.19 , pp. 8817-8821
    • Matzuk, M.M.1    Finegold, M.J.2    Mather, J.P.3
  • 74
    • 1542713361 scopus 로고    scopus 로고
    • Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry
    • Michalkiewicz E., Sandrini R., Figueiredo B., et al. Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. J. Clin. Oncol. 2004, 22(5):838-845.
    • (2004) J. Clin. Oncol. , vol.22 , Issue.5 , pp. 838-845
    • Michalkiewicz, E.1    Sandrini, R.2    Figueiredo, B.3
  • 75
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca Luna R., Wagner D.S., Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995, 378(6553):203-206.
    • (1995) Nature , vol.378 , Issue.6553 , pp. 203-206
    • Montes de Oca Luna, R.1    Wagner, D.S.2    Lozano, G.3
  • 76
    • 0033054345 scopus 로고    scopus 로고
    • The expression of inhibin/activin subunits in the human adrenal cortex and its tumours
    • Munro L.M., Kennedy A., McNicol A.M. The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. J. Endocrinol. 1999, 161(2):341-347.
    • (1999) J. Endocrinol. , vol.161 , Issue.2 , pp. 341-347
    • Munro, L.M.1    Kennedy, A.2    McNicol, A.M.3
  • 77
    • 0027336378 scopus 로고
    • P53 mutations in sporadic adrenocortical tumors
    • Ohgaki H., Kleihues P., Heitz P.U. P53 mutations in sporadic adrenocortical tumors. Int. J. Cancer 1993, 54(3):408-410.
    • (1993) Int. J. Cancer , vol.54 , Issue.3 , pp. 408-410
    • Ohgaki, H.1    Kleihues, P.2    Heitz, P.U.3
  • 78
    • 33745194153 scopus 로고    scopus 로고
    • Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription
    • Ohkubo S., Tanaka T., Taya Y., et al. Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. J. Biol. Chem. 2006, 281(25):16943-16950.
    • (2006) J. Biol. Chem. , vol.281 , Issue.25 , pp. 16943-16950
    • Ohkubo, S.1    Tanaka, T.2    Taya, Y.3
  • 79
    • 10944236962 scopus 로고    scopus 로고
    • Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
    • Olive K.P., Tuveson D.A., Ruhe Z.C., et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 2004, 119(6):847-860.
    • (2004) Cell , vol.119 , Issue.6 , pp. 847-860
    • Olive, K.P.1    Tuveson, D.A.2    Ruhe, Z.C.3
  • 80
    • 0142157701 scopus 로고    scopus 로고
    • Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype
    • Olivier M., Goldgar D.E., Sodha N., et al. Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype. Cancer Res. 2003, 63(20):6643-6650.
    • (2003) Cancer Res. , vol.63 , Issue.20 , pp. 6643-6650
    • Olivier, M.1    Goldgar, D.E.2    Sodha, N.3
  • 81
    • 84857112531 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression, Invest New Drugs
    • Palani, C.D., Beck, J.F. and Sonnemann, J., 2010. Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression, Invest New Drugs.
    • (2010)
    • Palani, C.D.1    Beck, J.F.2    Sonnemann, J.3
  • 82
    • 73849107145 scopus 로고    scopus 로고
    • Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome
    • Palmero E.I., Achatz M.I., Ashton-Prolla P., et al. Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome. Curr. Opin. Oncol. 2010, 22(1):64-69.
    • (2010) Curr. Opin. Oncol. , vol.22 , Issue.1 , pp. 64-69
    • Palmero, E.I.1    Achatz, M.I.2    Ashton-Prolla, P.3
  • 83
    • 38949125411 scopus 로고    scopus 로고
    • Detection of R337H, a germline TP53 mutation predisposing to multiple cancers, in asymptomatic women participating in a breast cancer screening program in Southern Brazil
    • Palmero E.I., Schuler-Faccini L., Caleffi M., et al. Detection of R337H, a germline TP53 mutation predisposing to multiple cancers, in asymptomatic women participating in a breast cancer screening program in Southern Brazil. Cancer Lett. 2008, 261(1):21-25.
    • (2008) Cancer Lett. , vol.261 , Issue.1 , pp. 21-25
    • Palmero, E.I.1    Schuler-Faccini, L.2    Caleffi, M.3
  • 84
    • 34047207337 scopus 로고    scopus 로고
    • TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes
    • Petitjean A., Achatz M.I., Borresen-Dale A.L., et al. TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes. Oncogene 2007, 26(15):2157-2165.
    • (2007) Oncogene , vol.26 , Issue.15 , pp. 2157-2165
    • Petitjean, A.1    Achatz, M.I.2    Borresen-Dale, A.L.3
  • 85
    • 34248379012 scopus 로고    scopus 로고
    • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database
    • Petitjean A., Mathe E., Kato S., et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum. Mutat. 2007, 28(6):622-629.
    • (2007) Hum. Mutat. , vol.28 , Issue.6 , pp. 622-629
    • Petitjean, A.1    Mathe, E.2    Kato, S.3
  • 86
    • 79951857698 scopus 로고    scopus 로고
    • Inherited germline TP53 mutation encodes a protein with an aberrant C-terminal motif in a case of pediatric adrenocortical tumor
    • Pinto E.M., Ribeiro R.C., Kletter G.B., et al. Inherited germline TP53 mutation encodes a protein with an aberrant C-terminal motif in a case of pediatric adrenocortical tumor. Fam. Cancer 2011, 10(1):141-146.
    • (2011) Fam. Cancer , vol.10 , Issue.1 , pp. 141-146
    • Pinto, E.M.1    Ribeiro, R.C.2    Kletter, G.B.3
  • 87
    • 42149133853 scopus 로고    scopus 로고
    • Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms and the susceptibility to gliomas in individuals from Southeast Brazil
    • Pinto G.R., Yoshioka F.K., Silva R.L., et al. Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms and the susceptibility to gliomas in individuals from Southeast Brazil. Genet. Mol. Res. 2008, 7(1):207-216.
    • (2008) Genet. Mol. Res. , vol.7 , Issue.1 , pp. 207-216
    • Pinto, G.R.1    Yoshioka, F.K.2    Silva, R.L.3
  • 88
    • 77953492371 scopus 로고    scopus 로고
    • Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
    • Popowicz G.M., Czarna A., Wolf S., et al. Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle 2010, 9(6).
    • (2010) Cell Cycle , vol.9 , Issue.6
    • Popowicz, G.M.1    Czarna, A.2    Wolf, S.3
  • 89
    • 0034064682 scopus 로고    scopus 로고
    • P53-the link between inflammation and cancer?
    • Portwine C. P53-the link between inflammation and cancer?. Pediatr. Res. 2000, 47(5):573.
    • (2000) Pediatr. Res. , vol.47 , Issue.5 , pp. 573
    • Portwine, C.1
  • 90
    • 78449270065 scopus 로고    scopus 로고
    • Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers
    • Ragazzon B., Libe R., Gaujoux S., et al. Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers. Cancer Res. 2010, 70(21):8276-8281.
    • (2010) Cancer Res. , vol.70 , Issue.21 , pp. 8276-8281
    • Ragazzon, B.1    Libe, R.2    Gaujoux, S.3
  • 91
    • 79956035239 scopus 로고    scopus 로고
    • Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy
    • Rao B., van Leeuwen I.M., Higgins M., et al. Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy. Oncotarget 2010, 1(7):639-650.
    • (2010) Oncotarget , vol.1 , Issue.7 , pp. 639-650
    • Rao, B.1    van Leeuwen, I.M.2    Higgins, M.3
  • 92
    • 70350234715 scopus 로고    scopus 로고
    • Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats
    • Rao C.V., Steele V.E., Swamy M.V., et al. Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats. Cancer Res. 2009, 69(20):8175-8182.
    • (2009) Cancer Res. , vol.69 , Issue.20 , pp. 8175-8182
    • Rao, C.V.1    Steele, V.E.2    Swamy, M.V.3
  • 93
    • 77951224332 scopus 로고    scopus 로고
    • Identification and characterization of the first small molecule inhibitor of MDMX
    • Reed D., Shen Y., Shelat A.A., et al. Identification and characterization of the first small molecule inhibitor of MDMX. J. Biol. Chem. 2010, 285(14):10786-10796.
    • (2010) J. Biol. Chem. , vol.285 , Issue.14 , pp. 10786-10796
    • Reed, D.1    Shen, Y.2    Shelat, A.A.3
  • 94
    • 0028177520 scopus 로고
    • P53 mutations in human adrenocortical neoplasms: immunohistochemical and molecular studies
    • Reincke M., Karl M., Travis W.H., et al. P53 mutations in human adrenocortical neoplasms: immunohistochemical and molecular studies. J. Clin. Endocrinol. Metab. 1994, 78(3):790-794.
    • (1994) J. Clin. Endocrinol. Metab. , vol.78 , Issue.3 , pp. 790-794
    • Reincke, M.1    Karl, M.2    Travis, W.H.3
  • 95
    • 0035979262 scopus 로고    scopus 로고
    • An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma
    • Ribeiro R.C., Sandrini F., Figueiredo B., et al. An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. Proc. Natl. Acad. Sci. USA 2001, 98(16):9330-9335.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.16 , pp. 9330-9335
    • Ribeiro, R.C.1    Sandrini, F.2    Figueiredo, B.3
  • 96
    • 42449114966 scopus 로고    scopus 로고
    • Transcriptional control of human p53-regulated genes
    • Riley T., Sontag E., Chen P., et al. Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 2008, 9(5):402-412.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , Issue.5 , pp. 402-412
    • Riley, T.1    Sontag, E.2    Chen, P.3
  • 97
    • 33847365838 scopus 로고    scopus 로고
    • MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis
    • Rinaldo C., Prodosmo A., Mancini F., et al. MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis. Mol. Cell. 2007, 25(5):739-750.
    • (2007) Mol. Cell. , vol.25 , Issue.5 , pp. 739-750
    • Rinaldo, C.1    Prodosmo, A.2    Mancini, F.3
  • 98
    • 0037192628 scopus 로고    scopus 로고
    • Characterization of the p53-rescue drug CP-31398 in vitro and in living cells
    • Rippin T.M., Bykov V.J., Freund S.M., et al. Characterization of the p53-rescue drug CP-31398 in vitro and in living cells. Oncogene 2002, 21(14):2119-2129.
    • (2002) Oncogene , vol.21 , Issue.14 , pp. 2119-2129
    • Rippin, T.M.1    Bykov, V.J.2    Freund, S.M.3
  • 99
    • 79551512486 scopus 로고    scopus 로고
    • P53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma
    • Roh J.L., Kang S.K., Minn I., et al. P53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. Oral Oncol. 2011, 47(1):8-15.
    • (2011) Oral Oncol. , vol.47 , Issue.1 , pp. 8-15
    • Roh, J.L.1    Kang, S.K.2    Minn, I.3
  • 100
    • 33845530151 scopus 로고    scopus 로고
    • The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes
    • Ruijs M.W., Schmidt M.K., Nevanlinna H., et al. The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes. Eur. J. Hum. Genet. 2007, 15(1):110-114.
    • (2007) Eur. J. Hum. Genet. , vol.15 , Issue.1 , pp. 110-114
    • Ruijs, M.W.1    Schmidt, M.K.2    Nevanlinna, H.3
  • 101
    • 25444529023 scopus 로고    scopus 로고
    • P53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1
    • Salvioli S., Bonafe M., Barbi C., et al. P53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1. Cell Cycle 2005, 4(9):1264-1271.
    • (2005) Cell Cycle , vol.4 , Issue.9 , pp. 1264-1271
    • Salvioli, S.1    Bonafe, M.2    Barbi, C.3
  • 102
    • 74049140048 scopus 로고    scopus 로고
    • Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways
    • Schetter A.J., Heegaard N.H., Harris C.C. Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis 2010, 31(1):37-49.
    • (2010) Carcinogenesis , vol.31 , Issue.1 , pp. 37-49
    • Schetter, A.J.1    Heegaard, N.H.2    Harris, C.C.3
  • 103
    • 84857114380 scopus 로고    scopus 로고
    • SEER (Surveillance Epidemiology and End Results) Program, SEER*Stat Database: Incidence - SEER 9 Regs Research Data, Nov 2010 Sub (1973-2008) - Linked To County Attributes - Total U.S., 1969-2009 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April
    • SEER (Surveillance Epidemiology and End Results) Program, SEER*Stat Database: Incidence - SEER 9 Regs Research Data, Nov 2010 Sub (1973-2008) - Linked To County Attributes - Total U.S., 1969-2009 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2011, based on the November 2010 submission.
  • 104
    • 79955507146 scopus 로고    scopus 로고
    • Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in Southeast Brazil
    • Seidinger A.L., Mastellaro M.J., Paschoal Fortes F., et al. Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in Southeast Brazil. Cancer 2011, 117(10):2228-2235.
    • (2011) Cancer , vol.117 , Issue.10 , pp. 2228-2235
    • Seidinger, A.L.1    Mastellaro, M.J.2    Paschoal Fortes, F.3
  • 105
    • 49649110984 scopus 로고    scopus 로고
    • Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome
    • Shlien A., Tabori U., Marshall C.R., et al. Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome. Proc. Natl. Acad. Sci. USA 2008, 105(32):11264-11269.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , Issue.32 , pp. 11264-11269
    • Shlien, A.1    Tabori, U.2    Marshall, C.R.3
  • 106
    • 33646043449 scopus 로고    scopus 로고
    • Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors
    • Slater E.P., Diehl S.M., Langer P., et al. Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors. Eur. J. Endocrinol. 2006, 154(4):587-598.
    • (2006) Eur. J. Endocrinol. , vol.154 , Issue.4 , pp. 587-598
    • Slater, E.P.1    Diehl, S.M.2    Langer, P.3
  • 107
    • 39749122693 scopus 로고    scopus 로고
    • Adrenocortical carcinoma survival rates correlated to genomic copy number variants
    • Stephan E.A., Chung T.H., Grant C.S., et al. Adrenocortical carcinoma survival rates correlated to genomic copy number variants. Mol. Cancer Ther. 2008, 7(2):425-431.
    • (2008) Mol. Cancer Ther. , vol.7 , Issue.2 , pp. 425-431
    • Stephan, E.A.1    Chung, T.H.2    Grant, C.S.3
  • 108
    • 33847691863 scopus 로고    scopus 로고
    • Younger age of cancer initiation is associated with shorter telomere length in Li-Fraumeni syndrome
    • Tabori U., Nanda S., Druker H., et al. Younger age of cancer initiation is associated with shorter telomere length in Li-Fraumeni syndrome. Cancer Res. 2007, 67(4):1415-1418.
    • (2007) Cancer Res. , vol.67 , Issue.4 , pp. 1415-1418
    • Tabori, U.1    Nanda, S.2    Druker, H.3
  • 109
    • 0034383398 scopus 로고    scopus 로고
    • P53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
    • Takekawa M., Adachi M., Nakahata A., et al. P53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J. 2000, 19(23):6517-6526.
    • (2000) EMBO J. , vol.19 , Issue.23 , pp. 6517-6526
    • Takekawa, M.1    Adachi, M.2    Nakahata, A.3
  • 110
    • 67349284323 scopus 로고    scopus 로고
    • Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2
    • Teufel D.P., Bycroft M., Fersht A.R. Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2. Oncogene 2009, 28(20):2112-2118.
    • (2009) Oncogene , vol.28 , Issue.20 , pp. 2112-2118
    • Teufel, D.P.1    Bycroft, M.2    Fersht, A.R.3
  • 111
    • 0032907105 scopus 로고    scopus 로고
    • Two polymorphic variants of wild-type p53 differ biochemically and biologically
    • Thomas M., Kalita A., Labrecque S., et al. Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol. Cell. Biol. 1999, 19(2):1092-1100.
    • (1999) Mol. Cell. Biol. , vol.19 , Issue.2 , pp. 1092-1100
    • Thomas, M.1    Kalita, A.2    Labrecque, S.3
  • 112
    • 70349320378 scopus 로고    scopus 로고
    • 2009 version of the Chompret criteria for Li Fraumeni syndrome, J Clin Oncol. 27(26), e108-9; author reply e110
    • Tinat, J., Bougeard, G., Baert-Desurmont, S. et al., 2009. 2009 version of the Chompret criteria for Li Fraumeni syndrome, J Clin Oncol. 27(26), e108-9; author reply e110.
    • (2009)
    • Tinat, J.1    Bougeard, G.2    Baert-Desurmont, S.3
  • 113
    • 0037260192 scopus 로고    scopus 로고
    • Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1)
    • Tracey W.R., Allen M.C., Frazier D.E., et al. Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc. Drug Rev. 2003, 21(1):17-32.
    • (2003) Cardiovasc. Drug Rev. , vol.21 , Issue.1 , pp. 17-32
    • Tracey, W.R.1    Allen, M.C.2    Frazier, D.E.3
  • 114
    • 79955991034 scopus 로고    scopus 로고
    • Mechanism-specific signatures for small-molecule p53 activators
    • Van Leeuwen I.M., Higgins M., Campbell J., et al. Mechanism-specific signatures for small-molecule p53 activators. Cell Cycle 2011, 10(10).
    • (2011) Cell Cycle , vol.10 , Issue.10
    • Van Leeuwen, I.M.1    Higgins, M.2    Campbell, J.3
  • 115
    • 0026536536 scopus 로고
    • Adrenal glands of mouse and rat do not synthesize androgens
    • Van Weerden W.M., Bierings H.G., Van Steenbrugge G.J., et al. Adrenal glands of mouse and rat do not synthesize androgens. Life Sci. 1992, 50(12):857-861.
    • (1992) Life Sci. , vol.50 , Issue.12 , pp. 857-861
    • Van Weerden, W.M.1    Bierings, H.G.2    Van Steenbrugge, G.J.3
  • 116
    • 0033365202 scopus 로고    scopus 로고
    • Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors
    • Varley J.M., McGown G., Thorncroft M., et al. Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors. Am. J. Hum. Genet. 1999, 65(4):995-1006.
    • (1999) Am. J. Hum. Genet. , vol.65 , Issue.4 , pp. 995-1006
    • Varley, J.M.1    McGown, G.2    Thorncroft, M.3
  • 117
    • 4344610526 scopus 로고    scopus 로고
    • Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics
    • Vassilev L.T. Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics. Cell Cycle 2004, 3(4):419-421.
    • (2004) Cell Cycle , vol.3 , Issue.4 , pp. 419-421
    • Vassilev, L.T.1
  • 118
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev L.T., Vu B.T., Graves B., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004, 303(5659):844-848.
    • (2004) Science , vol.303 , Issue.5659 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3
  • 119
    • 33846899456 scopus 로고    scopus 로고
    • Restoration of p53 function leads to tumour regression in vivo
    • Ventura A., Kirsch D.G., McLaughlin M.E., et al. Restoration of p53 function leads to tumour regression in vivo. Nature 2007, 445(7128):661-665.
    • (2007) Nature , vol.445 , Issue.7128 , pp. 661-665
    • Ventura, A.1    Kirsch, D.G.2    McLaughlin, M.E.3
  • 120
    • 77954537044 scopus 로고    scopus 로고
    • Regulation of tumor suppressor p53 at the RNA level
    • Vilborg A., Wilhelm M.T., Wiman K.G. Regulation of tumor suppressor p53 at the RNA level. J. Mol. Med. 2010, 88(7):645-652.
    • (2010) J. Mol. Med. , vol.88 , Issue.7 , pp. 645-652
    • Vilborg, A.1    Wilhelm, M.T.2    Wiman, K.G.3
  • 122
    • 0027985697 scopus 로고
    • High frequency of germline p53 mutations in childhood adrenocortical cancer
    • Wagner J., Portwine C., Rabin K., et al. High frequency of germline p53 mutations in childhood adrenocortical cancer. J. Natl. Cancer Inst. 1994, 86(22):1707-1710.
    • (1994) J. Natl. Cancer Inst. , vol.86 , Issue.22 , pp. 1707-1710
    • Wagner, J.1    Portwine, C.2    Rabin, K.3
  • 123
    • 0034651712 scopus 로고    scopus 로고
    • Adrenocortical carcinoma: clinical and laboratory observations
    • Wajchenberg B.L., Albergaria Pereira M.A., Medonca B.B., et al. Adrenocortical carcinoma: clinical and laboratory observations. Cancer 2000, 88(4):711-736.
    • (2000) Cancer , vol.88 , Issue.4 , pp. 711-736
    • Wajchenberg, B.L.1    Albergaria Pereira, M.A.2    Medonca, B.B.3
  • 124
    • 0032878145 scopus 로고    scopus 로고
    • Intron variants of the p53 gene are associated with increased risk for ovarian cancer but not in carriers of BRCA1 or BRCA2 germline mutations
    • Wang-Gohrke S., Weikel W., Risch H., et al. Intron variants of the p53 gene are associated with increased risk for ovarian cancer but not in carriers of BRCA1 or BRCA2 germline mutations. Br. J. Cancer 1999, 81(1):179-183.
    • (1999) Br. J. Cancer , vol.81 , Issue.1 , pp. 179-183
    • Wang-Gohrke, S.1    Weikel, W.2    Risch, H.3
  • 125
    • 33846683317 scopus 로고    scopus 로고
    • Gene expression profiling of childhood adrenocortical tumors
    • West A.N., Neale G.A., Pounds S., et al. Gene expression profiling of childhood adrenocortical tumors. Cancer Res. 2007, 67(2):600-608.
    • (2007) Cancer Res. , vol.67 , Issue.2 , pp. 600-608
    • West, A.N.1    Neale, G.A.2    Pounds, S.3
  • 126
    • 33744931918 scopus 로고    scopus 로고
    • Identification of a novel germ line variant hotspot mutant p53-R175L in pediatric adrenal cortical carcinoma
    • West A.N., Ribeiro R.C., Jenkins J., et al. Identification of a novel germ line variant hotspot mutant p53-R175L in pediatric adrenal cortical carcinoma. Cancer Res. 2006, 66(10):5056-5062.
    • (2006) Cancer Res. , vol.66 , Issue.10 , pp. 5056-5062
    • West, A.N.1    Ribeiro, R.C.2    Jenkins, J.3
  • 128
    • 0027497040 scopus 로고
    • Adrenal cortical carcinoma. Epidemiology and treatment with mitotane and a review of the literature
    • Wooten M.D., King D.K. Adrenal cortical carcinoma. Epidemiology and treatment with mitotane and a review of the literature. Cancer 1993, 72(11):3145-3155.
    • (1993) Cancer , vol.72 , Issue.11 , pp. 3145-3155
    • Wooten, M.D.1    King, D.K.2
  • 129
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • Xue W., Zender L., Miething C., et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007, 445(7128):656-660.
    • (2007) Nature , vol.445 , Issue.7128 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3
  • 130
    • 20444369867 scopus 로고    scopus 로고
    • Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
    • Yang Y., Ludwig R.L., Jensen J.P., et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell 2005, 7(6):547-559.
    • (2005) Cancer Cell , vol.7 , Issue.6 , pp. 547-559
    • Yang, Y.1    Ludwig, R.L.2    Jensen, J.P.3
  • 131
    • 34848901685 scopus 로고    scopus 로고
    • The p53 mutation «gradient effect» and its clinical implications
    • Zambetti G.P. The p53 mutation «gradient effect» and its clinical implications. J. Cell. Physiol. 2007, 213(2):370-373.
    • (2007) J. Cell. Physiol. , vol.213 , Issue.2 , pp. 370-373
    • Zambetti, G.P.1
  • 132
    • 0032830530 scopus 로고    scopus 로고
    • Analysis of genomic alterations in sporadic adrenocortical lesions. Gain of chromosome 17 is an early event in adrenocortical tumorigenesis
    • Zhao J., Speel E.J., Muletta-Feurer S., et al. Analysis of genomic alterations in sporadic adrenocortical lesions. Gain of chromosome 17 is an early event in adrenocortical tumorigenesis. Am. J. Pathol. 1999, 155(4):1039-1045.
    • (1999) Am. J. Pathol. , vol.155 , Issue.4 , pp. 1039-1045
    • Zhao, J.1    Speel, E.J.2    Muletta-Feurer, S.3
  • 133
    • 17844392396 scopus 로고    scopus 로고
    • Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function
    • Zheng S.J., Lamhamedi-Cherradi S.E., Wang P., et al. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes 2005, 54(5):1423-1428.
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1423-1428
    • Zheng, S.J.1    Lamhamedi-Cherradi, S.E.2    Wang, P.3


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