Helicobacter pylori relies primarily on the purine salvage pathway for purine nucleotide biosynthesis

Journal of Bacteriology

Volumn 194, Issue 4, 2012, Pages 839-854

  Liechti, George ^a   Goldberg, Joanna B ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; APT PROTEIN; BACTERIAL PROTEIN; DEOD PROTEIN; GPT PROTEIN; NUCLEOSIDE PHOSPHORYLASE; PHOSPHORIBOSYLTRANSFERASE; PURINE; PURINE NUCLEOTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIUM MUTANT; CONTROLLED STUDY; CULTURE MEDIUM; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HELICOBACTER PYLORI; NONHUMAN; NUCLEOTIDE METABOLISM; NUTRIENT; PRIORITY JOURNAL; PROTEIN PROCESSING; PURINE SYNTHESIS; SIGNAL TRANSDUCTION;

ADENINE PHOSPHORIBOSYLTRANSFERASE; HELICOBACTER PYLORI; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PENTOSYLTRANSFERASES; PURINE NUCLEOSIDES; PURINE NUCLEOTIDES; PURINES;

HELICOBACTER PYLORI;

EID: 84857089796     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.05757-11     Document Type: Article

References (73)

1. Alm RA, Trust TJ. 1999. Analysis of the genetic diversity of Helicobacter pylori: the tale of two genomes. J. Mol. Med. 77:834-846.
2. An S, Kumar R, Sheets ED, Benkovic SJ. 2008. Reversible compartmentalization of de novo purine biosynthetic complexes in living cells. Science 320:103-106.
3. Baltrus DA, et al. 2009. The complete genome sequence of Helicobacter pylori strain G27. J. Bacteriol. 191:447-448.
4. Batey RT, Gilbert SD, Montange RK. 2004. Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine. Nature 432:411-415.
5. Berg DE, Hoffman PS, Appelmelk BJ, Kusters JG. 1997. The Helicobacter pylori genome sequence: genetic factors for long life in the gastric mucosa. Trends Microbiol. 5:468-474.
6. Bjorkholm B, et al. 2001. Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori. Proc. Natl. Acad. Sci. U. S. A. 98:14607-14612.
7. Blaser MJ. 1997. The versatility of Helicobacter pylori in the adaptation to the human stomach. J. Physiol. Pharmacol. 48:307-314.
8. Brault JJ, Terjung RL. 2001. Purine salvage to adenine nucleotides in different skeletal muscle fiber types. J. Appl. Physiol. 91:231-238.
9. Brubaker RR. 1970. Interconversion of purine mononucleotides in Pasteurella pestis. Infect. Immun. 1:446-454.
10. Bury-Mone S, et al. 2004. Responsiveness to acidity via metal ion regulators mediates virulence in the gastric pathogen Helicobacter pylori. Mol. Microbiol. 53:623-638.
11. Chalker AF, et al. 2001. Systematic identification of selective essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesis. J. Bacteriol. 183:1259-1268.
12. Chekeni FB, et al. 2010. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature 467:863-867.
13. Cover TL, Tummuru MK, Cao P, Thompson SA, Blaser MJ. 1994. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J. Biol. Chem. 269:10566-10573.
14. Croxen MA, Sisson G, Melano R, Hoffman PS. 2006. The Helicobacter pylori chemotaxis receptor TlpB (HP0103) is required for pH taxis and for colonization of the gastric mucosa. J. Bacteriol. 188:2656-2665.
15. Deo SS, Tseng WC, Saini R, Coles RS, Athwal RS. 1985. Purification and characterization of Escherichia coli xanthine-guanine phosphoribosyltransferase produced by plasmid pSV2gpt. Biochim. Biophys. Acta 839: 233-239.
16. Doig P, et al. 1999. Helicobacter pylori physiology predicted from genomic comparison of two strains. Microbiol. Mol. Biol. Rev. 63:675-707.
17. Doyle PS, Kanaani J, Wang CC. 1998. Hypoxanthine, guanine, xanthine phosphoribosyltransferase activity in Cryptosporidium parvum. Exp. Parasitol. 89:9-15.
18. Duckworth M, Menard A, Megraud F, Mendz GL. 2006. Bioinformatic analysis of Helicobacter pylori XGPRTase: a potential therapeutic target. Helicobacter 11:287-295.
19. Dunn BE, Cohen H, Blaser MJ. 1997. Helicobacter pylori. Clin. Microbiol. Rev. 10:720-741.
20. Endo T, Uratani B, Freese E. 1983. Purine salvage pathways of Bacillus subtilis and effect of guanine on growth of GMP reductase mutants. J. Bacteriol. 155:169-179.
21. Eppinger M, et al. 2006. Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines. PLoS Genet. 2:e120.
22. Falush D, et al. 2003. Traces of human migrations in Helicobacter pylori populations. Science 299:1582-1585.
23. Fields PI, Swanson RV, Haidaris CG, Heffron F. 1986. Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. Proc. Natl. Acad. Sci. U. S. A. 83:5189-5193.
24. Foynes S, et al. 2000. Helicobacter pylori possesses two CheY response regulators and a histidine kinase sensor, CheA, which are essential for chemotaxis and colonization of the gastric mucosa. Infect. Immun. 68: 2016-2023.
25. Friedmin M. 1950. Desoxyribose-1-phosphate. II. The isolation of crystalline desoxyribose-1-phosphate. J. Biol. Chem. 184:449-459.
26. Gollapalli DR, et al. 2010. Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases. Chem. Biol. 17:1084-1091.
27. Goodwin A, et al. 1998. Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase. Mol. Microbiol. 28:383-393.
28. Hartwick RA, Krstulovic AM, Brown PR. 1979. Identification and quantitation of nucleosides, bases and other UV-absorbing compounds in serum, using reversed-phase high-performance liquid chromatography. II. Evaluation of human sera. J. Chromatogr. 186:659-676.
29. Hazell SL, Graham DY. 1990. Unsaturated fatty acids and viability of Helicobacter (Campylobacter) pylori. J. Clin. Microbiol. 28:1060-1061.
30. Hazell SL, Markesich DC, Evans DJ, Evans DG, Graham DY. 1989. Influence of media supplements on growth and survival of Campylobacter pylori. Eur. J. Clin. Microbiol. Infect. Dis. 8:597-602.
31. Hedstrom L. 2009. IMP dehydrogenase: structure, mechanism, and inhibition. Chem. Rev. 109:2903-2928.
32. Hedstrom L, Liechti G, Goldberg JB, Gollapalli DR. 2011. The antibiotic potential of prokaryotic IMP dehydrogenase inhibitors. Curr. Med. Chem. 18:1909-1918.
33. Husnain SI, Thomas MS. 2008. Downregulation of the Escherichia coli guaB promoter by FIS. Microbiology 154:1729-1738.
34. Husnain SI, Busby SJ, Thomas MS. 2009. Downregulation of the Escherichia coli guaB promoter by upstream-bound cyclic AMP receptor protein. J. Bacteriol. 191:6094-6104.
35. Jenkins A, et al. 2011. Role of purine biosynthesis in Bacillus anthracis pathogenesis and virulence. Infect. Immun. 79:153-166.
36. Jewett MW, et al. 2009. GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle. J. Bacteriol. 191:6231-6241.
37. Kennemann L, et al. 2011. Helicobacter pylori genome evolution during human infection. Proc. Natl. Acad. Sci. U. S. A. 108:5033-5038.
38. Keough DT, et al. 2009. Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J. Med. Chem. 52:4391-4399.
39. Keough DT, et al. 2010. Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy. Mol. Biochem. Parasitol. 173:165-169.
40. Kotloff KL, et al. 2000. Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humans. Infect. Immun. 68:1034-1039.
41. Lara-Ramirez EE, et al. 2011. New implications on genomic adaptation derived from the Helicobacter pylori genome comparison. PLoS One 6:e17300.
42. Lawrence KA, Jewett MW, Rosa PA, Gherardini FC. 2009. Borrelia burgdorferi bb0426 encodes a 2'-deoxyribosyltransferase that plays a central role in purine salvage. Mol. Microbiol. 72:1517-1529.
43. Mandal M, Boese B, Barrick JE, Winkler WC, Breaker RR. 2003. Riboswitches control fundamental biochemical pathways in Bacillus subtilis and other bacteria. Cell 113:577-586.
44. Marais A, Mendz GL, Hazell SL, Megraud F. 1999. Metabolism and genetics of Helicobacter pylori: the genome era. Microbiol. Mol. Biol. Rev. 63:642-674.
45. Marshall BJ, Warren JR. 1984. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet i:1311-1315.
46. Martinelli LK, et al. 2011. Recombinant Escherichia coli GMP reductase: kinetic, catalytic and chemical mechanisms, and thermodynamics of enzyme-ligand binary complex formation. Mol. Biosyst. 7:1289-1305.
47. Maurelli AT, Fernandez RE, Bloch CA, Rode CK, Fasano A. 1998. "Black holes" and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 95:3943-3948.
48. McFarland WC, Stocker BA. 1987. Effect of different purine auxotrophic mutations on mouse-virulence of a Vi-positive strain of Salmonella dublin and of two strains of Salmonella typhimurium. Microb. Pathog. 3:129-141.
49. Mendz GL, Shepley AJ, Hazell SL, Smith MA. 1997. Purine metabolism and the microaerophily of Helicobacter pylori. Arch. Microbiol. 168:448-456.
50. Mendz GL, Jimenez BM, Hazell SL, Gero AM, O'Sullivan WJ. 1994. Salvage synthesis of purine nucleotides by Helicobacter pylori. J. Appl. Bacteriol. 77:674-681.
51. Nedenskov P. 1994. Nutritional requirements for growth of Helicobacter pylori. Appl. Environ. Microbiol. 60:3450-3453.
52. Oyston PC, et al. 2010. A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection. Microb. Pathog. 48:191-195.
53. Parsonnet J. 1995. The incidence of Helicobacter pylori infection. Aliment. Pharmacol. Ther. 9(Suppl. 2):45-51.
54. 8 barrel enzymes. Nat. Chem. Biol. 7:950-958.
55. Pettersson J, et al. 2007. Purine salvage pathways among Borrelia species. Infect. Immun. 75:3877-3884.
56. Polissi A, et al. 1998. Large-scale identification of virulence genes from Streptococcus pneumoniae. Infect. Immun. 66:5620-5629.
57. Pornbanlualap S, Chalopagorn P. 2011. Adenosine deaminase from Streptomyces coelicolor: recombinant expression, purification and characterization. Protein Expr. Purif. 78:167-173.
58. Reynolds DJ, Penn CW. 1994. Characteristics of Helicobacter pylori growth in a defined medium and determination of its amino acid requirements. Microbiology 140:2649-2656.
59. Rodriguez M, Good TA, Wales ME, Hua JP, Wild JR. 2005. Modeling allosteric regulation of de novo pyrimidine biosynthesis in Escherichia coli. J. Theor. Biol. 234:299-310.
60. Ropp PA, Traut TW. 1991. Allosteric regulation of purine nucleoside phosphorylase. Arch. Biochem. Biophys. 288:614-620.
61. Ropp PA, Traut TW. 1991. Purine nucleoside phosphorylase. Allosteric regulation of a dissociating enzyme. J. Biol. Chem. 266:7682-7687.
62. Sampei G, et al. 2010. Crystal structures of glycinamide ribonucleotide synthetase, PurD, from thermophilic eubacteria. J. Biochem. 148:429-438.
63. Santiago AE, et al. 2009. Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes. Vaccine 27:2426-2436.
64. Sharma CM, et al. 2010. The primary transcriptome of the major human pathogen Helicobacter pylori. Nature 464:250-255.
65. Testerman TL, McGee DJ, Mobley HL. 2001. Helicobacter pylori growth and urease detection in the chemically defined medium Ham's F-12 nutrient mixture. J. Clin. Microbiol. 39:3842-3850.
66. Testerman TL, Conn PB, Mobley HL, McGee DJ. 2006. Nutritional requirements and antibiotic resistance patterns of Helicobacter species in chemically defined media. J. Clin. Microbiol. 44:1650-1658.
67. Thiele I, Vo TD, Price ND, Palsson BO. 2005. Expanded metabolic reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an in silico genome-scale characterization of single- and double-deletion mutants. J. Bacteriol. 187:5818-5830.
68. Tomb JF, et al. 1997. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388:539-547.
69. van Amsterdam K, van der Ende A. 2004. Nutrients released by gastric epithelial cells enhance Helicobacter pylori growth. Helicobacter 9:614-621.
70. Wang Y, Roos KP, Taylor DE. 1993. Transformation of Helicobacter pylori by chromosomal metronidazole resistance and by a plasmid with a selectable chloramphenicol resistance marker. J. Gen. Microbiol. 139: 2485-2493.
71. Wishart DS, et al. 2007. HMDB: the Human Metabolome Database. Nucleic Acids Res. 35:D521-D526.
72. Yamaoka Y. 2009. Helicobacter pylori typing as a tool for tracking human migration. Clin. Microbiol. Infect. 15:829-834.
73. Zanotti G, Cendron L. 2010. Functional and structural aspects of Helicobacter pylori acidic stress response factors. IUBMB Life 62:715-723.