Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase

Molecular Microbiology

Volumn 28, Issue 2, 1998, Pages 383-393

  Goodwin, Avery ^a   Kersulyte, Dangeruta ^b   Sisson, Gary ^a   Veldhuyzen Van Zanten, Sander J O ^c   Berg, Douglas E ^b   Hoffman, Paul S ^a,c  

^a DALHOUSIE UNIVERSITY   (Canada)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

METRONIDAZOLE; NITROREDUCTASE;

ALLELE; ARTICLE; COSMID; DNA SEQUENCE; DNA TRANSFER; DRUG RESISTANCE; ENZYME DEFICIENCY; GENOTYPE; HELICOBACTER PYLORI; MOLECULAR CLONING; MUTATION; NUCLEIC ACID BASE SUBSTITUTION; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BASE SEQUENCE; ESCHERICHIA COLI; GENE TRANSFER, HORIZONTAL; GENES, BACTERIAL; HELICOBACTER PYLORI; HUMANS; METRONIDAZOLE; MOLECULAR SEQUENCE DATA; MUTATION; NITROREDUCTASES; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

ENTERIC BACTERIA; ESCHERICHIA COLI; HELICOBACTER PYLORI; NEGIBACTERIA; PROKARYOTA;

EID: 0031953727     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1998.00806.x     Document Type: Article

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