-
2
-
-
20044382800
-
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone
-
Zhao R., Davey M., Hsu Y.C., Kaplanek P., Tong A., Parsons A.B., Krogan N., Cagney G., Mai D., Greenblatt J., Boone C., Emili A., Houry W.A. Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell 2005, 120:715-727.
-
(2005)
Cell
, vol.120
, pp. 715-727
-
-
Zhao, R.1
Davey, M.2
Hsu, Y.C.3
Kaplanek, P.4
Tong, A.5
Parsons, A.B.6
Krogan, N.7
Cagney, G.8
Mai, D.9
Greenblatt, J.10
Boone, C.11
Emili, A.12
Houry, W.A.13
-
3
-
-
0024421221
-
Hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures
-
Borkovich K.A., Farrelly F.W., Finkelstein D.B., Taulien J., Lindquist S. hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures. Mol. Cell. Biol. 1989, 9:3919-3930.
-
(1989)
Mol. Cell. Biol.
, vol.9
, pp. 3919-3930
-
-
Borkovich, K.A.1
Farrelly, F.W.2
Finkelstein, D.B.3
Taulien, J.4
Lindquist, S.5
-
4
-
-
0035939668
-
Hsp90: a specialized but essential protein-folding tool
-
Young J.C., Moarefi I., Hartl F.U. Hsp90: a specialized but essential protein-folding tool. J. Cell Biol. 2001, 154:267-273.
-
(2001)
J. Cell Biol.
, vol.154
, pp. 267-273
-
-
Young, J.C.1
Moarefi, I.2
Hartl, F.U.3
-
5
-
-
78649346692
-
The heat shock response: life on the verge of death
-
Richter K., Haslbeck M., Buchner J. The heat shock response: life on the verge of death. Mol. Cell 2010, 40:253-266.
-
(2010)
Mol. Cell
, vol.40
, pp. 253-266
-
-
Richter, K.1
Haslbeck, M.2
Buchner, J.3
-
6
-
-
43549102208
-
HSP90: the Rosetta stone for cellular protein dynamics?
-
Dezwaan D.C., Freeman B.C. HSP90: the Rosetta stone for cellular protein dynamics?. Cell Cycle 2008, 7:1006-1012.
-
(2008)
Cell Cycle
, vol.7
, pp. 1006-1012
-
-
Dezwaan, D.C.1
Freeman, B.C.2
-
7
-
-
77953916528
-
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
-
Taipale M., Jarosz D.F., Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat. Rev. Mol. Cell Biol. 2010, 11:515-528.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 515-528
-
-
Taipale, M.1
Jarosz, D.F.2
Lindquist, S.3
-
8
-
-
0030925683
-
Steroid receptor interactions with heat shock protein and immunophilin chaperones
-
Pratt W.B., Toft D.O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 1997, 18:306-360.
-
(1997)
Endocr. Rev.
, vol.18
, pp. 306-360
-
-
Pratt, W.B.1
Toft, D.O.2
-
9
-
-
0036810352
-
Heat-shock protein 90, a chaperone for folding and regulation
-
Picard D. Heat-shock protein 90, a chaperone for folding and regulation. Cell. Mol. Life Sci. 2002, 59:1640-1648.
-
(2002)
Cell. Mol. Life Sci.
, vol.59
, pp. 1640-1648
-
-
Picard, D.1
-
10
-
-
34848926209
-
Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches
-
McClellan A.J., Xia Y., Deutschbauer A.M., Davis R.W., Gerstein M., Frydman J. Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches. Cell 2007, 131:121-135.
-
(2007)
Cell
, vol.131
, pp. 121-135
-
-
McClellan, A.J.1
Xia, Y.2
Deutschbauer, A.M.3
Davis, R.W.4
Gerstein, M.5
Frydman, J.6
-
11
-
-
36148976786
-
Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells
-
Neckers L., Kern A., Tsutsumi S. Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells. Chem. Biol. 2007, 14:1204-1206.
-
(2007)
Chem. Biol.
, vol.14
, pp. 1204-1206
-
-
Neckers, L.1
Kern, A.2
Tsutsumi, S.3
-
12
-
-
77954945333
-
Targeting the dynamic HSP90 complex in cancer
-
Trepel J., Mollapour M., Giaccone G., Neckers L. Targeting the dynamic HSP90 complex in cancer. Nat. Rev. Cancer 2010, 10:537-549.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 537-549
-
-
Trepel, J.1
Mollapour, M.2
Giaccone, G.3
Neckers, L.4
-
13
-
-
74249085361
-
Update on Hsp90 inhibitors in clinical trial
-
Kim Y.S., Alarcon S.V., Lee S., Lee M.J., Giaccone G., Neckers L., Trepel J.B. Update on Hsp90 inhibitors in clinical trial. Curr. Top. Med. Chem. 2009, 9:1479-1492.
-
(2009)
Curr. Top. Med. Chem.
, vol.9
, pp. 1479-1492
-
-
Kim, Y.S.1
Alarcon, S.V.2
Lee, S.3
Lee, M.J.4
Giaccone, G.5
Neckers, L.6
Trepel, J.B.7
-
14
-
-
1842782331
-
Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance
-
Sangster T.A., Lindquist S., Queitsch C. Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance. Bioessays 2004, 26:348-362.
-
(2004)
Bioessays
, vol.26
, pp. 348-362
-
-
Sangster, T.A.1
Lindquist, S.2
Queitsch, C.3
-
15
-
-
4143095430
-
Altered Hsp90 function in cancer: a unique therapeutic opportunity
-
Bagatell R., Whitesell L. Altered Hsp90 function in cancer: a unique therapeutic opportunity. Mol. Cancer Ther. 2004, 3:1021-1030.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 1021-1030
-
-
Bagatell, R.1
Whitesell, L.2
-
16
-
-
14844303887
-
Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy
-
Muller P., Ceskova P., Vojtesek B. Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy. J. Biol. Chem. 2005, 280:6682-6691.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 6682-6691
-
-
Muller, P.1
Ceskova, P.2
Vojtesek, B.3
-
17
-
-
34548658230
-
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
-
Dai C., Whitesell L., Rogers A.B., Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 2007, 130:1005-1018.
-
(2007)
Cell
, vol.130
, pp. 1005-1018
-
-
Dai, C.1
Whitesell, L.2
Rogers, A.B.3
Lindquist, S.4
-
18
-
-
0037030713
-
Hsp90 as a capacitor of phenotypic variation
-
Queitsch C., Sangster T.A., Lindquist S. Hsp90 as a capacitor of phenotypic variation. Nature 2002, 417:618-624.
-
(2002)
Nature
, vol.417
, pp. 618-624
-
-
Queitsch, C.1
Sangster, T.A.2
Lindquist, S.3
-
19
-
-
0032569851
-
Hsp90 as a capacitor for morphological evolution
-
Rutherford S.L., Lindquist S. Hsp90 as a capacitor for morphological evolution. Nature 1998, 396:336-342.
-
(1998)
Nature
, vol.396
, pp. 336-342
-
-
Rutherford, S.L.1
Lindquist, S.2
-
20
-
-
78650644709
-
Hsp90 and environmental stress transform the adaptive value of natural genetic variation
-
Jarosz D.F., Lindquist S. Hsp90 and environmental stress transform the adaptive value of natural genetic variation. Science 2010, 330:1820-1824.
-
(2010)
Science
, vol.330
, pp. 1820-1824
-
-
Jarosz, D.F.1
Lindquist, S.2
-
21
-
-
0037315208
-
Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery
-
Pratt W.B., Toft D.O. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp. Biol. Med. (Maywood) 2003, 228:111-133.
-
(2003)
Exp. Biol. Med. (Maywood)
, vol.228
, pp. 111-133
-
-
Pratt, W.B.1
Toft, D.O.2
-
22
-
-
0027484097
-
Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes
-
Smith D.F. Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes. Mol. Endocrinol. 1993, 7:1418-1429.
-
(1993)
Mol. Endocrinol.
, vol.7
, pp. 1418-1429
-
-
Smith, D.F.1
-
23
-
-
0027405024
-
Hsc70, immunoglobulin heavy chain binding protein, and Hsp90 differ in their ability to stimulate transport of precursor proteins into mammalian microsomes
-
Wiech H., Buchner J., Zimmermann M., Zimmermann R., Jakob U. Hsc70, immunoglobulin heavy chain binding protein, and Hsp90 differ in their ability to stimulate transport of precursor proteins into mammalian microsomes. J. Biol. Chem. 1993, 268:7414-7421.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 7414-7421
-
-
Wiech, H.1
Buchner, J.2
Zimmermann, M.3
Zimmermann, R.4
Jakob, U.5
-
25
-
-
77950224150
-
Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage
-
Pratt W.B., Morishima Y., Peng H.M., Osawa Y. Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Exp. Biol. Med. (Maywood) 2010, 235:278-289.
-
(2010)
Exp. Biol. Med. (Maywood)
, vol.235
, pp. 278-289
-
-
Pratt, W.B.1
Morishima, Y.2
Peng, H.M.3
Osawa, Y.4
-
26
-
-
65449117176
-
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
-
Gamerdinger M., Hajieva P., Kaya A.M., Wolfrum U., Hartl F.U., Behl C. Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J. 2009, 28:889-901.
-
(2009)
EMBO J.
, vol.28
, pp. 889-901
-
-
Gamerdinger, M.1
Hajieva, P.2
Kaya, A.M.3
Wolfrum, U.4
Hartl, F.U.5
Behl, C.6
-
27
-
-
0037258854
-
Intracellular localization of the 90 kDA heat shock protein (HSP90alpha) determined by expression of a EGFP-HSP90alpha-fusion protein in unstressed and heat stressed 3T3 cells
-
Langer T., Rosmus S., Fasold H. Intracellular localization of the 90 kDA heat shock protein (HSP90alpha) determined by expression of a EGFP-HSP90alpha-fusion protein in unstressed and heat stressed 3T3 cells. Cell Biol. Int. 2003, 27:47-52.
-
(2003)
Cell Biol. Int.
, vol.27
, pp. 47-52
-
-
Langer, T.1
Rosmus, S.2
Fasold, H.3
-
28
-
-
0031873752
-
The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review
-
Csermely P., Schnaider T., Soti C., Prohaszka Z., Nardai G. The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review. Pharmacol. Ther. 1998, 79:129-168.
-
(1998)
Pharmacol. Ther.
, vol.79
, pp. 129-168
-
-
Csermely, P.1
Schnaider, T.2
Soti, C.3
Prohaszka, Z.4
Nardai, G.5
-
29
-
-
11844277123
-
The HSP90 chaperone complex, an emerging force in plant development and phenotypic plasticity
-
Sangster T.A., Queitsch C. The HSP90 chaperone complex, an emerging force in plant development and phenotypic plasticity. Curr. Opin. Plant Biol. 2005, 8:86-92.
-
(2005)
Curr. Opin. Plant Biol.
, vol.8
, pp. 86-92
-
-
Sangster, T.A.1
Queitsch, C.2
-
30
-
-
0034817255
-
The Hsp90 family of proteins in Arabidopsis thaliana
-
Krishna P., Gloor G. The Hsp90 family of proteins in Arabidopsis thaliana. Cell Stress Chaperones 2001, 6:238-246.
-
(2001)
Cell Stress Chaperones
, vol.6
, pp. 238-246
-
-
Krishna, P.1
Gloor, G.2
-
31
-
-
67651216183
-
Arabidopsis ROF1 (FKBP62) modulates thermotolerance by interacting with HSP90.1 and affecting the accumulation of HsfA2-regulated sHSPs
-
Meiri D., Breiman A. Arabidopsis ROF1 (FKBP62) modulates thermotolerance by interacting with HSP90.1 and affecting the accumulation of HsfA2-regulated sHSPs. Plant J. 2009, 59:387-399.
-
(2009)
Plant J.
, vol.59
, pp. 387-399
-
-
Meiri, D.1
Breiman, A.2
-
32
-
-
0034603178
-
The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties
-
Felts S.J., Owen B.A., Nguyen P., Trepel J., Donner D.B., Toft D.O. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J. Biol. Chem. 2000, 275:3305-3312.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3305-3312
-
-
Felts, S.J.1
Owen, B.A.2
Nguyen, P.3
Trepel, J.4
Donner, D.B.5
Toft, D.O.6
-
33
-
-
0010625474
-
Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts
-
Shiu R.P., Pouyssegur J., Pastan I. Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts. Proc. Natl. Acad. Sci. U. S. A. 1977, 74:3840-3844.
-
(1977)
Proc. Natl. Acad. Sci. U. S. A.
, vol.74
, pp. 3840-3844
-
-
Shiu, R.P.1
Pouyssegur, J.2
Pastan, I.3
-
34
-
-
45849149632
-
Extracellular HSP90: conquering the cell surface
-
Sidera K., Patsavoudi E. Extracellular HSP90: conquering the cell surface. Cell Cycle 2008, 7:1564-1568.
-
(2008)
Cell Cycle
, vol.7
, pp. 1564-1568
-
-
Sidera, K.1
Patsavoudi, E.2
-
35
-
-
2942716692
-
Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness
-
Eustace B.K., Sakurai T., Stewart J.K., Yimlamai D., Unger C., Zehetmeier C., Lain B., Torella C., Henning S.W., Beste G., Scroggins B.T., Neckers L., Ilag L.L., Jay D.G. Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness. Nat. Cell Biol. 2004, 6:507-514.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 507-514
-
-
Eustace, B.K.1
Sakurai, T.2
Stewart, J.K.3
Yimlamai, D.4
Unger, C.5
Zehetmeier, C.6
Lain, B.7
Torella, C.8
Henning, S.W.9
Beste, G.10
Scroggins, B.T.11
Neckers, L.12
Ilag, L.L.13
Jay, D.G.14
-
36
-
-
0024044382
-
Ancient heat shock gene is dispensable
-
Bardwell J.C., Craig E.A. Ancient heat shock gene is dispensable. J. Bacteriol. 1988, 170:2977-2983.
-
(1988)
J. Bacteriol.
, vol.170
, pp. 2977-2983
-
-
Bardwell, J.C.1
Craig, E.A.2
-
37
-
-
49649113716
-
Conserved conformational changes in the ATPase cycle of human Hsp90
-
Richter K., Soroka J., Skalniak L., Leskovar A., Hessling M., Reinstein J., Buchner J. Conserved conformational changes in the ATPase cycle of human Hsp90. J. Biol. Chem. 2008, 283:17757-17765.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 17757-17765
-
-
Richter, K.1
Soroka, J.2
Skalniak, L.3
Leskovar, A.4
Hessling, M.5
Reinstein, J.6
Buchner, J.7
-
38
-
-
0033985080
-
GHKL, an emergent ATPase/kinase superfamily
-
Dutta R., Inouye M. GHKL, an emergent ATPase/kinase superfamily. Trends Biochem. Sci. 2000, 25:24-28.
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 24-28
-
-
Dutta, R.1
Inouye, M.2
-
39
-
-
0029003444
-
Structural organization of procaryotic and eucaryotic Hsp90. Influence of divalent cations on structure and function
-
Jakob U., Meyer I., Bugl H., Andre S., Bardwell J.C., Buchner J. Structural organization of procaryotic and eucaryotic Hsp90. Influence of divalent cations on structure and function. J. Biol. Chem. 1995, 270:14412-14419.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 14412-14419
-
-
Jakob, U.1
Meyer, I.2
Bugl, H.3
Andre, S.4
Bardwell, J.C.5
Buchner, J.6
-
40
-
-
37249011744
-
The ATPase cycle of the endoplasmic chaperone Grp94
-
Frey S., Leskovar A., Reinstein J., Buchner J. The ATPase cycle of the endoplasmic chaperone Grp94. J. Biol. Chem. 2007, 282:35612-35620.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 35612-35620
-
-
Frey, S.1
Leskovar, A.2
Reinstein, J.3
Buchner, J.4
-
41
-
-
45549104450
-
The ATPase cycle of the mitochondrial Hsp90 analog Trap1
-
Leskovar A., Wegele H., Werbeck N.D., Buchner J., Reinstein J. The ATPase cycle of the mitochondrial Hsp90 analog Trap1. J. Biol. Chem. 2008, 283:11677-11688.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 11677-11688
-
-
Leskovar, A.1
Wegele, H.2
Werbeck, N.D.3
Buchner, J.4
Reinstein, J.5
-
42
-
-
77951601227
-
Bacterial Hsp90 - desperately seeking clients
-
Buchner J. Bacterial Hsp90 - desperately seeking clients. Mol. Microbiol. 2010, 76:540-544.
-
(2010)
Mol. Microbiol.
, vol.76
, pp. 540-544
-
-
Buchner, J.1
-
43
-
-
77951610740
-
HtpG, the prokaryotic homologue of Hsp90, stabilizes a phycobilisome protein in the cyanobacterium Synechococcus elongatus PCC 7942
-
Sato T., Minagawa S., Kojima E., Okamoto N., Nakamoto H. HtpG, the prokaryotic homologue of Hsp90, stabilizes a phycobilisome protein in the cyanobacterium Synechococcus elongatus PCC 7942. Mol. Microbiol. 2010, 76:576-589.
-
(2010)
Mol. Microbiol.
, vol.76
, pp. 576-589
-
-
Sato, T.1
Minagawa, S.2
Kojima, E.3
Okamoto, N.4
Nakamoto, H.5
-
44
-
-
10744221887
-
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery
-
Meyer P., Prodromou C., Liao C., Hu B., Mark Roe S., Vaughan C.K., Vlasic I., Panaretou B., Piper P.W., Pearl L.H. Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO J. 2004, 23:511-519.
-
(2004)
EMBO J.
, vol.23
, pp. 511-519
-
-
Meyer, P.1
Prodromou, C.2
Liao, C.3
Hu, B.4
Mark Roe, S.5
Vaughan, C.K.6
Vlasic, I.7
Panaretou, B.8
Piper, P.W.9
Pearl, L.H.10
-
45
-
-
75949106173
-
Asymmetric activation of the hsp90 dimer by its cochaperone aha1
-
Retzlaff M., Hagn F., Mitschke L., Hessling M., Gugel F., Kessler H., Richter K., Buchner J. Asymmetric activation of the hsp90 dimer by its cochaperone aha1. Mol. Cell 2010, 37:344-354.
-
(2010)
Mol. Cell
, vol.37
, pp. 344-354
-
-
Retzlaff, M.1
Hagn, F.2
Mitschke, L.3
Hessling, M.4
Gugel, F.5
Kessler, H.6
Richter, K.7
Buchner, J.8
-
47
-
-
0037013152
-
Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release
-
Fontana J., Fulton D., Chen Y., Fairchild T.A., McCabe T.J., Fujita N., Tsuruo T., Sessa W.C. Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ. Res. 2002, 90:866-873.
-
(2002)
Circ. Res.
, vol.90
, pp. 866-873
-
-
Fontana, J.1
Fulton, D.2
Chen, Y.3
Fairchild, T.A.4
McCabe, T.J.5
Fujita, N.6
Tsuruo, T.7
Sessa, W.C.8
-
48
-
-
33747878717
-
Structure of an Hsp90-Cdc37-Cdk4 complex
-
Vaughan C.K., Gohlke U., Sobott F., Good V.M., Ali M.M., Prodromou C., Robinson C.V., Saibil H.R., Pearl L.H. Structure of an Hsp90-Cdc37-Cdk4 complex. Mol. Cell 2006, 23:697-707.
-
(2006)
Mol. Cell
, vol.23
, pp. 697-707
-
-
Vaughan, C.K.1
Gohlke, U.2
Sobott, F.3
Good, V.M.4
Ali, M.M.5
Prodromou, C.6
Robinson, C.V.7
Saibil, H.R.8
Pearl, L.H.9
-
49
-
-
79953308070
-
Substrate binding drives large-scale conformational changes in the hsp90 molecular chaperone
-
Street T.O., Lavery L.A., Agard D.A. Substrate binding drives large-scale conformational changes in the hsp90 molecular chaperone. Mol. Cell 2011, 42:96-105.
-
(2011)
Mol. Cell
, vol.42
, pp. 96-105
-
-
Street, T.O.1
Lavery, L.A.2
Agard, D.A.3
-
50
-
-
79953202216
-
Enforced N-domain proximity stimulates Hsp90 ATPase activity and is compatible with function in vivo
-
Pullen L., Bolon D.N. Enforced N-domain proximity stimulates Hsp90 ATPase activity and is compatible with function in vivo. J. Biol. Chem. 2011, 286:11091-11098.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 11091-11098
-
-
Pullen, L.1
Bolon, D.N.2
-
51
-
-
0034646511
-
Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
-
Scheufler C., Brinker A., Bourenkov G., Pegoraro S., Moroder L., Bartunik H., Hartl F.U., Moarefi I. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell 2000, 101:199-210.
-
(2000)
Cell
, vol.101
, pp. 199-210
-
-
Scheufler, C.1
Brinker, A.2
Bourenkov, G.3
Pegoraro, S.4
Moroder, L.5
Bartunik, H.6
Hartl, F.U.7
Moarefi, I.8
-
52
-
-
0033081968
-
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
-
Prodromou C., Siligardi G., O'Brien R., Woolfson D.N., Regan L., Panaretou B., Ladbury J.E., Piper P.W., Pearl L.H. Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones. EMBO J. 1999, 18:754-762.
-
(1999)
EMBO J.
, vol.18
, pp. 754-762
-
-
Prodromou, C.1
Siligardi, G.2
O'Brien, R.3
Woolfson, D.N.4
Regan, L.5
Panaretou, B.6
Ladbury, J.E.7
Piper, P.W.8
Pearl, L.H.9
-
53
-
-
0031846768
-
Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants
-
Chen S., Sullivan W.P., Toft D.O., Smith D.F. Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants. Cell Stress Chaperones 1998, 3:118-129.
-
(1998)
Cell Stress Chaperones
, vol.3
, pp. 118-129
-
-
Chen, S.1
Sullivan, W.P.2
Toft, D.O.3
Smith, D.F.4
-
54
-
-
33646176246
-
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex
-
Ali M.M., Roe S.M., Vaughan C.K., Meyer P., Panaretou B., Piper P.W., Prodromou C., Pearl L.H. Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature 2006, 440:1013-1017.
-
(2006)
Nature
, vol.440
, pp. 1013-1017
-
-
Ali, M.M.1
Roe, S.M.2
Vaughan, C.K.3
Meyer, P.4
Panaretou, B.5
Piper, P.W.6
Prodromou, C.7
Pearl, L.H.8
-
55
-
-
33750008686
-
Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements
-
Shiau A.K., Harris S.F., Southworth D.R., Agard D.A. Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell 2006, 127:329-340.
-
(2006)
Cell
, vol.127
, pp. 329-340
-
-
Shiau, A.K.1
Harris, S.F.2
Southworth, D.R.3
Agard, D.A.4
-
56
-
-
61949349758
-
Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90
-
Hessling M., Richter K., Buchner J. Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90. Nat. Struct. Mol. Biol. 2009, 16:287-293.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 287-293
-
-
Hessling, M.1
Richter, K.2
Buchner, J.3
-
57
-
-
61949212626
-
The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis
-
Mickler M., Hessling M., Ratzke C., Buchner J., Hugel T. The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis. Nat. Struct. Mol. Biol. 2009, 16:281-286.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 281-286
-
-
Mickler, M.1
Hessling, M.2
Ratzke, C.3
Buchner, J.4
Hugel, T.5
-
58
-
-
0032541344
-
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
-
Panaretou B., Prodromou C., Roe S.M., O'Brien R., Ladbury J.E., Piper P.W., Pearl L.H. ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO J. 1998, 17:4829-4836.
-
(1998)
EMBO J.
, vol.17
, pp. 4829-4836
-
-
Panaretou, B.1
Prodromou, C.2
Roe, S.M.3
O'Brien, R.4
Ladbury, J.E.5
Piper, P.W.6
Pearl, L.H.7
-
59
-
-
0032539709
-
Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence
-
Scheibel T., Weikl T., Buchner J. Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:1495-1499.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 1495-1499
-
-
Scheibel, T.1
Weikl, T.2
Buchner, J.3
-
60
-
-
0036303385
-
Stimulation of the weak ATPase activity of human hsp90 by a client protein
-
McLaughlin S.H., Smith H.W., Jackson S.E. Stimulation of the weak ATPase activity of human hsp90 by a client protein. J. Mol. Biol. 2002, 315:787-798.
-
(2002)
J. Mol. Biol.
, vol.315
, pp. 787-798
-
-
McLaughlin, S.H.1
Smith, H.W.2
Jackson, S.E.3
-
61
-
-
36849083947
-
Dimerization of Hsp90 is required for in vivo function. Design and analysis of monomers and dimers
-
Wayne N., Bolon D.N. Dimerization of Hsp90 is required for in vivo function. Design and analysis of monomers and dimers. J. Biol. Chem. 2007, 282:35386-35395.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 35386-35395
-
-
Wayne, N.1
Bolon, D.N.2
-
62
-
-
56849131626
-
Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle
-
Southworth D.R., Agard D.A. Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle. Mol. Cell 2008, 32:631-640.
-
(2008)
Mol. Cell
, vol.32
, pp. 631-640
-
-
Southworth, D.R.1
Agard, D.A.2
-
63
-
-
77958005847
-
Dynamics of heat shock protein 90 C-terminal dimerization is an important part of its conformational cycle
-
Ratzke C., Mickler M., Hellenkamp B., Buchner J., Hugel T. Dynamics of heat shock protein 90 C-terminal dimerization is an important part of its conformational cycle. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:16101-16106.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 16101-16106
-
-
Ratzke, C.1
Mickler, M.2
Hellenkamp, B.3
Buchner, J.4
Hugel, T.5
-
64
-
-
0036931438
-
Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1
-
Panaretou B., Siligardi G., Meyer P., Maloney A., Sullivan J.K., Singh S., Millson S.H., Clarke P.A., Naaby-Hansen S., Stein R., Cramer R., Mollapour M., Workman P., Piper P.W., Pearl L.H., Prodromou C. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Mol. Cell 2002, 10:1307-1318.
-
(2002)
Mol. Cell
, vol.10
, pp. 1307-1318
-
-
Panaretou, B.1
Siligardi, G.2
Meyer, P.3
Maloney, A.4
Sullivan, J.K.5
Singh, S.6
Millson, S.H.7
Clarke, P.A.8
Naaby-Hansen, S.9
Stein, R.10
Cramer, R.11
Mollapour, M.12
Workman, P.13
Piper, P.W.14
Pearl, L.H.15
Prodromou, C.16
-
65
-
-
4444291743
-
The co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle
-
Richter K., Walter S., Buchner J. The co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle. J. Mol. Biol. 2004, 342:1403-1413.
-
(2004)
J. Mol. Biol.
, vol.342
, pp. 1403-1413
-
-
Richter, K.1
Walter, S.2
Buchner, J.3
-
66
-
-
0742269688
-
The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)
-
Roe S.M., Ali M.M., Meyer P., Vaughan C.K., Panaretou B., Piper P.W., Prodromou C., Pearl L.H. The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell 2004, 116:87-98.
-
(2004)
Cell
, vol.116
, pp. 87-98
-
-
Roe, S.M.1
Ali, M.M.2
Meyer, P.3
Vaughan, C.K.4
Panaretou, B.5
Piper, P.W.6
Prodromou, C.7
Pearl, L.H.8
-
67
-
-
0032567434
-
Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery
-
Chen S., Smith D.F. Hop as an adaptor in the heat shock protein 70 (Hsp70) and hsp90 chaperone machinery. J. Biol. Chem. 1998, 273:35194-35200.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35194-35200
-
-
Chen, S.1
Smith, D.F.2
-
68
-
-
0032473425
-
The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions
-
Das A.K., Cohen P.W., Barford D. The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. EMBO J. 1998, 17:1192-1199.
-
(1998)
EMBO J.
, vol.17
, pp. 1192-1199
-
-
Das, A.K.1
Cohen, P.W.2
Barford, D.3
-
69
-
-
0032488906
-
Hop modulates Hsp70/Hsp90 interactions in protein folding
-
Johnson B.D., Schumacher R.J., Ross E.D., Toft D.O. Hop modulates Hsp70/Hsp90 interactions in protein folding. J. Biol. Chem. 1998, 273:3679-3686.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3679-3686
-
-
Johnson, B.D.1
Schumacher, R.J.2
Ross, E.D.3
Toft, D.O.4
-
70
-
-
0027985148
-
Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae
-
Chang H.C., Lindquist S. Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae. J. Biol. Chem. 1994, 269:24983-24988.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 24983-24988
-
-
Chang, H.C.1
Lindquist, S.2
-
71
-
-
0030921056
-
Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin
-
Silverstein A.M., Galigniana M.D., Chen M.S., Owens-Grillo J.K., Chinkers M., Pratt W.B. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. J. Biol. Chem. 1997, 272:16224-16230.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16224-16230
-
-
Silverstein, A.M.1
Galigniana, M.D.2
Chen, M.S.3
Owens-Grillo, J.K.4
Chinkers, M.5
Pratt, W.B.6
-
72
-
-
31444454302
-
The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90
-
Wandinger S.K., Suhre M.H., Wegele H., Buchner J. The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90. EMBO J. 2006, 25:367-376.
-
(2006)
EMBO J.
, vol.25
, pp. 367-376
-
-
Wandinger, S.K.1
Suhre, M.H.2
Wegele, H.3
Buchner, J.4
-
73
-
-
0042815093
-
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system
-
Brychzy A., Rein T., Winklhofer K.F., Hartl F.U., Young J.C., Obermann W.M. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. EMBO J. 2003, 22:3613-3623.
-
(2003)
EMBO J.
, vol.22
, pp. 3613-3623
-
-
Brychzy, A.1
Rein, T.2
Winklhofer, K.F.3
Hartl, F.U.4
Young, J.C.5
Obermann, W.M.6
-
74
-
-
47749122973
-
Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain
-
Srikakulam R., Liu L., Winkelmann D.A. Unc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domain. PLoS One 2008, 3:e2137.
-
(2008)
PLoS One
, vol.3
-
-
Srikakulam, R.1
Liu, L.2
Winkelmann, D.A.3
-
75
-
-
0037169028
-
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin
-
Barral J.M., Hutagalung A.H., Brinker A., Hartl F.U., Epstein H.F. Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosin. Science 2002, 295:669-671.
-
(2002)
Science
, vol.295
, pp. 669-671
-
-
Barral, J.M.1
Hutagalung, A.H.2
Brinker, A.3
Hartl, F.U.4
Epstein, H.F.5
-
76
-
-
36849030809
-
FK506-binding protein 52 phosphorylation: a potential mechanism for regulating steroid hormone receptor activity
-
Cox M.B., Riggs D.L., Hessling M., Schumacher F., Buchner J., Smith D.F. FK506-binding protein 52 phosphorylation: a potential mechanism for regulating steroid hormone receptor activity. Mol. Endocrinol. 2007, 21:2956-2967.
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 2956-2967
-
-
Cox, M.B.1
Riggs, D.L.2
Hessling, M.3
Schumacher, F.4
Buchner, J.5
Smith, D.F.6
-
77
-
-
0028027504
-
A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23
-
Johnson J.L., Toft D.O. A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23. J. Biol. Chem. 1994, 269:24989-24993.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 24989-24993
-
-
Johnson, J.L.1
Toft, D.O.2
-
78
-
-
0037416154
-
The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo
-
Riggs D.L., Roberts P.J., Chirillo S.C., Cheung-Flynn J., Prapapanich V., Ratajczak T., Gaber R., Picard D., Smith D.F. The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. EMBO J. 2003, 22:1158-1167.
-
(2003)
EMBO J.
, vol.22
, pp. 1158-1167
-
-
Riggs, D.L.1
Roberts, P.J.2
Chirillo, S.C.3
Cheung-Flynn, J.4
Prapapanich, V.5
Ratajczak, T.6
Gaber, R.7
Picard, D.8
Smith, D.F.9
-
79
-
-
0027170713
-
P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors
-
Tai P.K., Chang H., Albers M.W., Schreiber S.L., Toft D.O., Faber L.E. P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. Biochemistry 1993, 32:8842-8847.
-
(1993)
Biochemistry
, vol.32
, pp. 8842-8847
-
-
Tai, P.K.1
Chang, H.2
Albers, M.W.3
Schreiber, S.L.4
Toft, D.O.5
Faber, L.E.6
-
80
-
-
0031053574
-
Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor
-
Nair S.C., Rimerman R.A., Toran E.J., Chen S., Prapapanich V., Butts R.N., Smith D.F. Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. Mol. Cell. Biol. 1997, 17:594-603.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 594-603
-
-
Nair, S.C.1
Rimerman, R.A.2
Toran, E.J.3
Chen, S.4
Prapapanich, V.5
Butts, R.N.6
Smith, D.F.7
-
81
-
-
0030050335
-
Cyclophilin 40 (CyP-40), mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding
-
Ratajczak T., Carrello A. Cyclophilin 40 (CyP-40), mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding. J. Biol. Chem. 1996, 271:2961-2965.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2961-2965
-
-
Ratajczak, T.1
Carrello, A.2
-
82
-
-
0034602390
-
Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties
-
Mayr C., Richter K., Lilie H., Buchner J. Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties. J. Biol. Chem. 2000, 275:34140-34146.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34140-34146
-
-
Mayr, C.1
Richter, K.2
Lilie, H.3
Buchner, J.4
-
83
-
-
0037518202
-
Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle
-
Richter K., Muschler P., Hainzl O., Reinstein J., Buchner J. Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle. J. Biol. Chem. 2003, 278:10328-10333.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10328-10333
-
-
Richter, K.1
Muschler, P.2
Hainzl, O.3
Reinstein, J.4
Buchner, J.5
-
84
-
-
31344453190
-
Substrate transfer from the chaperone Hsp70 to Hsp90
-
Wegele H., Wandinger S.K., Schmid A.B., Reinstein J., Buchner J. Substrate transfer from the chaperone Hsp70 to Hsp90. J. Mol. Biol. 2006, 356:802-811.
-
(2006)
J. Mol. Biol.
, vol.356
, pp. 802-811
-
-
Wegele, H.1
Wandinger, S.K.2
Schmid, A.B.3
Reinstein, J.4
Buchner, J.5
-
85
-
-
0037830586
-
Sti1 is a novel activator of the Ssa proteins
-
Wegele H., Haslbeck M., Reinstein J., Buchner J. Sti1 is a novel activator of the Ssa proteins. J. Biol. Chem. 2003, 278:25970-25976.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25970-25976
-
-
Wegele, H.1
Haslbeck, M.2
Reinstein, J.3
Buchner, J.4
-
86
-
-
0037205411
-
Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70×Hop×Hsp90 complexes
-
Brinker A., Scheufler C., Von Der Mulbe F., Fleckenstein B., Herrmann C., Jung G., Moarefi I., Hartl F.U. Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70×Hop×Hsp90 complexes. J. Biol. Chem. 2002, 277:19265-19275.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 19265-19275
-
-
Brinker, A.1
Scheufler, C.2
Von Der Mulbe, F.3
Fleckenstein, B.4
Herrmann, C.5
Jung, G.6
Moarefi, I.7
Hartl, F.U.8
-
87
-
-
67651163397
-
The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90
-
Gaiser A.M., Brandt F., Richter K. The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90. J. Mol. Biol. 2009, 391:621-634.
-
(2009)
J. Mol. Biol.
, vol.391
, pp. 621-634
-
-
Gaiser, A.M.1
Brandt, F.2
Richter, K.3
-
88
-
-
75149171461
-
HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP
-
Yi F., Doudevski I., Regan L. HOP is a monomer: investigation of the oligomeric state of the co-chaperone HOP. Protein Sci. 2010, 19:19-25.
-
(2010)
Protein Sci.
, vol.19
, pp. 19-25
-
-
Yi, F.1
Doudevski, I.2
Regan, L.3
-
89
-
-
78650983812
-
Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle
-
Li J., Richter K., Buchner J. Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle. Nat. Struct. Mol. Biol. 2011, 18:61-66.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 61-66
-
-
Li, J.1
Richter, K.2
Buchner, J.3
-
90
-
-
0142215475
-
Global analysis of protein expression in yeast
-
Ghaemmaghami S., Huh W.K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Global analysis of protein expression in yeast. Nature 2003, 425:737-741.
-
(2003)
Nature
, vol.425
, pp. 737-741
-
-
Ghaemmaghami, S.1
Huh, W.K.2
Bower, K.3
Howson, R.W.4
Belle, A.5
Dephoure, N.6
O'Shea, E.K.7
Weissman, J.S.8
-
91
-
-
0031832233
-
SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins
-
Fang Y., Fliss A.E., Rao J., Caplan A.J. SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol. Cell. Biol. 1998, 18:3727-3734.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 3727-3734
-
-
Fang, Y.1
Fliss, A.E.2
Rao, J.3
Caplan, A.J.4
-
92
-
-
21344449336
-
Novel interaction of the Hsp90 chaperone machine with Ssl2, an essential DNA helicase in Saccharomyces cerevisiae
-
Flom G., Weekes J., Johnson J.L. Novel interaction of the Hsp90 chaperone machine with Ssl2, an essential DNA helicase in Saccharomyces cerevisiae. Curr. Genet. 2005, 47:368-380.
-
(2005)
Curr. Genet.
, vol.47
, pp. 368-380
-
-
Flom, G.1
Weekes, J.2
Johnson, J.L.3
-
93
-
-
33644746255
-
Effect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces cerevisiae
-
Flom G., Weekes J., Williams J.J., Johnson J.L. Effect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces cerevisiae. Genetics 2006, 172:41-51.
-
(2006)
Genetics
, vol.172
, pp. 41-51
-
-
Flom, G.1
Weekes, J.2
Williams, J.J.3
Johnson, J.L.4
-
94
-
-
0032484127
-
The assembly of progesterone receptor-hsp90 complexes using purified proteins
-
Kosano H., Stensgard B., Charlesworth M.C., McMahon N., Toft D. The assembly of progesterone receptor-hsp90 complexes using purified proteins. J. Biol. Chem. 1998, 273:32973-32979.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32973-32979
-
-
Kosano, H.1
Stensgard, B.2
Charlesworth, M.C.3
McMahon, N.4
Toft, D.5
-
95
-
-
79251560849
-
Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation
-
Gangaraju V.K., Yin H., Weiner M.M., Wang J., Huang X.A., Lin H. Drosophila Piwi functions in Hsp90-mediated suppression of phenotypic variation. Nat. Genet. 2011, 43:153-158.
-
(2011)
Nat. Genet.
, vol.43
, pp. 153-158
-
-
Gangaraju, V.K.1
Yin, H.2
Weiner, M.M.3
Wang, J.4
Huang, X.A.5
Lin, H.6
-
96
-
-
77954939833
-
Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy
-
Marozkina N.V., Yemen S., Borowitz M., Liu L., Plapp M., Sun F., Islam R., Erdmann-Gilmore P., Townsend R.R., Lichti C.F., Mantri S., Clapp P.W., Randell S.H., Gaston B., Zaman K. Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:11393-11398.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 11393-11398
-
-
Marozkina, N.V.1
Yemen, S.2
Borowitz, M.3
Liu, L.4
Plapp, M.5
Sun, F.6
Islam, R.7
Erdmann-Gilmore, P.8
Townsend, R.R.9
Lichti, C.F.10
Mantri, S.11
Clapp, P.W.12
Randell, S.H.13
Gaston, B.14
Zaman, K.15
-
97
-
-
77949438155
-
Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis
-
Koulov A.V., Lapointe P., Lu B., Razvi A., Coppinger J., Dong M.Q., Matteson J., Laister R., Arrowsmith C., Yates J.R., Balch W.E. Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis. Mol. Biol. Cell 2010, 21:871-884.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 871-884
-
-
Koulov, A.V.1
Lapointe, P.2
Lu, B.3
Razvi, A.4
Coppinger, J.5
Dong, M.Q.6
Matteson, J.7
Laister, R.8
Arrowsmith, C.9
Yates, J.R.10
Balch, W.E.11
-
98
-
-
0033741503
-
Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90
-
Chadli A., Bouhouche I., Sullivan W., Stensgard B., McMahon N., Catelli M.G., Toft D.O. Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:12524-12529.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 12524-12529
-
-
Chadli, A.1
Bouhouche, I.2
Sullivan, W.3
Stensgard, B.4
McMahon, N.5
Catelli, M.G.6
Toft, D.O.7
-
99
-
-
0033581021
-
The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes
-
Grenert J.P., Johnson B.D., Toft D.O. The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes. J. Biol. Chem. 1999, 274:17525-17533.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17525-17533
-
-
Grenert, J.P.1
Johnson, B.D.2
Toft, D.O.3
-
100
-
-
0028266874
-
Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes
-
Johnson J.L., Beito T.G., Krco C.J., Toft D.O. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol. Cell. Biol. 1994, 14:1956-1963.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 1956-1963
-
-
Johnson, J.L.1
Beito, T.G.2
Krco, C.J.3
Toft, D.O.4
-
101
-
-
0032760261
-
An unstructured C-terminal region of the Hsp90 co-chaperone p23 is important for its chaperone function
-
Weikl T., Abelmann K., Buchner J. An unstructured C-terminal region of the Hsp90 co-chaperone p23 is important for its chaperone function. J. Mol. Biol. 1999, 293:685-691.
-
(1999)
J. Mol. Biol.
, vol.293
, pp. 685-691
-
-
Weikl, T.1
Abelmann, K.2
Buchner, J.3
-
102
-
-
33845215386
-
The Hsp90 cochaperone p23 is essential for perinatal survival
-
Grad I., McKee T.A., Ludwig S.M., Hoyle G.W., Ruiz P., Wurst W., Floss T., Miller C.A., Picard D. The Hsp90 cochaperone p23 is essential for perinatal survival. Mol. Cell. Biol. 2006, 26:8976-8983.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 8976-8983
-
-
Grad, I.1
McKee, T.A.2
Ludwig, S.M.3
Hoyle, G.W.4
Ruiz, P.5
Wurst, W.6
Floss, T.7
Miller, C.A.8
Picard, D.9
-
103
-
-
79960452274
-
Global functional map of the p23 molecular chaperone reveals an extensive cellular network
-
Echtenkamp F.J., Zelin E., Oxelmark E., Woo J.I., Andrews B.J., Garabedian M., Freeman B.C. Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Mol. Cell 2011, 43:229-241.
-
(2011)
Mol. Cell
, vol.43
, pp. 229-241
-
-
Echtenkamp, F.J.1
Zelin, E.2
Oxelmark, E.3
Woo, J.I.4
Andrews, B.J.5
Garabedian, M.6
Freeman, B.C.7
-
104
-
-
0029075280
-
Binding of p23 and hsp90 during assembly with the progesterone receptor
-
Johnson J.L., Toft D.O. Binding of p23 and hsp90 during assembly with the progesterone receptor. Mol. Endocrinol. 1995, 9:670-678.
-
(1995)
Mol. Endocrinol.
, vol.9
, pp. 670-678
-
-
Johnson, J.L.1
Toft, D.O.2
-
105
-
-
0032538995
-
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
-
Obermann W.M., Sondermann H., Russo A.A., Pavletich N.P., Hartl F.U. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. J. Cell Biol. 1998, 143:901-910.
-
(1998)
J. Cell Biol.
, vol.143
, pp. 901-910
-
-
Obermann, W.M.1
Sondermann, H.2
Russo, A.A.3
Pavletich, N.P.4
Hartl, F.U.5
-
106
-
-
31344474558
-
The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins
-
McLaughlin S.H., Sobott F., Yao Z.P., Zhang W., Nielsen P.R., Grossmann J.G., Laue E.D., Robinson C.V., Jackson S.E. The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. J. Mol. Biol. 2006, 356:746-758.
-
(2006)
J. Mol. Biol.
, vol.356
, pp. 746-758
-
-
McLaughlin, S.H.1
Sobott, F.2
Yao, Z.P.3
Zhang, W.4
Nielsen, P.R.5
Grossmann, J.G.6
Laue, E.D.7
Robinson, C.V.8
Jackson, S.E.9
-
107
-
-
1342294313
-
The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex
-
Morishima Y., Kanelakis K.C., Murphy P.J., Lowe E.R., Jenkins G.J., Osawa Y., Sunahara R.K., Pratt W.B. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. J. Biol. Chem. 2003, 278:48754-48763.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 48754-48763
-
-
Morishima, Y.1
Kanelakis, K.C.2
Murphy, P.J.3
Lowe, E.R.4
Jenkins, G.J.5
Osawa, Y.6
Sunahara, R.K.7
Pratt, W.B.8
-
108
-
-
0029852803
-
Chaperone function of Hsp90-associated proteins
-
Bose S., Weikl T., Bugl H., Buchner J. Chaperone function of Hsp90-associated proteins. Science 1996, 274:1715-1717.
-
(1996)
Science
, vol.274
, pp. 1715-1717
-
-
Bose, S.1
Weikl, T.2
Bugl, H.3
Buchner, J.4
-
109
-
-
0029852712
-
Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23
-
Freeman B.C., Toft D.O., Morimoto R.I. Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23. Science 1996, 274:1718-1720.
-
(1996)
Science
, vol.274
, pp. 1718-1720
-
-
Freeman, B.C.1
Toft, D.O.2
Morimoto, R.I.3
-
110
-
-
0034725641
-
Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone
-
Weaver A.J., Sullivan W.P., Felts S.J., Owen B.A., Toft D.O. Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. J. Biol. Chem. 2000, 275:23045-23052.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23045-23052
-
-
Weaver, A.J.1
Sullivan, W.P.2
Felts, S.J.3
Owen, B.A.4
Toft, D.O.5
-
111
-
-
78650342694
-
Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors
-
Gaiser A.M., Kretzschmar A., Richter K. Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors. J. Biol. Chem. 2010, 285:40921-40932.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 40921-40932
-
-
Gaiser, A.M.1
Kretzschmar, A.2
Richter, K.3
-
112
-
-
0037036458
-
Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37
-
Siligardi G., Panaretou B., Meyer P., Singh S., Woolfson D.N., Piper P.W., Pearl L.H., Prodromou C. Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. J. Biol. Chem. 2002, 277:20151-20159.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 20151-20159
-
-
Siligardi, G.1
Panaretou, B.2
Meyer, P.3
Singh, S.4
Woolfson, D.N.5
Piper, P.W.6
Pearl, L.H.7
Prodromou, C.8
-
113
-
-
0023057566
-
Nucleotide sequence of the yeast cell division cycle start genes CDC28, CDC36, CDC37, and CDC39, and a structural analysis of the predicted products
-
Ferguson J., Ho J.Y., Peterson T.A., Reed S.I. Nucleotide sequence of the yeast cell division cycle start genes CDC28, CDC36, CDC37, and CDC39, and a structural analysis of the predicted products. Nucleic Acids Res. 1986, 14:6681-6697.
-
(1986)
Nucleic Acids Res.
, vol.14
, pp. 6681-6697
-
-
Ferguson, J.1
Ho, J.Y.2
Peterson, T.A.3
Reed, S.I.4
-
114
-
-
0019162297
-
The selection of S. cerevisiae mutants defective in the start event of cell division
-
Reed S.I. The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 1980, 95:561-577.
-
(1980)
Genetics
, vol.95
, pp. 561-577
-
-
Reed, S.I.1
-
115
-
-
0029658298
-
CDC37 is required for p60v-src activity in yeast
-
Dey B., Lightbody J.J., Boschelli F. CDC37 is required for p60v-src activity in yeast. Mol. Biol. Cell 1996, 7:1405-1417.
-
(1996)
Mol. Biol. Cell
, vol.7
, pp. 1405-1417
-
-
Dey, B.1
Lightbody, J.J.2
Boschelli, F.3
-
116
-
-
0022574582
-
Interaction of the Rous sarcoma virus protein pp 60src with the cellular proteins pp50 and pp90
-
Brugge J.S. Interaction of the Rous sarcoma virus protein pp 60src with the cellular proteins pp50 and pp90. Curr. Top. Microbiol. Immunol. 1986, 123:1-22.
-
(1986)
Curr. Top. Microbiol. Immunol.
, vol.123
, pp. 1-22
-
-
Brugge, J.S.1
-
118
-
-
0036923905
-
Aha, another regulator for hsp90 chaperones
-
Mayer M.P., Nikolay R., Bukau B. Aha, another regulator for hsp90 chaperones. Mol. Cell 2002, 10:1255-1256.
-
(2002)
Mol. Cell
, vol.10
, pp. 1255-1256
-
-
Mayer, M.P.1
Nikolay, R.2
Bukau, B.3
-
119
-
-
0037593900
-
Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone
-
Lotz G.P., Lin H., Harst A., Obermann W.M. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. J. Biol. Chem. 2003, 278:17228-17235.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 17228-17235
-
-
Lotz, G.P.1
Lin, H.2
Harst, A.3
Obermann, W.M.4
-
120
-
-
33750842131
-
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis
-
Wang X., Venable J., LaPointe P., Hutt D.M., Koulov A.V., Coppinger J., Gurkan C., Kellner W., Matteson J., Plutner H., Riordan J.R., Kelly J.W., Yates J.R., Balch W.E. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell 2006, 127:803-815.
-
(2006)
Cell
, vol.127
, pp. 803-815
-
-
Wang, X.1
Venable, J.2
LaPointe, P.3
Hutt, D.M.4
Koulov, A.V.5
Coppinger, J.6
Gurkan, C.7
Kellner, W.8
Matteson, J.9
Plutner, H.10
Riordan, J.R.11
Kelly, J.W.12
Yates, J.R.13
Balch, W.E.14
-
121
-
-
0034968225
-
Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40
-
Pirkl F., Buchner J. Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. J. Mol. Biol. 2001, 308:795-806.
-
(2001)
J. Mol. Biol.
, vol.308
, pp. 795-806
-
-
Pirkl, F.1
Buchner, J.2
-
122
-
-
0026495863
-
Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes
-
Peattie D.A., Harding M.W., Fleming M.A., DeCenzo M.T., Lippke J.A., Livingston D.J., Benasutti M. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. Proc. Natl. Acad. Sci. U. S. A. 1992, 89:10974-10978.
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 10974-10978
-
-
Peattie, D.A.1
Harding, M.W.2
Fleming, M.A.3
DeCenzo, M.T.4
Lippke, J.A.5
Livingston, D.J.6
Benasutti, M.7
-
123
-
-
67349114546
-
Cyclophilin 40: an Hsp90-cochaperone associated with apo-steroid receptors
-
Ratajczak T., Ward B.K., Cluning C., Allan R.K. Cyclophilin 40: an Hsp90-cochaperone associated with apo-steroid receptors. Int. J. Biochem. Cell Biol. 2009, 41:1652-1655.
-
(2009)
Int. J. Biochem. Cell Biol.
, vol.41
, pp. 1652-1655
-
-
Ratajczak, T.1
Ward, B.K.2
Cluning, C.3
Allan, R.K.4
-
124
-
-
0029807530
-
A cyclophilin function in Hsp90-dependent signal transduction
-
Duina A.A., Chang H.C., Marsh J.A., Lindquist S., Gaber R.F. A cyclophilin function in Hsp90-dependent signal transduction. Science 1996, 274:1713-1715.
-
(1996)
Science
, vol.274
, pp. 1713-1715
-
-
Duina, A.A.1
Chang, H.C.2
Marsh, J.A.3
Lindquist, S.4
Gaber, R.F.5
-
125
-
-
28444439801
-
Insights into the catalytic mechanism of peptidyl prolyl cis/trans isomerases
-
Fanghanel J., Fischer G. Insights into the catalytic mechanism of peptidyl prolyl cis/trans isomerases. Front. Biosci. 2004, 9:3453-3478.
-
(2004)
Front. Biosci.
, vol.9
, pp. 3453-3478
-
-
Fanghanel, J.1
Fischer, G.2
-
126
-
-
0033490140
-
Expression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer
-
Ward B.K., Mark P.J., Ingram D.M., Minchin R.F., Ratajczak T. Expression of the estrogen receptor-associated immunophilins, cyclophilin 40 and FKBP52, in breast cancer. Breast Cancer Res. Treat. 1999, 58:267-280.
-
(1999)
Breast Cancer Res. Treat.
, vol.58
, pp. 267-280
-
-
Ward, B.K.1
Mark, P.J.2
Ingram, D.M.3
Minchin, R.F.4
Ratajczak, T.5
-
127
-
-
0042318859
-
Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity
-
Sumanasekera W.K., Tien E.S., Davis J.W., Turpey R., Perdew G.H., Vanden Heuvel J.P. Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. Biochemistry 2003, 42:10726-10735.
-
(2003)
Biochemistry
, vol.42
, pp. 10726-10735
-
-
Sumanasekera, W.K.1
Tien, E.S.2
Davis, J.W.3
Turpey, R.4
Perdew, G.H.5
Vanden Heuvel, J.P.6
-
128
-
-
0033551511
-
Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization
-
Meyer B.K., Perdew G.H. Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization. Biochemistry 1999, 38:8907-8917.
-
(1999)
Biochemistry
, vol.38
, pp. 8907-8917
-
-
Meyer, B.K.1
Perdew, G.H.2
-
129
-
-
0033669662
-
Aryl hydrocarbon (Ah) receptor levels are selectively modulated by hsp90-associated immunophilin homolog XAP2
-
Meyer B.K., Petrulis J.R., Perdew G.H. Aryl hydrocarbon (Ah) receptor levels are selectively modulated by hsp90-associated immunophilin homolog XAP2. Cell Stress Chaperones 2000, 5:243-254.
-
(2000)
Cell Stress Chaperones
, vol.5
, pp. 243-254
-
-
Meyer, B.K.1
Petrulis, J.R.2
Perdew, G.H.3
-
130
-
-
0035104164
-
The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor
-
Kazlauskas A., Sundstrom S., Poellinger L., Pongratz I. The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor. Mol. Cell. Biol. 2001, 21:2594-2607.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2594-2607
-
-
Kazlauskas, A.1
Sundstrom, S.2
Poellinger, L.3
Pongratz, I.4
-
131
-
-
0028858097
-
Identification of functional domains of the aryl hydrocarbon receptor
-
Fukunaga B.N., Probst M.R., Reisz-Porszasz S., Hankinson O. Identification of functional domains of the aryl hydrocarbon receptor. J. Biol. Chem. 1995, 270:29270-29278.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 29270-29278
-
-
Fukunaga, B.N.1
Probst, M.R.2
Reisz-Porszasz, S.3
Hankinson, O.4
-
132
-
-
34447543047
-
The Bcl-2 regulator FKBP38-calmodulin-Ca2+ is inhibited by Hsp90
-
Edlich F., Erdmann F., Jarczowski F., Moutty M.C., Weiwad M., Fischer G. The Bcl-2 regulator FKBP38-calmodulin-Ca2+ is inhibited by Hsp90. J. Biol. Chem. 2007, 282:15341-15348.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 15341-15348
-
-
Edlich, F.1
Erdmann, F.2
Jarczowski, F.3
Moutty, M.C.4
Weiwad, M.5
Fischer, G.6
-
133
-
-
33750219537
-
Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90
-
Okamoto T., Nishimura Y., Ichimura T., Suzuki K., Miyamura T., Suzuki T., Moriishi K., Matsuura Y. Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. EMBO J. 2006, 25:5015-5025.
-
(2006)
EMBO J.
, vol.25
, pp. 5015-5025
-
-
Okamoto, T.1
Nishimura, Y.2
Ichimura, T.3
Suzuki, K.4
Miyamura, T.5
Suzuki, T.6
Moriishi, K.7
Matsuura, Y.8
-
134
-
-
0035807022
-
Identification of amino acids in the tetratricopeptide repeat and C-terminal domains of protein phosphatase 5 involved in autoinhibition and lipid activation
-
Kang H., Sayner S.L., Gross K.L., Russell L.C., Chinkers M. Identification of amino acids in the tetratricopeptide repeat and C-terminal domains of protein phosphatase 5 involved in autoinhibition and lipid activation. Biochemistry 2001, 40:10485-10490.
-
(2001)
Biochemistry
, vol.40
, pp. 10485-10490
-
-
Kang, H.1
Sayner, S.L.2
Gross, K.L.3
Russell, L.C.4
Chinkers, M.5
-
135
-
-
52249108496
-
Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37
-
Vaughan C.K., Mollapour M., Smith J.R., Truman A., Hu B., Good V.M., Panaretou B., Neckers L., Clarke P.A., Workman P., Piper P.W., Prodromou C., Pearl L.H. Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Mol. Cell 2008, 31:886-895.
-
(2008)
Mol. Cell
, vol.31
, pp. 886-895
-
-
Vaughan, C.K.1
Mollapour, M.2
Smith, J.R.3
Truman, A.4
Hu, B.5
Good, V.M.6
Panaretou, B.7
Neckers, L.8
Clarke, P.A.9
Workman, P.10
Piper, P.W.11
Prodromou, C.12
Pearl, L.H.13
-
136
-
-
0037086347
-
Regulatory role of SGT1 in early R gene-mediated plant defenses
-
Austin M.J., Muskett P., Kahn K., Feys B.J., Jones J.D., Parker J.E. Regulatory role of SGT1 in early R gene-mediated plant defenses. Science 2002, 295:2077-2080.
-
(2002)
Science
, vol.295
, pp. 2077-2080
-
-
Austin, M.J.1
Muskett, P.2
Kahn, K.3
Feys, B.J.4
Jones, J.D.5
Parker, J.E.6
-
137
-
-
33845959149
-
Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p
-
Catlett M.G., Kaplan K.B. Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p. J. Biol. Chem. 2006, 281:33739-33748.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 33739-33748
-
-
Catlett, M.G.1
Kaplan, K.B.2
-
138
-
-
1942436961
-
Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain
-
Lee Y.T., Jacob J., Michowski W., Nowotny M., Kuznicki J., Chazin W.J. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. J. Biol. Chem. 2004, 279:16511-16517.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 16511-16517
-
-
Lee, Y.T.1
Jacob, J.2
Michowski, W.3
Nowotny, M.4
Kuznicki, J.5
Chazin, W.J.6
-
139
-
-
57049133465
-
Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants
-
Kadota Y., Amigues B., Ducassou L., Madaoui H., Ochsenbein F., Guerois R., Shirasu K. Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants. EMBO Rep. 2008, 9:1209-1215.
-
(2008)
EMBO Rep.
, vol.9
, pp. 1209-1215
-
-
Kadota, Y.1
Amigues, B.2
Ducassou, L.3
Madaoui, H.4
Ochsenbein, F.5
Guerois, R.6
Shirasu, K.7
-
140
-
-
0141705339
-
HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis
-
Takahashi A., Casais C., Ichimura K., Shirasu K. HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:11777-11782.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 11777-11782
-
-
Takahashi, A.1
Casais, C.2
Ichimura, K.3
Shirasu, K.4
-
141
-
-
77955480981
-
Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors
-
Zhang M., Kadota Y., Prodromou C., Shirasu K., Pearl L.H. Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors. Mol. Cell 2010, 39:269-281.
-
(2010)
Mol. Cell
, vol.39
, pp. 269-281
-
-
Zhang, M.1
Kadota, Y.2
Prodromou, C.3
Shirasu, K.4
Pearl, L.H.5
-
142
-
-
39049143941
-
Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation
-
Zhao R., Kakihara Y., Gribun A., Huen J., Yang G., Khanna M., Costanzo M., Brost R.L., Boone C., Hughes T.R., Yip C.M., Houry W.A. Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J. Cell Biol. 2008, 180:563-578.
-
(2008)
J. Cell Biol.
, vol.180
, pp. 563-578
-
-
Zhao, R.1
Kakihara, Y.2
Gribun, A.3
Huen, J.4
Yang, G.5
Khanna, M.6
Costanzo, M.7
Brost, R.L.8
Boone, C.9
Hughes, T.R.10
Yip, C.M.11
Houry, W.A.12
-
143
-
-
77957816357
-
The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity
-
Eckert K., Saliou J.M., Monlezun L., Vigouroux A., Atmane N., Caillat C., Quevillon-Cheruel S., Madiona K., Nicaise M., Lazereg S., Van Dorsselaer A., Sanglier-Cianferani S., Meyer P., Morera S. The Pih1-Tah1 cochaperone complex inhibits Hsp90 molecular chaperone ATPase activity. J. Biol. Chem. 2010, 285:31304-31312.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 31304-31312
-
-
Eckert, K.1
Saliou, J.M.2
Monlezun, L.3
Vigouroux, A.4
Atmane, N.5
Caillat, C.6
Quevillon-Cheruel, S.7
Madiona, K.8
Nicaise, M.9
Lazereg, S.10
Van Dorsselaer, A.11
Sanglier-Cianferani, S.12
Meyer, P.13
Morera, S.14
-
144
-
-
37549067731
-
Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling
-
Riggs D.L., Cox M.B., Tardif H.L., Hessling M., Buchner J., Smith D.F. Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling. Mol. Cell. Biol. 2007, 27:8658-8669.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 8658-8669
-
-
Riggs, D.L.1
Cox, M.B.2
Tardif, H.L.3
Hessling, M.4
Buchner, J.5
Smith, D.F.6
-
145
-
-
0027439595
-
Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70
-
Smith D.F., Sullivan W.P., Marion T.N., Zaitsu K., Madden B., McCormick D.J., Toft D.O. Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. Mol. Cell. Biol. 1993, 13:869-876.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 869-876
-
-
Smith, D.F.1
Sullivan, W.P.2
Marion, T.N.3
Zaitsu, K.4
Madden, B.5
McCormick, D.J.6
Toft, D.O.7
-
146
-
-
0026543821
-
Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events
-
Smith D.F., Stensgard B.A., Welch W.J., Toft D.O. Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events. J. Biol. Chem. 1992, 267:1350-1356.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 1350-1356
-
-
Smith, D.F.1
Stensgard, B.A.2
Welch, W.J.3
Toft, D.O.4
-
147
-
-
0037023732
-
HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor
-
Hernandez M.P., Chadli A., Toft D.O. HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. J. Biol. Chem. 2002, 277:11873-11881.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 11873-11881
-
-
Hernandez, M.P.1
Chadli, A.2
Toft, D.O.3
-
148
-
-
33748747967
-
Defining the requirements for Hsp40 and Hsp70 in the Hsp90 chaperone pathway
-
Cintron N.S., Toft D. Defining the requirements for Hsp40 and Hsp70 in the Hsp90 chaperone pathway. J. Biol. Chem. 2006, 281:26235-26244.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 26235-26244
-
-
Cintron, N.S.1
Toft, D.2
-
149
-
-
43249105354
-
P23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity
-
Forafonov F., Toogun O.A., Grad I., Suslova E., Freeman B.C., Picard D. p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity. Mol. Cell. Biol. 2008, 28:3446-3456.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 3446-3456
-
-
Forafonov, F.1
Toogun, O.A.2
Grad, I.3
Suslova, E.4
Freeman, B.C.5
Picard, D.6
-
150
-
-
0034102339
-
The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies
-
Freeman B.C., Felts S.J., Toft D.O., Yamamoto K.R. The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. Genes Dev. 2000, 14:422-434.
-
(2000)
Genes Dev.
, vol.14
, pp. 422-434
-
-
Freeman, B.C.1
Felts, S.J.2
Toft, D.O.3
Yamamoto, K.R.4
-
151
-
-
0035980061
-
Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein
-
Zhao Y.G., Gilmore R., Leone G., Coffey M.C., Weber B., Lee P.W. Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein. J. Biol. Chem. 2001, 276:32822-32827.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32822-32827
-
-
Zhao, Y.G.1
Gilmore, R.2
Leone, G.3
Coffey, M.C.4
Weber, B.5
Lee, P.W.6
-
152
-
-
35348858091
-
Post-translational modification of heat-shock protein 90: impact on chaperone function
-
Scroggins B.T., Neckers L. Post-translational modification of heat-shock protein 90: impact on chaperone function. Expert Opin. Drug Discov. 2007, 2.
-
(2007)
Expert Opin. Drug Discov.
, vol.2
-
-
Scroggins, B.T.1
Neckers, L.2
-
153
-
-
35848929277
-
Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase
-
Duval M., Le Boeuf F., Huot J., Gratton J.P. Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase. Mol. Biol. Cell 2007, 18:4659-4668.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 4659-4668
-
-
Duval, M.1
Le Boeuf, F.2
Huot, J.3
Gratton, J.P.4
-
154
-
-
50249168335
-
Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias
-
Kurokawa M., Zhao C., Reya T., Kornbluth S. Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. Mol. Cell. Biol. 2008, 28:5494-5506.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 5494-5506
-
-
Kurokawa, M.1
Zhao, C.2
Reya, T.3
Kornbluth, S.4
-
155
-
-
75949112264
-
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function
-
Mollapour M., Tsutsumi S., Donnelly A.C., Beebe K., Tokita M.J., Lee M.J., Lee S., Morra G., Bourboulia D., Scroggins B.T., Colombo G., Blagg B.S., Panaretou B., Stetler-Stevenson W.G., Trepel J.B., Piper P.W., Prodromou C., Pearl L.H., Neckers L. Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Mol. Cell 2010, 37:333-343.
-
(2010)
Mol. Cell
, vol.37
, pp. 333-343
-
-
Mollapour, M.1
Tsutsumi, S.2
Donnelly, A.C.3
Beebe, K.4
Tokita, M.J.5
Lee, M.J.6
Lee, S.7
Morra, G.8
Bourboulia, D.9
Scroggins, B.T.10
Colombo, G.11
Blagg, B.S.12
Panaretou, B.13
Stetler-Stevenson, W.G.14
Trepel, J.B.15
Piper, P.W.16
Prodromou, C.17
Pearl, L.H.18
Neckers, L.19
-
156
-
-
79952665421
-
Threonine 22 phosphorylation attenuates hsp90 interaction with cochaperones and affects its chaperone activity
-
Mollapour M., Tsutsumi S., Truman A.W., Xu W., Vaughan C.K., Beebe K., Konstantinova A., Vourganti S., Panaretou B., Piper P.W., Trepel J.B., Prodromou C., Pearl L.H., Neckers L. Threonine 22 phosphorylation attenuates hsp90 interaction with cochaperones and affects its chaperone activity. Mol. Cell 2011, 41:672-681.
-
(2011)
Mol. Cell
, vol.41
, pp. 672-681
-
-
Mollapour, M.1
Tsutsumi, S.2
Truman, A.W.3
Xu, W.4
Vaughan, C.K.5
Beebe, K.6
Konstantinova, A.7
Vourganti, S.8
Panaretou, B.9
Piper, P.W.10
Trepel, J.B.11
Prodromou, C.12
Pearl, L.H.13
Neckers, L.14
-
157
-
-
80053425012
-
Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity
-
Mollapour M., Tsutsumi S., Kim Y.S., Trepel J., Neckers L. Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity. Oncotarget 2011, 2:407-417.
-
(2011)
Oncotarget
, vol.2
, pp. 407-417
-
-
Mollapour, M.1
Tsutsumi, S.2
Kim, Y.S.3
Trepel, J.4
Neckers, L.5
-
158
-
-
0024357643
-
The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues
-
Lees-Miller S.P., Anderson C.W. The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues. J. Biol. Chem. 1989, 264:17275-17280.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 17275-17280
-
-
Lees-Miller, S.P.1
Anderson, C.W.2
-
159
-
-
79955559070
-
Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex
-
Deb T.B., Zuo A.H., Wang Y., Barndt R.J., Cheema A.K., Sengupta S., Coticchia C.M., Johnson M.D. Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex. Am. J. Physiol. Cell Physiol. 2011, 300:C1139-C1154.
-
(2011)
Am. J. Physiol. Cell Physiol.
, vol.300
-
-
Deb, T.B.1
Zuo, A.H.2
Wang, Y.3
Barndt, R.J.4
Cheema, A.K.5
Sengupta, S.6
Coticchia, C.M.7
Johnson, M.D.8
-
160
-
-
1642268986
-
Hsp90 isoforms: functions, expression and clinical importance
-
Sreedhar A.S., Kalmar E., Csermely P., Shen Y.F. Hsp90 isoforms: functions, expression and clinical importance. FEBS Lett. 2004, 562:11-15.
-
(2004)
FEBS Lett.
, vol.562
, pp. 11-15
-
-
Sreedhar, A.S.1
Kalmar, E.2
Csermely, P.3
Shen, Y.F.4
-
161
-
-
70349326246
-
Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery
-
Miyata Y. Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery. Cell. Mol. Life Sci. 2009, 66:1840-1849.
-
(2009)
Cell. Mol. Life Sci.
, vol.66
, pp. 1840-1849
-
-
Miyata, Y.1
-
162
-
-
49649108912
-
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion
-
Yang Y., Rao R., Shen J., Tang Y., Fiskus W., Nechtman J., Atadja P., Bhalla K. Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. Cancer Res. 2008, 68:4833-4842.
-
(2008)
Cancer Res.
, vol.68
, pp. 4833-4842
-
-
Yang, Y.1
Rao, R.2
Shen, J.3
Tang, Y.4
Fiskus, W.5
Nechtman, J.6
Atadja, P.7
Bhalla, K.8
-
163
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs J.J., Murphy P.J., Gaillard S., Zhao X., Wu J.T., Nicchitta C.V., Yoshida M., Toft D.O., Pratt W.B., Yao T.P. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol. Cell 2005, 18:601-607.
-
(2005)
Mol. Cell
, vol.18
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.2
Gaillard, S.3
Zhao, X.4
Wu, J.T.5
Nicchitta, C.V.6
Yoshida, M.7
Toft, D.O.8
Pratt, W.B.9
Yao, T.P.10
-
164
-
-
22844432021
-
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors
-
Bali P., Pranpat M., Bradner J., Balasis M., Fiskus W., Guo F., Rocha K., Kumaraswamy S., Boyapalle S., Atadja P., Seto E., Bhalla K. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J. Biol. Chem. 2005, 280:26729-26734.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26729-26734
-
-
Bali, P.1
Pranpat, M.2
Bradner, J.3
Balasis, M.4
Fiskus, W.5
Guo, F.6
Rocha, K.7
Kumaraswamy, S.8
Boyapalle, S.9
Atadja, P.10
Seto, E.11
Bhalla, K.12
-
165
-
-
79956094244
-
Histone deacetylase 6 and heat shock protein 90 control the functions of foxp3+ T-regulatory cells
-
de Zoeten E.F., Wang L., Butler K., Beier U.H., Akimova T., Sai H., Bradner J.E., Mazitschek R., Kozikowski A.P., Matthias P., Hancock W.W. Histone deacetylase 6 and heat shock protein 90 control the functions of foxp3+ T-regulatory cells. Mol. Cell. Biol. 2011, 31:2066-2078.
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 2066-2078
-
-
de Zoeten, E.F.1
Wang, L.2
Butler, K.3
Beier, U.H.4
Akimova, T.5
Sai, H.6
Bradner, J.E.7
Mazitschek, R.8
Kozikowski, A.P.9
Matthias, P.10
Hancock, W.W.11
-
166
-
-
33846014703
-
An acetylation site in the middle domain of Hsp90 regulates chaperone function
-
Scroggins B.T., Robzyk K., Wang D., Marcu M.G., Tsutsumi S., Beebe K., Cotter R.J., Felts S., Toft D., Karnitz L., Rosen N., Neckers L. An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol. Cell 2007, 25:151-159.
-
(2007)
Mol. Cell
, vol.25
, pp. 151-159
-
-
Scroggins, B.T.1
Robzyk, K.2
Wang, D.3
Marcu, M.G.4
Tsutsumi, S.5
Beebe, K.6
Cotter, R.J.7
Felts, S.8
Toft, D.9
Karnitz, L.10
Rosen, N.11
Neckers, L.12
-
167
-
-
0009621605
-
Dynamic activation of endothelial nitric oxide synthase by Hsp90
-
Garcia-Cardena G., Fan R., Shah V., Sorrentino R., Cirino G., Papapetropoulos A., Sessa W.C. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 1998, 392:821-824.
-
(1998)
Nature
, vol.392
, pp. 821-824
-
-
Garcia-Cardena, G.1
Fan, R.2
Shah, V.3
Sorrentino, R.4
Cirino, G.5
Papapetropoulos, A.6
Sessa, W.C.7
-
168
-
-
20844444338
-
S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities
-
Martinez-Ruiz A., Villanueva L., Gonzalez de Orduna C., Lopez-Ferrer D., Higueras M.A., Tarin C., Rodriguez-Crespo I., Vazquez J., Lamas S. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:8525-8530.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 8525-8530
-
-
Martinez-Ruiz, A.1
Villanueva, L.2
Gonzalez de Orduna, C.3
Lopez-Ferrer, D.4
Higueras, M.A.5
Tarin, C.6
Rodriguez-Crespo, I.7
Vazquez, J.8
Lamas, S.9
-
169
-
-
70449710842
-
Hsp90 is regulated by a switch point in the C-terminal domain
-
Retzlaff M., Stahl M., Eberl H.C., Lagleder S., Beck J., Kessler H., Buchner J. Hsp90 is regulated by a switch point in the C-terminal domain. EMBO Rep. 2009, 10:1147-1153.
-
(2009)
EMBO Rep.
, vol.10
, pp. 1147-1153
-
-
Retzlaff, M.1
Stahl, M.2
Eberl, H.C.3
Lagleder, S.4
Beck, J.5
Kessler, H.6
Buchner, J.7
-
170
-
-
4143063780
-
From chromatin to cancer: a new histone lysine methyltransferase enters the mix
-
Sims R.J., Reinberg D. From chromatin to cancer: a new histone lysine methyltransferase enters the mix. Nat. Cell Biol. 2004, 6:685-687.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 685-687
-
-
Sims, R.J.1
Reinberg, D.2
-
171
-
-
60849123479
-
Hsp90 affecting chromatin remodeling might explain transgenerational epigenetic inheritance in Drosophila
-
Ruden D.M., Lu X. Hsp90 affecting chromatin remodeling might explain transgenerational epigenetic inheritance in Drosophila. Curr. Genomics 2008, 9:500-508.
-
(2008)
Curr. Genomics
, vol.9
, pp. 500-508
-
-
Ruden, D.M.1
Lu, X.2
-
172
-
-
4143074854
-
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
-
Hamamoto R., Furukawa Y., Morita M., Iimura Y., Silva F.P., Li M., Yagyu R., Nakamura Y. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. Nat. Cell Biol. 2004, 6:731-740.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 731-740
-
-
Hamamoto, R.1
Furukawa, Y.2
Morita, M.3
Iimura, Y.4
Silva, F.P.5
Li, M.6
Yagyu, R.7
Nakamura, Y.8
-
173
-
-
33644929027
-
Enhanced SMYD3 expression is essential for the growth of breast cancer cells
-
Hamamoto R., Silva F.P., Tsuge M., Nishidate T., Katagiri T., Nakamura Y., Furukawa Y. Enhanced SMYD3 expression is essential for the growth of breast cancer cells. Cancer Sci. 2006, 97:113-118.
-
(2006)
Cancer Sci.
, vol.97
, pp. 113-118
-
-
Hamamoto, R.1
Silva, F.P.2
Tsuge, M.3
Nishidate, T.4
Katagiri, T.5
Nakamura, Y.6
Furukawa, Y.7
-
174
-
-
84934439633
-
Molecular interaction network of the Hsp90 chaperone system
-
Zhao R., Houry W.A. Molecular interaction network of the Hsp90 chaperone system. Adv. Exp. Med. Biol. 2007, 594:27-36.
-
(2007)
Adv. Exp. Med. Biol.
, vol.594
, pp. 27-36
-
-
Zhao, R.1
Houry, W.A.2
-
175
-
-
0022537770
-
Association of the heat shock protein hsp90 with steroid hormone receptors and tyrosine kinase oncogene products
-
Ziemiecki A., Catelli M.G., Joab I., Moncharmont B. Association of the heat shock protein hsp90 with steroid hormone receptors and tyrosine kinase oncogene products. Biochem. Biophys. Res. Commun. 1986, 138:1298-1307.
-
(1986)
Biochem. Biophys. Res. Commun.
, vol.138
, pp. 1298-1307
-
-
Ziemiecki, A.1
Catelli, M.G.2
Joab, I.3
Moncharmont, B.4
-
176
-
-
0025370373
-
Mapping the HSP90 binding region of the glucocorticoid receptor
-
Howard K.J., Holley S.J., Yamamoto K.R., Distelhorst C.W. Mapping the HSP90 binding region of the glucocorticoid receptor. J. Biol. Chem. 1990, 265:11928-11935.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 11928-11935
-
-
Howard, K.J.1
Holley, S.J.2
Yamamoto, K.R.3
Distelhorst, C.W.4
-
177
-
-
0027291238
-
Heat-shock protein hsp90 governs the activity of pp 60v-src kinase
-
Xu Y., Lindquist S. Heat-shock protein hsp90 governs the activity of pp 60v-src kinase. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:7074-7078.
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 7074-7078
-
-
Xu, Y.1
Lindquist, S.2
-
178
-
-
0346003805
-
Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis
-
Momose F., Naito T., Yano K., Sugimoto S., Morikawa Y., Nagata K. Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis. J. Biol. Chem. 2002, 277:45306-45314.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45306-45314
-
-
Momose, F.1
Naito, T.2
Yano, K.3
Sugimoto, S.4
Morikawa, Y.5
Nagata, K.6
-
179
-
-
34247265509
-
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses
-
Mayor A., Martinon F., De Smedt T., Petrilli V., Tschopp J. A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat. Immunol. 2007, 8:497-503.
-
(2007)
Nat. Immunol.
, vol.8
, pp. 497-503
-
-
Mayor, A.1
Martinon, F.2
De Smedt, T.3
Petrilli, V.4
Tschopp, J.5
-
180
-
-
77956898581
-
HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II
-
Boulon S., Pradet-Balade B., Verheggen C., Molle D., Boireau S., Georgieva M., Azzag K., Robert M.C., Ahmad Y., Neel H., Lamond A.I., Bertrand E. HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II. Mol. Cell 2010, 39:912-924.
-
(2010)
Mol. Cell
, vol.39
, pp. 912-924
-
-
Boulon, S.1
Pradet-Balade, B.2
Verheggen, C.3
Molle, D.4
Boireau, S.5
Georgieva, M.6
Azzag, K.7
Robert, M.C.8
Ahmad, Y.9
Neel, H.10
Lamond, A.I.11
Bertrand, E.12
-
181
-
-
0025175208
-
Reduced levels of hsp90 compromise steroid receptor action in vivo
-
Picard D., Khursheed B., Garabedian M.J., Fortin M.G., Lindquist S., Yamamoto K.R. Reduced levels of hsp90 compromise steroid receptor action in vivo. Nature 1990, 348:166-168.
-
(1990)
Nature
, vol.348
, pp. 166-168
-
-
Picard, D.1
Khursheed, B.2
Garabedian, M.J.3
Fortin, M.G.4
Lindquist, S.5
Yamamoto, K.R.6
-
182
-
-
0025711816
-
The relationship between glucocorticoid receptor binding to Hsp90 and receptor function
-
Pratt W.B., Dalman F.C., Meshinchi S., Scherrer L.C. The relationship between glucocorticoid receptor binding to Hsp90 and receptor function. Nippon Naibunpi Gakkai Zasshi 1990, 66:1185-1197.
-
(1990)
Nippon Naibunpi Gakkai Zasshi
, vol.66
, pp. 1185-1197
-
-
Pratt, W.B.1
Dalman, F.C.2
Meshinchi, S.3
Scherrer, L.C.4
-
183
-
-
0037428164
-
Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70
-
Young J.C., Hoogenraad N.J., Hartl F.U. Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell 2003, 112:41-50.
-
(2003)
Cell
, vol.112
, pp. 41-50
-
-
Young, J.C.1
Hoogenraad, N.J.2
Hartl, F.U.3
-
184
-
-
8544273285
-
Hsp90 enhances degradation of oxidized calmodulin by the 20 S proteasome
-
Whittier J.E., Xiong Y., Rechsteiner M.C., Squier T.C. Hsp90 enhances degradation of oxidized calmodulin by the 20 S proteasome. J. Biol. Chem. 2004, 279:46135-46142.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 46135-46142
-
-
Whittier, J.E.1
Xiong, Y.2
Rechsteiner, M.C.3
Squier, T.C.4
-
185
-
-
0035824621
-
Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex
-
Guo Y., Guettouche T., Fenna M., Boellmann F., Pratt W.B., Toft D.O., Smith D.F., Voellmy R. Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. J. Biol. Chem. 2001, 276:45791-45799.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 45791-45799
-
-
Guo, Y.1
Guettouche, T.2
Fenna, M.3
Boellmann, F.4
Pratt, W.B.5
Toft, D.O.6
Smith, D.F.7
Voellmy, R.8
-
186
-
-
0032555685
-
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1
-
Zou J., Guo Y., Guettouche T., Smith D.F., Voellmy R. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell 1998, 94:471-480.
-
(1998)
Cell
, vol.94
, pp. 471-480
-
-
Zou, J.1
Guo, Y.2
Guettouche, T.3
Smith, D.F.4
Voellmy, R.5
-
187
-
-
0027475243
-
Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases
-
Nadeau K., Das A., Walsh C.T. Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases. J. Biol. Chem. 1993, 268:1479-1487.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 1479-1487
-
-
Nadeau, K.1
Das, A.2
Walsh, C.T.3
-
188
-
-
33846471075
-
Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance
-
Geller R., Vignuzzi M., Andino R., Frydman J. Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance. Genes Dev. 2007, 21:195-205.
-
(2007)
Genes Dev.
, vol.21
, pp. 195-205
-
-
Geller, R.1
Vignuzzi, M.2
Andino, R.3
Frydman, J.4
-
189
-
-
78650732854
-
Heat shock protein 90 facilitates formation of the HBV capsid via interacting with the HBV core protein dimers
-
Shim H.Y., Quan X., Yi Y.S., Jung G. Heat shock protein 90 facilitates formation of the HBV capsid via interacting with the HBV core protein dimers. Virology 2011, 410:161-169.
-
(2011)
Virology
, vol.410
, pp. 161-169
-
-
Shim, H.Y.1
Quan, X.2
Yi, Y.S.3
Jung, G.4
-
190
-
-
65449118855
-
Heat-shock protein 90 is essential for stabilization of the hepatitis C virus nonstructural protein NS3
-
Ujino S., Yamaguchi S., Shimotohno K., Takaku H. Heat-shock protein 90 is essential for stabilization of the hepatitis C virus nonstructural protein NS3. J. Biol. Chem. 2009, 284:6841-6846.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 6841-6846
-
-
Ujino, S.1
Yamaguchi, S.2
Shimotohno, K.3
Takaku, H.4
-
191
-
-
0036149214
-
Molecular chaperone Hsp90 is important for vaccinia virus growth in cells
-
Hung J.J., Chung C.S., Chang W. Molecular chaperone Hsp90 is important for vaccinia virus growth in cells. J. Virol. 2002, 76:1379-1390.
-
(2002)
J. Virol.
, vol.76
, pp. 1379-1390
-
-
Hung, J.J.1
Chung, C.S.2
Chang, W.3
-
192
-
-
18744384675
-
The cellular chaperone heat shock protein 90 facilitates Flock House virus RNA replication in Drosophila cells
-
Kampmueller K.M., Miller D.J. The cellular chaperone heat shock protein 90 facilitates Flock House virus RNA replication in Drosophila cells. J. Virol. 2005, 79:6827-6837.
-
(2005)
J. Virol.
, vol.79
, pp. 6827-6837
-
-
Kampmueller, K.M.1
Miller, D.J.2
-
193
-
-
79951470779
-
Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen
-
Dmochewitz L., Lillich M., Kaiser E., Jennings L.D., Lang A.E., Buchner J., Fischer G., Aktories K., Collier R.J., Barth H. Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen. Cell. Microbiol. 2011, 13:359-373.
-
(2011)
Cell. Microbiol.
, vol.13
, pp. 359-373
-
-
Dmochewitz, L.1
Lillich, M.2
Kaiser, E.3
Jennings, L.D.4
Lang, A.E.5
Buchner, J.6
Fischer, G.7
Aktories, K.8
Collier, R.J.9
Barth, H.10
-
194
-
-
0041856090
-
The hostcell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol
-
Haug G., Leemhuis J., Tiemann D., Meyer D.K., Aktories K., Barth H. The hostcell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol. J. Biol. Chem. 2003, 278:32266-32274.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32266-32274
-
-
Haug, G.1
Leemhuis, J.2
Tiemann, D.3
Meyer, D.K.4
Aktories, K.5
Barth, H.6
-
195
-
-
67649858826
-
Specific Arabidopsis HSP90.2 alleles recapitulate RAR1 cochaperone function in plant NB-LRR disease resistance protein regulation
-
Hubert D.A., He Y., McNulty B.C., Tornero P., Dangl J.L. Specific Arabidopsis HSP90.2 alleles recapitulate RAR1 cochaperone function in plant NB-LRR disease resistance protein regulation. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:9556-9563.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 9556-9563
-
-
Hubert, D.A.1
He, Y.2
McNulty, B.C.3
Tornero, P.4
Dangl, J.L.5
-
197
-
-
0347087451
-
Molecular chaperone Hsp90 associates with resistance protein N and its signaling proteins SGT1 and Rar1 to modulate an innate immune response in plants
-
Liu Y., Burch-Smith T., Schiff M., Feng S., Dinesh-Kumar S.P. Molecular chaperone Hsp90 associates with resistance protein N and its signaling proteins SGT1 and Rar1 to modulate an innate immune response in plants. J. Biol. Chem. 2004, 279:2101-2108.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 2101-2108
-
-
Liu, Y.1
Burch-Smith, T.2
Schiff, M.3
Feng, S.4
Dinesh-Kumar, S.P.5
-
198
-
-
37549046440
-
The hsp90 molecular chaperone modulates multiple telomerase activities
-
Toogun O.A., Dezwaan D.C., Freeman B.C. The hsp90 molecular chaperone modulates multiple telomerase activities. Mol. Cell. Biol. 2008, 28:457-467.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 457-467
-
-
Toogun, O.A.1
Dezwaan, D.C.2
Freeman, B.C.3
-
199
-
-
67650337568
-
The Hsp82 molecular chaperone promotes a switch between unextendable and extendable telomere states
-
DeZwaan D.C., Toogun O.A., Echtenkamp F.J., Freeman B.C. The Hsp82 molecular chaperone promotes a switch between unextendable and extendable telomere states. Nat. Struct. Mol. Biol. 2009, 16:711-716.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 711-716
-
-
DeZwaan, D.C.1
Toogun, O.A.2
Echtenkamp, F.J.3
Freeman, B.C.4
-
200
-
-
33845617101
-
Hsp90 increases LIM kinase activity by promoting its homo-dimerization
-
Li R., Soosairajah J., Harari D., Citri A., Price J., Ng H.L., Morton C.J., Parker M.W., Yarden Y., Bernard O. Hsp90 increases LIM kinase activity by promoting its homo-dimerization. FASEB J. 2006, 20:1218-1220.
-
(2006)
FASEB J.
, vol.20
, pp. 1218-1220
-
-
Li, R.1
Soosairajah, J.2
Harari, D.3
Citri, A.4
Price, J.5
Ng, H.L.6
Morton, C.J.7
Parker, M.W.8
Yarden, Y.9
Bernard, O.10
-
201
-
-
33744931946
-
Hsp90 recognizes a common surface on client kinases
-
Citri A., Harari D., Shohat G., Ramakrishnan P., Gan J., Lavi S., Eisenstein M., Kimchi A., Wallach D., Pietrokovski S., Yarden Y. Hsp90 recognizes a common surface on client kinases. J. Biol. Chem. 2006, 281:14361-14369.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14361-14369
-
-
Citri, A.1
Harari, D.2
Shohat, G.3
Ramakrishnan, P.4
Gan, J.5
Lavi, S.6
Eisenstein, M.7
Kimchi, A.8
Wallach, D.9
Pietrokovski, S.10
Yarden, Y.11
-
202
-
-
64149128633
-
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail
-
Gould C.M., Kannan N., Taylor S.S., Newton A.C. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J. Biol. Chem. 2009, 284:4921-4935.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 4921-4935
-
-
Gould, C.M.1
Kannan, N.2
Taylor, S.S.3
Newton, A.C.4
-
203
-
-
33646269303
-
Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases
-
Terasawa K., Yoshimatsu K., Iemura S., Natsume T., Tanaka K., Minami Y. Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases. Mol. Cell. Biol. 2006, 26:3378-3389.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 3378-3389
-
-
Terasawa, K.1
Yoshimatsu, K.2
Iemura, S.3
Natsume, T.4
Tanaka, K.5
Minami, Y.6
-
204
-
-
7044227709
-
Oncogenic mutations reduce the stability of SRC kinase
-
Falsone S.F., Leptihn S., Osterauer A., Haslbeck M., Buchner J. Oncogenic mutations reduce the stability of SRC kinase. J. Mol. Biol. 2004, 344:281-291.
-
(2004)
J. Mol. Biol.
, vol.344
, pp. 281-291
-
-
Falsone, S.F.1
Leptihn, S.2
Osterauer, A.3
Haslbeck, M.4
Buchner, J.5
-
205
-
-
79953898670
-
Closing in on the hsp90 chaperone-client relationship
-
Richter K., Buchner J. Closing in on the hsp90 chaperone-client relationship. Structure 2011, 19:445-446.
-
(2011)
Structure
, vol.19
, pp. 445-446
-
-
Richter, K.1
Buchner, J.2
-
206
-
-
0028940309
-
Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo
-
Jakob U., Lilie H., Meyer I., Buchner J. Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo. J. Biol. Chem. 1995, 270:7288-7294.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7288-7294
-
-
Jakob, U.1
Lilie, H.2
Meyer, I.3
Buchner, J.4
-
207
-
-
10344239940
-
Hsp90 chaperones wild-type p53 tumor suppressor protein
-
Walerych D., Kudla G., Gutkowska M., Wawrzynow B., Muller L., King F.W., Helwak A., Boros J., Zylicz A., Zylicz M. Hsp90 chaperones wild-type p53 tumor suppressor protein. J. Biol. Chem. 2004, 279:48836-48845.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 48836-48845
-
-
Walerych, D.1
Kudla, G.2
Gutkowska, M.3
Wawrzynow, B.4
Muller, L.5
King, F.W.6
Helwak, A.7
Boros, J.8
Zylicz, A.9
Zylicz, M.10
-
208
-
-
77957804652
-
ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein
-
Walerych D., Gutkowska M., Klejman M.P., Wawrzynow B., Tracz Z., Wiech M., Zylicz M., Zylicz A. ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein. J. Biol. Chem. 2010, 285:32020-32028.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 32020-32028
-
-
Walerych, D.1
Gutkowska, M.2
Klejman, M.P.3
Wawrzynow, B.4
Tracz, Z.5
Wiech, M.6
Zylicz, M.7
Zylicz, A.8
-
209
-
-
0037143625
-
CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90
-
Rudiger S., Freund S.M., Veprintsev D.B., Fersht A.R. CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:11085-11090.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 11085-11090
-
-
Rudiger, S.1
Freund, S.M.2
Veprintsev, D.B.3
Fersht, A.R.4
-
210
-
-
79955642720
-
The client protein p53 adopts a molten globule-like state in the presence of Hsp90
-
Park S.J., Borin B.N., Martinez-Yamout M.A., Dyson H.J. The client protein p53 adopts a molten globule-like state in the presence of Hsp90. Nat. Struct. Mol. Biol. 2011, 18:537-541.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 537-541
-
-
Park, S.J.1
Borin, B.N.2
Martinez-Yamout, M.A.3
Dyson, H.J.4
-
211
-
-
84857046446
-
Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53
-
Hagn F., Lagleder S., Retzlaff M., Rohrberg J., Demmer O., Richter K., Buchner J., Kessler H. Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. Nat. Struct. Mol. Biol. 2011.
-
(2011)
Nat. Struct. Mol. Biol.
-
-
Hagn, F.1
Lagleder, S.2
Retzlaff, M.3
Rohrberg, J.4
Demmer, O.5
Richter, K.6
Buchner, J.7
Kessler, H.8
-
212
-
-
33947117494
-
Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing
-
Li W., Li Y., Guan S., Fan J., Cheng C.F., Bright A.M., Chinn C., Chen M., Woodley D.T. Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing. EMBO J. 2007, 26:1221-1233.
-
(2007)
EMBO J.
, vol.26
, pp. 1221-1233
-
-
Li, W.1
Li, Y.2
Guan, S.3
Fan, J.4
Cheng, C.F.5
Bright, A.M.6
Chinn, C.7
Chen, M.8
Woodley, D.T.9
|