Introduction of DNA enzyme for Egr-1 into tubulointerstitial fibroblasts by electroporation reduced interstitial α-smooth muscle actin expression and fibrosis in unilateral ureteral obstruction (UUO) rats

Gene Therapy

Volumn 9, Issue 8, 2002, Pages 495-502

  Nakamura, H ^a   Isaka, Y ^a   Tsujie, M ^a   Rupprecht, H D ^b   Akagi, Y ^a   Ueda, N ^c   Imai, E ^a   Hori, M ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MUNICH   (Germany)

^c NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Electroporation; Erg 1; Interstitial fibrosis; TGF ; SMA

Indexed keywords

ALPHA ACTIN; CATALASE; COLLAGEN TYPE 1; DEOXYRIBONUCLEASE; MESSENGER RNA; PENTOBARBITAL; TRANSCRIPTION FACTOR EGR 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTROPORATION; ENZYME INDUCTION; FIBROSIS; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; INTERSTITIUM; MALE; MYOFIBROBLAST; NONHUMAN; NORTHERN BLOTTING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; URETER OBSTRUCTION;

ACTINS; ANIMALS; CELL LINE; COLLAGEN TYPE I; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; ELECTROPORATION; FIBROSIS; GENE EXPRESSION; GENE THERAPY; IMMEDIATE-EARLY PROTEINS; KIDNEY; RATS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; URETERAL OBSTRUCTION;

ANIMALIA;

EID: 85047699291     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301681     Document Type: Article

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