Novel Tanshinone II A ternary solid dispersion pellets prepared by a single-step technique: In vitro and in vivo evaluation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 80, Issue 2, 2012, Pages 426-432

  Li, Jin ^a   Liu, Pan ^a   Liu, Jian Ping ^a   Zhang, Wen Li ^a   Yang, Ji Kun ^a   Fan, Yong Qing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Combined carriers; In vitro dissolution study; In vivo evaluation; Poloxamer 188; Polyvinylpyrrolidone; Ternary solid dispersion pellets

Indexed keywords

DRUG CARRIER; NANOCOATING; POLOXAMER; POVIDONE; TANSHINONE IIA;

ANALYTIC METHOD; AREA UNDER THE CURVE; CONFERENCE PAPER; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG PELLET; DRUG SCREENING; DRUG SOLUBILITY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; SCANNING ELECTRON MICROSCOPY; SINGLE STEP TECHNIQUE; SOLID DISPERSION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CARDIOVASCULAR AGENTS; DITERPENES, ABIETANE; DRUG CARRIERS; MALE; POLOXAMER; POVIDONE; RABBITS; SOLUBILITY; TIME FACTORS;

EID: 84856604281     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.11.003     Document Type: Conference Paper

References (52)

1. L. Zhou, Z. Zuo, and M.S.S. Chow Danshen: an overview of its chemistry pharmacology, pharmacokinetics, and clinical use J. Clin. Pharmacol. 45 2005 1345
2. Ks) potassium channels Eur. J. Pharmacol. 590 2008 317 321
3. J. Gao, G. Yang, R. Pi, R. Li, P. Wang, H. Zhang, K. Le, S. Chen, and P. Liu Tanshinone II A protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis Transl. Res. 151 2008 79 87
4. J. Li, G. Wang, P. Li, and H. Hao Simultaneous determination of tanshinone II A and cryptotanshinone in rat plasma by liquid chromatography-electrospray ionisation-mass spectrometry J. Chromatogr. B 826 2005 26 30 (Pubitemid 41446430)
5. C.D. Li, J.P. Liu, Z. Z Zeng, and Y.X. Zheng Study on the solubility and permeability of tanshinone II A and on the excipients increasing the solubility and permeability Lishizhen Med. Materia Med. Res. 19 2008 1724 1726
6. L. Wang, X. Jiang, W. Xu, and C. Li Complexation of tanshinone II A with 2-hydroxypropyl-β-cyclodextrin: effect on aqueous solubility, dissolution rate, and intestinal absorption behavior in rats Int. J. Pharm. 341 2007 58 67 (Pubitemid 47090205)
7. H. Hao, G. Wang, N. Cui, J. Li, L. Xie, and Z. Ding Pharmacokinetics, absorption and tissue distribution of tanshinone II A solid dispersion Planta Med. 72 2006 1311 1317 (Pubitemid 44862033)
8. H. Hao, G. Wang, N. Cui, J. Li, L. Xie, and Z. Ding Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation Curr. Drug Metba. 8 2007 137 149 (Pubitemid 46218680)
9. J. Yuan, S. Mao, Q. Shen, S. Hou, and Y. He Influence of solid dispersion technique combination on dissolution of tanshinone II A J. Chinese Mater. Med. 34 2009 685 689
10. R. Gandhi, C. Lal Kaul, and R. Panchagnula Extrusion and spheronization in the development of oral controlled-release dosage forms Pharm. Sci. Technol. Today 2 1999 160 170 (Pubitemid 29195749)
11. N. Zerrouk, C. Chemtob, P. Arnaud, S. Toscani, and J. Dugue In vitro and in vivo evaluation of carbamazepine-PEG 6000 solid dispersions Int. J. Pharm. 225 2001 49 62 (Pubitemid 32728199)
12. G.F. Palmieri, F. Cantalamessa, P. Di Martino, C. Nasuti, and S. Martelli Lonidamine solid dispersions: in vitro and in vivo evaluation Drug Dev. Ind. Pharm. 28 2002 1241 1250 (Pubitemid 35416653)
13. S. Lee, K. Nam, M.S. Kim, S.W. Jun, J.S. Park, J.S. Woo, and S.J. Hwang Preparation and characterization of solid dispersions of itraconazole by using aerosol solvent extraction system for improvement in drug solubility and bioavailability Arch. Pharm. Res. 28 2005 866 874 (Pubitemid 43080167)
14. M. Arias, J. Gines, J. Moyano, and A. Rabasco The application of solid dispersion technique with D-mannitol to the improvement in oral absorption of triamterene J. Drug Target 2 1994 45 51 (Pubitemid 24106959)
15. A. Serajuddin Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs J. Pharm. Sci. 88 1999 1058 1066
16. C.W. Lin, and T.M. Cham Effect of particle size on the available surface area of nifedipine from nifedipine-polyethylene glycol 6000 solid dispersions Int. J. Pharm. 127 1996 261 272
17. O.I. Corrigan Mechanisms of dissolution of fast release solid dispersions Drug Dev. Ind. Pharm. 11 1985 697 724 (Pubitemid 15067853)
18. D. Van Drooge, W. Hinrichs, and H. Frijlink Anomalous dissolution behaviour of tablets prepared from sugar glass-based solid dispersions J. Control Rel. 97 2004 441 452 (Pubitemid 38802946)
19. W.I. Higuchi, N.A. Mir, and S.J. Desai Dissolution rates of polyphase mixtures J. Pharm. Sci. 54 1965 1405 1410
20. M.R. Visser, L. Baert, G. Klooster, L. Schueller, M. Geldof, I. Vanwelkenhuysen, H. de Kock, S. De Meyer, H.W. Frijlink, and J. Rosier Inulin solid dispersion technology to improve the absorption of the BCS Class IV drug TMC240 Eur. J. Pharm. Biopharm. 74 2010 233 238
21. X. Wang, A. Michoel, and G. Van den Mooter Solid state characteristics of ternary solid dispersions composed of PVP VA64, Myrj 52 and itraconazole Int. J. Pharm. 303 2005 54 61 (Pubitemid 41318021)
22. H.N. Joshi, R.W. Tejwani, M. Davidovich, V.P. Sahasrabudhe, M. Jemal, M.S. Bathala, S.A. Varia, and A. Serajuddin Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol-polysorbate 80 mixture Int. J. Pharm. 269 2004 251 258 (Pubitemid 38032837)
23. R. Jachowicz, E. Nürnberg, B. Pieszczek, B. Kluczykowska, and A. Maciejewska Solid dispersion of ketoprofen in pellets Int. J. Pharm. 206 2000 13 21
24. T. Vasconcelos, B. Sarmento, and P. Costa Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs Drug Discov. Today 12 2007 1068 1075 (Pubitemid 350186132)
25. H.O. Ho, H.L. Su, T. Tsai, and M.T. Sheu The preparation and characterization of solid dispersions on pellets using a fluidized-bed system Int. J. Pharm. 139 1996 223 229 (Pubitemid 26276286)
26. I. Ghebre-Sellassie, R.H. Gordon, M.B. Fawzi, and R.U. Nesbitt Evaluation of a high-speed pelletization process and equipment Drug Dev. Ind. Pharm. 11 1985 1523 1541 (Pubitemid 15042158)
27. W. Zhang, J. Liu, X. Liu, and Z. Chen Stealth tanshinone II A-loaded solid lipid nanoparticles: effects of poloxamer 188 coating on in vitro phagocytosis and in vivo pharmacokinetics in rats Acta Pharm. Sinica 44 2009 1421 1428
28. Y. Zhang, M. Huo, J. Zhou, and S. Xie PKSolver: an add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel Comput. Meth. Prog. Biol. 99 2010 306 314
29. Z. Yong A data analysis program in pharmacokinetics base on microsoft excel-development and validation of PKSlover 1.0 J. Math. Med. 20 2007 58 61
30. P. Srinarong, J. Faber, M. Visser, W. Hinrichs, and H. Frijlink Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants Eur. J. Pharm. Biopharm. 73 2009 154 161
31. M. Yoshioka, B.C. Hancock, and G. Zografi Inhibition of indomethacin crystallization in poly (vinylpyrrolidone) coprecipitates J. Pharm. Sci. 84 1995 983 986
32. S.L. Shamblin, and G. Zografi Enthalpy relaxation in binary amorphous mixtures containing sucrose Pharm. Res. 15 1998 1828 1834 (Pubitemid 29034830)
33. H. Bley, B. Fussnegger, and R. Bodmeier Characterization and stability of solid dispersions based on PEG/polymer blends Int. J. Pharm. 390 2010 165 173
34. Y. Kawabata, K. Yamamoto, K. Debari, S. Onoue, and S. Yamada Novel crystalline solid dispersion of tranilast with high photostability and improved oral bioavailability Eur. J. Pharm. Sci. 39 2010 256 262
35. P. Thybo, B.L. Pedersen, L. Hovgaard, R. Holm, and A. Müllertz Characterization and Physical Stability of Spray Dried Solid Dispersions of Probucol and PVP-K30 Pharm. Dev. Technol. 13 2008 375 386
36. A. Paradkar, A.A. Ambike, B.K. Jadhav, and K. Mahadik Characterization of curcumin-PVP solid dispersion obtained by spray drying Int. J. Pharm. 271 2004 281 286 (Pubitemid 38210105)
37. J. Akbuga, A. Gursoy, and E. Kendi The preparation and stability of fast release furosemide-PVP solid dispersion Drug Dev. Ind. Pharm. 14 1988 1439 1464
38. J.L. Ford The effect of particle size on some in vitro and in vivo properties of indomethacin-polyethylene glycol 6000 solid dispersion Drug Dev. Ind. Pharm. 12 1986 1777 1793
39. J.K. Pandit, and B.K. Khakurel In vitro and in vivo evaluation of some fast release dosage forms of hydrochlorothiazide Drug Dev. Ind. Pharm. 10 1984 1709 1724 (Pubitemid 15127392)
40. S. Okonogi, and S. Puttipipatkhachorn Dissolution improvement of high drug-loaded solid dispersion AAPS Pharm. Sci. Technol. 7 2006 148 153
41. P. Mura, J. Moyano, M. González-Rodríguez, A. Rabasco-Alvaréz, M. Cirri, and F. Maestrelli Characterization and dissolution properties of ketoprofen in binary and ternary solid dispersions with polyethylene glycol and surfactants Drug Dev. Ind. Pharm. 31 2005 425 434 (Pubitemid 41289155)
42. P. Mura, M. Faucci, A. Manderioli, G. Bramanti, and P. Parrini Thermal behavior and dissolution properties of naproxen from binary and ternary solid dispersions Drug Dev. Ind. Pharm. 25 1999 257 264 (Pubitemid 29108671)
43. K.R. Morris, G.T. Knipp, and A. Serajuddin Structural properties of polyethylene glycol-polysorbate 80 mixture, a solid dispersion vehicle J. Pharm. Sci. 81 1992 1185 1188 (Pubitemid 23018125)
44. M. Aldén, J. Tegenfeldt, and E. Sj kvist Structure of solid dispersions in the system polyethylene glycol-griseofulvin with additions of sodium dodecyl sulphate Int. J. Pharm. 83 1982 47 52
45. M. Aldén, J. Tegenfeldt, and E.S. Saers Structures formed by interactions in solid dispersions of the system polyethylene glycol-griseofulvin with charged and non charged surfactants added Int. J. Pharm. 94 1993 31 38 (Pubitemid 23204048)
46. A. Serajuddin, P.C. Sheen, D. Mufson, D.F. Bernstein, and M.A. Augustine Physicochemical basis of increased bioavailability of a poorly water-soluble drug following oral administration as organic solutions J. Pharm. Sci. 77 1988 325 329
47. A.N. Ghebremeskel, C. Vemavarapu, and M. Lodaya Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: selection of polymer-surfactant combinations using solubility parameters and testing the processability Int. J. Pharm. 328 2007 119 129 (Pubitemid 44895482)
48. W.G. Chambliss, R.W. Cleary, R. Fischer, A.B. Jones, P. Skierkowski, W. Nicholes, and A.H. Kibbe Effect of docusate sodium on drug release from a controlled-release dosage form J. Pharm. Sci. 70 1981 1248 1251 (Pubitemid 12166549)
49. C. Leuner, and J. Dressman Improving drug solubility for oral delivery using solid dispersions Eur. J. Pharm. Biopharm. 50 2000 47 60 (Pubitemid 30326688)
50. A. Serajuddin, P.C. Sheen, D. Mufson, D.F. Bernstein, and M.A. Augustine Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water-soluble drug from solid dispersions J. Pharm. Sci. 77 1988 414 417 (Pubitemid 19080862)
51. D. Bikiaris, G.Z. Papageorgiou, A. Stergiou, E. Pavlidou, E. Karavas, F. Kanaze, and M. Georgarakis Physicochemical studies on solid dispersions of poorly water-soluble drugs: evaluation of capabilities and limitations of thermal analysis techniques Thermochim. Acta 439 2005 58 67 (Pubitemid 41688353)
52. G. Van den Mooter, I. Weuts, T. De Ridder, and N. Blaton Evaluation of Inutec SP1 as a new carrier in the formulation of solid dispersions for poorly soluble drugs Int. J. Pharm. 316 2006 1 6 (Pubitemid 43765697)