The preparation and characterization of solid dispersions on pellets using a fluidized-bed system

International Journal of Pharmaceutics

Volumn 139, Issue 1-2, 1996, Pages 223-229

  Ho, Hsiu O ^a   Su, Huei Lin ^a   Tsai, Tsuimin ^a   Sheu, Ming Thau ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Fluidized bed system; Hydroxypropylmethylcellulose (HPMC); Nifedipine; Solid dispersions

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; NIFEDIPINE; POLYSORBATE 80;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DISSOLUTION; DRUG DOSAGE FORM; DRUG SOLUBILITY; EVAPORATION; PARTICLE SIZE; PRIORITY JOURNAL; SOLID;

EID: 0030576575     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(96)04594-2     Document Type: Article

References (13)

1. Abdou, H.M., Dissolution, Bioavailability and Bioequivalence, Merck Printing Company, 1989, pp. 53-72.
2. Chiou, W.L. and Riegelman, S., Oral absorption of griseofulvin in dog: increased absorption via solid dispersion in polyethylene glycol 6000. J. Pharm. Sci., 59 (1970) 937-941.
3. Chiou, W.L. and Riegelman, S., Pharmaceutical applications of solid dispersion system. J. Pharm. Sci., 60 (1971a) 1281-1302.
4. Chiou, W.L. and Riegelman, S., Absorption characteristics of solid dispersed and micronized griseofulvin in man. J. Pharm. Sci., 60 (1971b) 1377-1380.
5. Chiou, W.L., Pharmaceutical applications of solid dispersion systems: X-ray diffraction and aqueous solubility studies on griseofulvin-polyethylene glycol 6000 systems. J. Pharm. Sci., 66 (1977) 989-991.
6. Ford, J.L., The current status of solid dispersions. Pharm. Acta Helv., 61 (1986) 69-88.
7. Ghebre-Sellasie, I., Gordon, R.H., Fawzi, M.B. and Nesbitt, R.U., Evaluation of a high speed pelletization process and equipment. Drug Dev. Ind. Pharm., 11 (1985) 1523-1541.
8. Mahta, A.M., Valazza, M.J. and Abele, S.E., Evaluation of fluid-bed process for enteric coating systems. Pharm. Technol., 10 (1986) 46-56.
9. Morimoto, K., Tabata, H. and Morisaka, K., Nasal absorption of nifedipine from gel preparations in rats. Chem. Pharm. Bull., 35 (1987) 3041-3044.
10. Nakagawa, H., Application of solid dispersion to prepare some oral dosage form. In Lin, S.Y., Hu, O.Y.-P., Matsuda Y., Kawashitna Y. (Eds.), Advances in Pharmaceutics and Pharmaceutical Technology. Proc. ROC-JAPAN Symp. on Pharmaceutical Technology, November 22-25, 1989, pp. 203-211.
11. Otsuka, M., Onone, M. and Matsuda, Y., Hygroscopic stability and dissolution properties of spray-dried solid dispersion of furosemide with Eudragit. J. Pharm. Sci., 82 (1993) 32-38.
12. Sekiguchi, K. and Obi, N., Studies on absorption of eutectic mixture: I. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfatriazole in man. Chem. Pharm. Bull., 9 (1961) 866-872.
13. Sugimoto, I., Kuchiki, A., Nakagawa, H., Tohgo, K., Kondo, S., Iwane, I. and Takahashi, K., Dissolution and absorption of nifrdipine from nifedipine-polyvinyl pyrrolidone coprecipitates. Drug Dev. Ind. Pharm., 6 (1980) 137-160.