Complexation of tanshinone IIA with 2-hydroxypropyl-β-cyclodextrin: Effect on aqueous solubility, dissolution rate, and intestinal absorption behavior in rats

International Journal of Pharmaceutics

Volumn 341, Issue 1-2, 2007, Pages 58-67

  Wang, Ling ^a,b   Jiang, Xuehua ^b   Xu, Weijuan ^b   Li, Chenrui ^b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Dissolution study; Hydroxypropyl cyclodextrin; Inclusion complex; Intestinal absorption; Solubility study; Tanshinone IIA

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; TANSHINONE; WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DISSOLUTION; DRUG ABSORPTION; DRUG SOLUBILITY; DUODENUM; EPITHELIUM CELL; GASTROINTESTINAL TRACT; ILEUM; INTESTINE FUNCTION; JEJUNUM; MALE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BETA-CYCLODEXTRINS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG CARRIERS; DRUG COMPOUNDING; DRUGS, CHINESE HERBAL; DUODENUM; ILEUM; INTESTINAL ABSORPTION; INTESTINE, SMALL; JEJUNUM; KINETICS; MALE; PERMEABILITY; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 34447633909     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.03.046     Document Type: Article

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