Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol-polysorbate 80 mixture

International Journal of Pharmaceutics

Volumn 269, Issue 1, 2004, Pages 251-258

  Joshi, Hemant N ^a,b   Tejwani, Ravindra W ^a   Davidovich, Martha ^a   Sahasrabudhe, Vaishali P ^a,c   Jemal, Mohammed ^a   Bathala, Mohinder S ^a   Varia, Sailesh A ^a   Serajuddin, Abu T M ^a,d  

^a BRISTOL MYERS SQUIBB   (United States)

^b Barr Laboratories Inc   (United States)

^c PFIZER INC   (United States)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Bioavailability enhancement; Polyethylene glycol; Polysorbate 80; Poorly soluble drug; Solid dispersion

Indexed keywords

BILE ACID; MACROGOL 3350; POLYSORBATE 80;

ALKALINITY; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DISPERSION; DOG; DRUG CAPSULE; DRUG FORMULATION; DRUG SOLUBILITY; GASTROINTESTINAL ABSORPTION; MALE; NONHUMAN; PH MEASUREMENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SOLUBILIZATION;

EID: 0346157322     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.09.002     Document Type: Article

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