Enthalpy relaxation in binary amorphous mixtures containing sucrose

Pharmaceutical Research

Volumn 15, Issue 12, 1998, Pages 1828-1834

  Shamblin, Sheri L ^a   Zografi, George ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Amorphous mixtures; Enthalpy relaxation; Glass transition temperatures; Molecular mobility; Sucrose

Indexed keywords

DEXTRAN; POVIDONE; POVIDONE DERIVATIVE; SUCROSE; TREHALOSE;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STABILITY; ENTHALPY; FREEZE DRYING; PRIORITY JOURNAL; TEMPERATURE; X RAY POWDER DIFFRACTION;

BIOCOMPATIBLE MATERIALS; CALORIMETRY, DIFFERENTIAL SCANNING; COLD; CRYSTALLIZATION; DEXTRANS; DRUG STORAGE; GLASS; MOLECULAR WEIGHT; PHARMACEUTIC AIDS; POLYVINYLS; POVIDONE; SUCROSE; TEMPERATURE; THERMODYNAMICS; TIME FACTORS; TREHALOSE;

EID: 0032422473     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011997721086     Document Type: Article

References (19)

1. B. C. Hancock and G. Zografi. Characteristics and significance of the amorphous state in pharmaceutical systems. J. Pharm. Sci. 86:1-12 (1997).
2. A. Saleki-Gerhardt and G. Zografi. Non-isothermal and isothermal crystallization of sucrose from the amorphous state. Pharm. Res. 11:1166-1173 (1994).
3. S. L. Shamblin, E. Y. Huang, and G. Zografi. The effects of colyophilized polymeric additives on the glass transition temperature and crystallization of amorphous sucrose. J. Therm. Anal. 47:1567-1579 (1996).
4. J. Cowie and R. Ferguson. Physical aging studies in poly(vinyl methyl ether). 1. Enthalpy relaxation as a function of aging temperature. Macromol. 22:2307-2312 (1989).
5. B. C. Hancock, S. L. Shamblin, and G. Zografi. The molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures. Pharm. Res. 12:799-806 (1995).
6. S. L. Shamblin. The Characteristics of Sucrose-Polymer Mixtures in the Amorphous State. Ph.D. Thesis, The University of Wisconsin-Madison, Madison, 1997.
7. S. P. Duddu, G. Zhang, and P. R. Dal Monte. The relationship between protein aggregation and molecular mobility below the glass transition temperature of lyophilized formulations containing a monoclonal antibody. Pharm. Res. 14:596-599 (1997).
8. G. Blond. Mechanical properties of frozen model solutions. J. Food Eng. 22:253-269 (1994).
9. V. Buhler, Kollidone, Second ed., BASF Aktiengesellschaft, Ludwigshafen, 1993.
10. S. L. Shamblin, L. S. Taylor, and G. Zografi. The mixing behavior of binary amorphous systems. J. Pharm. Sci. 87:694-701 (1998).
11. I. M. Hodge. Enthalpy relaxation and recovery in amorphous materials. J. Non-Cryst. Solids 169:211-266 (1994).
12. L. C. E. Struik. Physical Aging in Amorphous Polymers and Other Materials, Elsevier Scientific Publishing Company, New York, 1978.
13. A. Brunacci, J. Cowie, R. Ferguson, and I. McEwen. Enthalpy relaxation in glassy polystyrenes: 1. Polymer 38:865-870 (1997).
14. M. D. Ediger, C. A. Angell, and S. R. Nagel. Supercooled liquids and glasses. J. Phys. Chem. 100:13200-13212 (1996).
15. K. Karatasos, S. H. Anastasiadis, A. J. Semenov, G. Fytas, M. Pitsikalis, and N. Hadijichristidis. Composition fluctuation effects on dielectric normal-mode relaxation in diblock copolymers I. Weak segregation regime. Macromol. 27:3543-3552 (1994).
16. A. A. C. M. Oudhuis and G. ten Brinke. Enthalpy relaxation and concentration fluctuations in blends of polystyrene and poly(oxy-2,6-dimethyl-1,4-phenylene). Macromol. 25:698-702 (1992).
17. J. R. Fried, F. E. Karasz, and W. J. MacKnight. Compatibility of poly(2,6-dimethyl-1,4-phenylene oxide) (ppo)/poly(styrene-co-4-chlorostyrene) blends. I. Differential scanning calorimetry and density studies. Macromol. 11:150-158 (1978).
18. K. Assman and H. A. Schneider. The thermal analysis of polymer blends of poly(ethylene oxide)/poly(methyl methacrylate). J. Therm. Anal. 35:459-468 (1989).
19. J. A. Pomposo, I. Eguiazabal, E. Calahorra, and M. Cortazar. Glass transition behaviour and interactions in poly(p-vinyl phenol)/polymethacrylate blends. Polymer 34:95-102 (1993).