Characterization and dissolution properties of ketoprofen in binary and ternary solid dispersions with polyethylene glycol and surfactants

Drug Development and Industrial Pharmacy

Volumn 31, Issue 4-5, 2005, Pages 425-434

  Mura, P ^a,c   Moyano, J R ^b   Gonzalez Rodriguez M L ^b   Rabasco Alvarez A M ^b   Cirri, M ^a   Maestrelli, F ^a  

^a Polo Scientifico Universitario   (Italy)

^b Depto Farmacia Y Tecn F   (Spain)

^c Dipartimento di Scienze Farmaceutiche   (Italy)

Author keywords

Ketoprofen; Polyethylene glycol; Sodium dodecyl sulfate; Surfactants; Ternary solid dispersions

Indexed keywords

ANIONIC SURFACTANT; DOCUSATE SODIUM; DODECYL SULFATE SODIUM; KETOPROFEN; MACROGOL; NONIONIC SURFACTANT; POLYSORBATE 60;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; EVAPORATION; MICROSCOPY; PHYSICAL CHEMISTRY; REACTION TIME; SCANNING ELECTRON MICROSCOPY; SOLID; SOLUBILIZATION; X RAY POWDER DIFFRACTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALORIMETRY, DIFFERENTIAL SCANNING; DRUG CARRIERS; KETOPROFEN; MICROSCOPY, ELECTRON, SCANNING; POLYETHYLENE GLYCOLS; SOLUBILITY; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 24744466906     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040500214621     Document Type: Article

References (20)

1. Cirri, M., Mura, P., Rabasco, A. M., Ginés, J. M., Moyano, J. R., & González-Rodríguez, M. L. (2004). Characterization of ibuproxam binary and ternary dispersions with hydrophilic carriers. Drug Development and Industrial Pharmacy, 30, 65-74.
2. Corrigan, O. I., & Timoney, R. F. (1976). The influence of polyethylene glycols on the dissolution properties of hydroflumetiazide. Pharmaceutica Acta Helvetiae, 51, 268-271.
3. Craig, D. Q. M. (2002). The mechanisms of drug release from solid dispersions in water-soluble polymers. International Journal of Pharmaceutics, 231, 131-144.
4. Craig, D. Q. M., & Newton, J. M. (1992). The dissolution of nortriptyline HCl from polyethylene glycol solid dispersions. International Journal of Pharmaceutics, 78, 175-182.
5. Jachowicz, R., Nürnberg, E., Pieszczek, B., Kluczykowska, B., & Maciejewska, A. (2000). Solid dispersion of ketoprofen in pellets. International Journal of Pharmaceutics, 206, 13-21.
6. Khan, K. A. (1975). The concept of dissolution efficiency. Journal of Pharmacy and Pharmacology, 27, 48-49.
7. Leuner, C., & Dressman, J. (2000). Improving drug solubility for oral delivery using solid dispersions. European Journal of Pharmaceutical Sciences, 50, 47-60.
8. Margarit, M. V., Rodriguez, I. C., & Cerezo, A. (1994). Physical characteristics and dissolution kinetics of solid dispersions of ketoprofen on polyethylene glycol 6000. International Journal of Pharmaceutics, 108, 101-107.
9. Mukerjee, P., & Mysels, K. J. (1971). Critical Micelle Concentrations of Aqueous Surfactant Systems. Washington, DC: National Standard Reference Data Series, National Bureau of Standards.
10. Mura, P., Manderioli, A., Bramanti, G., & Ceccarelli, L. (1996). The properties of solid dispersions of naproxen in various polyethylene glycols. Drug Development and Industrial Pharmacy, 22, 909-916.
11. Mura, P., Faucci, M. T., Manderioli, A., & Bramanti, G. (1999). Thermal behavior and dissolution properties of naproxen from binary and ternary solid dispersions. Drug Development and Industrial Pharmacy, 25, 257-264.
12. Najib, N. M., & Suleiman, M. S. (1989). Characterization of a diflunisal polyethylene glycol solid dispersion system. International Journal of Pharmaceutics, 51, 225-232.
13. Roger, J. A., & Anderson, A. J. (1982). Physical characteristic and dissolution profiles of ketoprofen-urea solid dispersion. Pharmaceutica Acta Helvetiae, 57, 276-282.
14. Schachter, D. M., Xiong, J., & Tirol, G. C. (2004). Solid state NMR perspective of drug-polymer solid solutions: a model system base on poly(ethylene oxide). International Journal of Pharmaceutics, 281, 89-101.
15. Serajuddin, A. T. M. (1999). Solid dispersions of poorly-water-soluble drugs: early premises, subsequent problems and recent breakthroughs. Journal of Pharmaceutical Sciences, 88, 1058-1066.
16. Sheen, P. C., Khetarpal, V. K., Cariola, M. C., & Rowlings, C. E. (1995). Formulation studies of a poorly water-soluble drug in solid dispersions to improve bioavailability. International Journal of Pharmaceutics, 118, 221-227.
17. Sjökvist, E., Nystrom, C., & Alden, M. (1991). Physicochemical aspects of drug release. The effect of sodium dodecylsulphate additions on the structure and dissolution of a drug in solid dispersions. International Journal of Pharmaceutics, 68, 53-62.
18. Takayama, K., Nambu, N., & Nagai, T. (1982). Factors affecting the dissolution of ketoprofen from solid dispersions in various water-soluble polymers. Chemical and Pharmaceutical Bulletin, 3, 3013-3019.
19. Veiga, M. D., Bernad, M. J., & Escobar, C. (1993). Thermal behaviour of drugs from binary and ternary system. International Journal of Pharmaceutics, 89, 119-124.
20. Vippagunta, S. R., Maul, K. A., Tallavajhala, S., & Grant, D. J. W. (2002). Solid-state characterization of nifedipine solid dispersions. International Journal of Pharmaceutics, 236, 111-123.