The PSD-95/nNOS complex: New drugs for depression?

Pharmacology and Therapeutics

Volumn 133, Issue 2, 2012, Pages 218-229

  Doucet, Marika V ^a   Harkin, Andrew ^a   Dev, Kumlesh K ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Depression; NMDA receptors; nNOS; PDZ domains; Protein protein interactions; PSD 95

Indexed keywords

AGOMELATINE; AMFEBUTAMONE; AMITRIPTYLINE; ARIPIPRAZOLE; CITALOPRAM; CLOMIPRAMINE; DESIPRAMINE; DOSULEPIN; DULOXETINE; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; FLUVOXAMINE MALEATE; IMIPRAMINE; IPRONIAZID; ISOCARBOXAZID; LAMOTRIGINE; LEVOTHYROXINE SODIUM; LITHIUM CARBONATE; MAPROTILINE; MIANSERIN; MILNACIPRAN; MIRTAZAPINE; MOCLOBEMIDE; NEFAZODONE; NORTRIPTYLINE; OLANZAPINE; OPTIMAX; PAROXETINE; PHENELZINE; QUETIAPINE; REBOXETINE; SELEGILINE; SERTRALINE; TIANEPTINE; TRANYLCYPROMINE; TRAZODONE; TRIMIPRAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VENLAFAXINE; XEROQUEL; ZIPRASIDONE; ZL 006;

CENTRAL NERVOUS SYSTEM; CEREBELLUM; CLINICAL TRIAL (TOPIC); CORPUS STRIATUM; DISEASE MODEL; HIPPOCAMPUS; HUMAN; LATERAL AMYGDALA; LOCUS CERULEUS; MAJOR DEPRESSION; NONHUMAN; PARKINSON DISEASE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RETT SYNDROME; REVIEW; SIGNAL TRANSDUCTION; STROKE; TEMPORAL CORTEX; TEMPORAL LOBE;

ANIMALS; ANTIDEPRESSIVE AGENTS; DEPRESSION; GUANYLATE KINASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MOLECULAR TARGETED THERAPY; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE TYPE I; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION;

EID: 84856450634     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.11.005     Document Type: Review

References (124)

1. M. aan het Rot, K.A. Collins, J.W. Murrough, A.M. Perez, D.L. Reich, D.S. Charney, and S.J. Mathew Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression Biological Psychiatry 67 2010 139 145
2. M. Aarts, Y. Liu, L. Liu, S. Besshoh, M. Arundine, J.W. Gurd, Y.T. Wang, M.W. Salter, and M. Tymianski Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions Science 298 2002 846 850 (Pubitemid 35231541)
3. M.M. Aarts, and M. Tymianski Novel treatment of excitotoxicity: targeted disruption of intracellular signalling from glutamate receptors Biochemical Pharmacology 66 2003 877 886 (Pubitemid 37083584)
4. W.K. Alderton, C.E. Cooper, and R.G. Knowles Nitric oxide synthases: structure, function and inhibition Biochemical Journal 357 2001 593 615 (Pubitemid 32735142)
5. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, Text Revision, DSM-IV-TR 2000 American Psychiatric Association Washington
6. A.E. Autry, M. Adachi, E. Nosyreva, E.S. Na, M.F. Los, P.F. Cheng, E.T. Kavalali, and L.M. Monteggia NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses Nature 475 2011 91 95
7. A.T. Bender, A.M. Silverstein, D.R. Demady, K.C. Kanelakis, S. Noguchi, W.B. Pratt, and Y. Osawa Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo Journal of Biological Chemistry 274 1999 1472 1478
8. M. Beneyto, L.V. Kristiansen, A. Oni-Orisan, R.E. McCullumsmith, and J.H. Meador-Woodruff Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders Neuropsychopharmacology 32 2007 1888 1902 (Pubitemid 47258508)
9. M. Beneyto, and J.H. Meador-Woodruff Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder Neuropsychopharmacology 33 2008 2175 2186 (Pubitemid 351992080)
10. R.M. Berman, A. Cappiello, A. Anand, D.A. Oren, G.R. Heninger, D.S. Charney, and J.H. Krystal Antidepressant effects of ketamine in depressed patients Biological Psychiatry 47 2000 351 354 (Pubitemid 30109248)
11. S. Blackshaw, M.J. Eliasson, A. Sawa, C.C. Watkins, D. Krug, A. Gupta, T. Arai, R.J. Ferrante, and S.H. Snyder Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity Neuroscience 119 2003 979 990 (Pubitemid 36776448)
12. D. Blum-Degen, T. Heinemann, J. Lan, V. Pedersen, F. Leblhuber, W. Paulus, P. Riederer, and M. Gerlach Characterization and regional distribution of nitric oxide synthase in the human brain during normal ageing Brain Research 834 1999 128 135 (Pubitemid 29332017)
13. G. Bonanno, R. Giambelli, L. Raiteri, E. Tiraboschi, S. Zappettini, L. Musazzi, M. Raiteri, G. Racagni, and M. Popoli Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampus Journal of Neuroscience 25 2005 3270 3279 (Pubitemid 40471335)
14. D.S. Bredt, and S.H. Snyder Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme Proceedings of the National Academy of Sciences of the United States of America 87 1990 682 685
15. J.E. Brenman, D.S. Chao, S.H. Gee, A.W. McGee, S.E. Craven, D.R. Santillano, Z. Wu, F. Huang, H. Xia, M.F. Peters, S.C. Froehner, and D.S. Bredt Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains Cell 84 1996 757 767 (Pubitemid 26094205)
16. S. Broer The SLC6 orphans are forming a family of amino acid transporters Neurochemistry International 48 2006 559 567
17. A. Burette, U. Zabel, R.J. Weinberg, H.H. Schmidt, and J.G. Valtschanoff Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus Journal of Neuroscience 22 2002 8961 8970 (Pubitemid 35379066)
18. J.R. Calabrese, R.F. Huffman, R.L. White, S. Edwards, T.R. Thompson, J.A. Ascher, E.T. Monaghan, and R.A. Leadbetter Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trials Bipolar Disorders 10 2008 323 333 (Pubitemid 351637697)
19. J. Cao, J.I. Viholainen, C. Dart, H.K. Warwick, M.L. Leyland, and M.J. Courtney The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death The Journal of Cell Biology 168 2005 117 126 (Pubitemid 40111062)
20. B. Chanrion, C. Mannoury la Cour, F. Bertaso, M. Lerner-Natoli, M. Freissmuth, M.J. Millan, J. Bockaert, and P. Marin Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity Proceedings of the National Academy of Sciences of the United States of America 104 2007 8119 8124 (Pubitemid 47185885)
21. K.S. Christopherson, B.J. Hillier, W.A. Lim, and D.S. Bredt PSD-95 assembles a ternary complex with the N-methyl-d-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain Journal of Biological Chemistry 274 1999 27467 27473
22. K.S. Christopherson, N.T. Sweeney, S.E. Craven, R. Kang, D. El-Husseini Ael, and D.S. Bredt Lipid- and protein-mediated multimerization of PSD-95: implications for receptor clustering and assembly of synaptic protein networks Journal of Cell Science 116 2003 3213 3219 (Pubitemid 37038969)
23. J.F. Cryan, and B.E. Leonard 5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response Human Psychopharmacology 15 2000 113 135 (Pubitemid 30199285)
24. J.F. Deakin, J. Lees, S. McKie, J.E. Hallak, S.R. Williams, and S.M. Dursun Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study Archives of General Psychiatry 65 2008 154 164 (Pubitemid 351214314)
25. K.K. Dev Making protein interactions druggable: targeting PDZ domains Nature Reviews. Drug Discovery 3 2004 1047 1056 (Pubitemid 39642367)
26. N. Diazgranados, L.A. Ibrahim, N.E. Brutsche, R. Ameli, I.D. Henter, D.A. Luckenbaugh, R. Machado-Vieira, and C.A. Zarate Jr. Rapid resolution of suicidal ideation after a single infusion of an N-methyl-d-aspartate antagonist in patients with treatment-resistant major depressive disorder The Journal of Clinical Psychiatry 71 2010 1605 1611
27. R. Dingledine, K. Borges, D. Bowie, and S.F. Traynelis The glutamate receptor ion channels Pharmacological Reviews 51 1999 7 61 (Pubitemid 29113865)
28. J. Dreyer, M. Schleicher, A. Tappe, K. Schilling, T. Kuner, G. Kusumawidijaja, W. Muller-Esterl, S. Oess, and R. Kuner Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity Journal of Neuroscience 24 2004 10454 10465 (Pubitemid 39552630)
29. R.S. Duman Depression: a case of neuronal life and death? Biological Psychiatry 56 2004 140 145 (Pubitemid 38969145)
30. A.E. El-Husseini, S.E. Craven, D.M. Chetkovich, B.L. Firestein, E. Schnell, C. Aoki, and D.S. Bredt Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering The Journal of Cell Biology 148 2000 159 172
31. K. Erreger, P.E. Chen, D.J. Wyllie, and S.F. Traynelis Glutamate receptor gating Critical Reviews in Neurobiology 16 2004 187 224 (Pubitemid 40314700)
32. J. Fan, C.M. Cowan, L.Y. Zhang, M.R. Hayden, and L.A. Raymond Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease Journal of Neuroscience 29 2009 10928 10938
33. W. Feng, and M. Zhang Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density Nature Reviews Neuroscience 10 2009 87 99
34. J.M. Ferguson, and R.N. Shingleton An open-label, flexible-dose study of memantine in major depressive disorder Clinical Neuropharmacology 30 2007 136 144 (Pubitemid 46871863)
35. A.M. Feyissa, A. Chandran, C.A. Stockmeier, and B. Karolewicz Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression Progress in Neuro-Psychopharmacology & Biological Psychiatry 33 2009 70 75
36. B.L. Firestein, and D.S. Bredt Interaction of neuronal nitric-oxide synthase and phosphofructokinase-M Journal of Biological Chemistry 274 1999 10545 10550
37. S.K. Florio, C. Loh, S.M. Huang, A.E. Iwamaye, K.F. Kitto, K.W. Fowler, J.A. Treiberg, J.S. Hayflick, J.M. Walker, C.A. Fairbanks, and Y. Lai Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents British Journal of Pharmacology 158 2009 494 506
38. C.L. Franke, R. Palm, M. Dalby, H.C. Schoonderwaldt, L. Hantson, B. Eriksson, L. Lang-Jenssen, and J. Smakman Flunarizine in stroke treatment (FIST): a double-blind, placebo-controlled trial in Scandinavia and the Netherlands Acta Neurologica Scandinavica 93 1996 56 60 (Pubitemid 26033957)
39. J. Garthwaite, S.L. Charles, and R. Chess-Williams Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain Nature 336 1988 385 388
40. F.X. Guix, I. Uribesalgo, M. Coma, and F.J. Munoz The physiology and pathophysiology of nitric oxide in the brain Progress in Neurobiology 76 2005 126 152 (Pubitemid 41242885)
41. C.N. Hall, and D. Attwell Assessing the physiological concentration and targets of nitric oxide in brain tissue The Journal of Physiology 586 2008 3597 3615
42. A.J. Harkin, K.H. Bruce, B. Craft, and I.A. Paul Nitric oxide synthase inhibitors have antidepressant-like properties in mice. 1. Acute treatments are active in the forced swim test European Journal of Pharmacology 372 1999 207 213 (Pubitemid 29255959)
43. A. Harkin, T.J. Connor, M.P. Burns, and J.P. Kelly Nitric oxide synthase inhibitors augment the effects of serotonin re-uptake inhibitors in the forced swimming test European Neuropsychopharmacology 14 2004 274 281 (Pubitemid 38649083)
44. K. Hashimoto Emerging role of glutamate in the pathophysiology of major depressive disorder Brain Research Reviews 61 2009 105 123
45. H. Hering, and M. Sheng Dendritic spines: structure, dynamics and regulation Nature Reviews Neuroscience 2 2001 880 888 (Pubitemid 33674075)
46. B.J. Hillier, K.S. Christopherson, K.E. Prehoda, D.S. Bredt, and W.A. Lim Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex Science 284 1999 812 815 (Pubitemid 29291348)
47. A.J. Hobbs, A. Higgs, and S. Moncada Inhibition of nitric oxide synthase as a potential therapeutic target Annual Review of Pharmacology and Toxicology 39 1999 191 220 (Pubitemid 29222557)
48. C.A. Hoeffer, and E. Klann mTOR signaling: at the crossroads of plasticity, memory and disease Trends in Neurosciences 33 2010 67 75
49. J. Horn, R.J. de Haan, M. Vermeulen, and M. Limburg Very Early Nimodipine Use in Stroke (VENUS): a randomized, double-blind, placebo-controlled trial Stroke 32 2001 461 465 (Pubitemid 32155235)
50. J. Horn, and M. Limburg Calcium antagonists for acute ischemic stroke Cochrane Database of Systematic Reviews Issue 1 2000 Art. No.: CD001928. doi: 10.1002/14651858.CD001928
51. Y.P. Hsueh, E. Kim, and M. Sheng Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95 Neuron 18 1997 803 814 (Pubitemid 27232790)
52. Y.P. Hsueh, and M. Sheng Requirement of N-terminal cysteines of PSD-95 for PSD-95 multimerization and ternary complex formation, but not for binding to potassium channel Kv1.4 Journal of Biological Chemistry 274 1999 532 536 (Pubitemid 29035094)
53. S.R. Jaffrey, A.M. Snowman, M.J. Eliasson, N.A. Cohen, and S.H. Snyder CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95 Neuron 20 1998 115 124 (Pubitemid 28078354)
54. S.R. Jaffrey, and S.H. Snyder Nitric oxide: a neural messenger Annual Review of Cell and Developmental Biology 11 1995 417 440 (Pubitemid 26019610)
55. S.R. Jaffrey, and S.H. Snyder PIN: an associated protein inhibitor of neuronal nitric oxide synthase Science 274 1996 774 777 (Pubitemid 26398255)
56. C.S. Jernigan, D.B. Goswami, M.C. Austin, A.H. Iyo, A. Chandran, C.A. Stockmeier, and B. Karolewicz The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 2011 1774 1779
57. L.V. Kalia, G.M. Pitcher, K.A. Pelkey, and M.W. Salter PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex EMBO Journal 25 2006 4971 4982 (Pubitemid 44607041)
58. L.V. Kalia, and M.W. Salter Interactions between Src family protein tyrosine kinases and PSD-95 Neuropharmacology 45 2003 720 728 (Pubitemid 38340358)
59. B. Karolewicz, C.A. Stockmeier, and G.A. Ordway Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression Neuropsychopharmacology 30 2005 1557 1567 (Pubitemid 41153128)
60. B. Karolewicz, K. Szebeni, T. Gilmore, D. Maciag, C.A. Stockmeier, and G.A. Ordway Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression The International Journal of Neuropsychopharmacology 12 2009 143 153
61. B. Karolewicz, K. Szebeni, C.A. Stockmeier, L. Konick, J.C. Overholser, G. Jurjus, B.L. Roth, and G.A. Ordway Low nNOS protein in the locus coeruleus in major depression Journal of Neurochemistry 91 2004 1057 1066 (Pubitemid 39587444)
62. E. Kim, and M. Sheng PDZ domain proteins of synapses Nature Reviews Neuroscience 5 2004 771 781 (Pubitemid 39336214)
63. M.A. Kohli, S. Lucae, P.G. Saemann, M.V. Schmidt, A. Demirkan, K. Hek, D. Czamara, M. Alexander, D. Salyakina, S. Ripke, D. Hoehn, M. Specht, A. Menke, J. Hennings, A. Heck, C. Wolf, M. Ising, S. Schreiber, M. Czisch, M.B. Muller, M. Uhr, T. Bettecken, A. Becker, J. Schramm, M. Rietschel, W. Maier, B. Bradley, K.J. Ressler, M.M. Nothen, S. Cichon, I.W. Craig, G. Breen, C.M. Lewis, A. Hofman, H. Tiemeier, C.M. van Duijn, F. Holsboer, B. Muller-Myhsok, and E.B. Binder The neuronal transporter gene SLC6A15 confers risk to major depression Neuron 70 2011 252 265
64. K. Komeima, Y. Hayashi, Y. Naito, and Y. Watanabe Inhibition of neuronal nitric-oxide synthase by calcium/calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells Journal of Biological Chemistry 275 2000 28139 28143
65. H.C. Kornau, L.T. Schenker, M.B. Kennedy, and P.H. Seeburg Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95 Science 269 1995 1737 1740
66. L. Kranaster, J. Kammerer-Ciernioch, C. Hoyer, and A. Sartorius Clinically favourable effects of ketamine as an anaesthetic for electroconvulsive therapy: a retrospective study European Archives of Psychiatry and Clinical Neuroscience 261 8 2011 575 582
67. V. Krishnan, and E.J. Nestler The molecular neurobiology of depression Nature 455 2008 894 902
68. L.V. Kristiansen, and J.H. Meador-Woodruff Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression Schizophrenia Research 78 2005 87 93 (Pubitemid 41188327)
69. G.L. Larkin, and A.L. Beautrais A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department The International Journal of Neuropsychopharmacology 2011 1 5
70. A.J. Law, C.S. Weickert, M.J. Webster, M.M. Herman, J.E. Kleinman, and P.J. Harrison Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation European Journal of Neuroscience 18 2003 1197 1205 (Pubitemid 37115039)
71. N. Li, B. Lee, R.J. Liu, M. Banasr, J.M. Dwyer, M. Iwata, X.Y. Li, G. Aghajanian, and R.S. Duman mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists Science 329 2010 959 964
72. N. Li, R.J. Liu, J.M. Dwyer, M. Banasr, B. Lee, H. Son, X.Y. Li, G. Aghajanian, and R.S. Duman Glutamate N-methyl-d-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure Biological Psychiatry 69 2011 754 761
73. I.A. Lim, D.D. Hall, and J.W. Hell Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102 Journal of Biological Chemistry 277 2002 21697 21711 (Pubitemid 34952321)
74. X. Lin, B. Sun, M. Liang, Y.Y. Liang, A. Gast, J. Hildebrand, F.C. Brunicardi, F. Melchior, and X.H. Feng Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding Molecular Cell 11 2003 1389 1396 (Pubitemid 36645156)
75. R. Machado-Vieira, H.K. Manji, and C.A. Zarate The role of the tripartite glutamatergic synapse in the pathophysiology and therapeutics of mood disorders The Neuroscientist 15 2009 525 539
76. S. Maeng, C.A. Zarate Jr., J. Du, R.J. Schloesser, J. Mccammon, G. Chen, and H.K. Manji Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors Biological Psychiatry 63 2008 349 352 (Pubitemid 351146651)
77. P. Manivet, S. Mouillet-Richard, J. Callebert, C.G. Nebigil, L. Maroteaux, S. Hosoda, O. Kellermann, and J.M. Launay PDZ-dependent activation of nitric-oxide synthases by the serotonin 2B receptor Journal of Biological Chemistry 275 2000 9324 9331 (Pubitemid 30185155)
78. J.J. Mann The medical management of depression The New England Journal of Medicine 353 2005 1819 1834
79. O. Mutlu, G. Ulak, A. Laugeray, and C. Belzung Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl) phenyl] imidazole (TRIM) in unpredictable chronic mild stress procedure in mice Pharmacology Biochemistry and Behavior 92 2009 82 87
80. J.C. Nelson The STAR*D study: a four-course meal that leaves us wanting more The American Journal of Psychiatry 163 2006 1864 1866 (Pubitemid 44807772)
81. M. Niethammer, E. Kim, and M. Sheng Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases Journal of Neuroscience 16 1996 2157 2163 (Pubitemid 26154327)
82. S. Nudmamud-Thanoi, and G.P. Reynolds The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders Neuroscience Letters 372 2004 173 177 (Pubitemid 39505251)
83. R.M. Oliveira, F.S. Guimaraes, and J.F. Deakin Expression of neuronal nitric oxide synthase in the hippocampal formation in affective disorders Brazilian Journal of Medical and Biological Research 41 2008 333 341 (Pubitemid 351761067)
84. G. Paslakis, M. Gilles, A. Meyer-Lindenberg, and M. Deuschle Oral administration of the NMDA receptor antagonist S-ketamine as add-on therapy of depression: a case series Pharmacopsychiatry 43 2010 33 35
85. I.A. Paul, and P. Skolnick Glutamate and depression: clinical and preclinical studies Annals of the New York Academy of Sciences 1003 2003 250 272 (Pubitemid 38083061)
86. H.M. Peng, Y. Morishima, K.M. Clapp, M. Lau, W.B. Pratt, and Y. Osawa Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination Biochemistry 48 2009 8483 8490
87. R.X. Petrie, I.C. Reid, and C.A. Stewart The N-methyl-d-aspartate receptor, synaptic plasticity, and depressive disorder. A critical review Pharmacology and Therapeutics 87 2000 11 25 (Pubitemid 30618985)
88. L.E. Phelps, N. Brutsche, J.R. Moral, D.A. Luckenbaugh, H.K. Manji, and C.A. Zarate Jr. Family history of alcohol dependence and initial antidepressant response to an N-methyl-d-aspartate antagonist Biological Psychiatry 65 2009 181 184
89. C. Pittenger, V. Coric, M. Banasr, M. Bloch, J.H. Krystal, and G. Sanacora Riluzole in the treatment of mood and anxiety disorders CNS Drugs 22 2008 761 786
90. C. Pittenger, G. Sanacora, and J.H. Krystal The NMDA receptor as a therapeutic target in major depressive disorder CNS & Neurological Disorders Drug Targets 6 2007 101 115 (Pubitemid 46681771)
91. S.H. Preskorn, B. Baker, S. Kolluri, F.S. Menniti, M. Krams, and J.W. Landen An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-d-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder Journal of Clinical Psychopharmacology 28 2008 631 637
92. R.B. Price, M.K. Nock, D.S. Charney, and S.J. Mathew Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression Biological Psychiatry 66 2009 522 526
93. G.A. Rameau, D.S. Tukey, E.D. Garcin-Hosfield, R.F. Titcombe, C. Misra, L. Khatri, E.D. Getzoff, and E.B. Ziff Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death Journal of Neuroscience 27 2007 3445 3455 (Pubitemid 46515122)
94. G.M. Riefler, and B.L. Firestein Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS Journal of Biological Chemistry 276 2001 48262 48268
95. F. Saitoh, Q.B. Tian, A. Okano, H. Sakagami, H. Kondo, and T. Suzuki NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity Journal of Biological Chemistry 279 2004 29461 29468 (Pubitemid 38915825)
96. G. Sanacora, D.L. Rothman, G. Mason, and J.H. Krystal Clinical studies implementing glutamate neurotransmission in mood disorders Annals of the New York Academy of Sciences 1003 2003 292 308 (Pubitemid 38083063)
97. G. Sanacora, C.A. Zarate, J.H. Krystal, and H.K. Manji Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders Nature Reviews. Drug Discovery 7 2008 426 437 (Pubitemid 351619114)
98. R. Sattler, Z. Xiong, W.Y. Lu, M. Hafner, J.F. Macdonald, and M. Tymianski Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein Science 284 1999 1845 1848
99. R.H. Scannevin, and R.L. Huganir Postsynaptic organization and regulation of excitatory synapses Nature Reviews Neuroscience 1 2000 133 141
100. J.J. Schildkraut The catecholamine hypothesis of affective disorders: a review of supporting evidence The American Journal of Psychiatry 122 1965 509 522
101. E. Schnell, M. Sizemore, S. Karimzadegan, L. Chen, D.S. Bredt, and R.A. Nicoll Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number Proceedings of the National Academy of Sciences of the United States of America 99 2002 13902 13907 (Pubitemid 35215478)
102. Y. Serulle, S. Zhang, I. Ninan, D. Puzzo, M. McCarthy, L. Khatri, O. Arancio, and E.B. Ziff A GluR1-cGKII interaction regulates AMPA receptor trafficking Neuron 56 2007 670 688 (Pubitemid 350102028)
103. P. Skolnick, P. Popik, and R. Trullas Glutamate-based antidepressants: 20 years on Trends in Pharmacological Sciences 30 2009 563 569
104. F.X. Soriano, M.A. Martel, S. Papadia, A. Vaslin, P. Baxter, C. Rickman, J. Forder, M. Tymianski, R. Duncan, M. Aarts, P. Clarke, D.J. Wyllie, and G.E. Hardingham Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand Journal of Neuroscience 28 2008 10696 10710
105. Z. Su, M.A. Blazing, D. Fan, and S.E. George The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation Journal of Biological Chemistry 270 1995 29117 29122
106. H.S. Sun, T.A. Doucette, Y. Liu, Y. Fang, L. Teves, M. Aarts, C.L. Ryan, P.B. Bernard, A. Lau, J.P. Forder, M.W. Salter, Y.T. Wang, R.A. Tasker, and M. Tymianski Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat Stroke 39 2008 2544 2553
107. H. Tochio, Y.K. Mok, Q. Zhang, H.M. Kan, D.S. Bredt, and M. Zhang Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain Journal of Molecular Biology 303 2000 359 370
108. H. Tochio, S. Ohki, Q. Zhang, M. Li, and M. Zhang Solution structure of a protein inhibitor of neuronal nitric oxide synthase Natural Structural Biology 5 1998 965 969 (Pubitemid 28506629)
109. C. Toro, and J.F. Deakin NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder Schizophrenia Research 80 2005 323 330 (Pubitemid 41713658)
110. P. Vallance, and J. Leiper Blocking NO synthesis: how, where and why? Nature Reviews. Drug Discovery 1 2002 939 950 (Pubitemid 37361600)
111. V.J. Venema, H. Ju, R. Zou, and R.C. Venema Interaction of neuronal nitric-oxide synthase with caveolin-3 in skeletal muscle. Identification of a novel caveolin scaffolding/inhibitory domain Journal of Biological Chemistry 272 1997 28187 28190 (Pubitemid 27517753)
112. V. Volke, G. Wegener, M. Bourin, and E. Vasar Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2- trifluoromethylphenyl)-imidazole in mice Behavioural Brain Research 140 2003 141 147 (Pubitemid 36313249)
113. Y. Watanabe, T. Song, K. Sugimoto, M. Horii, N. Araki, H. Tokumitsu, T. Tezuka, T. Yamamoto, and M. Tokuda Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase Biochemical Journal 372 2003 465 471 (Pubitemid 36723892)
114. G. Wegener, and V. Volke Nitric oxide synthase inhibitors as antidepressants Pharmaceuticals 3 2010 273 299
115. WHO Mental Health: Facing the Challenges, Building Solutions: Report from the WHO European Ministerial Conference 2005 World Health Organization Regional Office for Europe
116. M.L. Wong, and J. Licinio From monoamines to genomic targets: a paradigm shift for drug discovery in depression Nature Reviews. Drug Discovery 3 2004 136 151 (Pubitemid 38239775)
117. T. Yamauchi Molecular constituents and phosphorylation-dependent regulation of the post-synaptic density Mass Spectrometry Reviews 21 2002 266 286
118. C.A. Zarate Jr., J.A. Quiroz, J.B. Singh, K.D. Denicoff, G. de Jesus, D.A. Luckenbaugh, D.S. Charney, and H.K. Manji An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression Biological Psychiatry 57 2005 430 432 (Pubitemid 40215774)
119. C.A. Zarate Jr., J.B. Singh, P.J. Carlson, N.E. Brutsche, R. Ameli, D.A. Luckenbaugh, D.S. Charney, and H.K. Manji A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression Archives of General Psychiatry 63 2006 856 864 (Pubitemid 44188478)
120. C.A. Zarate Jr., J. Singh, and H.K. Manji Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder Biological Psychiatry 59 2006 1006 1020 (Pubitemid 43849653)
121. C.A. Zarate Jr., J.B. Singh, J.A. Quiroz, G. de Jesus, K.K. Denicoff, D.A. Luckenbaugh, H.K. Manji, and D.S. Charney A double-blind, placebo-controlled study of memantine in the treatment of major depression The American Journal of Psychiatry 163 2006 153 155 (Pubitemid 43050119)
122. Q.G. Zhou, Y. Hu, Y. Hua, M. Hu, C.X. Luo, X. Han, X.J. Zhu, B. Wang, J.S. Xu, and D.Y. Zhu Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis Journal of Neurochemistry 103 2007 1843 1854 (Pubitemid 350126635)
123. L. Zhou, F. Li, H.B. Xu, C.X. Luo, H.Y. Wu, M.M. Zhu, W. Lu, X. Ji, Q.G. Zhou, and D.Y. Zhu Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95 Nature Medicine 16 2010 1439 1443
124. L. Zhou, and D.Y. Zhu Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications Nitric Oxide 20 2009 223 230