Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding

Molecular Cell

Volumn 11, Issue 5, 2003, Pages 1389-1396

  Lin, Xia ^a   Sun, Baohua ^a   Liang, Min ^a   Liang, Yao Yun ^a   Gast, Andreas ^b   Hildebrand, Jeffrey ^c   Brunicardi, F Charles ^a   Melchior, Frauke ^b   Feng, Xin Hua ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BIOACCUMULATION; CELLULAR DISTRIBUTION; CHEMICAL INTERACTION; CONTROLLED STUDY; ENZYME MODIFICATION; GENE MUTATION; NONHUMAN; PROTEIN BINDING; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

EID: 0038054467     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(03)00175-8     Document Type: Article

References (34)

1. Boyd J., Subramanian T., Schaeper U., La Regina M., Bayley S., Chinnadurai G. A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. EMBO J. 12:1993;469-478.
2. Chinnadurai G. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell. 9:2002;213-224.
3. Desterro J., Thomson J., Hay R.T. Ubch9 conjugates SUMO but not ubiquitin. FEBS Lett. 417:1997;297-300.
4. Desterro J., Rodriguez M., Kemp G., Hay R. Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. J. Biol. Chem. 274:1999;10618-10624.
5. Feng X.-H., Derynck R. Mammalian two-hybrid. protein-protein interaction in TGF-β signaling Methods Mol. Biol. 177:2001;221-239.
6. INK4B transcription in response to TGF-β EMBO J. 19:2000;5178-5193.
7. INK4B. Mol. Cell. 9:2002;133-143.
8. Freiman R., Tjian R. Regulating the regulators. lysine modifications make their mark Cell. 112:2003;11-17.
9. Gong L., Kamitani T., Fujise K., Caskey L., Yeh E. Preferential interaction of sentrin with a ubiquitin-conjugating enzyme, Ubc9. J. Biol. Chem. 272:1997;28198-28201.
10. Hay R. Protein modification by SUMO. Trends Biochem. Sci. 26:2001;332-333.
11. Hildebrand J., Soriano P. Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol. Cell. Biol. 22:2002;5296-5307.
12. Hochstrasser M. Evolution and function of ubiquitin-like protein-conjugation systems. Nat. Cell Biol. 2:2000;E153-E157.
13. Hochstrasser M. Sp-ring for sumo. new functions bloom for a ubiquitin-like protein Cell. 107:2001;5-8.
14. Jackson P. A new RING for SUMO. wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases Genes Dev. 15:2001;3053-3058.
15. Kagey M., Melhuish T., Wotton D. The polycomb protein Pc2 is a SUMO E3. Cell. 113:2003;127-137.
16. Kahyo T., Nishida T., Yasuda H. Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol. Cell. 8:2001;713-718.
17. Katsanis N., Fisher E. A novel C-terminal binding protein (CtBP2) is closely related to CtBP1 and maps to human chromosome 21q21.3. Genomics. 47:1998;294-299.
18. Koipally J., Georgopoulos K. Ikaros-CtIP interactions do not require CtBP and participate in a deacetylase-independent mode of repression. J. Biol. Chem. 277:2002;23143-23149.
19. Lin X., Liang M., Liang Y.-Y., Brunicardi F.C., Melchior F., Feng X.-H. Activation of TGF-β signaling by SUMO modification of tumor suppressor Smad4/DPC4. J. Biol. Chem. in press:2003.
20. Mahajan R., Delphin C., Guan T., Gerace L., Melchior F. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell. 88:1997;97-107.
21. Matunis M., Coutavas E., Blobel G. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J. Cell Biol. 135:1996;1457-1470.
22. Melchior F. SUMO-nonclassical ubiquitin. Annu. Rev. Cell Dev. Biol. 16:2000;591-626.
23. Muller S., Dejean A. Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption. J. Virol. 73:1999;5137-5143.
24. Pichler A., Gast A., Seeler J., Dejean A., Melchior F. The nucleoporin RanBP2 has SUMO-1 E3 ligase activity. Cell. 108:2002;109-120.
25. Postigo A., Dean D. ZEB represses transcription through interaction with the corepressor CtBP. Proc. Natl. Acad. Sci. USA. 96:1999;6683-6688.
26. Riefler G., Firestein B. Binding of neuronal nitric-oxide synthase (nNOS) to CtBP changes the localization of CtBP from the nucleus to the cytosol. a novel function for targeting by the PDZ domain of nNOS J. Biol. Chem. 276:2001;48262-48268.
27. Schaeper U., Boyd J., Verma S., Uhlmann E., Subramanian T., Chinnadurai G. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc. Natl. Acad. Sci. USA. 92:1995;10467-10471.
28. Schmidt D., Muller S. Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. Proc. Natl. Acad. Sci. USA. 99:2002;2872-2877.
29. Turner J., Crossley M. Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators. EMBO J. 17:1998;5129-5140.
30. Verger A., Perdomo J., Crossley M. Modification with SUMO. a role in transcriptional regulation EMBO Rep. 4:2003;137-142.
31. Weigert R., Silletta M.G., Spano S., Turacchio G., Cericola C., Colanzi A., Senatore S., Mancini R., Polishchuk E., Salmona M.et al. CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid. Nature. 402:1999;429-433.
32. Zhang C., McKinsey T., Lu J., Olson E. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J. Biol. Chem. 276:2001;35-39.
33. Zhang Q., Piston D.W., Goodman R.H. Regulation of a corepressor function by nuclear NADH. Science. 295:2002;1895-1987.
34. Zhong S., Muller S., Ronchetti S., Freemont P., Dejean A., Pandolfi P. Role of SUMO-1-modified PML in nuclear body formation. Blood. 95:2000;2748-2752.