Flunarizine in stroke treatment (FIST): A double-blind, placebo-controlled trial in Scandinavia and the Netherlands

Acta Neurologica Scandinavica

Volumn 93, Issue 1, 1996, Pages 56-60

  Franke, C L ^a   Palm, R ^b   Dalby, M ^c   Schoonderwaldt, H C ^d   Hantson, L ^e   Eriksson, B ^f   Lang Jenssen, L ^g   Smakman, J ^h  

^a Zuyderland Medical Centre   (Netherlands)

^b CENTRAL HOSPITAL   (Sweden)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e JANSSEN RESEARCH FOUNDATION   (Belgium)

^f Janssen Pharma AB   (Sweden)

^g Janssen Pharma A S   (Denmark)

^h Janssen Cilag BV Netherlands   (Netherlands)

Author keywords

Calcium entry blocker; Clinical trial; Double blind; Flunarizine; Stroke treatment

Indexed keywords

FLUNARIZINE; PLACEBO;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NETHERLANDS; RANDOMIZED CONTROLLED TRIAL; SCANDINAVIA; STROKE; THROMBOPHLEBITIS;

EID: 0030057032     PISSN: 00016314     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0404.1996.tb00171.x     Document Type: Article

References (23)

1. GARCIA JH. The evolution of brain infarcts. A review. J Neuropathol Exp Neurol 1992: 51: 387-393.
2. LEES KR. Therapeutic interventions in acute stroke. Br J Clin Pharmacol 1992: 34: 486-493.
3. MOHR JP, ORGOGOZO JM, HARRISON MJG et al. Metaanalysis of oral nimodipine trials in acute ischemic stroke. Cerebrovasc Dis 1994: 4: 197-203.
4. FARBER JL. Biology of disease. Membrane injury and calcium homeostasis in the pathogenesis of coagulative necrosis. Lab Invest 1982: 47: 114-123.
5. Trust Study Group. Randomized, double-blind, placebo-controlled trial of nimodipine in acute stroke. Lancet 1990: 336: 1205-1209.
6. The American Nimodipine Study Group. Clinical trial of nimodipine in acute ischaemic stroke. Stroke 1992: 23: 3-8.
7. Louis P. A double-blind placebo-controlled prophylactic study of flunarizine (Sibelium®) in migraine. Headache 1981: 21: 235-239.
8. OOSTERVELD WJ. Flunarizine in vertigo. A double-blind placebo-controlled cross-over evaluation of a constant-dose schedule. ORL J Otorhinolaryngol Relat Spec 1982: 44: 72-80.
9. HÖLLER M, DIERKING H, DENGLER KT, TEGTMEIER F, PETERS T. Effect of flunarizine on extracellular ion concentration in the rat brain under hypoxia and ischaemia. In: BATTISTINE N, COURBIER R, FIORANI P, PLUM F, FIESCHI C, eds. Acute brain ischaemia Medical and surgical therapy. New York: Raven Press: 1986: 229-236.
10. WAUQUIER A, MELIS W, JANSSEN PAJ. Long-term neurological assessment of the post-resuscitative effects of flunarizine, verapamil and nimodipine in a new model of global complete ischaemia. Neuropharmacology 1989: 28: 837-846.
11. DE RYCK M. Animal models of cerebral stroke: pharmacological protection of function. Eur Neurol 1990: 30 (suppl. 2): 21-27.
12. TAKAHASHI K, AKAIKE N. Calcium antagonist effects on low-threshold (T-type) calcium current in rat isolated hippocampal CA1 pyramidal neurons. J Pharmacol Exp Ther 1991: 256: 169-175.
13. LIMBURG M, HIJDRA A. Flunarizine in acute ischaemic stroke: a pilot study. Eur Neurol 1990: 30: 121-122.
14. HÜLSER PJ, BERNHART H, MARBACH C, KORNHUBER HH. Treatment with an IV calcium overload blocker (flunarizine) in acute stroke: a pilot study. Eur Arch Psychiatry Neurol Sci 1988: 237: 253-257.
15. HÜLSER PJ, KORNHUBER AW, KORNHUBER HH. Treatment of acute stroke with calcium antagonists. Eur Neurol 1990: 30 (Suppl. 2): 35-38.
16. ORGOGOZO JM, CAPILDEO R, ANAGNOSTOU CN et al. [Development of a neurological rating scale for the clinical evaluation of infarcts of the medial cerebral artery] (in French). Presse Med 1983: 48: 3039-3044.
17. ORGOGOZO JM. Evaluation of treatments in ischaemic-stroke patients. In: AMERY WK, BOUSSER MG, ROSE FC, eds. Clinical trial methodology in stroke. London: Baillière Tindall: 1989: 35-53.
18. MAHONEY FL, BARTHEL DW. Functional evaluation: the Barthel Index. Md State Med J 1965: 15: 61-65.
19. COLLIN C, WADE DT, DAVIS S, HORNE V. The Barthel ADL index: a reliability study. Int Disability Study 1988: 10: 61-63.
20. RANKIN J. Cerebral vascular accidents in patients over the age of 60. 2. Prognosis, Scott Med J 1957: 2: 200-215.
21. BAMFORD JL, SANDERCOCK PAG, WARLOW CP, SLATTERY J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke 1989: 20: 828.
22. HANTSON L, TRITSMANS L, GHEUENS J, PEELMANS B, CORTEN I. The effect of flunarizine in the treatment of acute ischaemic stroke: a parallel group, double-blind, placebo-controlled trial (FLU-INT-1). Beerse, Belgium: Janssen Research Foundation, 1993.
23. KORNHUBER HH, HARTUNG J, HERRLINGER JD et al. Flunarizine in ischaemic stroke; a randomized, multicentre, placebo-controlled, double blind study. Neurol Psychiatry Brain Res 1993: 1: 1-8.