Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: Pathogenicity analysis of reported somatic mtDNA mutations in tumors

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Pereira, Luísa ^a,b   Soares, Pedro ^a   Máximo, Valdemar ^a,b   Samuels, David C ^c  

^a UNIVERSITY OF PORTO   (Portugal)

^b University of Porto   (Portugal)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

AMINO ACID SUBSTITUTION; ARTICLE; CARCINOGENICITY; CLINICAL EVALUATION; CONTROLLED STUDY; ELECTRON TRANSPORT; GENE EXPRESSION REGULATION; GENE LOCATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR PATHOLOGY; MOLECULAR PHYLOGENY; MUTATIONAL ANALYSIS; NEOPLASM; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; POPULATION RISK; PREDICTION; RISK ASSESSMENT; SOMATIC MUTATION; TUMOR ESCAPE; GENETIC SELECTION; GENETICS; MUTATION; PHENOTYPE; PHYLOGENY; REVIEW;

DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; HUMANS; MITOCHONDRIAL PROTEINS; MUTATION; NEOPLASMS; PHENOTYPE; PHYLOGENY; SELECTION, GENETIC;

EID: 84856420412     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-53     Document Type: Article

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