Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: A study with emphasis on Hürthle cell tumors

American Journal of Pathology

Volumn 160, Issue 5, 2002, Pages 1857-1865

  Máximo, Valdemar ^a   Soares, Paula ^a,b   Lima, Jorge ^a   Cameselle Teijeiro, José ^d   Sobrinho Simões, Manuel ^a,b,c  

^a UNIVERSITY OF PORTO   (Portugal)

^b Faculty of Engineering of Porto   (Portugal)

^c HOSPITAL DE SÃO JOÃO   (Portugal)

^d University Hospital of Santiago de Compostela   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA POLYMORPHISM; DNA SEQUENCE; GENE DELETION; GENE FREQUENCY; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MITOCHONDRIAL GENETICS; ONCOCYTOMA; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; THYROID ADENOMA; THYROID CANCER; THYROID FOLLICULAR CARCINOMA; THYROID PAPILLARY CARCINOMA;

EID: 0036095510     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61132-7     Document Type: Article

References (60)

1. Hashimoto thyroiditis is associated with defects of cytochrome-c oxidase in oxyphil Askanazy cells and with the common deletion (4,977) of mitochondrial DNA
2. Hurthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance
3. Solitary, multiple, and familial oxyphil tumours of the thyroid gland
4. A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2
5. Fidelity of mammalian DNA polymerases
6. Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene
7. Covalent binding of polycyclic aromatic compounds to mitochondrial and nuclear DNA
8. Role of superoxide dismutase in cancer: A review
9. Hypermutability and mismatch repair deficiency in RER+ tumor cells
10. Microsatellite Instability, mismatch repair deficiency, and genetic defects in human cancer cell lines
11. Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: Evidence for separate mitochondrial and nuclear functions
12. Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: Evidence for mismatch repair systems in mitochondrial genome
13. Mutations in mitochondrial control region DNA in gastric tumours of Japanese patients
14. Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma
15. Nuclear and mitochondrial genome instability in human breast cancer
16. Comments on mutations in mitochondrial control region DNA in gastric tumours of Japanese patients
17. Microsatellite instability, mitochondrial DNA large deletions, and mitochondrial DNA mutations in gastric carcinoma
18. The common deletion of mitochondrial DNA is found in goitres and thyroid tumors with and without oxyphil cell change
19. Somatic mitochondrial mutation in gastric cancer
20. Mitochondrial gene mutation, but not large-scale deletion, is a feature of colorectal carcinomas with mitochondrial microsatellite instability
21. Somatic mutations of the mitochondrial genome in human colorectal tumours
22. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids
23. Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours
24. Mitochondrial DNA 'common' deletion in Hurthle cell lesions of the thyroid
25. Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin's tumour
26. Analysis of nuclear and mitochondrial DNA alterations in thyroid and renal oncocytic tumors
27. Functional and molecular analysis of mitochondria in thyroid oncocytoma
28. Histological typing of thyroid tumors
29. Tumors of the thyroid gland
30. The frequency of 4977 base pair deletion of mitochondrial DNA in various types of liver disease and in normal liver
31. Coordinate expression of nuclear and mitochondrial genes involved in energy production in carcinoma and oncocytoma
32. Mitochondrial myopathies. Clinical, morphological and biochemical aspects
33. Mitochondrial diseases and myopathies: A series of muscle biopsy specimens with ultrastructural changes in the mitochondria
34. Kearns-Sayre syndrome: Oncocytic transformation of choroid plexus epithelium
35. Oncocytic transformation of choroid plexus epithelium
36. Involvement of choroid plexus in mitochondrial encephalomyopathy (MELAS)
37. The unusual structures of the hot-regions flanking large-scale deletions in human mitochondrial DNA
38. Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder
39. Maintenance and integrity of the mitochondrial genome: A plethora of nuclear genes in the budding yeast
40. Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems
41. Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors
42. Mitochondrial genetics: A paradigm for aging and degenerative diseases?
43. Oxidative damage to DNA: Relation to species metabolic rate and life span
44. Oxidants, antioxidants, and the degenerative diseases of aging
45. Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: A slip-replication model and metabolic therapy
46. Absence of microsatellite instability in thyroid carcinomas
47. Benign and malignant thyroid lesions show instability at microsatellite loci
48. Prevalence of minisatellite and microsatellite instability in radiation-induced post-Chernobyl pediatric thyroid carcinomas
49. Microsatellite instability in thyroid tumours and tumour-like lesions
50. High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection
51. Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations
52. Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes
53. Suppression of a mitochondrial tRNA gene mutation phenotype associated with changes in the nuclear background
54. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
55. Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice
56. Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy
57. Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors
58. Assembly of functional proton-translocating ATPase complex in yeast mitochondria with cytoplasmically synthesized subunit 8, a polypeptide normally encoded within the organelle
59. Localization on mitochondrial DNA of mutations leading to a loss of rutamycin-sensitive adenosine triphosphatase
60. Absence of electron transport (Rho° state) restores growth of a manganese-superoxide dismutase-deficient Saccharomyces cerevisiae in hyperoxia. Evidence for electron transport as a major source of superoxide generation in vivo