Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma

Human Molecular Genetics

Volumn 17, Issue 7, 2008, Pages 986-995

  Gasparre, Giuseppe ^a,e   Hervouet, Eric ^b,c,d   de Laplanche, Elodie ^b,c,d   Demont, Jocelyne ^b,c,d   Pennisi, Lucia Fiammetta ^a   Colombel, Marc ^f   Mège Lechevallier, Florence ^g   Scoazec, Jean Yves ^g   Bonora, Elena ^a   Smeets, Roel ^h   Smeitink, Jan ^h   Lazar, Vladimir ^g   Lespinasse, James ^h   Giraud, Sophie ^d   Godinot, Catherine ^b,c,d   Romeo, Giovanni ^a   Simonnet, Hélène ^b,c,d,e  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITÉ LYON 1   (France)

^d CNRS   (France)

^e EDOUARD HERRIOT HOSPITAL   (France)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^g INSTITUT GUSTAVE ROUSSY   (France)

^h CENTRE HOSPITALIER DE CHAMBÉRY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CITRATE SYNTHASE; CYTOCHROME C OXIDASE; DNA DIRECTED DNA POLYMERASE GAMMA; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE;

ARTICLE; CARCINOGENESIS; CELL DIVISION; COMPARATIVE GENOMIC HYBRIDIZATION; COMPLEX I DEFICIENCY; CONTROLLED STUDY; DNA SEQUENCE; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE MUTATION; GENE REARRANGEMENT; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; KARYOTYPING; KIDNEY TUMOR; MITOCHONDRION; ONCOCYTOMA; OXIDATIVE PHOSPHORYLATION; POINT MUTATION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC MUTATION; TUMOR GROWTH;

ADENOMA, OXYPHILIC; CELL CULTURE TECHNIQUES; CELL NUCLEUS; CELL PROLIFERATION; CITRATE (SI)-SYNTHASE; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ELECTRON TRANSPORT COMPLEX I; GENE AMPLIFICATION; GLUCOSE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY NEOPLASMS; NADH DEHYDROGENASE; NUCLEIC ACID HYBRIDIZATION; OXIDATIVE PHOSPHORYLATION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA;

EID: 41149143265     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddm371     Document Type: Article

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