Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 21, 2007, Pages 9001-9006

  Gasparre, Giuseppe ^a   Porcelli, Anna Maria ^b   Bonora, Elena ^a   Pennisi, Lucia Fiammetta ^a   Toller, Matteo ^c   Iommarini, Luisa ^b   Ghelli, Anna ^b   Moretti, Massimo ^c   Betts, Christine M ^b   Martinelli, Giuseppe Nicola ^a   Ceroni, Alberto Rinaldi ^b   Curcio, Francesco ^c   Carelli, Valerio ^b   Rugolo, Michela ^b   Tallini, Giovanni ^b   Romeo, Giovanni ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF UDINE   (Italy)

Author keywords

Damaging mutation; Heteroplasmy; Homoplasmy; Microenvironment; Oncocytic tumors

Indexed keywords

MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); PROTEIN SUBUNIT; TUMOR MARKER;

ARTICLE; BREAST TUMOR; CANCER GENETICS; CONTROLLED STUDY; DNA DETERMINATION; DNA SEQUENCE; ELECTRON MICROSCOPY; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MUTATIONAL ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; THYROID TUMOR; CELL CULTURE; GENETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; THYROID PARAFOLLICULAR CELL;

BASE SEQUENCE; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; HUMANS; MUTATION; OXYPHIL CELLS; PHENOTYPE; PROTEIN SUBUNITS; THYROID NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 34547480470     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0703056104     Document Type: Article

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