In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: Key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH

International Journal of Cancer

Volumn 130, Issue 7, 2012, Pages 1511-1520

  Chiche, Johanna ^a   Fur, Yann Le ^b   Vilmen, Christophe ^b   Frassineti, Frédéric ^c   Daniel, Laurent ^c   Halestrap, Andrew P ^d   Cozzone, Patrick J ^b   Pouysségur, Jacques ^a   Lutz, Norbert W ^b  

^a CENTRE ANTOINE LACASSAGNE   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c University of the Mediterranean Aix Marseille II   (France)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

cancer therapy; metabolism; proton transport; tumor pH

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MONOCARBOXYLATE TRANSPORTER 4; SODIUM PROTON EXCHANGE PROTEIN 1;

ALKALINITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL METABOLISM; CELL PH; CONTROLLED STUDY; DNA MODIFICATION; EXTRACELLULAR PH; FIBROBLAST CULTURE; GENETIC VARIABILITY; GLYCOLYSIS; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE PHOSPHORYLATION; PH; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTON TRANSPORT; STEADY STATE; TUMOR GROWTH; TUMOR REGRESSION; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CRICETINAE; FIBROBLASTS; GENES, RAS; GLYCOLYSIS; HYDROGEN-ION CONCENTRATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ION EXCHANGE; ION TRANSPORT; MICE; MICE, NUDE; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; MUTATION; NECROSIS; OXIDATIVE PHOSPHORYLATION; PHOSPHOLIPIDS; PROTONS; SODIUM-HYDROGEN ANTIPORTER;

EID: 84856327997     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26125     Document Type: Article

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