M cell-targeted mucosal vaccine strategies

Current Topics in Microbiology and Immunology

Volumn 354, Issue 1, 2012, Pages 39-52

  Yamamoto, M ^a   Pascual, D W ^b   Kiyono, H ^c  

^a NIHON UNIVERSITY   (Japan)

^b MONTANA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; AGGLUTININ; BACTERIAL PROTEIN; CHOLERA TOXIN; DNA VACCINE; ESCHERICHIA COLI ENTEROTOXIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN A; IMMUNOLOGICAL ADJUVANT; INVASIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY NKM 16 2 4; PEPTIDE; POLYLYSINE; PROTEIN FIMH; REOVIRUS PROTEIN SIGMA 1; TYROSYLGLUTAMINYLCYSTYLSERYLTYROSYLTHREONYLMETHIONYLPROLYLHISTIDYLPROLYLPROLYLVALINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AERODIGESTIVE SYSTEM; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CELLULAR IMMUNITY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DIGESTIVE SYSTEM; DRUG DELIVERY SYSTEM; DRUG SAFETY; HUMAN; HUMORAL IMMUNITY; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; INTESTINE CELL; LYMPH FOLLICLE; LYMPHOID CELL; MICROFOLD CELL; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; TARGET CELL;

ANIMALS; EPITHELIUM; HUMANS; INTESTINES; MUCOUS MEMBRANE; VACCINES;

EID: 84856187491     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82_2011_134     Document Type: Review

References (72)

1. Bockman DE, Cooper MD (1973) Pinocytosis by epithelium associated with lymphoid follicles in the bursa of Fabricius, appendix, and Peyer's patches. An electron microscopic study. Am J Anat 136:455-477
2. Chieppa M, Rescigno M, Huang AY et al (2006) Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med 203:2841-2852 (Pubitemid 46026162)
3. Clark MA, Hirst BH, Jepson MA (1998) M-cell surface beta 1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer's patch M cells. Infect Immun 66:1237-1243 (Pubitemid 28101170)
4. Craig SW, Cebra JJ (1971) Peyer's patches: an enriched source of precursors for IgA-producing immunocytes in the rabbit. J Exp Med 134:188-200
5. De Haan L, Verweij WR, Feil IK et al (1996) Mutants of the Escherichia coli heat-labile enterotoxin with reduced ADP-ribosylation activity or no activity retain the immunogenic properties of the native holotoxin. Infect Immun 64:5413-5416 (Pubitemid 26404013)
6. Debard N, Sierro F, Browning J et al (2001) Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches. Gastroenterology 120:1173-1182 (Pubitemid 32246671)
7. Debertin AS, Tschernig T, Tonjes H et al (2003) Nasal-associated lymphoid tissue (NALT): frequency and localization in young children. Clin Exp Immunol 134:503-507 (Pubitemid 37542092)
8. Di Tommaso A, Saletti G, Pizza M et al (1996) Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant. Infect Immun 64:974-979 (Pubitemid 26069681)
9. Douce G, Fontana M, Pizza M et al (1997) Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin. Infect Immun 65:2821-2828 (Pubitemid 27264113)
10. Faria AM, Weiner HL (1999) Oral tolerance: mechanisms and therapeutic applications. Adv Immunol 73:153-264 (Pubitemid 29300430)
11. Faria AM, Maron R, Ficker SM et al (2003) Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis. J Autoimmun 20:135-145 (Pubitemid 36349072)
12. Finzi G, Cornaggia M, Capella C et al (1993) Cathepsin E in follicle associated epithelium of intestine and tonsils: localization to M cells and possible role in antigen processing. Histochemistry 99:201-211 (Pubitemid 23103534)
13. Fleeton MN, Contractor N, Leon F et al (2004) Peyer's patch dendritic cells process viral antigen from apoptotic epithelial cells in the intestine of reovirus-infected mice. J Exp Med 200:235-245 (Pubitemid 38982182)
14. Frey A, Giannasca KT, Weltzin R et al (1996) Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting. J Exp Med 184:1045-1059 (Pubitemid 26313562)
15. Fujihashi K, Dohi T, Rennert PD et al (2001a) Peyer's patches are required for oral tolerance to proteins. Proc Natl Acad Sci USA 98:3310-3315 (Pubitemid 32220842)
16. Fujihashi K, Kato H, van Ginkel FW et al (2001b) A revisit of mucosal IgA immunity and oral tolerance. Acta Odontol Scand 59:301-308 (Pubitemid 33636616)
17. Giuliani MM, Del Giudice G, Giannelli V et al (1998) Mucosal adjuvanticity and immunoge-nicity of LTR72, a novel mutant of Escherichia coli heat-labile enterotoxin with partial knockout of ADP-ribosyltransferase activity. J Exp Med 187:1123-1132 (Pubitemid 28176412)
18. Golovkina TV, Shlomchik M, Hannum L et al (1999) Organogenic role of B lymphocytes in mucosal immunity. Science 286:1965-1968 (Pubitemid 129515907)
19. Hase K, Kawano K, Nochi T et al (2009) Uptake through glycoprotein 2 of FimH(F) bacteria by M cells initiates mucosal immune response. Nature 462:226-230
20. Higgins LM, Lambkin I, Donnelly G et al (2004) In vivo phage display to identify M cell-targeting ligands. Pharm Res 21:695-705 (Pubitemid 38457294)
21. Holmgren J, Czerkinsky C (2005) Mucosal immunity and vaccines. Nat Med 11:S45-S53 (Pubitemid 40562303)
22. Izcue A, Coombes JL, Powrie F (2009) Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 27:313-338
23. Jahnsen FL, Strickland DH, Thomas JA et al (2006) Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus. J Immunol 177:5861-5867 (Pubitemid 44628799)
24. Jang MH, Kweon MN, Iwatani K et al (2004) Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc Natl Acad Sci USA 101:6110-6115 (Pubitemid 38520536)
25. Jones BD, Ghori N, Falkow S (1994) Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches. J Exp Med 180:15-23 (Pubitemid 24181051)
26. Jun S, Gilmore W, Callis G et al (2005) A live diarrheal vaccine imprints a Th2 cell bias and acts as an anti-inflammatory vaccine. J Immunol 175:6733-6740 (Pubitemid 41598917)
27. Kandori H, Hirayama K, Takeda M et al (1996) Histochemical, lectin-histochemical and morphometrical characteristics of intestinal goblet cells of germfree and conventional mice. Exp Anim 45:155-160 (Pubitemid 126419624)
28. Karchev T, Kabakchiev P (1984) M-cells in the epithelium of the nasopharyngeal tonsil. Rhinology 22:201-210 (Pubitemid 14033980)
29. Kerneis S, Bogdanova A, Kraehenbuhl JP et al (1997) Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria. Science 277:949-952 (Pubitemid 27366679)
30. Kiyono H, Fukuyama S (2004) NALT-versus Peyer's-patch-mediated mucosal immunity. Nat Rev Immunol 4:699-710 (Pubitemid 39223076)
31. Kiyono H, Kunisawa J, McGhee J et al (2008) The mucosal immune system. In: Paul WE (ed) Fundamental immunology. Lippincott-Raven, Philadelphia
32. Kraehenbuhl JP, Neutra MR (2000) Epithelial M cells: differentiation and function. Annu Rev Cell Dev Biol 16:301-332 (Pubitemid 32037509)
33. Kunisawa J, Fukuyama S, Kiyono H (2005) Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system. Curr Mol Med 5:557-572 (Pubitemid 41236556)
34. Kunisawa J, Nochi T, Kiyono H (2008) Immunological commonalities and distinctions between airway and digestive immunity. Trends Immunol 29:505-513
35. Lemiale F, Kong WP, Akyurek LM et al (2003) Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system. J Virol 77:10078-10087 (Pubitemid 37122089)
36. Lewis DJ, Huo Z, Barnett S et al (2009) Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS One 4:e6999
37. Lloyd CM, Hawrylowicz CM (2009) Regulatory T cells in asthma. Immunity 31:438-449
38. Lycke N (2005) From toxin to adjuvant: basic mechanisms for the control of mucosal IgA immunity and tolerance. Immunol Lett 97:193-198 (Pubitemid 40326951)
39. Manocha M, Pal PC, Chitralekha KT et al (2005) Enhanced mucosal and systemic immune response with intranasal immunization of mice with HIV peptides entrapped in PLG microparticles in combination with Ulex europaeus-I lectin as M cell target. Vaccine 23:5599-5617 (Pubitemid 41608610)
40. Martinoli C, Chiavelli A, Rescigno M (2007) Entry route of Salmonella typhimurium directs the type of induced immune response. Immunity 27:975-984 (Pubitemid 50013977)
41. Mowat AM (2003) Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 3:331-341 (Pubitemid 37328685)
42. Murai M, Turovskaya O, Kim G et al (2009) Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol 10:1178-1184
43. Mutsch M, Zhou W, Rhodes P et al (2004) Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland. N Engl J Med 350:896-903 (Pubitemid 38252537)
44. Neutra MR, Frey A, Kraehenbuhl JP (1996) Epithelial M cells: gateways for mucosal infection and immunization. Cell 86:345-348 (Pubitemid 26272074)
45. Neutra MR, Phillips TL, Mayer EL et al (1987) Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch. Cell Tissue Res 247: 537-546 (Pubitemid 17019581)
46. Niedergang F, Kraehenbuhl JP (2000) Much ado about M cells. Trends Cell Biol 10:137-146
47. Niess JH, Brand S, Gu X et al (2005) CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307:254-258 (Pubitemid 40116240)
48. Nochi T, Yuki Y, Matsumura A et al (2007) A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses. J Exp Med 204:2789-2796 (Pubitemid 350179549)
49. Ogra PL, Faden H, Welliver RC (2001) Vaccination strategies for mucosal immune responses. Clin Microbiol Rev 14:430-445 (Pubitemid 32294678)
50. Owen RL (1977) Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer's patches in the normal unobstructed mouse intestine: an ultrastructural study. Gastroenterology 72:440-451 (Pubitemid 8036720)
51. Owen RL, Jones AL (1974) Epithelial cell specialization within human Peyer's patches: an ultrastructural study of intestinal lymphoid follicles. Gastroenterology 66:189-203
52. Rescigno M, Urbano M, Valzasina B et al (2001) Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2:361-367 (Pubitemid 33706348)
53. Rynda A, Maddaloni M, Mierzejewska D et al (2008) Low-dose tolerance is mediated by the microfold cell ligand, reovirus protein sigma1. J Immunol 180:5187-5200
54. Sakaguchi S, Ono M, Setoguchi R et al (2006) Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev 212:8-27 (Pubitemid 44116697)
55. Sakaguchi S, Yamaguchi T, Nomura T et al (2008) Regulatory T cells and immune tolerance. Cell 133:775-787 (Pubitemid 351707693)
56. Savidge TC, Smith MW (1995) Evidence that membranous (M) cell genesis is immuno-regulated. Adv Exp Med Biol:239-241
57. Sicinski P, Rowinski J, Warchol JB et al (1990) Poliovirus type 1 enters the human host through intestinal M cells. Gastroenterology 98:56-58 (Pubitemid 20017783)
58. Suzuki H, Sekine S, Kataoka K et al (2008) Ovalbumin-protein sigma 1 M-cell targeting facilitates oral tolerance with reduction of antigen-specific CD4+ T cells. Gastroenterology 135:917-925
59. Teitelbaum R, Schubert W, Gunther L et al (1999) The M cell as a portal of entry to the lung for the bacterial pathogen Mycobacterium tuberculosis. Immunity 10:641-650 (Pubitemid 29302917)
60. Terahara K, Yoshida M, Igarashi O et al (2008) Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells. J Immunol 180:7840-7846
61. Tsuji M, Komatsu N, Kawamoto S et al (2009) Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 323:1488-1492
62. Unutmaz D, Pulendran B (2009) The gut feeling of Treg cells: IL-10 is the silver lining during colitis. Nat Immunol 10:1141-1143
63. Van Ginkel FW, Jackson RJ, Yuki Y et al (2000) Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues. J Immunol 165:4778-4782
64. Wang X, Hone DM, Haddad A et al (2003) M cell DNA vaccination for CTL immunity to HIV. J Immunol 171:4717-4725 (Pubitemid 37310589)
65. Wang X, Kochetkova I, Haddad A et al (2005) Transgene vaccination using Ulex europaeus agglutinin I (UEA-1) for targeted mucosal immunization against HIV-1 envelope. Vaccine 23:3836-3842 (Pubitemid 40704748)
66. Weiner HL (2000) Oral tolerance, an active immunologic process mediated by multiple mechanisms. J Clin Invest 106:935-937
67. Wu Y, Boysun MJ, Csencsits KL et al (2000) Gene transfer facilitated by a cellular targeting molecule, reovirus protein sigma1. Gene Ther 7:61-69 (Pubitemid 30077150)
68. Wu Y, Wang X, Csencsits KL et al (2001) M cell-targeted DNA vaccination. Proc Natl Acad Sci USA 98:9318-9323 (Pubitemid 32743914)
69. Xiao BG, Link H (1997) Mucosal tolerance: a two-edged sword to prevent and treat autoimmune diseases. Clin Immunol Immunopathol 85:119-128 (Pubitemid 27512953)
70. Yamamoto M, Briles DE, Yamamoto S et al (1998) A nontoxic adjuvant for mucosal immunity to pneumococcal surface protein A. J Immunol 161:4115-4121 (Pubitemid 28468991)
71. Yamamoto M, McGhee JR, Hagiwara Y et al (2001) Genetically manipulated bacterial toxin as a new generation mucosal adjuvant. Scand J Immunol 53:211-217 (Pubitemid 32193685)
72. Yamamoto S, Kiyono H, Yamamoto M et al (1997) A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci USA 94:5267-5272 (Pubitemid 27214772)