A revisit of mucosal IgA immunity and oral tolerance

Acta Odontologica Scandinavica

Volumn 59, Issue 5, 2001, Pages 301-308

  Fujihashi, Kohtaro ^a   Kato, Hirotomo ^a   Van Ginkel, Frederik W ^a   Koga, Toshiya ^a   Boyaka, Prosper N ^a   Jackson, Raymond J ^a   Kato, Rie ^a   Hagiwara, Yukari ^a   Etani, Yuri ^a   Goma, Iwao ^a   Fujihashi, Keiko ^a   Kiyono, Hiroshi ^a   McGhee, Jerry R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Aging; Mucosa; Tolerance; Toxicity; Vaccines

Indexed keywords

CHOLERA TOXIN; SECRETORY IMMUNOGLOBULIN; VACCINE;

AGING; ANIMAL; CENTRAL NERVOUS SYSTEM; DRUG EFFECT; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; MOUSE; MOUTH MUCOSA; MUCOSAL IMMUNITY; PEYER PATCH; REVIEW;

ADMINISTRATION, INHALATION; AGING; ANIMALS; CENTRAL NERVOUS SYSTEM; CHOLERA TOXIN; HUMANS; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A, SECRETORY; MICE; MOUTH MUCOSA; PEYER'S PATCHES; VACCINES, CONJUGATE;

EID: 18044403931     PISSN: 00016357     EISSN: None     Source Type: Journal    
DOI: 10.1080/000163501750541174     Document Type: Article

References (64)

1. McGhee JR, Kiyono H. Mucosal immunology. In: Paul WE, editor. Fundamental immunology. 4th ed. San Diego (CA): Academic Press; 1999. p. 909-45.
2. McGhee JR, Lamm ME, Strober W. Mucosal immune responses: an overview. In: Ogra PL, Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, editors. Mucosal immunology. 2nd ed. San Diego (GA): Academic Press; 1999. p. 485-506.
3. Kato T, Owen RL. Structure and function of intestinal mucosal epithelium. In: Ogra PL, Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, editors. Mucosal immunology. 2nd ed. San Diego (CA): Academic Press; 1999. p. 115-32.
4. Tomasi TB. Oral tolerance. Transplantation 1980;29:353-6.
5. Mowat AM. The regulation of immune responses to dietary protein antigens. Immunol Today 1987; 8:93-8.
6. Weiner HL, Friedman A, Miller A, Khoury SJ. Al-Sabbagh A, Santos L, et al. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 1994;12:809-37.
7. Challacombe SJ, Tomasi TB. Systemic tolerance and secretory immunity after oral immunization. J Exp Med 1980;152:1459-72.
8. Mowat AM, Weiner HL. Oral tolerance: physiological basis and clinical applications. In: Ogra PL, Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, editors. Mucosal immunology. 2nd ed. San Diego (CA): Academic Press; 1998. p. 587-618.
9. Mayer L. Oral tolerance: new approaches, new problems. Clin Immunol 2000;94:1-8.
10. Wardrop RM, Whitacre CC. Oral tolerance in the treatment of inflammatory autoimmune diseases. Inflamm Res 1999;48:106-19.
11. MacDonald, TT. T cell immunity to oral allergens. Curr Opin Immunol 1998;10:620-7.
12. Holt PG. Mucosal immunity in relation to the development of oral tolerance/sensitization. Allergy 1998;53:16-9.
13. Strobel S, Mowat AM. Immune responses to dietary antigens: oral tolerance. Immunol Today 1998;19:173-81.
14. Strober W, Kelsall B, Marth T. Oral tolerance. J Clin Immunol 1998;18:1-30.
15. Fujihashi, K, McGhee JR, Yamamoto M, Hiroi T, Kiyono H. Role of γΔ T cells in the regulation of mucosal IgA response and oral tolerance. Ann NY Acad Sci 1996;778:55-63.
16. Thomas HC, Parrott MV. The induction of tolerance to a soluble protein antigen by oral administration. Immunology 1971;27: 631-9.
17. Kagnoff MF. Effects of antigen-feeding on intestinal and systemic immune responses. IV. Similarity between the suppressor factor in mice after crythrocyte-lysate injection and crythrocyte feeding. Gastroenterology 1980;79:1-61.
18. Kiyono H, Babb JL, Michalek SM, McGhee JR. Cellular basis for elevated IgA responses in C3H/HeJ mice. J Immunol 1980; 125:732-7.
19. Kiyono H, McGhee JR, Wannemuchlen MJ, Michalek SM. Lack of oral tolerance in C3H/HeJ mice. J Exp Med 1982;155:605-10.
20. Mattingly JA, Waksman BH. Immunologic suppression after oral administration of antigen. I. Specific suppressor cells formed in rat Peyer's patches after oral administration of sheep erythrocytes and their systemic migration. J Immunol 1978;121:1878-83.
21. Mowat AM, Lamont AG, Parrott DM. Suppressor T cells, antigen-presenting cells and the role of I-J restriction in oral tolerance to ovalbumin. Immunology 1988;64:141-5.
22. Richman LK, Graeff AS, Yarchoan R, Strober W. Simultaneous induction of antigen-specific IgA helper T cells and IgG suppressor T cells in the murine Peyer's patch after protein feeding. J Immunol 1981;126:2079-83.
23. Ngan J, Kind LS. Suppressor T cells for IgE and IgG in Peyer's patches of mice made tolerant by the oral administration of ovalbumin. J Immunol 1978;120:861-5.
24. Elson CO, Ealding W. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin. J Immunol 1984;132:2736-41.
25. Xu-Amano J, Kiyono H, Jackson RJ, Staats HF, Fujihashi K, Burrows PD, et al. Helper T cell subsets for immunoglobulin A responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med 1993;178:1309-20.
26. Clements JD, Hartzog NM, Lyon FL. Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens. Vaccine 1988;6:269-77.
27. Marinaro M, Staats HF, Hiroi T, Jackson RJ, Coste M, Boyaka PN, et al. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J Immunol 1995;155:4621-9.
28. Takahashi I, Kiyono H, Marinaro M, Jackson RJ, Nakagawa I, Fujihashi K, et al. Mechanisms for mucosal immunogenicity and adjuvanticity of Escherichia coli labile enterotoxin. J Infect Dis 1996;173:627-35.
29. Tsuji T, Inoue T, Miyama A, Okamoto K, Honda T, Miwatani T. A single amino acid substitution in the A subunit of Escherichia coli enterotoxin results in a loss of its toxic activity. J Biol Chem 1990;265:22520-5.
30. Sixma TK, Pronk SE, Kalk KH, van Zanten BA, Berghuis AM, Hol WG. Lactose binding to heat labile enterotoxin revealed by X-ray crystallography. Nature 1992;355:561-4.
31. Lycke N, Tsuji T, Holmgren J. The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity. Eur J Immunol 1992;22: 2277-81.
32. Komase K, Tamura S-I, Matsuo K, Watanabe K, Hattori N, Odaka A, et al. Mutants of Escherichia coli heat-labile enterotoxin as an adjuvant for nasal influenza vaccine. Vaccine 1998;16:248-54.
33. Douce G, Turcotie C, Cropley I, Roberts M, Pizza M, Domenghini M, et al. Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants. Proc Natl Acad Sci USA 1995;92:1644-8.
34. Dickinson BL, Clements JD. Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity. Infect Immun 1995;63:1617-23.
35. Pizza M, Domenighini M, Hol W, Giannelli V, Fontana MR, Giuliani MM, et al. Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis. Mol Microbiol 1994;14:51-60.
36. Di Tommaso A, Saletti G, Pizza M, Rappuoli R, Dougan G, Abrignani S, et al. Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant. Infect Immun 1996;64:974-9.
37. Yamamoto S, Takeda Y, Yamamoto M, Kurazono H, Imaoka K, Yamamoto M, et al. Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrhoeagenicity but retain adjuvanticity. J Exp Med 1997;185:1203-10.
38. Yamamoto S, Kiyono H, Yamamoto M, Imaoka K, Yamamoto M. Fujihashi K, et al. A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc Natl Acad Sci USA 1997;94:5267-72.
39. Lencer WI, Hirst TR, Holmes RK. Membrane traffic and the cellular uptake of cholera toxin. Biochim Biophys Acta 1999; 1450:177-90.
40. Bourguignon P, Bisteau M. Abarca J, Veenstra S, Hermand P. Henderickx V, et al. Reactogenicity in the nose and the brain of enterotoxins administered intranasally to mice. In: Proceedings of the Cold Spring Harbor Conference on Molecular Approaches to Vaccine Design; 1999 Dec 2-5. p. 23.
41. van Ginkel FW, Jackson, RJ, Yuki Y. McGhee JR. Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues. J Immunol 2000;165:4778-82.
42. Koga T, McGhee JR, Kato H, Kato R, Kiyono H, Fujihashi K. Evidence for early aging in the mucosal immune system. J Immunol 2000;165:5352-9.
43. Czerkinsky C, Anjuere F, McGhee JR, George-Chandy A, Holmgren J, Kieny MP, et al. Mucosal immunity and tolerance: relevance to vaccine development. Immunol Rev 1999;170:197-222.
44. Elson CO, Ealding W. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen. J Immunol 1984;133:2892-7.
45. Kato H, Fujihashi K, Kalo R, McGhee JR. Prior oral tolerization abrogates cholera toxin-induced IgA responses in gastrointestinal tract. J Immunol 2001;166:3114-21.
46. De Togni P, Goellner J, Ruddle NH, Streeter PR, Fick A. Mariathasan S, et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 1994;264:703-7.
47. Banks TA, Rouse BT, Kerley MK, Blair PJ, Godfrey VL, Kuklin NA, et al. Lymphotoxin-α-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol 1995;155:1685-93.
48. Alimzhanov MB, Kuprash DV, Kosco VM, Luz A, Turetskaya RL, Tarakhovsky A, et al. Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice. Proc Natl Acad Sci USA 1997;94:9302-7.
49. Koni PA, Sacca R, Lawton P, Browning JL, Ruddle NH, Flavell RA. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity 1997;6:491-500.
50. Koni PA, Flavell RA. A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: genetic evidence of synergism with lymphotoxin β. J Exp Med 1998; 187:1977-83.
51. Futterer A, Mink K, Luz A, Kosco VM, Pfeffer K. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 1998;9:59-70.
52. Rennert PD, Browning JL, Mebius R, Mackay F, Hochman PS. Surface lymphotoxin α/β complex is required for the development of peripheral lymphoid organs. J Exp Med 1990;184:1999-2006.
53. Rennert PD, James D, Mackay F, Browning JL, Hochman PS. Lymph node genesis is induced by signaling through the lympholoxin β receptor. Immunity 1998;9:71-9.
54. Rennert PD, Browning JL, Hochman PS. Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization. Intern Immunol 1997;9:1627-39.
55. Fujihashi K, Dohi T, Rennert PD, Koga T, Kiyono H, McGhee JR. Peyer's patches are required for oral tolerance to proteins. Proc Natl Acad Sci USA 2001;98:3310-5.
56. Shroff KE, Meslin K, Cebra JJ. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infect Immun 1995;63: 3904-13.
57. Wannemuehler MJ, Kiyono H, Babb JL, Michalek SM, McGhee JR. Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance induction. J Immunol 1982;129:959-65.
58. Kramer DR, Cebra JJ. Early appearance of "natural" mucosal IgA responses and germinal centers in suckling mice developing in the absence of maternal antibodies. J Immunol 1995;154: 2051-62.
59. Coffman RL, Lebman DA, Shrader B. Transforming growth factor □ specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J Exp Med 1989; 170:1039-44.
60. Sonoda E, Matsumoto R, Hitoshi Y, Ishii T, Sugimoto M, Araki S, et al. Transforming growth factor β induces IgA production and acts additively with interleukin 5 for IgA production. J Exp Med 1989;170:1415-20.
61. Mowat AM, Steel M, Leishman AJ, Garside P. Normal induction of oral tolerance in the absence of a functional IL-12-dependcnl IFN-γ signaling pathway. J Immunol 1999;163:4728-36.
62. Gonnella PA, Chen Y, Inobe J, Komagala Y, Quartulli M, Weiner HL. In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice. J Immunol 1998;160:4708-18.
63. Yamamoto M, Rennert PD, McGhee JR, Kweon M-N, Yamamoto S, Dohi T, et al. An alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the GI tract. J Immunol 2000;164:5184-91.
64. Viney JL, Mowat AM, O'Malley JM, Williamson E, Fanger NA. Expanding dendritic cells in vivo enhances the induction of oral tolerance. J Immunol 1998;160:5815-25.