A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 10, 1997, Pages 5267-5272

  Yamamoto, Shingo ^a,b   Kiyono, Hiroshi ^a,c   Yamamoto, Masafumi ^a   Imaoka, Koichi ^a   Yamamoto, Miho ^a   Fujihashi, Kohtaro ^a   Van Ginkel, Frederik W ^a   Noda, Masatoshi ^d   Takeda, Yoshifumi ^e   McGhee, Jerry R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b KYOTO UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d CHIBA UNIVERSITY   (Japan)

^e NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

cholera toxin mutant; mucosal immunity; Th1 and Th2 subsets

Indexed keywords

CHOLERA TOXIN; IMMUNOGLOBULIN E; INTERLEUKIN 4; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENYLALANINE;

ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; ESCHERICHIA COLI; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE DIAGNOSIS; VIBRIO CHOLERAE;

ANIMALS; ANTIBODY FORMATION; CD4-POSITIVE T-LYMPHOCYTES; CHOLERA TOXIN; CYTOKINES; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKINS; INTESTINAL MUCOSA; LUNG; LYMPH NODES; MICE; MICE, INBRED C57BL; OVALBUMIN; PEYER'S PATCHES; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; RNA, MESSENGER; SPLEEN; TH2 CELLS;

EID: 0007205169     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.10.5267     Document Type: Article

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