A live diarrheal vaccine imprints a Th2 cell bias and acts as an anti-inflammatory vaccine

Journal of Immunology

Volumn 175, Issue 10, 2005, Pages 6733-6740

  Jun, Sangmu ^a   Gilmore, Wendy ^b   Callis, Gayle ^a   Rynda, Agnieszka ^a   Haddad, Asmahan ^a   Pascual, David W ^a  

^a MONTANA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; ANTIINFLAMMATORY AGENT; COLONIZATION FACTOR ANTIGEN I; ESCHERICHIA COLI ENDOTOXIN; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; LIVE VACCINE; PROTEOLIPID; PROTEOLIPID PROTEIN[139-151]; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DIARRHEA; DOWN REGULATION; ESCHERICHIA COLI; EXPRESSION VECTOR; FEMALE; FIMBRIA; GRAY MATTER; IMMUNOSTIMULATION; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; MACROPHAGE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SALMONELLA; SPINAL CORD; TH2 CELL; WHITE MATTER;

EID: 27744460743     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.10.6733     Document Type: Article

References (61)

1. Boedeker, E. C. 2005. Vaccines for enterotoxigenic Escherichia coli: current status. Curr. Opin. Gastroenterol. 21: 15-19.
2. Field, M., L. H. Graf, W. J. Laird, and P. L. Smith. 1978. Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration and ion transport in the small intestine. Proc. Natl. Acad. Sci. USA 75: 2800-2804.
3. Clements, J. D., and R. A. Finkelstein. 1978. Demonstration of shared and unique immunologic determinants in enterotoxins from V. cholerae and E. coli. Infect. Immun. 22: 709-713.
4. Spangler, B. D. 1992. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol. Rev. 56: 622-647.
5. Evans, D. J., Jr., and D. G. Evans. 1990. Colonization factor antigens of human pathogens. Curr. Top. Microbiol. Immunol. 151: 129-145.
6. Edelman, R., R. G. Russell, G. Losonsky, B. D. Tall, C. O. Tacket, M. M. Levine, and D. H. Lewis. 1993. Immunization of rabbits with enterotoxigenic E. coli colonization factor antigen (CFA/I) encapsulated in biodegradable microspheres of poly (lactide-co-glycolide). Vaccine 11: 155-158.
7. Evans, D. G., D. Y. Graham, D. J. Evans, Jr., and A. Opekun. 1984. Administration of purified colonization factor antigens (CFA/I, CFA/II) of enterotoxigenic Escherichia coli to volunteers. Gastroenterology 87: 934-940.
8. Levine, M., J. G. Morris, G. Losonsky, E. Boedeker, and B. Rowe. 1986. Fimbriae (pili) adhesins as vaccine. In Protein-Carbohydrate Interactions in Biological Systems: Molecular Biology of Microbial Pathogenicity. D. L. Lark, S. Normark, B.-E. Uhlin, and H. Wolf-Watz, eds. Academic Press, London, pp. 143-145.
9. Giron, J. A., J.-G. Xu, C. R. González, D. Hone, J. B. Kaper, and M. M. Levine. 1995. Simultaneous expression of CFA/I and CS3 colonization factor antigens of enterotoxigenic Escherichia coli by ΔaroC, ΔaroD Salmonella typhi vaccine strain CVD 908. Vaccine 13: 939-946.
10. Pascual, D. W., D. M. Hone, S. Hall, F. W. van Ginkel, M. Yamamoto, N. Walters, K. Fujihashi, R. J. Powell, S. Wu, J. L. VanCott, et al. 1999. Expression of recombinant enterotoxigenic Escherichia coli colonization factor antigen I by Salmonella typhimurium elicits a biphasic T helper cell response. Infect. Immun. 67: 6249-6256.
11. - Salmonella vaccines. Microb. Path. 13: 477-491.
12. + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin A responses. Infect. Immun. 64: 1516-1525.
13. VanCott, J. L., H. F. Staats, D. W. Pascual, M. Roberts, S. N. Chatfield, M. Yamamoto, S. Yamamoto, P. B. Carter, H. Kiyono and J. R. McGhee. 1996. Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J. Immunol. 156: 1504-1514.
14. Pascual, D. W., T. Trunkle, and J. Sura. 2002. Fimbriated Salmonella enterica serovar typhimurium abates the initial inflammatory responses by macrophages. Infect. Immun. 70: 4273-4281.
15. Smith, M. E., N. L. Eller, H. F. McFarland, M. K. Racke, and C. S. Raine. 1999. Age dependence of clinical and pathological manifestations of autoimmune demyelination: implications for multiple sclerosis. Am. J. Pathol. 155: 1147-1161.
16. Hemmer, B., M. Vergelli, P. Calabresi, T. Huang, M. F. McFarland, and R. Martin. 1996. Cytokine phenotype of human autoreactive T cell clones specific for the immunodominant myelin basic protein peptide (83-99). J. Neurosci. Res. 45: 852-862.
17. Swanborg, R. H. 1995. Experimental autoimmune encephalomyelitis in rodent as a model for human demyelinating disease. Clin. Immunol. Immunopatholol. 77: 4-13.
18. Shaw, M. K., C. Kim, H. W. Hao, F. Chen, and H. Y. Tse. 1996. Induction of myelin basic protein-specific experimental autoimmune encephalomyelitis in C57BL/6 mice: mapping of T cell epitopes and T cell receptor Vβ gene segment usage. J. Neurosci. Res. 45: 690-699.
19. Adelman, M., J. Wood, I. Benzel, P. Fiori, H. Lassman, J. M. Matthieu, M. V. Gardiner, K. Dommair, and C. Linington. 1991. The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat. J. Neuroimmunol. 63: 17-27.
20. Brosnan, C. F., M. K. Racke, and K. Selmaj. 1997. An investigational approach to disease therapy. In Multiple Sclerosis: Clinical and Pathogenelic Basis. C. S. Raine, H. F. McFarland, and W. W. Tourtellotte, eds. Chapman & Hall, London, pp. 325-340.
21. Olsson, T. 1996. Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis. Neurology 45: S11-S15.
22. Juedes, A. E., P. Hjelmstrom, C. M. Bergman, A. L. Neild, and N. H. Ruddle. 2000. Kinetics and cellular origin of cytokines in the central nervous system: insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J. Immunol. 164: 419-426.
23. Karpus, W. J., and R. M. Ransohoff. 1998. Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis. J. Immunol. 161: 2667-2671.
24. Faria, A. M., and H. L. Weiner. 1999. Oral tolerance: mechanisms and therapeutic applications. Adv. Immunol. 73: 153-264.
25. Bettelli, E., M. P. Das, E. D. Howard, H. L. Weiner, R. A. Sobel, and V. K. Kuchroo. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deflcient and transgenic mice. J. Immunol. 161: 3299-3306.
26. Deborah, A. Y., L. D. Lowe, S. S. Booth, M. J. Whitters, L. Nicholson, V. K. Kuchroo, and M. Collins. 2000. IL-4, IL-10, IL-13, and TGF-β from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis. J. Immunol. 164: 3563-3572.
27. Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1996. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application tion to autoimmune disease therapy. Cell 80: 707-718.
28. Racke, M. K., A. Bonomo, D. E. Scott, B. Cannella, A. Levine, C. S. Raine, E. M. Shevach, and M. Röcken. 1994. Cytokine induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180: 1961-1966.
29. Shaw, M. K., J. B. Lorens, A. Dhawan., R. Dalcanto, H. Y. Tse, A. B. Tran, C. Bonpane, S. L. Eswaran, S. Brocke, N. Sarvetnick, et al. 1997. Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J. Exp. Med. 185: 1711-1714.
30. Whitacre, C. C., I. E. Gienapp, C. G. Oros., and D. M. Bitar. 1991. Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy. J. Immunol. 147: 2155-2163.
31. Al-Sabbagh, A., A. Miller, L. M. Santos, and H. L. Weiner. 1994. Antigen-driven tissue-specific suppression following oral tolerance: orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur. J. Immunol. 24: 2104-2109.
32. Smilek, D. E., D. C. Wraith, S. Hodgkinson, S. Dwivedy. L. Steinman, and H. O. McDevitt. 1991. A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 88: 9633-9637.
33. Kuchroo, V. K., J. M. Greer, D. Kaul, G. Ishioka, A. Franco, A. Sette, R. A. Sobel, and M. B. Lees. 1994. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by diverse T cell repertoire. J. Immunol. 153: 3326-3336.
34. Falcone, M., and B. R. Bloom. 1997. A T helper cell 2 (Th2) immune responses against non-self antigens modifies the cytokine profile of autoimmune T cells and protects against experimental allergic encephalomyelitis. J. Exp. Med. 185: 901-907.
35. Chen, Y., V. K. Kuchroo, J. Inobe, D. A. Hafler, and H. L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265: 1237-1240.
36. Chen, Y., J. Inobe, R. Marks, P. Gonnella, V. K. Kuchroo, and H. L. Weiner. 1995. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 376: 177-180.
37. Fiori, P., G. Ristori, A. Cacciani, C. Buttinelli, M. Falcone, S. di Giovanni, C. Montesperelli, C. Pozzilli, and M. Salvetti. 1997. Down-regulation of cell-surface CD4 co-receptor expression and modulation of experimental allergic encephalomyelitis. Int. Immunol 9: 541-545.
38. St. Louis, J., S. Uniyal, L. Xu, E.-L. Chan, B. Singh, B. M. C. Chan, and G. H. Strejan. 2001. Tolerance induction by acylated peptides: suppression of EAE in the mouse with palmitoylated PLP peptides. J. Neuroimmunol. 115: 79-90.
39. Kluver, H., and E. Barrera E. 1953. A method for the combined staining of cells and fibers in the nervous system. J. Neuropath. Exp. Neurol. 12: 400-403.
40. Pascual, D. W., M. D. White, T. Larson, and N. Walters. 2001. Impaired mucosal immunity in L-selectin-deficient mice orally immunized with a Salmonella vaccine vector. J. Immunol. 167: 407-415.
41. Jutila, M. A., T. K. Kishimoto, and M. Finken. 1991. Low-dose chymotrypsin treatment inhibits neutrophil migration into sites of inflammation in vivo: effects on Mac-1 and MEL-14 adhesion protein expression and function. Cell, Immunol. 132: 201-214.
42. Wang, X., P. Hillemeyer, and D. W. Pascual. 2003. Segregation of mechanisms for cytotoxic T lymphocyte killing between lungs and regional lymph nodes subsequent to intratracheal delivery of adenovirus 2 vector. Viral Immunol. 16: 525-539.
43. Adorini, L., J. C. Guery, and S. Trembleau. 1996. Manipulation of the Th1/Th2 cell balance; an approach to treat human autoimmune disease? Autoimmunity 23: 53-68.
44. Kidd, P. 2003. Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern. Med. Rev. 8: 223-246.
45. Smith, M. E., N. L. Eller, H. F. McFarland, M. K. Racke, and C. S. Raine. 1999. Age dependence of clinical and pathological manifestations of autoimmune demyelination. Am. J. Pathol. 155: 1147-1161.
46. Teuscher, C., J. Y. Bunn, P. D. Fillmore, R. J. Butterfield, J. F. Zachary, and E. P. Blankenhorn. 2004. Gender, age, and season at immunization uniquely influence the genetic control of susceptibility to histopathological lesions and clinical signs of experimental allergic encephalomyelitis. Am. J. Pathol. 165: 1593-1602.
47. Sewell, D. L., E. K. Reinke, C. Do, L. H. Hogan, R. B. Fritz, M. Sandor, and Z. Fabry. 2003. Infection with Mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis. Clin. Diagn. Lab. Immunol. 10: 564-572.
48. Ristori, G., M. G. Buzzi, U. Sabatini, E. Giugni, S. Bastianello, F. Viselli, C. Butinelli, S. Ruggieri, and C. Colonnese. 1999. Use of bacilli Calmette-Guérin (BCG) in multiple sclerosis. Neurology 53: 1588-1589.
49. Cash, E., A Minty, P. Ferrara, D. Caput, D. Fradellizi, and O. Rott. 1994, Macrophage inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats. J. Immunol. 153: 4258-4267.
50. Mckenzie, A. N., J. A. Culpepper, R. Waal, M. F. Briere, J. Pummonen, G. Aversa, A. Sato, W. Dang, B. G. Cocks, S. Menon, et al. 1993. Interleukin 13, a T-cell-derived cytokine that regulates human and monocyte and B-cell function. Proc. Natl. Acad. Sci. USA 90: 3735-3739.
51. El-Gayer, S., H. Thuring-Nahler, H. Pfeilschifter, M. Röllinghoff, and C. Bogdan. 2003. Translational control of inducible nitric oxide synthase by IL-13 and arginin availability in inflammatory macrophage. J. Immunol. 171: 4561-4568.
52. Dawson, T. M., M, Sasaki, M. Gonzalez-Zulueta, and V. L. Dawson. 1998. Regulation of neuronal nitric oxide synthase and identification of novel nitric oxide signaling pathways. Prog. Brain Res. 118: 3-11.
53. Zurawski, S. M., F. Vege Jr., B. Huyghe, and G. Zurawski. 1993. Receptor for interleukin 13 and interleukin 4 are complex and share a novel component that functions in signal transduction. EMBO J. 12: 2663-2670.
54. Nagelkerken, L., B. Blauw, and M. Tielemans. 1997. IL-4 abrogates the inhibitory effect of IL-10 on the development of experimental allergic encephalomyelitis in SJL mice. Int. Immunol. 9: 1243-1251.
55. + regulatory T cells. Int. Immunol 16: 249-256.
56. Cua, D. J., H. Groux, D. R. Hinton, S. A. Stolhman, and R. L. Coffman. 1999. Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 189: 1005-1010.
57. Cannella, B., Y. L. Gao, C. Brosnan, and C. S. Raine. 1996. IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J. Neurosci. Res. 45: 735-746.
58. Grzych, J. M., E. Pearce, A. Cheever, Z. A. Caulada, P. Casper, S. Heiny, F. Lewis, and A. Sher. 1991. Egg deposition is the major stimulus for the production of the Th2 cytokines in murine schistosomiasis mansoni. J. Immunol. 146: 1322-1327.
59. La Flamme, A. C., K. Ruddenklau, and B. T. Bäckström. 2003. Schitosomiasis decreases central nervous system inflammation and alters progression of experimental autoimmune encephalomyelitis. Infect. Immun. 71: 4996-5004.
60. Sewell, D., Z. Qing, E. Reinke, D. Elliot, J. Weinstock, M. Sandor, and Z. Fabry. 2003. Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. Int. Immunol. 15: 59-69.
61. Wickelgren, I. 2004. Immunotherapy: can worms tame the immune system? Science 305: 170-171.