메뉴 건너뛰기




Volumn 354, Issue 1, 2012, Pages 157-179

Mucosal immunity and HIV-1 infection: Applications for mucosal AIDS vaccine development

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CPG OLIGODEOXYNUCLEOTIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; HUMAN IMMUNODEFICIENCY VIRUS PCLUS3 18IIIB ENVELOPE PEPTIDE VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN A; INTERLEUKIN 12; MVA89.6 VACCINE; PEPTIDE VACCINE; SECRETORY IMMUNOGLOBULIN; SIMIAN IMMUNODEFICIENCY VIRUS VACCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84856185924     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82_2010_119     Document Type: Review
Times cited : (30)

References (153)
  • 1
    • 33646003876 scopus 로고    scopus 로고
    • Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys
    • Acierno PM, Schmitz JE, Gorgone DA et al (2006) Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys. J Immunol 176:5338-5345
    • (2006) J Immunol , vol.176 , pp. 5338-5345
    • Acierno, P.M.1    Schmitz, J.E.2    Gorgone, D.A.3
  • 2
    • 70350532251 scopus 로고    scopus 로고
    • Strategies for optimizing targeting and delivery of mucosal HIV vaccines
    • Ahlers JD, Belyakov IM (2009a) Strategies for optimizing targeting and delivery of mucosal HIV vaccines. Eur J Immunol 39:2657-2669
    • (2009) Eur J Immunol , vol.39 , pp. 2657-2669
    • Ahlers, J.D.1    Belyakov, I.M.2
  • 3
    • 66549107429 scopus 로고    scopus 로고
    • Strategies for recruiting and targeting dendritic cells for optimizing HIV vaccines
    • Ahlers JD, Belyakov IM (2009b) Strategies for recruiting and targeting dendritic cells for optimizing HIV vaccines. Trends Mol Med 15:263-274
    • (2009) Trends Mol Med , vol.15 , pp. 263-274
    • Ahlers, J.D.1    Belyakov, I.M.2
  • 4
    • 77749242569 scopus 로고    scopus 로고
    • Lessons learned from natural infection: Focusing on the design of protective T cell vaccines for HIV/AIDS
    • Ahlers JD, Belyakov IM (2010a) Lessons learned from natural infection: focusing on the design of protective T cell vaccines for HIV/AIDS. Trends Immunol 31:120-130
    • (2010) Trends Immunol , vol.31 , pp. 120-130
    • Ahlers, J.D.1    Belyakov, I.M.2
  • 5
    • 77950343170 scopus 로고    scopus 로고
    • Memories that last forever: Strategies for optimizing vaccine T-cell memory
    • Ahlers JD, Belyakov IM (2010b) Memories that last forever: strategies for optimizing vaccine T-cell memory. Blood 115:1678-1689
    • (2010) Blood , vol.115 , pp. 1678-1689
    • Ahlers, J.D.1    Belyakov, I.M.2
  • 6
    • 77957342368 scopus 로고    scopus 로고
    • New paradigms for generating effective CD8+ T cell responses against HIV-1/AIDS
    • Ahlers JD, Belyakov IM (2010c) New paradigms for generating effective CD8+ T cell responses against HIV-1/AIDS. Discov Med 9:528-537
    • (2010) Discov Med , vol.9 , pp. 528-537
    • Ahlers, J.D.1    Belyakov, I.M.2
  • 7
    • 0034922197 scopus 로고    scopus 로고
    • Mechanisms of cytokine synergy essential for vaccine protection against viral challenge
    • Ahlers JD, Belyakov IM, Matsui S et al (2001a) Mechanisms of cytokine synergy essential for vaccine protection against viral challenge. Int Immunol 13:897-908 (Pubitemid 32685202)
    • (2001) International Immunology , vol.13 , Issue.7 , pp. 897-908
    • Ahlers, J.D.1    Belyakov, I.M.2    Matsui, S.3    Berzofsky, J.A.4
  • 8
    • 0035158344 scopus 로고    scopus 로고
    • Signals delivered through TCR instruct IL-12 receptor (IL-12R) expression: IL-12 and tumor necrosis factor-α synergize for IL-12R expression at low antigen dose
    • Ahlers JD, Belyakov IM, Matsui S et al (2001b) Signals delivered through TCR instruct IL-12R expression: IL-12 and TNFa synergize for IL-12R expression at low antigen dose. Int Immunol 13:1433-1442 (Pubitemid 33049127)
    • (2001) International Immunology , vol.13 , Issue.11 , pp. 1433-1442
    • Ahlers, J.D.1    Belyakov, I.M.2    Matsui, S.3    Berzofsky, J.A.4
  • 9
    • 0036789939 scopus 로고    scopus 로고
    • A push-pull approach to maximize vaccine efficacy: Abrogating suppression with an IL-13 inhibitor while augmenting help with GM-CSF and CD40L
    • Ahlers JD, Belyakov IM, Terabe M et al (2002) A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with GM-CSF and CD40L. Proc Natl Acad Sci USA 99:13020-13025
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13020-13025
    • Ahlers, J.D.1    Belyakov, I.M.2    Terabe, M.3
  • 10
    • 0037404151 scopus 로고    scopus 로고
    • Cytokine, chemokine, and costimulatory molecule modulation to enhance efficacy of HIV vaccines
    • DOI 10.2174/1566524033479843
    • Ahlers JD, Belyakov IM, Berzofsky JA (2003) Cytokine, chemokine and costimulatory molecule modulation to enhance efficacy of HIV vaccines. Curr Mol Med 3:285-301 (Pubitemid 36443226)
    • (2003) Current Molecular Medicine , vol.3 , Issue.3 , pp. 285-301
    • Ahlers, J.D.1    Belyakov, I.M.2    Berzofsky, J.A.3
  • 16
    • 2942530690 scopus 로고    scopus 로고
    • Influence of coinfecting pathogens on HIV expression: Evidence for a role of Toll-like receptors
    • Bafica A, Scanga CA, Schito M et al (2004) Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors. J Immunol 172:7229-7234 (Pubitemid 38747580)
    • (2004) Journal of Immunology , vol.172 , Issue.12 , pp. 7229-7234
    • Bafica, A.1    Scanga, C.A.2    Schito, M.3    Chaussabel, D.4    Sher, A.5
  • 17
    • 38149096202 scopus 로고    scopus 로고
    • Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope
    • Barnett SW, Srivastava IK, Kan E et al (2008) Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope. AIDS 22:339-348
    • (2008) AIDS , vol.22 , pp. 339-348
    • Barnett, S.W.1    Srivastava, I.K.2    Kan, E.3
  • 18
    • 0033766645 scopus 로고    scopus 로고
    • Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
    • Barouch DH, Santra S, Schmitz JE et al (2000) Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 290:486-492
    • (2000) Science , vol.290 , pp. 486-492
    • Barouch, D.H.1    Santra, S.2    Schmitz, J.E.3
  • 19
    • 0026633459 scopus 로고
    • Cells and cytokines in mucosal immunity and inflammation
    • Beagley KW, Elson CO (1992) Cells and cytokines in mucosal immunity and inflammation. Gastroenterol Clin North Am 21:347-366
    • (1992) Gastroenterol Clin North Am , vol.21 , pp. 347-366
    • Beagley, K.W.1    Elson, C.O.2
  • 21
    • 53849132002 scopus 로고    scopus 로고
    • Functional CD8(F) CTLs in mucosal sites and HIV infection: Moving forward toward a mucosal AIDS vaccine
    • Belyakov IM, Ahlers JD (2008) Functional CD8(F) CTLs in mucosal sites and HIV infection: moving forward toward a mucosal AIDS vaccine. Trends Immunol 29:574-585
    • (2008) Trends Immunol , vol.29 , pp. 574-585
    • Belyakov, I.M.1    Ahlers, J.D.2
  • 22
    • 73349104433 scopus 로고    scopus 로고
    • What role does the route of immunization play in the generation of protective immunity against mucosal pathogens?
    • Belyakov IM, Ahlers JD (2009b) What role does the route of immunization play in the generation of protective immunity against mucosal pathogens? J Immunol 183:6883-6892
    • (2009) J Immunol , vol.183 , pp. 6883-6892
    • Belyakov, I.M.1    Ahlers, J.D.2
  • 23
    • 61449181174 scopus 로고    scopus 로고
    • Comment on "trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination
    • Belyakov IM, Ahlers JD (2009a) Comment on "trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination". J Immunol 182: 1779-1780
    • (2009) J Immunol , vol.182 , pp. 1779-1780
    • Belyakov, I.M.1    Ahlers, J.D.2
  • 24
    • 4344678042 scopus 로고    scopus 로고
    • Mucosal AIDS vaccines: Current status and future directions
    • Belyakov IM, Ahlers JD, Berzofsky JA (2004a) Mucosal AIDS vaccines: current status and future directions. Expert Rev Vaccines 3: Suppl 65-73
    • (2004) Expert Rev Vaccines , vol.3 , Issue.SUPPL. , pp. 65-73
    • Belyakov, I.M.1    Ahlers, J.D.2    Berzofsky, J.A.3
  • 25
    • 1642381854 scopus 로고    scopus 로고
    • Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccines
    • DOI 10.1016/S1074-7613(04)00053-6, PII S1074761304000536
    • Belyakov IM, Berzofsky JA (2004b) Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccines. Immunity 20:247-253 (Pubitemid 38388227)
    • (2004) Immunity , vol.20 , Issue.3 , pp. 247-253
    • Belyakov, I.M.1    Berzofsky, J.A.2
  • 29
    • 4344653030 scopus 로고    scopus 로고
    • Use of rIL-12 for enhancing the mucosal cytotoxic T lymphocyte response to a peptide HIV vaccine
    • Belyakov IM, Kelsall B, Strober W et al (1998c) Use of rIL-12 for enhancing the mucosal cytotoxic T lymphocyte response to a peptide HIV vaccine. J Invest Med 46:216A
    • (1998) J Invest Med , vol.46
    • Belyakov, I.M.1    Kelsall, B.2    Strober, W.3
  • 31
    • 0031660670 scopus 로고    scopus 로고
    • Induction of a mucosal cytotoxic T-lymphocyte response by intrarectal immunization with a replication-deficient recombinant vaccinia virus expressing human immunodeficiency virus 89.6 envelope protein
    • Belyakov IM, Wyatt LS, Ahlers JD et al (1998d) Induction of mucosal CTL response by intrarectal immunization with a replication-deficient recombinant vaccinia virus expressing HIV 89.6 envelope protein. J Virol 72:8264-8272 (Pubitemid 28421824)
    • (1998) Journal of Virology , vol.72 , Issue.10 , pp. 8264-8272
    • Belyakov, I.M.1    Wyatt, L.S.2    Ahlers, J.D.3    Earl, P.4    Pendleton, C.D.5    Kelsall, B.L.6    Strober, W.7    Moss, B.8    Berzofsky, J.A.9
  • 33
    • 0034544623 scopus 로고    scopus 로고
    • Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific cytotoxic T lymphocytes
    • Belyakov IM, Ahlers JD, Clements JD et al (2000) Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific cytotoxic T lymphocytes. J Immunol 165:6454-6462
    • (2000) J Immunol , vol.165 , pp. 6454-6462
    • Belyakov, I.M.1    Ahlers, J.D.2    Clements, J.D.3
  • 36
    • 1642272033 scopus 로고    scopus 로고
    • Transcutaneous immunization induces mucosal CTLs and protective immunity by migration of primed skin dendritic cells
    • DOI 10.1172/JCI200420261
    • Belyakov IM, Hammond SA, Ahlers JD et al (2004) Transcutaneous immunization induces mucosal CTL and protective immunity by migration of primed skin dendritic cells. J Clin Invest 113:998-1007 (Pubitemid 38544121)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.7 , pp. 998-1007
    • Belyakov, I.M.1    Hammond, S.A.2    Ahlers, J.D.3    Glenn, G.M.4    Berzofsky, J.A.5
  • 37
    • 33750301915 scopus 로고    scopus 로고
    • + T cell immunity in the lung by CpG oligodeoxynucleotides increases protective efficacy of a modified vaccinia Ankara vaccine against lethal poxvirus infection even in a CD4-deficient host
    • Belyakov IM, Isakov D, Zhu Q et al (2006a) Enhancement of CD8+ T cell immunity in the lung by CpG ODN increases protective efficacy of a Modified Vaccinia Ankara vaccine against lethal poxvirus infection even in CD4-deficient host. J Immunol 177:6336-6343 (Pubitemid 44628852)
    • (2006) Journal of Immunology , vol.177 , Issue.9 , pp. 6336-6343
    • Belyakov, I.M.1    Isakov, D.2    Zhu, Q.3    Dzutsev, A.4    Klinman, D.5    Berzofsky, J.A.6
  • 38
    • 33645748846 scopus 로고    scopus 로고
    • Impact of vaccine-induced mucosal high avidity CD8+ CTLs in delay of AIDS-viral dissemination from mucosa
    • Belyakov IM, Kuznetsov VA, Kelsall B et al (2006b) Impact of vaccine-induced mucosal high avidity CD8+ CTLs in delay of AIDS-viral dissemination from mucosa. Blood 107:3258-3264
    • (2006) Blood , vol.107 , pp. 3258-3264
    • Belyakov, I.M.1    Kuznetsov, V.A.2    Kelsall, B.3
  • 39
    • 34249786561 scopus 로고    scopus 로고
    • + T cells
    • Belyakov IM, Isakov D, Zhu Q et al (2007a) A novel functional CTL avidity/activity compartmentalization to the site of mucosal immunization contributes to protection of macaques against simian/human immunodeficiency viral depletion of mucosal CD4+ T cells. J Immunol 178:7211-7221 (Pubitemid 46847447)
    • (2007) Journal of Immunology , vol.178 , Issue.11 , pp. 7211-7221
    • Belyakov, I.M.1    Isakov, D.2    Zhu, Q.3    Dzutsev, A.4    Berzofsky, J.A.5
  • 41
    • 53849088921 scopus 로고    scopus 로고
    • Generation of functionally active HIV-1 specific CD8(F) CTL in intestinal mucosa following mucosal, systemic or mixed prime-boost immunization
    • Belyakov IM, Ahlers JD, Nabel GJ et al (2008) Generation of functionally active HIV-1 specific CD8(F) CTL in intestinal mucosa following mucosal, systemic or mixed prime-boost immunization. Virology 381:106-115
    • (2008) Virology , vol.381 , pp. 106-115
    • Belyakov, I.M.1    Ahlers, J.D.2    Nabel, G.J.3
  • 42
    • 34248366936 scopus 로고    scopus 로고
    • Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells
    • DOI 10.1128/JVI.02362-06
    • Bennett MS, Ng HL, Dagarag M et al (2007) Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells. J Virol 81:4973-4980 (Pubitemid 46744409)
    • (2007) Journal of Virology , vol.81 , Issue.10 , pp. 4973-4980
    • Bennett, M.S.1    Ng, H.L.2    Dagarag, M.3    Ali, A.4    Yang, O.O.5
  • 43
    • 0035751961 scopus 로고    scopus 로고
    • Strategies for designing and optimizing new generation vaccines
    • Berzofsky JA, Ahlers JD, Belyakov IM (2001) Strategies for designing and optimizing new generation vaccines. Nature Reviews Immunology 1:209-219 (Pubitemid 33741959)
    • (2001) Nature Reviews Immunology , vol.1 , Issue.3 , pp. 209-219
    • Berzofsky, J.A.1    Ahlers, J.D.2    Belyakov, I.M.3
  • 44
    • 0032869689 scopus 로고    scopus 로고
    • Approaches to improve engineered vaccines for human immunodeficiency virus and other viruses that cause chronic infections
    • DOI 10.1111/j.1600-065X.1999.tb01336.x
    • Berzofsky JA, Ahlers JD, Derby MA, Pendleton CD, Arichi T, Belyakov IM (1999) Approaches to improve engineered vaccines for human immunodeficiency virus (HIV) and other viruses that cause chronic infections. Immunol Rev 170:151-172 (Pubitemid 29490752)
    • (1999) Immunological Reviews , vol.170 , pp. 151-172
    • Berzofsky, J.A.1    Ahlers, J.D.2    Derby, M.A.3    Pendleton, C.D.4    Arichi, T.5    Belyakov, I.M.6
  • 46
    • 0037103207 scopus 로고    scopus 로고
    • DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses
    • DOI 10.1182/blood-2002-01-0086
    • Biragyn A, Belyakov IM, Chow YH et al (2002) DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses. Blood 100:1153-1159 (Pubitemid 34864265)
    • (2002) Blood , vol.100 , Issue.4 , pp. 1153-1159
    • Biragyn, A.1    Belyakov, I.M.2    Chow, Y.-H.3    Dimitrov, D.S.4    Berzofsky, J.A.5    Kwak, L.W.6
  • 47
    • 0033081332 scopus 로고    scopus 로고
    • Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor β1 and β2 chain expression
    • DOI 10.1084/jem.189.3.541
    • Braun MC, He J, Wu C-Y, Kelsall BL (1999) Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor B1 and B2 chain expression. J Exp Med 189:541-552 (Pubitemid 29187376)
    • (1999) Journal of Experimental Medicine , vol.189 , Issue.3 , pp. 541-552
    • Braun, M.C.1    He, J.2    Wu, C.-Y.3    Kelsall, B.L.4
  • 49
    • 0032549622 scopus 로고    scopus 로고
    • An experimental prime-boost regimen leading to HIV type 1-specific mucosal and systemic immunity in BALB/c mice
    • Bruhl P, Kerschbaum A, Eibl MM et al (1998) An experimental prime-boost regimen leading to HIV type 1-specific mucosal and systemic immunity in BALB/c mice. AIDS Res Hum Retroviruses 14:401-407 (Pubitemid 28125698)
    • (1998) AIDS Research and Human Retroviruses , vol.14 , Issue.5 , pp. 401-407
    • Bruhl, P.1    Kerschbaum, A.2    Eibl, M.M.3    Mannhalter, J.W.4
  • 50
    • 39149119252 scopus 로고    scopus 로고
    • Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 DeltaV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin
    • Caputo A, Brocca-Cofano E, Castaldello A et al (2008) Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 DeltaV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin. Vaccine 26:1214-1227
    • (2008) Vaccine , vol.26 , pp. 1214-1227
    • Caputo, A.1    Brocca-Cofano, E.2    Castaldello, A.3
  • 52
    • 0035808514 scopus 로고    scopus 로고
    • Enteric microtubule depolymerization in HIV infection: A possible cause of HIV-associated enteropathy [2]
    • DOI 10.1097/00002030-200101050-00019
    • Clayton F, Kapetanovic S, Kotler DP (2001) Enteric microtubule depolymerization in HIV infection: a possible cause of HIV-associated enteropathy. AIDS 15:123-124 (Pubitemid 32055789)
    • (2001) AIDS , vol.15 , Issue.1 , pp. 123-124
    • Clayton, F.1    Kapetanovic, S.2    Kotler, D.P.3
  • 53
    • 33750093813 scopus 로고    scopus 로고
    • Prime-boost strategies in DNA vaccines
    • Dale CJ, Thomson S, De Rose R et al (2006) Prime-boost strategies in DNA vaccines. Methods Mol Med 127:171-197
    • (2006) Methods Mol Med , vol.127 , pp. 171-197
    • Dale, C.J.1    Thomson, S.2    De Rose, R.3
  • 54
    • 34548764423 scopus 로고    scopus 로고
    • Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    • DOI 10.1038/ni1511, PII NI1511
    • Denning TL, Wang YC, Patel SR et al (2007) Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8:1086-1094 (Pubitemid 47423756)
    • (2007) Nature Immunology , vol.8 , Issue.10 , pp. 1086-1094
    • Denning, T.L.1    Wang, Y.-C.2    Patel, S.R.3    Williams, I.R.4    Pulendran, B.5
  • 55
    • 0028985871 scopus 로고
    • Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity
    • Dickinson BL, Clements JD (1995) Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity. Infect Immun 63:1617-1623
    • (1995) Infect Immun , vol.63 , pp. 1617-1623
    • Dickinson, B.L.1    Clements, J.D.2
  • 56
    • 0002928722 scopus 로고    scopus 로고
    • Use of Escherichia coli heat-liable enterotoxin asan oral adjuvant
    • Academic Press New York
    • Dickinson BL, Clements JD (1996) Use of Escherichia coli heat-liable enterotoxin asan oral adjuvant. In: Mucosal Vaccines. Academic Press, New York, pp 73-87
    • (1996) Mucosal Vaccines , pp. 73-87
    • Dickinson, B.L.1    Clements, J.D.2
  • 59
    • 0026006344 scopus 로고
    • Clearance of influenza virus respiratory infection in mice lacking class i major histocompatibility complex-restricted CD8+ T cells
    • Eichelberger M, Allan W, Zijlstra M et al (1991) Clearance of influenza virus respiratory infection in mice lacking class I major histocompatibility complex-restricted CD8+ T cells. J Exp Med 174:875-880
    • (1991) J Exp Med , vol.174 , pp. 875-880
    • Eichelberger, M.1    Allan, W.2    Zijlstra, M.3
  • 60
    • 0001789953 scopus 로고    scopus 로고
    • Cholera toxin as a mucosal adjuvant
    • Kiyono H, McGhee JR, Ogra PL (eds Academic Press, San Diego
    • Elson CO (1996) Cholera toxin as a mucosal adjuvant. In: Kiyono H, McGhee JR, Ogra PL (eds) Mucosal Vaccines. Academic Press, San Diego, pp 59-72
    • (1996) Mucosal Vaccines , pp. 59-72
    • Elson, C.O.1
  • 61
    • 0034212408 scopus 로고    scopus 로고
    • The induction of systemic and mucosal immune responses to antigen-adjuvant compositions administered into the skin: Alterations in the migratory properties of dendritic cells appears to be important for stimulating mucosal immunity
    • PII S0264410X00000591
    • Enioutina EY, Visic D, Daynes RA (2000) The induction of systemic and mucosal immune responses to antigen-adjuvant compositions administered into the skin: alterations in the migratory properties of dendritic cells appears to be important for stimulating mucosal immunity. Vaccine 18:2753-2767 (Pubitemid 30211584)
    • (2000) Vaccine , vol.18 , Issue.24 , pp. 2753-2767
    • Enioutina, E.Y.1    Visic, D.2    Daynes, R.A.3
  • 62
    • 0035339883 scopus 로고    scopus 로고
    • Prime-boost immunization with DNA vaccine: Mucosal route of administration changes the rules
    • Eo SK, Gierynska M, Kamar AA et al (2001) Prime-boost immunization with DNA vaccine: mucosal route of administration changes the rules. J Immunol 166:5473-5479 (Pubitemid 32374168)
    • (2001) Journal of Immunology , vol.166 , Issue.9 , pp. 5473-5479
    • Eo, S.K.1    Gierynska, M.2    Kamar, A.A.3    Rouse, B.T.4
  • 65
    • 0027237806 scopus 로고
    • Antibodies to recombinant gp160 in mucosal secretions and sera of persons infected with HIV-1 and seronegative vaccine recipients
    • Funkhouser A, Clements ML, Slome S et al (1993) Antibodies to recombinant gp160 in mucosal secretions and sera of persons infected with HIV-1 and seronegative vaccine recipients. AIDS Res Hum Retroviruses 9:627-632 (Pubitemid 23231126)
    • (1993) AIDS Research and Human Retroviruses , vol.9 , Issue.7 , pp. 627-632
    • Funkhouser, A.1    Clements, M.L.2    Slome, S.3    Clayman, B.4    Viscidi, R.5
  • 66
    • 0029809510 scopus 로고    scopus 로고
    • Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization
    • Gallichan WS, Rosenthal KL (1996) Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization. J Exp Med 184:1879-1890 (Pubitemid 26404478)
    • (1996) Journal of Experimental Medicine , vol.184 , Issue.5 , pp. 1879-1890
    • Gallichan, W.S.1    Rosenthal, K.L.2
  • 67
    • 0032543212 scopus 로고    scopus 로고
    • Protective immunity does not correlate with the hierarchy of virus- specific cytotoxic T cell responses to naturally processed peptides
    • DOI 10.1084/jem.187.10.1647
    • Gallimore A, Dumrese T, Hengartner H et al (1998) Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. J Exp Med 187:1647-1657 (Pubitemid 28235106)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.10 , pp. 1647-1657
    • Gallimore, A.1    Dumrese, T.2    Hengartner, H.3    Zinkernagel, R.M.4    Rammensee, H.-G.5
  • 68
    • 0025748605 scopus 로고
    • Priming of influenza virus-specific cytotoxic T lymphocytes vivo by short synthetic peptides
    • Gao X-M, Zheng B, Liew FY et al (1991) Priming of influenza virus-specific cytotoxic T lymphocytes vivo by short synthetic peptides. J Immunol 147:3268-3273
    • (1991) J Immunol , vol.147 , pp. 3268-3273
    • Gao, X.-M.1    Zheng, B.2    Liew, F.Y.3
  • 69
    • 0038279752 scopus 로고    scopus 로고
    • Prime-boost immunization schedules based on influenza virus and vaccinia virus vectors potentiate cellular immune responses against human immunodeficiency virus Env protein systemically and in the genitorectal draining lymph nodes
    • DOI 10.1128/JVI.77.12.7048-7057.2003
    • Gherardi MM, Najera JL, Perez-Jimenez E et al (2003) Prime-boost immunization schedules based on influenza virus and vaccinia virus vectors potentiate cellular immune responses against human immunodeficiency virus Env protein systemically and in the genitorectal draining lymph nodes. J Virol 77:7048-7057 (Pubitemid 36666898)
    • (2003) Journal of Virology , vol.77 , Issue.12 , pp. 7048-7057
    • Gherardi, M.M.1    Najera, J.L.2    Perez-Jimenez, E.3    Guerra, S.4    Garcia-Sastre, A.5    Esteban, M.6
  • 70
    • 2442517281 scopus 로고    scopus 로고
    • Induction of HIV Immunity in the Genital Tract after Intranasal Delivery of a MVA Vector: Enhanced Immunogenicity after DNA Prime-Modified Vaccinia Virus Ankara Boost Immunization Schedule
    • Gherardi MM, Perez-Jimenez E, Najera JL et al (2004) Induction of HIV immunity in the genital tract after intranasal delivery of a MVA vector: enhanced immunogenicity after DNA prime-modified vaccinia virus Ankara boost immunization schedule. J Immunol 172:6209-6220 (Pubitemid 38621227)
    • (2004) Journal of Immunology , vol.172 , Issue.10 , pp. 6209-6220
    • Gherardi, M.M.1    Perez-Jimenez, E.2    Najera, J.L.3    Esteban, M.4
  • 71
    • 0032184817 scopus 로고    scopus 로고
    • Transcutaneous immunization with cholera toxin protects mice against lethal mucosal toxin challenge
    • Glenn GM, Scharton-Kersten T, Vassell R et al (1998) Transcutaneous immunization with cholera toxin protects mice against lethal mucosal toxin challenge. J Immunol 161:3211-3214
    • (1998) J Immunol , vol.161 , pp. 3211-3214
    • Glenn, G.M.1    Scharton-Kersten, T.2    Vassell, R.3
  • 73
    • 0034538134 scopus 로고    scopus 로고
    • Transcutaneous immunization induces mucosal and systemic immunity: A potent method for targeting immunity to the female reproductive tract
    • DOI 10.1016/S0161-5890(00)00074-2, PII S0161589000000742
    • Gockel CM, Bao S, Beagley KW (2000) Transcutaneous immunization induces mucosal and systemic immunity: a potent method for targeting immunity to the female reproductive tract. Mol Immunol 37:537-544 (Pubitemid 32001695)
    • (2000) Molecular Immunology , vol.37 , Issue.9 , pp. 537-544
    • Gockel, C.M.1    Bao, S.2    Beagley, K.W.3
  • 75
    • 0028100635 scopus 로고
    • Primary acute simian immunodeficiency virus infection of intestinal lymphoid tissue is associated with gastrointestinal dysfunction
    • Heise C, Miller CJ, Lackner A et al (1994) Primary acute simian immunodeficiency virus infection of intestinal lymphoid tissue is associated with gastrointestinal dysfunction. J Infect Dis 169:1116-1120 (Pubitemid 24303239)
    • (1994) Journal of Infectious Diseases , vol.169 , Issue.5 , pp. 1116-1120
    • Heise, C.1    Miller, C.J.2    Lackner, A.3    Dandekar, S.4
  • 76
    • 49649106712 scopus 로고    scopus 로고
    • Circumvention of regulatory CD4(R) T cell activity during cross-priming strongly enhances T cell-mediated immunity
    • Heit A, Gebhardt F, Lahl K et al (2008) Circumvention of regulatory CD4(R) T cell activity during cross-priming strongly enhances T cell-mediated immunity. Eur J Immunol 38:1585-1597
    • (2008) Eur J Immunol , vol.38 , pp. 1585-1597
    • Heit, A.1    Gebhardt, F.2    Lahl, K.3
  • 80
    • 33947146120 scopus 로고    scopus 로고
    • Mucosal priming with PEI/DNA complex and systemic boosting with recombinant TianTan vaccinia stimulate vigorous mucosal and systemic immune responses
    • DOI 10.1016/j.vaccine.2006.12.020, PII S0264410X06013508
    • Huang X, Xu J, Qiu C et al (2007) Mucosal priming with PEI/DNA complex and systemic boosting with recombinant TianTan vaccinia stimulate vigorous mucosal and systemic immune responses. Vaccine 25:2620-2629 (Pubitemid 46400929)
    • (2007) Vaccine , vol.25 , Issue.14 , pp. 2620-2629
    • Huang, X.1    Xu, J.2    Qiu, C.3    Ren, L.4    Liu, L.5    Wan, Y.6    Zhang, N.7    Peng, H.8    Shao, Y.9
  • 83
    • 56149112944 scopus 로고    scopus 로고
    • Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination
    • Kaufman DR, Liu J, Carville A et al (2008) Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination. J Immunol 181:4188-4198
    • (2008) J Immunol , vol.181 , pp. 4188-4198
    • Kaufman, D.R.1    Liu, J.2    Carville, A.3
  • 84
    • 0021157562 scopus 로고
    • Enteropathy associated with the acquired immunodeficiency syndrome
    • Kotler DP, Gaetz HP, Lange M et al (1984) Enteropathy associated with the acquired immunodeficiency syndrome. Ann Intern Med 101:421-428 (Pubitemid 14018034)
    • (1984) Annals of Internal Medicine , vol.101 , Issue.4 , pp. 421-428
    • Kotler, D.P.1    Gaetz, H.P.2    Lange, M.3
  • 85
    • 0037404116 scopus 로고    scopus 로고
    • The role of mucosal immunity in prevention of HIV transmission
    • DOI 10.2174/1566524033479852
    • Kozlowski PA, Neutra MR (2003) The role of mucosal immunity in prevention of HIV transmission. Curr Mol Med 3:217-228 (Pubitemid 36443221)
    • (2003) Current Molecular Medicine , vol.3 , Issue.3 , pp. 217-228
    • Kozlowski, P.A.1    Neutra, M.R.2
  • 86
    • 0030964959 scopus 로고    scopus 로고
    • Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women
    • Kozlowski PA, Cu-Uvin S, Neutra MR, Flanigan TP (1997) Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women. Infect Immun. 65:1387-1394 (Pubitemid 27146629)
    • (1997) Infection and Immunity , vol.65 , Issue.4 , pp. 1387-1394
    • Kozlowski, P.A.1    Cu-Uvin, S.2    Neutra, M.R.3    Flanigan, T.P.4
  • 87
    • 0032482190 scopus 로고    scopus 로고
    • Analysis of gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex
    • DOI 10.1084/jem.187.9.1373
    • Kuroda MJ, Schmitz JE, Barouch DH et al (1998) Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex. J Exp Med 187:1373-1381 (Pubitemid 28215397)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.9 , pp. 1373-1381
    • Kuroda, M.J.1    Schmitz, J.E.2    Barouch, D.H.3    Craiu, A.4    Allen, T.M.5    Sette, A.6    Watkins, D.I.7    Forman, M.A.8    Letvin, N.L.9
  • 88
    • 0037137529 scopus 로고    scopus 로고
    • Co-immunization of rhesus macaques with plasmid vectors expressing IFN-γ, GM-CSF, and SIV antigens enhances anti-viral humoral immunity but does not affect viremia after challenge with highly pathogenic virus
    • DOI 10.1016/S0264-410X(02)00391-2, PII S0264410X02003912
    • Lena P, Villinger F, Giavedoni L et al (2002) Co-immunization of rhesus macaques with plasmid vectors expressing IFN-gamma, GM-CSF, and SIV antigens enhances anti-viral humoral immunity but does not affect viremia after challenge with highly pathogenic virus. Vaccine 20(Suppl 4):A69-A79 (Pubitemid 35449409)
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 4
    • Lena, P.1    Villinger, F.2    Giavedoni, L.3    Miller, C.J.4    Rhodes, G.5    Luciw, P.6
  • 90
    • 42149106252 scopus 로고    scopus 로고
    • Novel vaccination protocol with two live mucosal vectors elicits strong cell-mediated immunity in the vagina and protects against vaginal virus challenge
    • Li Z, Zhang M, Zhou C et al (2008) Novel vaccination protocol with two live mucosal vectors elicits strong cell-mediated immunity in the vagina and protects against vaginal virus challenge. J Immunol 180:2504-2513
    • (2008) J Immunol , vol.180 , pp. 2504-2513
    • Li, Z.1    Zhang, M.2    Zhou, C.3
  • 91
    • 33846859326 scopus 로고    scopus 로고
    • + T cell responses in the gut
    • DOI 10.1016/j.vaccine.2006.11.044, PII S0264410X06012539
    • Lin SW, Cun AS, Harris-McCoy K et al (2007) Intramuscular rather than oral administration of replication-defective adenoviral vaccine vector induces specific CD8+ T cell responses in the gut. Vaccine 25:2187-2193 (Pubitemid 46227687)
    • (2007) Vaccine , vol.25 , Issue.12 , pp. 2187-2193
    • Lin, S.W.1    Cun, A.S.2    Harris-McCoy, K.3    Ertl, H.C.4
  • 92
    • 0021243967 scopus 로고
    • In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific
    • Lukacher AE, Braciale VL, Braciale TJ (1984) In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific. J Exp Med 160:814-826 (Pubitemid 14074780)
    • (1984) Journal of Experimental Medicine , vol.160 , Issue.3 , pp. 814-826
    • Lukacher, A.E.1    Braciale, V.L.2    Braciale, T.J.3
  • 93
    • 70350681198 scopus 로고    scopus 로고
    • Nasal DNA-MVA SIV vaccination provides more significant protection from progression to AIDS than a similar intramuscular vaccination
    • Manrique M, Kozlowski PA, Wang SW et al (2009) Nasal DNA-MVA SIV vaccination provides more significant protection from progression to AIDS than a similar intramuscular vaccination. Mucosal Immunol 2:536-550
    • (2009) Mucosal Immunol , vol.2 , pp. 536-550
    • Manrique, M.1    Kozlowski, P.A.2    Wang, S.W.3
  • 97
    • 33745810216 scopus 로고    scopus 로고
    • Stimulation history dictates memory CD8 T cell phenotype: Implications for prime-boost vaccination
    • Masopust D, Ha SJ, Vezys V et al (2006) Stimulation history dictates memory CD8 T cell phenotype: implications for prime-boost vaccination. J Immunol 177:831-839 (Pubitemid 44036583)
    • (2006) Journal of Immunology , vol.177 , Issue.2 , pp. 831-839
    • Masopust, D.1    Ha, S.-J.2    Vezys, V.3    Ahmed, R.4
  • 103
    • 0027945859 scopus 로고
    • Reassessment of the impact of mucosal immunity in infection with the human immunodeficiency virus (HIV) and design of relevant vaccines
    • DOI 10.1007/BF01540979
    • Mestecky J, Jackson S (1994) Reassessment of the impact of mucosal immunity in infection with the human immunodeficiency virus (HIV) and design of relevant vaccines. J Clin Immunol 14:259-272 (Pubitemid 24315636)
    • (1994) Journal of Clinical Immunology , vol.14 , Issue.5 , pp. 259-272
    • Mestecky, J.1    Jackson, S.2
  • 104
    • 0033997662 scopus 로고    scopus 로고
    • Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 Env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G)
    • DOI 10.1016/S0264-410X(99)00447-8, PII S0264410X99004478
    • Morris CB, Cheng E, Thanawastien A et al (2000) Effectiveness of intranasal immunization with HIV-gp160 Env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G). Vaccine 18:1944-1951 (Pubitemid 30122859)
    • (2000) Vaccine , vol.18 , Issue.18 , pp. 1944-1951
    • Morris, C.B.1    Cheng, E.2    Thanawastien, A.3    Cardenas-Freytag, L.4    Clements, J.D.5
  • 107
    • 33749831052 scopus 로고    scopus 로고
    • 7 integrin and an effector memory phenotype
    • DOI 10.1016/j.virol.2006.06.036, PII S0042682206004351
    • Neeson P, Boyer J, Kumar S et al (2006) A DNA prime-oral Listeria boost vaccine in rhesus macaques induces a SIV-specific CD8 T cell mucosal response characterized by high levels of alpha4beta7 integrin and an effector memory phenotype. Virology 354:299-315 (Pubitemid 44559651)
    • (2006) Virology , vol.354 , Issue.2 , pp. 299-315
    • Neeson, P.1    Boyer, J.2    Kumar, S.3    Lewis, M.G.4    Mattias, L.5    Veazey, R.6    Weiner, D.7    Paterson, Y.8
  • 108
    • 33644836224 scopus 로고    scopus 로고
    • Mucosal vaccines: The promise and the challenge
    • DOI 10.1038/nri1777, PII N1777
    • Neutra MR, Kozlowski PA (2006) Mucosal vaccines: the promise and the challenge. Nat Rev Immunol 6:148-158 (Pubitemid 43361590)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.2 , pp. 148-158
    • Neutra, M.R.1    Kozlowski, P.A.2
  • 111
    • 0036692980 scopus 로고    scopus 로고
    • Protection by SIV VLP DNA prime/protein boost following mucosal SIV challenge is markedly enhanced by IL-12/GM-CSF co-administration
    • O'Neill E, Martinez I, Villinger F et al (2002) Protection by SIV VLP DNA prime/protein boost following mucosal SIV challenge is markedly enhanced by IL-12/GM-CSF co-administration. J Med Primatol 31:217-227
    • (2002) J Med Primatol , vol.31 , pp. 217-227
    • O'Neill, E.1    Martinez, I.2    Villinger, F.3
  • 112
    • 33645793093 scopus 로고    scopus 로고
    • Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal SHIVKU2 RNA levels
    • Pal R, Venzon D, Santra S et al (2006) Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal SHIVKU2 RNA levels. J Virol 80:3732-3742
    • (2006) J Virol , vol.80 , pp. 3732-3742
    • Pal, R.1    Venzon, D.2    Santra, S.3
  • 113
    • 8644256745 scopus 로고    scopus 로고
    • Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting
    • DOI 10.1128/JVI.78.23.13163-13172.2004
    • Peacock JW, Nordone SK, Jackson SS et al (2004) Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting. J Virol 78:13163-13172 (Pubitemid 39507823)
    • (2004) Journal of Virology , vol.78 , Issue.23 , pp. 13163-13172
    • Peacock, J.W.1    Nordone, S.K.2    Jackson, S.S.3    Liao, H.-X.4    Letvin, N.L.5    Yafal, A.G.6    Gritz, L.7    Mazzara, G.P.8    Haynes, B.F.9    Staats, H.F.10
  • 114
    • 17844394454 scopus 로고    scopus 로고
    • mac251 intrarectal challenge following Ad-SIV priming by multiple mucosal routes and gp120 boosting in MPL-SE
    • DOI 10.1089/vim.2005.18.236
    • Pinczewski J, Zhao J, Malkevitch N et al (2005) Enhanced immunity and protective efficacy against SIVmac251 intrarectal challenge following ad-SIV priming by multiple mucosal routes and gp120 boosting in MPL-SE. Viral Immunol 18:236-243 (Pubitemid 40586462)
    • (2005) Viral Immunology , vol.18 , Issue.1 , pp. 236-243
    • Pinczewski, J.1    Zhao, J.2    Malkevitch, N.3    Patterson, L.J.4    Aldrich, K.5    Alvord, W.G.6    Robert-Guroff, M.7
  • 115
    • 0031567923 scopus 로고    scopus 로고
    • Intranasal immunization with ctl epitope peptides from HIV-1 or ovalbumin and the mucosal adjuvant cholera toxin induces peptide-specific CTLs and protection against tumor development in vivo
    • Porgador A, Staats HF, Faiola B et al (1997) Intranasal immunization with CTL epitope peptides from HIV-1 or ovalbumin and the mucosal adjuvant cholera toxin induces peptide-specific CTLs and protection against tumor development in vivo. J Immunol 158:834-841 (Pubitemid 127492661)
    • (1997) Journal of Immunology , vol.158 , Issue.2 , pp. 834-841
    • Porgador, A.1    Staats, H.F.2    Faiola, B.3    Gilboa, E.4    Palker, T.J.5
  • 116
    • 33746829947 scopus 로고    scopus 로고
    • Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1
    • DOI 10.1016/j.vaccine.2006.04.023, PII S0264410X06004567
    • Ranasinghe C, Medveczky JC, Woltring D et al (2006) Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1. Vaccine 24:5881-5895 (Pubitemid 44173003)
    • (2006) Vaccine , vol.24 , Issue.31-32 , pp. 5881-5895
    • Ranasinghe, C.1    Medveczky, J.C.2    Woltring, D.3    Gao, K.4    Thomson, S.5    Coupar, B.E.H.6    Boyle, D.B.7    Ramsay, A.J.8    Ramshaw, I.A.9
  • 118
    • 0033864920 scopus 로고    scopus 로고
    • Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvants
    • Scharton-Kersten T, Yu J, Vassell R et al (2000) Transcutaneous immunization with bacterial ADP-ribosylating exotoxins, subunits, and unrelated adjuvants. Infect Immun 68:5306-5313
    • (2000) Infect Immun , vol.68 , pp. 5306-5313
    • Scharton-Kersten, T.1    Yu, J.2    Vassell, R.3
  • 119
    • 0033524838 scopus 로고    scopus 로고
    • Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    • Schmitz JE, Kuroda MJ, Santra S et al (1999) Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283:857-860
    • (1999) Science , vol.283 , pp. 857-860
    • Schmitz, J.E.1    Kuroda, M.J.2    Santra, S.3
  • 120
    • 0034130519 scopus 로고    scopus 로고
    • In vivo induction of a high-avidity, high-frequency cytotoxic T- lymphocyte response is associated with antiviral protective immunity
    • DOI 10.1128/JVI.74.13.5769-5775.2000
    • Sedlik C, Dadaglio G, Saron MF et al (2000) In vivo induction of a high-avidity, high-frequency cytotoxic T-lymphocyte response is associated with antiviral protective immunity. J Virol 74:5769-5775 (Pubitemid 30412943)
    • (2000) Journal of Virology , vol.74 , Issue.13 , pp. 5769-5775
    • Sedlik, C.1    Dadaglio, G.2    Saron, M.F.3    Deriaud, E.4    Rojas, M.5    Casal, S.I.6    Leclerc, C.7
  • 121
    • 0042130558 scopus 로고    scopus 로고
    • Mucosal immunization with PLGA-microencapsulated DNA primes a SIV-specific CTL response revealed by boosting with cognate recombinant modified vaccinia virus Ankara
    • DOI 10.1016/S0042-6822(03)00282-4
    • Sharpe S, Hanke T, Tinsley-Bown A et al (2003) Mucosal immunization with PLGA-microencapsulated DNA primes a SIV-specific CTL response revealed by boosting with cognate recombinant modified vaccinia virus Ankara. Virology 313:13-21 (Pubitemid 37013591)
    • (2003) Virology , vol.313 , Issue.1 , pp. 13-21
    • Sharpe, S.1    Hanke, T.2    Tinsley-Bown, A.3    Dennis, M.4    Dowall, S.5    McMichael, A.6    Cranage, M.7
  • 123
    • 0035851332 scopus 로고    scopus 로고
    • + T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector
    • DOI 10.1016/S0264-410X(01)00330-9, PII S0264410X01003309
    • Shata MT, Reitz MS Jr, DeVico AL et al (2001) Mucosal and systemic HIV-1 Env-specific CD8(F) T-cells develop after intragastric vaccination with a Salmonella Env DNA vaccine vector. Vaccine 20:623-629 (Pubitemid 32973809)
    • (2001) Vaccine , vol.20 , Issue.3-4 , pp. 623-629
    • Shata, M.T.1    Reitz Jr., M.S.2    DeVico, A.L.3    Lewis, G.K.4    Hone, D.M.5
  • 124
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • Shevach EM (2002) CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol 2:389-400 (Pubitemid 37328746)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.6 , pp. 389-400
    • Shevach, E.M.1
  • 126
    • 0041751271 scopus 로고    scopus 로고
    • Molecular mechanisms and biological significance of CTL avidity
    • Snyder JT, Alexander-Miller MA, Berzofsky JA et al (2003) Molecular mechanisms and biological significance of CTL avidity. Curr HIV Res 1:287-294
    • (2003) Curr HIV Res , vol.1 , pp. 287-294
    • Snyder, J.T.1    Alexander-Miller, M.A.2    Berzofsky, J.A.3
  • 127
    • 0030030573 scopus 로고    scopus 로고
    • Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques
    • DOI 10.1084/jem.183.1.215
    • Spira AI, Marx PA, Patterson BK et al (1996) Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques. J Exp Med 183:215-225 (Pubitemid 26028761)
    • (1996) Journal of Experimental Medicine , vol.183 , Issue.1 , pp. 215-225
    • Spira, A.I.1    Marx, P.A.2    Patterson, B.K.3    Mahoney, J.4    Koup, R.A.5    Wolinsky, S.M.6    Ho, D.D.7
  • 128
    • 0033562987 scopus 로고    scopus 로고
    • IL-1 is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens
    • Staats HF, Ennis FA Jr (1999) IL-1 is an effective adjuvant for mucosal and systemic immune responses when coadministered with protein immunogens. J Immunol 162:6141-6147 (Pubitemid 29314975)
    • (1999) Journal of Immunology , vol.162 , Issue.10 , pp. 6141-6147
    • Staats, H.F.1    Ennis Jr., F.A.2
  • 131
    • 77953118149 scopus 로고    scopus 로고
    • Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques
    • Sui Y, Zhu Q, Gagnon S et al (2010) Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques. Proc Natl Acad Sci USA 107:9843-9848
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 9843-9848
    • Sui, Y.1    Zhu, Q.2    Gagnon, S.3
  • 134
    • 34548770610 scopus 로고    scopus 로고
    • + T cell functionality and mucosal homing
    • DOI 10.1016/j.virol.2007.05.028, PII S0042682207003844
    • Tatsis N,Lin SW, Harris-McCoy K et al(2007) Multiple immunizations with adenovirus and MVA vectors improve CD8+ T cell functionality and mucosal homing. Virology 367:156-167 (Pubitemid 47432788)
    • (2007) Virology , vol.367 , Issue.1 , pp. 156-167
    • Tatsis, N.1    Lin, S.-W.2    Harris-McCoy, K.3    Garber, D.A.4    Feinberg, M.B.5    Ertl, H.C.J.6
  • 135
    • 0022647790 scopus 로고
    • Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo
    • Taylor PM, Askonas BA (1986) Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo. Immunology 58:417-420 (Pubitemid 16097640)
    • (1986) Immunology , vol.58 , Issue.3 , pp. 417-420
    • Taylor, P.M.1    Askonas, B.A.2
  • 140
    • 0035893059 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 gag-specific vaginal immunity and protection after local immunizations with sindbis virus-based replicon particles
    • DOI 10.1086/324581
    • Vajdy M, Gardner J, Neidleman J et al (2001) Human immunodeficiency virus type 1 Gag-specific vaginal immunity and protection after local immunizations with sindbis virus-based replicon particles. J Infect Dis 184:1613-1616 (Pubitemid 33139750)
    • (2001) Journal of Infectious Diseases , vol.184 , Issue.12 , pp. 1613-1616
    • Vajdy, M.1    Gardner, J.2    Neidleman, J.3    Cuadra, L.4    Greer, C.5    Perri, S.6    O'Hagan, D.7    Polo, J.M.8
  • 142
    • 0037333823 scopus 로고    scopus 로고
    • + T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection
    • DOI 10.1086/368386
    • Veazey RS, Marx PA, Lackner AA (2003) Vaginal CD4+ T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency virus infection. J Inf Dis 187:769-776 (Pubitemid 36286937)
    • (2003) Journal of Infectious Diseases , vol.187 , Issue.5 , pp. 769-776
    • Veazey, R.S.1    Marx, P.A.2    Lackner, A.A.3
  • 144
    • 33845309415 scopus 로고    scopus 로고
    • Mucosal transmission of HIV-1: First stop dendritic cells
    • DOI 10.2174/138945006779025482
    • Wilkinson J, Cunningham AL (2006) Mucosal transmission of HIV-1: first stop dendritic cells. Curr Drug Targets 7:1563-1569 (Pubitemid 44873718)
    • (2006) Current Drug Targets , vol.7 , Issue.12 , pp. 1563-1569
    • Wilkinson, J.1    Cunningham, A.L.2
  • 145
    • 39449130853 scopus 로고    scopus 로고
    • Enhanced cell surface expression, immunogenicity and genetic stability resulting from a spontaneous truncation of HIV Env expressed by a recombinant MVA
    • DOI 10.1016/j.virol.2007.10.033, PII S0042682207007313
    • Wyatt LS, Belyakov IM, Earl PL et al (2008) Enhanced cell surface expression, immunogenicity and genetic stability resulting from a spontaneous truncation of HIV Env expressed by a recombinant MVA. Virology 372:260-272 (Pubitemid 351273747)
    • (2008) Virology , vol.372 , Issue.2 , pp. 260-272
    • Wyatt, L.S.1    Belyakov, I.M.2    Earl, P.L.3    Berzofsky, J.A.4    Moss, B.5
  • 146
    • 0027183310 scopus 로고
    • Helper T cell subsets for immunoglobulin A responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues
    • Xu-Amano J, Kiyono H, Jackson RJ, Staats HF, Fujihashi K, Burrows PD, Elson CO, Pillai S, McGhee JR (1993) Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J Exp Med 178:1309-1320 (Pubitemid 23277363)
    • (1993) Journal of Experimental Medicine , vol.178 , Issue.4 , pp. 1309-1320
    • Xu-Amano, J.1    Kiyono, H.2    Jackson, R.J.3    Staats, H.F.4    Fujihashi, K.5    Burrows, P.D.6    Elson, C.O.7    Pillai, S.8    McGhee, J.R.9
  • 147
    • 0033558363 scopus 로고    scopus 로고
    • Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers
    • Yee C, Savage PA, Lee PP et al (1999) Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J Immunol 162:2227-2234 (Pubitemid 29288845)
    • (1999) Journal of Immunology , vol.162 , Issue.4 , pp. 2227-2234
    • Yee, C.1    Savage, P.A.2    Lee, P.P.3    Davis, M.M.4    Greenberg, P.D.5
  • 149
    • 0033556322 scopus 로고    scopus 로고
    • High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy
    • Zeh HJ 3rd, Perry-Lalley D, Dudley ME et al (1999) High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy. J Immunol 162:989-994 (Pubitemid 29035425)
    • (1999) Journal of Immunology , vol.162 , Issue.2 , pp. 989-994
    • Zeh III, H.J.1    Perry-Lalley, D.2    Dudley, M.E.3    Rosenberg, S.A.4    Yang, J.C.5
  • 150
    • 0032742547 scopus 로고    scopus 로고
    • Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells
    • Zhang Z-Q, Schuler T, Zupancic M et al (1999) Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells. Science 286:1353-1357
    • (1999) Science , vol.286 , pp. 1353-1357
    • Zhang, Z.-Q.1    Schuler, T.2    Zupancic, M.3
  • 152
    • 55849138791 scopus 로고    scopus 로고
    • Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines
    • Zhu Q, Egelston C, Vivekanandhan A et al (2008) Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines. Proc Natl Acad Sci USA 105:16260-16265
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16260-16265
    • Zhu, Q.1    Egelston, C.2    Vivekanandhan, A.3
  • 153
    • 76649093262 scopus 로고    scopus 로고
    • Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice
    • Zhu Q, Egelston C, Gagnon S et al (2010) Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice. J Clin Invest 120:607-616
    • (2010) J Clin Invest , vol.120 , pp. 607-616
    • Zhu, Q.1    Egelston, C.2    Gagnon, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.