Novel vaccination protocol with two live mucosal vectors elicits strong cell-mediated immunity in the vagina and protects against vaginal virus challenge

Journal of Immunology

Volumn 180, Issue 4, 2008, Pages 2504-2513

  Li, Zhongxia ^a   Zhang, Manxin ^a   Zhou, Chenghui ^a   Zhao, Xinyan ^a   Iijima, Norifumi ^b   Frankel, Fred R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; DNA VACCINE; GAG PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; LIVE VACCINE;

ADENOVIRUS 5; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROTECTION; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG ADMINISTRATION; EFFECTOR CELL; FEMALE; HETEROSEXUALITY; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; IMMUNIZATION; IN VIVO STUDY; INNATE IMMUNITY; LAMINA PROPRIA; LISTERIA MONOCYTOGENES; MEMORY CELL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEXUAL TRANSMISSION; SPLEEN; VACCINATION; VACCINIA; VAGINA MUCOSA; VIRUS ATTENUATION; VIRUS RECOMBINANT; VIRUS TYPING; ANIMAL; BACILLUS SUBTILIS; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; GENE VECTOR; GENETICS; IMMUNOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; MUCOSA; ORAL DRUG ADMINISTRATION; VAGINA DISEASE; VIROLOGY;

ADMINISTRATION, ORAL; AIDS VACCINES; ANIMALS; BACILLUS SUBTILIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GENETIC VECTORS; HIV-1; IMMUNITY, CELLULAR; IMMUNIZATION, SECONDARY; INJECTIONS, INTRAPERITONEAL; LISTERIA MONOCYTOGENES; MICE; MICE, INBRED BALB C; MUCOUS MEMBRANE; VACCINES, ATTENUATED; VAGINAL DISEASES;

EID: 42149106252     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.4.2504     Document Type: Article

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