Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques

Journal of Experimental Medicine

Volumn 183, Issue 1, 1996, Pages 215-225

  Spira, Alexander I ^a   Marx, Preston A ^a   Patterson, Bruce K ^b   Mahoney, James ^c   Koup, Richard A ^a   Wolinsky, Steven M ^b   Ho, David D ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS INFECTION; RHESUS MONKEY; SEXUAL TRANSMISSION; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS DETECTION; VIRUS TRANSMISSION;

EID: 0030030573     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.1.215     Document Type: Article

References (46)

1. Padian, N., S. Shibosky, and N. Jewell. 1991. Female to male transmission of human immunodeficiency virus. JAMA. 266: 1664-1667.
2. Miller, C., J. McGhee, and M. Gardner. 1992. Mucosal immunity, HIV transmission, and AIDS. Lab. Invest. 68:129-145.
3. Zhu, T., H. Mo, N. Wang, D.S. Nam, Y. Cao, R.A. Koup, and D.D. Ho. 1993. Genotypic and phenotypic characterization of HIV-1 in patients with primary infection. Science (Wash. DC). 261:1179-1181.
4. Wolinsky, S.M., C. Wike, B. Korber, C. Hutto, W. Parks, L. Rosenblum, K. Kunstman, M. Furtado, and J. Munoz. 1992. Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants. Science (Wash. DC). 255:1134-1137.
5. Zhu, T., N. Wang, A. Carr, D.S. Nam, D.A. Cooper, and D.D. Ho. 1996. Genetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmission. J Virol. In press.
6. Roos, M., J. Lange, R. DeGoede, R. Couthino, P. Schelekens, F. Miedema, and M. Tersmette. 1992. Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection. J. Infect. Dis. 165:427-432.
7. Cornelissen, M., G. Mulder-Kampigna, J. Veenstra, F. Zorgdrager, C. Kuiken, S. Hartman, J. Dekker, L. van der Hoek, C. Sol, R. Coutinho, and J. Goudsmit. 1995. Syncytium-inducing SI phenotype suppression at seroconversion after intramuscular inoculation of a non-syncytium inducing/Si phenotypically mixed human immunodeficiency virus population. J. Virol. 69:1810-1818.
8. Zhang, L., P. Mackenzie, A. Cleland, E. Holmes, A. Leigh Brown, and P. Simmonds. 1993. Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection. J. Virol. 67: 3345-3356.
9. Cann, A., M. Churcher, M. Boyd, W. O'Brien, J. Zhao, J. Zack, and I. Chen. 1992. The region of the envelope gene of human immunodeficiency virus type 1 responsible for determination of cell tropism. J. Virol. 66:305-309.
10. Shioda, T., J. Levy, and C. Cheng-Mayer. 1991. Macrophage and T-cell line tropisms are determined by specific regions of the envelope gp120 gene. Nature (Lond.). 349:167-169.
11. Clark, S.J., M.S. Saag, W.D. Deker, S. Campell-Hill, J.L. Roberson, P.J. Veldkamp, J.C. Kappes, B.H. Hahn, and G.M. Shaw. 1991. High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection. N. Engl. J. Med. 324:954-960.
12. Daar, E., T. Moudgil, R. Meyer, and D.D. Ho. 1991 Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N. Engl. J. Med. 324:961-964.
13. Koup, R.A., J.T. Safrit, Y. Cao, C. Andrews, G. McLeod, W Borkowsky, C. Farthing, and D.D. Ho. 1994. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 68:4659-4665.
14. Wei, X., S.K. Ghosh, M.E. Taylor, V.A. Johnson, E. Emini, P. Deutsch, J.D. Lifson, S. Bonhoeffer, M.A. Nowak, B. Hahn, et al. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature (Lond.). 373:117-122.
15. Ho, D.D., A.U. Neumann, A.S. Perelson, W. Chen, J. Leonard, and M.H. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nantte (Lond.). 373:123-126.
16. Braathen, L., G. Ramirez, R. Hunze, and H. Gelderbloom. 1987. Langerhans cells as primary target cells for HIV infection. Lancet 2:1094.
17. + T-cells. Science (Wash. DC). 257.383-387.
18. Nuovo, G.J., A. Forde, P. MacConnell, and R. Fahrenwald. 1993. In situ detection of PCR-amplified HIV-1 nucleic acids and tumor necrosis factor cDNA in cervical tissues. Am. J. Pathol. 143:40-48.
19. Miller, C.J., N.J. Alexander, S. Sutjipto, A.A. Lackner, A. Gettie, A.G. Hendrickx, L.J. Lowenstine, M. Jennings, and P.A. Marx. 1989. Genital mucosal transmission of simian immunodeficiency virus: animal model for heterosexual transmission of human immunodeficiency virus. J. Virol. 63:4277-4284.
20. Miller, C.J., N.J. Alexander, P. Vogel, J. Anderson, and P.A. Marx. 1992. Mechanism of genital transmission of SEV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques. J. Med. Primatol. 21:64-68.
21. Miller, C.J., M. McChesney, and P.P. Moore. 1992. Langerhans cells, macrophages, and lymphocyte subsets in the cervix and vagina of rhesus macaques. Lab. Invest. 67:628-634.
22. Desrosiers, R.C. 1990. The simian immunodeficiency viruses Annu. Rev. Inmunol. 8:557-578.
23. Letvin, N.L., M.D. Daniel, P.K. Sehgal, R.C. Desrosiers, R.D. Hunt, L.M. Waldron, D.K. MacKoy, D.K. Schmidt, L.V. Chalifoux, and N.W. King. 1985. Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. Science (Wash. DC). 230:71-73.
24. Daniel, M.D., N.L. Lervin, N.W. King, M. Kannagi, P.K. Sehgal, R.D. Hunt, P.J. Kanki, M. Essex, and R.C. Desrosiers. 1985. Isolation of T-cell tropic virus HTLV-III like retrovirus from macaques. Science (Wash. DC). 228:1201-1204.
25. Dulbecco, R. 1988. End-point method measurement of the infectious titer of a viral sample. In Virology. 2nd ed. R. Dulbecco and H. Ginsberg, editors. J. B. Lippincott, Philadelphia, PA. 22-25.
26. Lohman, B., J. Higgins, M. Marthas, P.A. Marx, and N. Pederson. 1991. Development of simian immunodeficiency virus isolation, titration, and neutralization assays which use whole blood from rhesus monkeys and an antigen capture enzyme-linked immunosorbent assay. J. Clin. Microbiol. 29:2187-2192.
27. Hoxie, J., B. Haggarty, S. Bonser, J. Rackowski, H. Snah, and P. Kanki. 1988. Biological characterization of a simian immunodeficiency virus-like retrovirus HTLV-IV: evidence for CD4-associated molecules required for infection. J. Virol 62:2557-2568.
28. Moore, J.P., and Q.J. Sattentau. 1993. Detecting SIV gp120 and its interaction with soluble CD4 by ELISA. AIDS Res. Hum. Retroviruses. 9:1297-1299.
29. Kellogg, D., and S. Kwok. 1990. Detection of human immunodeficiency virus. In PCR Protocols. M. Innis, D. Gelfind, J. Sninsky, and T. White, editors. Academic Press, San Diego, CA. 337-347.
30. + T-cell immune responses induced by dendritic cells. Immunology. 85:467-474.
31. Yamashiro-Matsmura, S., and F. Matsamura. 1985. Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells. J. Biol. Chem. 260:5087-5097.
32. Clark, G. 1981. Staining Procedures, 4th ed. Williams and Wilkms, Baltimore, MD. 20-30.
33. Patterson, B.K., M. Till, P. Otto, C. Goolsby, M.R. Furtado, L.J. McBride, and S.M. Wolinsky. 1993. Detection of HIV-1 DNA and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry. Science (Wash. DC). 260.976-979.
34. Korber, B.T.M., K.J. Kunstman, B.K. Patterson, M. Furtado, M.M. Mcevilly, R. Levy, and S.M. Wolinsky. 1994. Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1 infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences. J. Virol. 68:7467-7481.
35. Pope, M.J., M.G.H. Betjes, N. Romani, H. Hirmand, P.U. Cameron, L. Hoffmann, S. Gezelter, G. Schuler, and R M. Steinman. 1994. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell. 78:389-398.
36. Hartmann, C. 1933. The Anatomy of the Rhesus Monkey. Hafner Publishing, New York. 259-260.
37. Roitt, I., J. Brostoff, and D. Male. 1989. Immunology. Gower Medical Publishing, London. 2.05-2.13.
38. Niedecken, H., G. Lutz, R. Bauer, and H. Kreysel. 1987. Langerhans cells as primary target and vehicle for transmission of HIV. Lancet 2:519-520.
39. Junquiera, L.C., J. Carniero, and R.O. Kelley. 1989. Basic Histology. 6th edition. Appleton and Lange, Norwalk, CT. 20-30.
40. Amerongen, H., R. Weltzin, C. Farnet, P. Michetti, W. Haseltine, and M. Neutra. 1991. Transepithelial transport of HIV-1 by intestinal M-cells: a mechanism for transmission of AIDS. J. Acquir. Immune Defic. Syndr. 4:760-765.
41. Tyler, K., and B. Fields. 1990. Pathogenesis of viral infections. In Field's Virology. 2nd edition. Raven Press, New York. 191-239.
42. Pavli, P., D. Hume, E. Van de Pol, and W. Doe. 1993. Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria. Immunology. 78:132-141.
43. Marx, P.A., R. Compans, A. Gettie, J. Staas, R. Gilley, M. Mulligan, G. Yamschikov, D. Chen, and J. Eldridge. 1993. Protection against vaginal SIV transmission with a microencapsulated vaccine. Science (Wash. DC). 260:1323-1327.
44. Miller, C.J., N.J. Alexander, S. Sutjipto, S. Joye, A.G. Hendrickx, M. Jennings, and P.A. Marx. 1990. Effect of viral dose and nonoxynol-9 on the genital transmission of SIV in rhesus macaques. J. Med. Primatol. 19:401-409.
45. Miller, C.J., M. Marthas, J. Torten, N.J. Alexander, J.P. Moore, G. Doncel, and A. Hendrickx. 1994. Intravaginal inoculation of rhesus macaques with cell free simian immunodeficiency virus results in persistent or transient viremia. J. Virol. 68:6391-6400.
46. Daniel, M.D., F. Kirchhoff, S.C. Czajak, P.K. Sehgal, and R.C. Desrosiers. 1992. Protective effects of a live attenuated vaccine with a deletion in the nef gene. Science (Wash. DC). 258.1938-1941.