Activating CTL precursors to reveal CTL function without skewing the repertoire by in vitro expansion

European Journal of Immunology

Volumn 31, Issue 12, 2001, Pages 3557-3566

  Belyakov, Igor M ^a   Wang, Jian ^b   Koka, Rima ^a   Ahlers, Jeffrey D ^a   Snyder, James T ^a   Tse, Richard ^a   Cox, Josephine ^c   Gibbs, James S ^b   Margulies, David H ^b   Berzofsky, Jay A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

Author keywords

Cellular activation; CTL; Flow cytometry; T cell receptor; T lymphocyte

Indexed keywords

CD8 ANTIGEN; MONOCLONAL ANTIBODY; PEPTIDE; T LYMPHOCYTE RECEPTOR; TETRAMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOTOXIC LYMPHOCYTE; IN VITRO STUDY; INCUBATION TIME; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; PROTEIN ANALYSIS; STAINING; T LYMPHOCYTE ACTIVATION;

ANIMALS; FEMALE; HEMATOPOIETIC STEM CELLS; HIV ENVELOPE PROTEIN GP160; HIV-1; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035660369     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200112)31:12<3557::AID-IMMU3557>3.0.CO;2-O     Document Type: Article

References (30)

1. HIV-specific cytotoxic T lymphocytes in seropositive individuals
2. Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge
3. Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific cytotoxic T lymphocytes
4. HIV type 1 vaccine-induced cytotoxic T cell responses in phase I clinical trials: Detection, characterization, and quantitation
5. Evaluation of cytotoxic T-lymphocyte responses in human and nonhuman primate subjects infected with human immunodeficiency virus type 1 or Simian/Human immunodeficiency virus
6. Phenotypic analysis of antigen-specific T lymphocytes
7. TAP-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino but not carboxy terminus of the peptide
8. Preferential Vb usage by cytotoxic T cells crossreactive between two epitopes of HIV-1 gp160 and degenerate in class I MHC restriction
9. Role of antigen, CD8, and cytotoxic T lymphocyte avidity in high dose antigen induction of apoptosis of effector CTL
10. Transient alteration of T cell fine specificity by a strong primary stimulus correlates with T cell receptor down-regulation
11. The T cell receptor Vb repertoire in HIV-1 infection and disease
12. Tumor-specific immune response: Current in vitro analyses may not reflect the in vivo immune status
13. A kinetic basis for T cell receptor repertoire selection during an immune response
14. Accessing complexity: The dynamics of virus-specific T cell responses
15. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
16. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers
17. Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent
18. Direct ex vivo kinetic and phenotypic analyses of CD8(+) T cell responses induced by DNA immunization
19. Cytotoxic T lymphocytes in HIV infection
20. The importance of mucosal CTL vs systemic CTL in reducing viral load after intrarectal challenge of rhesus macaques with pathogenic SHIV
21. Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus Ankara boost regimen
22. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
23. Antibodies directed against the MHC-I molecule H-2Dd complexed with an antigenic peptide: Similarities to a T cell receptor with the same specificity
24. Competitive inhibition in vivo and skewing of the T cell repertoire of antigen-specific CTL priming by an anti-peptide-MHC mAb
25. Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus
26. An immunodominant epitope of the HIV gp160 envelope glycoprotein recognized by class I MHC molecule-restricted murine cytotoxic T lymphocytes
27. Vaccinia virus expression vector: Coexpression of β-galactosidase provides visual screening of recombinant virus plaques
28. Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunity
29. Induction of mucosal CTL response by intrarectal immunization with a replication-deficient recombinant vaccinia virus expressing HIV 89.6 envelope protein
30. + cytotoxic T lymphocytes for resistance to mucosal-viral transmission in mice and enhancement of resistance by local administration of IL-12